Metformin, Heart Failure, And Lactic Acidosis: Is Metformin Absolutely Contraindicated?
Many patients with type 2 diabetes are denied treatment with metformin because of “contraindications” such as cardiac failure, which may not be absolute contraindications Summary points Treatment with metformin is not associated with an increased risk of lactic acidosis among patients with type 2 diabetes mellitus who have no cardiac, renal, or liver failure Despite increasing disregard of contraindications to metformin by physicians, the incidence of lactic acidosis has not increased, so metformin may be safe even in patients with “contraindications” The vast majority of case reports relating metformin to lactic acidosis report at least one other disease/illness that could result in lactic acidosis Use of metformin in patients with heart failure might be associated with lower mortality and morbidity, with no increase in hospital admissions and no documented increased risk of lactic acidosis Further studies are needed to assess the risk of lactic acidosis in patients with type 2 diabetes and traditional contraindications to metformin Metformin first became available in the United Kingdom in 1957 but was first prescribed in the United States only in 1995.w1 The mechanism of action has been extensively reviewed.w2 w3 The UK prospective diabetes study showed that metformin was associated with a lower mortality from cardiovascular disease than sulphonylureas or insulin in obese patients with type 2 diabetes mellitus.1 It was also associated with reduced all cause mortality, which was not seen in patients with equally well controlled blood glucose treated with sulphonylureas or insulin.1 Despite the evidence base for the benefits of metformin, concerns remain about its side effects and especially the perceived risk of lactic acidosis in the presence of renal, hepatic Continue reading >>
Drug information provided by: Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Abdominal or stomach discomfort cough or hoarseness decreased appetite diarrhea fast or shallow breathing fever or chills general feeling of discomfort lower back or side pain muscle pain or cramping painful or difficult urination sleepiness Less common Anxiety blurred vision chest discomfort cold sweats coma confusion cool, pale skin depression difficult or labored breathing dizziness fast, irregular, pounding, or racing heartbeat or pulse feeling of warmth headache increased hunger increased sweating nausea nervousness nightmares redness of the face, neck, arms, and occasionally, upper chest seizures shakiness shortness of breath slurred speech tightness in the chest unusual tiredness or weakness wheezing Rare Behavior change similar to being drunk difficulty with concentrating drowsiness lack or loss of strength restless sleep unusual sleepiness Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Acid or sour stomach belching bloated excess air or gas in the stomach or intestines full feeling heartburn indigestion loss of appetite metallic taste in the mouth passing of gas stomachache stom Continue reading >>
What Are The Side Effects Of Metformin?
Metformin is prescribed for people with type 2 diabetes. Like any medication, it carries the risk of side effects. The most common side effects from metformin include nausea, diarrhea, gas and upset stomach. These are most likely when you first start taking it and usually go away on their own. Until they do, you should try to take your metformin with a meal. You can also try reducing the amount you take for a few days and gradually increasing it until you’ve reached the amount your doctor has prescribed for you. Lactic acidosis is a very rare -- but very serious -- side effect. It happens most often in people with liver, kidney or respiratory diseases. Call your doctor right away if you have any of these symptoms of lactic acidosis: weakness, stomach pain or discomfort, fast and shallow breathing, sleepiness and muscle cramping. Although metformin doesn’t cause hypoglycemia by itself, if combined with other medications, vigorous exercise or too little food, it can make your blood glucose drop too low. Since low blood glucose can be dangerous, make sure that you and your family know the symptoms. These include feeling shaky, sweaty, hungry, and irritable. If you have these symptoms, take some quick-acting sugar. Good sources are three or four glucose tablets, a half-cup of fruit juice or regular soda, or a tablespoon of honey or sugar. You should call your doctor if you have side effects that don’t go away or if you have any symptoms of lactic acidosis. Metformin (prescribed to treat type 2 diabetes) can cause excessive gas and bloating, heartburn, headaches, a cough, muscle pain and a metallic taste in the mouth, but these side effects typically ease after a few weeks. Very rarely, metformin may cause a serious condition called lactic acidosis. Key signs include w Continue reading >>
Will You Have Nasal Congestion With Metformin - From Fda Reports - Ehealthme
Care Guide for people who have Cisc and Madura Foot NOTE: The study is based on active ingredients and brand name. Other drugs that have the same active ingredients (e.g. generic drugs) are NOT considered. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only, and has not been supported by scientific studies or clinical trials unless otherwise stated. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk. You may report adverse side effects to the FDA at or 1-800-FDA-1088 (1-800-332-1088). If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Continue reading >>
Side Effects Of Metformin: What You Should Know
Metformin is a prescription drug used to treat type 2 diabetes. It belongs to a class of medications called biguanides. People with type 2 diabetes have blood sugar (glucose) levels that rise higher than normal. Metformin doesn’t cure diabetes. Instead, it helps lower your blood sugar levels to a safe range. Metformin needs to be taken long-term. This may make you wonder what side effects it can cause. Metformin can cause mild and serious side effects, which are the same in men and women. Here’s what you need to know about these side effects and when you should call your doctor. Find out: Can metformin be used to treat type 1 diabetes? » Metformin causes some common side effects. These can occur when you first start taking metformin, but usually go away over time. Tell your doctor if any of these symptoms are severe or cause a problem for you. The more common side effects of metformin include: heartburn stomach pain nausea or vomiting bloating gas diarrhea constipation weight loss headache unpleasant metallic taste in mouth Lactic acidosis The most serious side effect metformin can cause is lactic acidosis. In fact, metformin has a boxed warning about this risk. A boxed warning is the most severe warning from the Food and Drug Administration (FDA). Lactic acidosis is a rare but serious problem that can occur due to a buildup of metformin in your body. It’s a medical emergency that must be treated right away in the hospital. See Precautions for factors that raise your risk of lactic acidosis. Call your doctor right away if you have any of the following symptoms of lactic acidosis. If you have trouble breathing, call 911 right away or go to the nearest emergency room. extreme tiredness weakness decreased appetite nausea vomiting trouble breathing dizziness lighthea Continue reading >>
Is Nasal Congestion A Side Effect Of Metformin ? ( Factmed.com )
Introduction This page is designed to help you determine the relationship, if any, between METFORMIN and NASAL CONGESTION. In doing so, we compare METFORMIN with other drugs that cause NASAL CONGESTION, to help you evaluate whether or not METFORMIN causes NASAL CONGESTION. Likewise, this page shows the most highly-reported side effects of METFORMIN, so you can see if NASAL CONGESTION ranks among METFORMIN's most well-known side effects. Reports of METFORMIN causing NASAL CONGESTION: 73 Reports of any side effect of METFORMIN : 22852 Percentage of METFORMIN patients where NASAL CONGESTION is a reported side effect: 0.3194% FDA reports of any drug causing NASAL CONGESTION : 9679 Average percentage for all medicated patients where NASAL CONGESTION is reported as a complication: 0.0607% Physician opinion on METFORMIN as adverse event culprit: Overall opinion for all reports of this drug: Most frequent diagnoses/indications for prescribing METFORMIN: TYPE 2 DIABETES MELLITUS ( 1542 patients ) PRODUCT USED FOR UNKNOWN INDICATION ( 1149 patients ) DRUG USE FOR UNKNOWN INDICATION ( 736 patients ) DIABETES MELLITUS NON-INSULIN-DEPENDENT ( 264 patients ) GLUCOSE TOLERANCE IMPAIRED ( 90 patients ) Is Metformin safe if you already have Macular Degeneration? I definately think Metformin (after about 6 years of use -2 500 mg tabs in AM/PM) have started to cause problems with my connective tissues. First it was Achilles tendonitis and now what seems like Tennis or Golfers elbow. Even my wrist have been hurting. I have done nothing to injure these areas. Also after running, I can tell I have muscle tears in my calves. I don't think people realize how Metformin really affects the whole body. I also was extremely B-12 deficient and anemic due to Metformin. I have to convince my Endocrin Continue reading >>
Metformin Side Effect
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community i am now on my second week of metformin, week 1 was 1 500mg each day. week 2 is 2 x 500mg per day. i have been experiencing sickness, diarreah, headaches, dizzy spells/lightheadness, racing heart, dry mouth. has anyone else experienced this amount of side effects?? i have been reading the other posts and see that some are experience one or two side effects, but i seem to have a few, should i be concerned or try and ride it out? im not trying to be wimpish and one good thing is i seem to have lost about 4lb since taking the metformin! I only had dry mouth and unusually, constipation. The constipation was easily delt with but the dry mouth, mainly at night persists. I had headaches in the early days and also felt dizzy a few times now you mention it! The good news is you just stick with it for at least a month and things settle down, apart from the damned dry mouth at night that is. If it has not settled down after a month or so ask your doc for the extended release version, more expensive but gentler on your system. My advice would be dont wait a month tell your GP or DN how bad you feel you dont need to put up with this .The SR metformin are more expensive than the usual met that they give you at first .Thats why you get them. I found that if I kept sipping water during the day that I didn't get headaches and didn't feel so dizzy. They seem to cause a bit of dehydration with me so lots of water is good (helps the constipation factor too). When I was first diagnosed with type 2 (6 years ago now) I was put onto metformin SR and gliclazide. These did seem to control the sugar levels but I didn't lose any weight. Eventually I was taking 4 metform SR and h Continue reading >>
Metformin And Sinuses
If this is your first visit, be sure tocheck out the FAQ by clicking thelink above. You may have to register before you can post: click the register link above to proceed. To start viewing messages,select the forum that you want to visit from the selection below. Anyone notice an increase in your sinus problems while taking metformin? I have been on it twice and each time I have sinus issues..ugh. Actually I've had sinus problems lately (never had sinus problems ever in my life) and just linked it to the colder weather but perhaps it is my Met? ------------------------------------------------------------------------------------------- Tracking calories & exercising - no gimmicks or diets! I don't know but to get a sinus infection each time I start metformin again is just weird. that and I am so tired on it. I just started Met not even a week ago and have had a non-stop headache ever since. I went to the doc today because I just couldn't live like this anymore. She insists it is not the Met but thinks it is a sinus infection. She started me on a prescription to get rid of the infection that I started when I woke up tonight to go to work. Anyways I hope the medication works!! Pregnant through IVF with #1 after TTC since 2005!! Continue reading >>
Another Q About Metformin
Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. Does taking Metformin cause chest/sinus congestion? Just wondering because it's the only new med I'm taking and I'm sneezing up mucous ever-so-often. It could be something else, but was just curious if there is a link. Does taking Metformin cause chest/sinus congestion? Just wondering because it's the only new med I'm taking and I'm sneezing up mucous ever-so-often. It could be something else, but was just curious if there is a link. I've also wondered about sinus congestion while taking metformin. Seems like I have had so much congestion and I have been on the metformin for some years now. I asked my endo but she never did answer me to my satisfaction. Please, if someone knows or can find out about this, keep us updated. Thank you Have no idea and have not heard of that affect from met. However my sinus/bronchial congestion have increased since about four weeks into the cotton falling. Since then we have had the wheat harvest, which throws up a lot of the pollen that showed up during the spring. The last couple of weeks they have been burning off those wheat fields and that puts up a lot of irritants the harvest missed. Oh, yes I have even smelled rag weed on and off for the last 3 weeks. When I was dx'd, I was told that since I now have diabetes everything will now affect me tenfold. So this might be why your now noticing it and not in the previous years. I've been on Met for the last 4 months and never had a cold or congestion. I haven't seen this as a side-effect of met. May be its a coincidence ? I'm a type 1 pumper, also taking Metformin (5 years) and can't say it attributes to any ches Continue reading >>
Metformin/rosiglitazone Side Effects In Detail - Drugs.com
Applies to metformin / rosiglitazone: oral tablet The most commonly reported adverse reports included upper respiratory tract infections, injury, and headache.[ Ref ] Very common (10% or more): Hypoglycemia (12%) Common (1% to 10%): Hypercholesterolemia, hyperlipidemia Common (1% to 10%): Hypoglycemia (8%), hypercholesterolemia Frequency not reported: Increases in waist and hip circumference Very rare (less than 0.01%): Lactic acidosis[ Ref ] The mechanism of weight gain is unclear, although it probably is due to a combination of fluid retention and fat accumulation. In the ADOPT monotherapy trial, the median weight change with rosiglitazone at 4 years was plus 3.5 kg; with metformin it was a weight loss of 2.4 kg. In drug-naive patients, no overall change in median weight was observed in clinical trials.[ Ref ] Overall data from rosiglitazone long-term trials including the RECORD, ADOPT, and DREAM trials (rosiglitazone n=6311; control n=7756) showed no difference in overall mortality or major adverse cardiovascular events; however, a meta-analysis of shorter-term trials suggests and increased risk for myocardial infarction with rosiglitazone compared with placebo. The RECORD trial (Rosiglitazone evaluated for Cardiac Outcomes and Regulation of Glycemia in Diabetes; mean age 58 years; 52% male) revealed no significant difference in cardiovascular hospitalization or cardiovascular death (primary outcome) among patients with type 2 diabetes receiving rosiglitazone add-on therapy (n=2220) compared with active control (n=2227); however, there was a significant difference in the incidence of CHF (secondary endpoint). In this trial, patients who had failed metformin or sulfonylurea monotherapy were randomized to add-on rosiglitazone or active control (add-on metformin for th Continue reading >>
Metformin Side Effects Or Just A Cold!
Hey fellow diabetics. Hope all are doing ok and keeping your bg in a good range. I am still fairly new at this and still have lots of questions. I have been taking metformin faithfully now for about a wk and half. About 4 days ago my throat started getting sore and now i've got a headache - which i never get headaches. My nose is a little stuffy - but it's my throat that's hurting the most. Would metformin do this? Thank you all for your help. It so nice to be able to turn to someone that knows what I'm going thru. angie I'm also suffering from cold/flulike symptoms. I think a lot of germs are floating around. Usually the side effects of metformin are more stomach related. Some do get headaches. If you have started limiting your carbs, it could be your body getting use to low carb. They actually call it the Atkins flu. But it may just be a cold from the changing weather. D.D. Family diabetic since 1997, on insulin 2000 Hey fellow diabetics. Hope all are doing ok and keeping your bg in a good range. I am still fairly new at this and still have lots of questions. I have been taking metformin faithfully now for about a wk and half. About 4 days ago my throat started getting sore and now i've got a headache - which i never get headaches. My nose is a little stuffy - but it's my throat that's hurting the most. Would metformin do this? Thank you all for your help. It so nice to be able to turn to someone that knows what I'm going thru. angie Could be spring allergies. Here in siberia when the snow melts you get to enjoy grass mold for a week or two my favorite female is still in bed not feeling the best. Continue reading >>
Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have kidney disease. Your doctor will probably tell you not to take metformin. Also, tell your doctor if you are over 65 years old and if you have ever had a heart attack; stroke; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency medical treatment); a coma; or heart or liver disease. Taking certain other medications with metformin may increase the risk of lactic acidosis. Tell your doctor if you are taking acetazolamide (Diamox), dichlorphenamide (Keveyis), methazolamide, topiramate (Topamax, in Qsymia), or zonisamide (Zonegran). Tell your doctor if you have recently had any of the following conditions, or if you develop them during treatment: serious infection; severe diarrhea, vomiting, or fever; or if you drink much less fluid than usual for any reason. You may have to stop taking metformin until you recover. If you are having surgery, including dental surgery, or any major medical procedure, tell the doctor that you are taking metformin. Also, tell your doctor if you plan to have any x-ray procedure in which dye is injected, especially if you drink or have ever drunk large amounts of alcohol or have or have had liver disease or heart failure. You may need to stop taking metformin before the procedure and wait 48 hours to restart treatment. Your doctor will tell you exactly when you should stop taking metformin and when you should start taking it again. If you experience any of the following symptoms, stop taking metformin and call your doctor immediately: extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizzi Continue reading >>
Metformin Hcl Side Effects By Likelihood And Severity
are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>
The Management Of Severe Nasal Congestion
The management of severe nasal congestion A 35yr old obese diabetic on metformin and sulfonylurea combination developed severe nasal congestion for which taken nasal steroid but not get relieved what drug should be prescribed for instant relief? Should steroids b stopped? It is unusual for nasal congestion not to at least partially respond to the regular use of intranasal steroids. Failure to do so could be due to at least three potential causes: Non-adherence to the prescribed dosing regimen. A structural abnormality blocking the nasal passage. Based on these potential causes, a suggested strategy of approach would be the following: As best you can, assure that the patient has been complying with the use of nasal steroids on a daily basis at the prescribed level. I am assuming also that they have been using the steroids regularly for at least two weeks since it may take that long for maximum response to occur. I think it is extremely important for you to determine whether or not a structural abnormality might be the cause of the persistent nasal obstruction. An endoscopic examination could be utilized looking for structures such as nasal polyps that could be causing a nonresponsive mechanical obstruction. You may miss such with a simple anterior exam of the nasal cavity. A CT scan of the nasal structures and sinus may also be of help in this regard. With the above two possibilities ruled out, further intensification of the medical therapy can be instituted without the risk of missing the failure of the patient to adhere or the presence of a structural abnormality. Normally in this type of situation, I would administer a brief course of oral corticosteroids (e.g., a 10 day taper beginning at 40 mg of prednisone or its equivalent). However, if you feel uncomfortable doi Continue reading >>
Can Metformin Cause Nasal Congestion?
Pepcid vs. Prilosec Vestura vs. Yaz Rephresh Pro B Side Effects Lacri Lube Alternative Primolut N Weight Gain Treato does not review third-party posts for accuracy of any kind, including for medical diagnosis or treatments, or events in general. Treato does not provide medical advice, diagnosis or treatment. Usage of the website does not substitute professional medical advice. The side effects featured here are based on those most frequently appearing in user posts on the Internet. The manufacturer's product labeling should always be consulted for a list of side effects most frequently appearing in patients during clinical studies. Talk to your doctor about which medications may be most appropriate for you. The information reflected here is dependent upon the correct functioning of our algorithm. From time-to-time, our system might experience bugs or glitches that affect the accuracy or correct application of mathematical algorithms. We will do our best to update the site if we are made aware of any malfunctioning or misapplication of these algorithms. We cannot guarantee results and occasional interruptions in updating may occur. Please continue to check the site for updated information. Continue reading >>