Yet Another Problem With Januvia
UPDATE (April 2, 2013): Before you take Byetta, Victoza, Onglyza, or Januvia please read about the new research that shows that they, and probably all incretin drugs, cause severely abnormal cell growth in the pancreas and precancerous tumors. You'll find that information HERE. Update (January, 2009) : A much more important problem with Januvia--that it promotes cancer by inhibiting a tumor suppressor gene researchers have called "the trigger for prostate cancer"--is discussed in this more recent blog post: More Research Shows Januvia and Glinides Inhibit Tumor Suppressor Gene DPP-4. Posted Dec 8, 2008. Original Post: If you have had or might get melanoma, ovarian cancer, lung cancer or prostate cancer, please read the above post before making your decision about whether Januvia is for you. Here is the original post that was posted 9/12/08: I have been hearing from people about a new, and, to me, very troubling problem with Januvia. The problem is this: now that doctors have decided that all people recently diagnosed with Type 2 Diabetes should be put on Januvia, prescriptions for the combination drug Janumet, which is made up of both Januvia and Metformin, are becoming much more frequent as a first prescription for diabetes. Metformin is a very safe drug that has been used safely for decades. The most recent follow up to the UKPDS study, the 20 year follow-up, which was just presented at the annual EASD conference found that at 20 years after the start of the study, "Patients treated with metformin had a 21% reduction in risk of any diabetes endpoint (P=0.01), a 30% reduction in risk of diabetes-related death (P=0.01), a 33% reduction in risk of MI (P=0.005), and a 27% reduction in risk of all cause mortality (P=0.002)." Metformin is a very good drug for people with Ty Continue reading >>
Januvia Side Effects Center
Januvia (sitagliptin) is an oral diabetes medicine for people with type 2 diabetes (non-insulin-dependent) diabetes. Januvia is sometimes used in combination with other diabetes medications, but is not for treating type 1 diabetes. Many people using Januvia do not have serious side effects. Side effects that may occur with Januvia include: headache, joint or muscle pain, nausea, stomach pain, diarrhea, or constipation. Although Januvia by itself usually does not cause low blood sugar (hypoglycemia), low blood sugar may occur if Januvia is prescribed with other anti-diabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. Tell your doctor if you have serious side effects of Januvia including pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, fast heart rate), urinating less than usual or not at all, swelling, weight gain, shortness of breath, or severe skin reaction (fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads [especially in the face or upper body] and causes blistering and peeling). The recommended dose of Januvia is 100 mg once daily. Januvia may interact with digoxin, probenecid, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfa drugs, monoamine oxidase inhibitors (MAOIs), or beta-blockers. Tell your doctor all prescription and over-the-counter medications you use. During pregnancy Januvia should be used only when prescribed. Pregnancy may cause or worsen diabetes. Your doctor may change your diabetes treatment during pregnancy. It is unknown if this drug passes into breast milk. Cons Continue reading >>
Sitagliptin For Diabetes Januvia
Take sitagliptin tablets once a day. Remember to follow any advice you have been given about your diet. The most common side-effects are feeling sick (nausea), headache, and nose or throat infections. About sitagliptin Type of medicine An antidiabetic medicine Used for Adults with type 2 diabetes mellitus Also called Januvia®; Janumet® (a combination tablet containing sitagliptin with metformin) Available as Tablets Insulin is a hormone which is made naturally in your body, in the pancreas. It helps to control the levels of sugar in your blood. If your body does not make enough insulin, or if it does not use the insulin it makes effectively, this results in the condition called sugar diabetes (diabetes mellitus). People with diabetes need treatment to control the amount of sugar (glucose) in their blood. This is because good control of blood glucose levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but, for other people, medicines like sitagliptin are given alongside the changes in diet. Sitagliptin works in part by increasing the amount of insulin produced by your body. It also reduces the amount of a substance called glucagon being produced by your pancreas. Glucagon causes your liver to produce more sugar, so by reducing the amount of glucagon in your body, this also helps to reduce the levels of glucose in your blood. Before taking sitagliptin Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking sitagliptin it is important that your doctor knows: If you are pregnant, trying for a baby or breast-feeding. If you have any problems with the way your kidneys w Continue reading >>
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Rhinorrhea, Cough And Fatigue In Patients Taking Sitagliptin
Rhinorrhea, cough and fatigue in patients taking sitagliptin 1Division of Rheumatology, Immunology, and Allergy, Georgetown University, Washington, DC, USA 2Department of Family Medicine, Quillen College of Medicine, East Tennessee State University, McMinnville, TN, USA Received 2009 Nov 9; Accepted 2010 May 12. Copyright 2010 Baraniuk and Jamieson; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Sitagliptin is a dipeptidyl peptidase-4 (DPP IV, CD26) inhibitor indicated for treatment of Type II diabetes as a second line therapy after metformin. We report fifteen sitagliptin intolerant patients who developed anterior and posterior rhinorrhea, cough, dyspnea, and fatigue. Symptoms typically developed within 1 to 8 weeks of starting, and resolved within 1 week of stopping the drug. Peak expiratory flow rates increased 34% in 8 patients who stopped sitagliptin. Similar changes were found in 4 out of 5 persons who had confirmatory readministration. Chart review identified 17 patients who tolerated sitagliptin and had no symptomatic changes. The sitagliptin intolerant group had higher rates of clinically diagnosed allergic rhinitis (15/15 vs. 6/18; p = 0.00005), Fisher's Exact test) and angiotensin converting enzyme inhibitor - induced cough (6/13 vs. 1/18; p = 0.012). Nasal and inhaled glucocorticoids may control the underlying allergic inflammation and abrogate this new sitagliptin - induced pharmacological syndrome. Potential mucosal and central nervous system mechanisms include disruption of neuropeptides and Continue reading >>
Januvia
are allergic to dapagliflozin or any of the ingredients in FARXIGA. Symptoms of a serious allergic reaction may include skin rash, raised red patches on your skin (hives), swelling of the face, lips, tongue, and throat that may cause difficulty in breathing or swallowing. If you have any of these symptoms, stop taking FARXIGA and contact your healthcare provider or go to the nearest hospital emergency room right away have severe kidney problems or are on dialysis. Your healthcare provider should do blood tests to check how well your kidneys are working before and during your treatment with FARXIGA Dehydration (the loss of body water and salt), which may cause you to feel dizzy, faint, lightheaded, or weak, especially when you stand up (orthostatic hypotension). You may be at a higher risk of dehydration if you have low blood pressure; take medicines to lower your blood pressure, including water pills (diuretics); are 65 years of age or older; are on a low salt diet, or have kidney problems Ketoacidosis occurred in people with type 1 and type 2 diabetes during treatment with FARXIGA. Ketoacidosis is a serious condition which may require hospitalization and may lead to death. Symptoms may include nausea, tiredness, vomiting, trouble breathing, and abdominal pain. If you get any of these symptoms, stop taking FARXIGA and call your healthcare provider right away. If possible, check for ketones in your urine or blood, even if your blood sugar is less than 250 mg/dL Kidney problems. Sudden kidney injury occurred in people taking FARXIGA. Talk to your doctor right away if you reduce the amount you eat or drink, or if you lose liquids; for example, from vomiting, diarrhea, or excessive heat exposure Serious urinary tract infections (UTI), some that lead to hospitalization, occu Continue reading >>
Important Information About The Side Effects Of
JANUMET What is the most important information I should know about JANUMET? Serious side effects can happen in people taking JANUMET, including: 1. Lactic Acidosis. Metformin, one of the medicines in JANUMET, can cause a rare but serious condition called lactic acidosis (a buildup of an acid in the blood) that can cause death. Lactic acidosis is a medical emergency and must be treated in the hospital. Call your doctor right away if you have any of the following symptoms, which could be signs of lactic acidosis: you feel cold in your hands or feet you feel dizzy or lightheaded you have a slow or irregular heartbeat you feel very weak or tired you have unusual (not normal) muscle pain you have trouble breathing you feel sleepy or drowsy you have stomach pains, nausea or vomiting Most people who have had lactic acidosis with metformin have other things that, combined with the metformin, led to the lactic acidosis. Tell your doctor if you have any of the following, because you have a higher chance for getting lactic acidosis with JANUMET if you: have severe kidney problems or your kidneys are affected by certain x-ray tests that use injectable dye have liver problems drink alcohol very often, or drink a lot of alcohol in short-term "binge" drinking get dehydrated (lose a large amount of body fluids). This can happen if you are sick with a fever, vomiting, or diarrhea. Dehydration can also happen when you sweat a lot with activity or exercise and do not drink enough fluids have surgery have a heart attack, severe infection, or stroke The best way to keep from having a problem with lactic acidosis from metformin is to tell your doctor if you have any of the problems in the list above. Your doctor may decide to stop your JANUMET for a while if you have any of these things. 2. Continue reading >>
Januvia: Side Effects, Reviews By Patients - Askapatient.com
Extreme tachycardia, trouble breathing, chest pressure and chest feeling heavy. Face pressure. Feeling like someone was choking me. Swelling feet, ankles and legs. Numbing & tingling in right arm and thrifty jaw. Nausea. Chest fluid. Feeling like I was going to have a heart attack. Horrible non stop fast and slow heartbeats and skipping or adding beats. Made me exhausted and sick feeling for weeks. Didnt know this had a black box warning and could cause heart failure. I hope theres no lasting damage done to my heart. Terrible medication. I was going into heart failure. Stopped it today and no more tachycardia or chest pain. Fluid in my lungs as flem is coughing up. Dangerous medication !!! I told my Dr. I was sick of taking Actos and wanted to try something else. Big mistake, Januvia gave me massive pain in one knee to the point where I could barely walk. I also went to an Orthopedic Surgeon just to have my knee checked out and they found nothing wrong. I've been off the drug for 4 weeks and the pain is better but not even closer to normal. Now back on Actos and my Blood Sugar count is actually worse than before I stared on Januvia. My numbers in the morning were always around 120, now they are in the 130's and a few have even been in the 150's. I think this stuff has done permanent damage, or is at least going to take a lot more time for me to recover. I had been taking Januvia 25 mg with Metformin ER for 4 months then the DR just increased it to Januvia 50 mg a day. Well, within 2 weeks, my finger joints hurt, and my fingers began swelling. Then, my ears seemed plugged all the time. Not much longer, the diarrhea set in just after eating or drinking anything. Then, I had diarrhea all day / night long. Finally, I was sooooo dizzy that I couldn't get out of bed and dry Continue reading >>
Will You Have Exhaustion, Fatigue, Lethargy, Tiredness, Weariness With Januvia - From Fda Reports - Ehealthme
Nausea (feeling of having an urge to vomit): 246 people, 18.87% Breathing Difficulty: 178 people, 13.65% * Approximation only. Some reports may have incomplete information. How to use the study: print a copy of the study and bring it to your health teams to ensure drug risks and benefits are fully discussed and understood. Do you take Januvia and have Exhaustion, fatigue, lethargy, tiredness, weariness? Share you experience to help people like you. Want to find out more about the FDA reports used in the study? You can request them from FDA. Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. ( latest outcomes from Januvia 42,437 users ) Exhaustion, fatigue, lethargy, tiredness, weariness Exhaustion, fatigue, lethargy, tiredness, weariness has been reported by people with multiple sclerosis, rheumatoid arthritis, hepatitis c, high blood pressure, depression ( latest reports from 406,377 Exhaustion, fatigue, lethargy, tiredness, weariness patients ). Drugs that are associated with Exhaustion, fatigue, lethargy, tiredness, weariness a b c d e f g h i j k l m n o p q r s t u v w x y z Related publications that referenced our studies Stricklin SM, Stoecker WV, Rader RK, Hood AF, Litt JZ, Schuman TP, "Persistent edematous-plaque photosensitivity observed with sitagliptin phosphate (Januvia)" , Dermatology online journal, 2012 Feb . Belice T, Yuce S, Kizilkaya B, Kurt A, Cure E, "Noncardiac pulmonary edema induced by sitagliptin treatment" , Journal of family medicine and primary care, 2014 Jan . Liao KF, Lin CL, Lai SW, Chen WC, "Sitagliptin use and risk of acute pancreatitis in type 2 diabetes mellitus: a population-based case-control study in Taiwan" , European journal of internal medicine, 2016 Jan . Analysis tools (to study 681 million Continue reading >>
Can Januvia Cause Tiredness?
Pepcid vs. Prilosec Vestura vs. Yaz Rephresh Pro B Side Effects Lacri Lube Alternative Primolut N Weight Gain Treato does not review third-party posts for accuracy of any kind, including for medical diagnosis or treatments, or events in general. Treato does not provide medical advice, diagnosis or treatment. Usage of the website does not substitute professional medical advice. The side effects featured here are based on those most frequently appearing in user posts on the Internet. The manufacturer's product labeling should always be consulted for a list of side effects most frequently appearing in patients during clinical studies. Talk to your doctor about which medications may be most appropriate for you. The information reflected here is dependent upon the correct functioning of our algorithm. From time-to-time, our system might experience bugs or glitches that affect the accuracy or correct application of mathematical algorithms. We will do our best to update the site if we are made aware of any malfunctioning or misapplication of these algorithms. We cannot guarantee results and occasional interruptions in updating may occur. Please continue to check the site for updated information. Continue reading >>
Important Safety Information
WHAT IS JANUVIA®? JANUVIA (jah-NEW-vee-ah) is a once-daily prescription pill that, along with diet and exercise, helps lower blood sugar levels in adults with type 2 diabetes. JANUVIA should not be used in patients with type 1 diabetes or with diabetic ketoacidosis (increased ketones in the blood or urine). If you have had pancreatitis (inflammation of the pancreas), it is not known if you have a higher chance of getting it while taking JANUVIA. Serious side effects can happen in people who take JANUVIA, including pancreatitis, which may be severe and lead to death. Before you start taking JANUVIA, tell your doctor if you've ever had pancreatitis. Stop taking JANUVIA and call your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis. Before you start taking JANUVIA, tell your doctor if you have ever had heart failure (your heart does not pump blood well enough) or have problems with your kidneys. Contact your doctor right away if you have increasing shortness of breath or trouble breathing (especially when you lie down); swelling or fluid retention (especially in the feet, ankles, or legs); an unusually fast increase in weight; or unusual tiredness. These may be symptoms of heart failure. Do not take JANUVIA if you are allergic to any of its ingredients, including sitagliptin. Symptoms of serious allergic reactions to JANUVIA, including rash, hives, and swelling of the face, lips, tongue, and throat that may cause difficulty breathing or swallowing, can occur. If you have any symptoms of a serious allergic reaction, stop taking JANUVIA and call your doctor right away. Kid Continue reading >>
Is Total Exhaustion Normal At This Stage?
Is total exhaustion normal at this stage? Is total exhaustion normal at this stage? I was diagnosed in early December and have been on Glumetza ER since May and Januvia for the past 7 weeks. I'm eating much lower carb than before diagnosis (but still about 80-100 carbs a day including lots of veggies, nuts, some legumes and high fiber grains), and am seeing some really good BG numbers - my average BG for the past month is 108, and I'm starting to see the occasional AM fasting number under 100. Before diagnosis, my A1C was 8.8% and my primary symptom was abnormal fatigue and lethargy, plus carb cravings. I felt pretty good for the first month of low-carbing and on my new medication schedule, with an uptick in energy, but the past few weeks I've felt awful. Zero energy, tired all the time, muscle weakness. I'm not super hungry (I think due to the Januvia) and don't really have carb cravings on my current diet. In fact I'm having some trouble getting enough calories due to lack of appetite. I'm steadily losing about 1 - 1.5 lbs a week without increasing exercise. I thought with getting my blood sugar lower I'd start to feel more like myself again! So my question is: Is this a normal phase due to the blood sugar changes or the low carb thing? I also read on this forum about a possible link between Metformin and unusual lethargy/fatigue in a few people. I did recently increase the Glumetza dosage, but the lethargy/fatigue kicked in about a week before the dosage increase. Or could it be a reaction to the alternative sweeteners I've been experimenting with? (Very small amounts of Truvia, Stevia, diet sodas, or agave nectar in recipes a couple of times a week.) I'm feeling discouraged because I don't know what to do next, and I haven't been able to increase my exercise like I Continue reading >>
Januvia
I'm maxed out on metformin (850 mg 3x/day) and glyburide (5mg 4x/day). Januvia, even without the other 2 meds, had my readings in the desired ranges in a day. It's only been 5 days, but so far VERY GOOD! Thanks! Started Januvia 100 mg once a day with in days I had joint pain so bad I did not want to get out of bed and the join pain has not went away its not as bad but still there. Chronic heart pain my heart beat so hard and fast I worried I was having a heart attack. My chest was/is sore I have congestion, I still have a fast heart beat off and on "This worries me". Shortness of breath. I was dizzy, chest colds, Very bad headache, Both hands were numb this was worse at night I would wake with my hands hurting I still have some numbness it is off and on and and mostly in my fingers now. I was so hoping Januvia would work for me. I do not think this drug was not tested well enough before the public was allowed to use it. I hope my side effects are not long term and no damage was caused and with time will go away. I was on another medication for type 2 diabetes and it didnot work for me. My doctor didn't want to take me off of it because he said it work for most people. Well, I change Doctors and the new Doctor stated me on Januvia 50 mg in the AM and 50 in the PM and it started to work at the end of the week, no side effects, my number was very close to normal and I feel GREAT . I even lost weight while on this medication. My husband is on 50 mg a day and doing great with no side effects. Family member had a rash with this medicine, and a friend said there was a new warning posted about a deadly disease called Stevens-Johnson syndrome associated with Januvia. I didn't find it in WebMd though. Is it true? Januvia (with metformin) has worked very well for me so far (3 mont Continue reading >>
Januvia Side Effects
Januvia is the brand name of the drug sitagliptin, which is used to treat type 2 diabetes. Type 2 diabetes is a disease in which the body doesn't make or use the hormone insulin normally, so it can't properly control your blood sugar levels. Januvia belongs to a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing levels of substances in the body that help lower blood sugar. Januvia may be taken alone or with other diabetes medications. It's often prescribed as a combination medicine called Janumet (which contains the drugs sitagliptin and metformin). Taking Januvia, along with adopting a healthy lifestyle, can reduce your risk of developing serious or life-threatening complications from diabetes, which may include heart disease, stroke, nerve damage, kidney problems, or eye problems. The U.S. Food and Drug Administration (FDA) approved Januvia in 2006. It's manufactured by Merck & Co. Januvia Warnings Januvia shouldn't be taken by people with type 1 diabetes (a disease in which the body doesn't produce any insulin) or diabetic ketoacidosis (a dangerous condition that can occur if high blood sugar is untreated). Before taking Januvia, tell your doctor if you have, or have ever had: Kidney disease Angioedema (swelling of the face, lips, tongue, throat, arms, or legs) Januvia may increase the risk of developing pancreatitis (swelling and inflammation of the pancreas). Be sure to tell your doctor if you've ever had any problems with your pancreas, or if you experience any of the following symptoms while taking Januvia: Severe pain in your upper stomach that spreads to your back Loss of appetite Fast heartbeat Severe nausea and vomiting Also, tell your doctor you're taking this medicine before having any type of surgery, including a dental Continue reading >>
Januvia Side Effects
Generic Name: sitagliptin Note: This document contains side effect information about sitagliptin. Some of the dosage forms listed on this page may not apply to the brand name Januvia. For the Consumer Applies to sitagliptin: oral tablet Along with its needed effects, sitagliptin (the active ingredient contained in Januvia) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking sitagliptin: Less common Anxiety blurred vision chills cold sweats confusion cool, pale skin depression dizziness fast heartbeat headache increased hunger loss of consciousness nausea nightmares seizures shakiness slurred speech unusual tiredness or weakness Incidence not known Blistering, peeling, loosening of the skin diarrhea hives or welts, itching, or skin rash large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs loss of appetite pains in the stomach, side, or abdomen, possibly radiating to the back puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue red skin lesions, often with a purple center redness of the skin severe joint pain sores, ulcers, or white spots in the mouth or on the lips vomiting Some side effects of sitagliptin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Body aches Continue reading >>
Januvia Smackdown
Get your ringside seats, Folks! A while back I posted about the Merck's new Type 2 oral drug Januvia (What It Doesn't Do), explaining how it apparently trumps competitors in terms of patient "tolerability." No other post has ever generated such ongoing reader energy, both positive and negative. Nearly every day, several new commentors weigh in, duking it out over the relative merits of Januvia. Most everyone seems to agree that Januvia reduces appetite, which is a good thing. But then again, Byetta is known for that effect as well. The key is question whether Januvia fulfills its core function of lowering blood glucose (BG) levels, and lives up to its no-side-effects promise. As of today, the score stands pretty much tied, as such: Total comments = 50 Positive = 10 Negative = 13 Mixed = 16 (liked some aspects of the drug but not others) Neutral = 11 (those asking or responding to questions only) Among the most vocal of the Pro Team: "I take Januvia and have for 6 months. I have no side effects. I have experienced a decrease in appetite. I have had no headaches or respiratory problems. My BG has gone down. It is a great drug." -- Mike "Januvia has been a positive thing for me. My sugar levels dropped from 240+ to 110 +/- 10 after fasting. I have taken 100 mg once per day for a month... I am not as hungry as before usage." -- Jim K. L. "I've been on Januvia for a little over three months and have lost over 15 pounds which I had put on with Actos. I've experienced no side effects, other than I am not hungry all of the time. For me it has been very effective..." -- Bill "I am substantially less hungry then I have felt in years ... and my BG hovers around 100 - 120 between meals/fasting, and 120 - 160 for a few hours after a heavy carb meal. The usual BG spikes of 180 - 200+ Continue reading >>
