Nsaid Lowers Glucose Levels In Type 2 Diabetes
NSAID Lowers Glucose Levels in Type 2 Diabetes Chronic low-grade inflammation found in many patients with diabetes Salsalate, a generic non-steroidal anti-inflammatory drug (NSAID) used to treat arthritis, significantly lowered blood glucose levels and decreased inflammatory mediators in patients with type 2 diabetes. Further research is needed to understand the side effects of this agent in patients with diabetes, the study authors noted in the July 2 issue of Annals of Internal Medicine. Epidemiologic studies have suggested that a low-grade, chronic inflammation is present in patients who have diabetes, and precedes and predicts the development of diabetes in people who do not yet have the disease, said lead author Allison B. Goldfine, MD, Associate Professor at Harvard Medical School and Section Head of Clinical Research at Joslin Diabetes Center, Boston, Massachusetts. Our study adds to a growing body of science to demonstrate that one can specifically target this low-grade inflammation to improve metabolism in patients with diabetes, she said. The study involved 286 participants with poorly controlled type 2 diabetes (A1C 7.0%-9.5%; mean A1C, 7.85%) despite treatment with diabetes medications, exercise, and dietary changes. None of the patients were taking insulin. The patients were randomized to salsalate 3.5 g per day or placebo in addition to their regular diabetes medications (ie, metformin, insulin secretagogue, or dipeptidyl peptidase-4 inhibitor, alone or in combination) for 48 weeks. Patients who were currently on insulin, thiazolidinediones, glucagon-like peptide-1 agonists, NSAIDs, warfarin, or uricosuric agents were not eligible for the trial. At 48 weeks, the salsalate group had a 37% lower mean change in A1c level compared to the placebo group (-0.53% Continue reading >>
- Drug that lowers blood sugar to combat type 2 diabetes ‘also helps fight obesity and heart disease’
- World's first diabetes app will be able to check glucose levels without drawing a drop of blood and will be able to reveal what a can of coke REALLY does to sugar levels
- How Cinnamon Lowers Blood Sugar and Fights Diabetes
Ibuprofen. | Diabetes Forum The Global Diabetes Community
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Ibuprofen can cause problems for non diabetics as well as diabetics so please be careful if you take them. My son, a healthy teenager, broke his ankle in several places just before Christmas. He was in a lot of pain for several weeks having had two plates and several screws fitted but thankfully is nearly mobile again. He is getting physio and hydrotherapy on the NHS. We saw his Consultant today for results for tests that were ordered and the Consultant was concerned that his kidney function tests were slightly below the normal range. When he discovered that his GP had prescribed ibuprofen since the onset he went ballistic and says that he will be phoning his GP. This Orthopedic Consultant is also a Urologist and specialises in Renal issues. He explained that he sees many people with decreased kidney function who take ibuprofen as an over the counter medicine and have no idea of the damage that it can do long term. I asked him how he felt about diabetics taking it? "Definitely not" was his reply. "There are other painkillers that can be prescribed which do not inhibit kidney function and I would hope that all GP's are aware of this issue. "If you need a painkiller than check with the pharmacist and make them aware that you are a diabetic. It affects kidneys and blood pressure and many diabetics have high blood pressure anyway". Luckily I have been told this by my GP and do not use them. He assured us that my son's discrepancies will return to normal in a few weeks now that he is not going to use them anymore. Thought it might be useful to post this here and make others aware. I have to say both my Oncologist and Endocrinologist have told me to use Ibu Continue reading >>
Non-steroidal Anti-inflammatory Drugs (nsaids): Making Safer Treatment Choices
No association with myocardial infarction No interaction with the antiplatelet effect of aspirin Paracetamol can be given for mild to moderate pain in adults at the recommended dose of 0.5 1 g, every four to six hours, to a maximum of 4 g per day.6 The major adverse effect associated with paracetamol is liver damage due to overdose and it should not be prescribed to patients with liver disease.6 Consider adding codeine to paracetamol in select patients If the risk of NSAID-related adverse events is high, it may be appropriate to consider adding codeine to paracetamol, in preference to NSAID treatment.11 For example, an older patient with osteoarthritis, diabetes and chronic kidney disease (CKD) may be particularly susceptible to the nephrotoxic effects of NSAIDs (see NSAIDs and renal function ). An appropriate starting dose of codeine in combination with paracetamol for mild to moderate pain in adults is 15 mg, every four hours, as required.6 Codeine can be given in doses up to 60 mg, if required, but the total dose should not exceed 240 mg per day.6 The main adverse effects of codeine are gastrointestinal disturbance and potential respiratory depression.6 The effectiveness of codeine may vary between individuals due to genetic differences in metabolism, and it may not be an appropriate choice for all patients (see: Paracetamol with codeine may have variable efficacy ). Combining paracetamol with NSAIDs may be appropriate The combination of paracetamol with NSAIDs may provide more effective analgesia for some patients, e.g. for post-surgical pain, than either medicine alone.12 This combination treatment may allow the dose of NSAID required to achieve analgesia to be reduced (compared to NSAID treatment alone) therefore reducing the amount NSAID-related risk the patient Continue reading >>
How Pain Relievers Can Affect Blood Sugar Levels
Many of us don’t even think about our blood sugar levels when we’re scrabbling through the medicine cabinet, looking for a pain reliever. We just want to make the pain disappear—stat. But people with diabetes do need to take that matter into consideration when they’re taking any medication. If you have type 2 diabetes, your doctor or diabetes educator has probably warned you to be vigilant about the effects that that your diet, your activity level, and any other medication you take on a regular basis can have on your blood sugar levels. You also need to be careful about any pain relieving medication that you take, even if it’s just on an occasional basis, because certain types of pain killers can lower or raise your blood sugar levels. NSAIDs There are times when you can easily treat pain with an over-the counter pain reliever. You may take a low dose of aspirin or a nonsteroidal anti-inflammatory drug (NSAID) like ibuprofen or naproxen to relieve the occasional headache or muscle pain. A regular dose is unlikely to affect your blood sugar levels, but a higher-than-usual dose may lower your blood sugar level. Talk to your doctor about what’s an appropriate dose for your occasional aches and pains so you don’t accidentally cause an episode of hypoglycemia. Another word of caution. You might have settled on an effective dose of a particular pain reliever that won’t drastically alter your blood sugar levels. But your diabetes puts you at elevated risk for certain other health conditions. So you may have other medical conditions you need to manage—and you will need to watch out for the effect any pain killers you take can have on those. For example, NSAIDS like ibuprofen and naproxen can increase your blood pressure. And they can affect your kidneys, too, Continue reading >>
Diabetes And Inflammation
Inactivity and obesity increase the risk for diabetes, but exactly how is unclear. Recent research suggests that inflammation inside the body plays a role in the development of type 2 diabetes. The good news: An "anti-inflammatory" diet and exercise plan can help prevent and treat type 2 diabetes. The effects of inflammation are familiar to anyone who has experienced a bug bite, rash, skin infection, or ankle sprain. In those situations, you will see swelling in the affected area. With type 2 diabetes, inflammation is internal. People with type 2 diabetes don't produce enough insulin or their bodies can't use the insulin adequately. Insulin is a hormone that is made by cells in the pancreas. It controls the amount of sugar in the blood. Insulin may also have an impact on tissue in the body. Its effects on tissue are influenced by many factors, including obesity and the accumulation of fat around the belly and on major organs in the abdomen. The fat cells can produce chemicals that lead to inflammation. Scientists are only beginning to understand the role this form of internal inflammation may play in the development of chronic diseases like diabetes. Decades ago, researchers identified higher levels of inflammation in the bodies of people with type 2 diabetes. The levels of certain inflammatory chemicals called cytokines are often higher in people with type 2 diabetes compared to people without diabetes. Obesity and inactivity have long been known to be the most important risk factors that drive the development of type 2 diabetes. How could carrying extra weight and sofa-sitting be connected to higher levels of inflammatory chemicals in the body and the development of diabetes? Researchers discovered that in people with type 2 diabetes, cytokine levels are elevated insi Continue reading >>
What Should People With Diabetes Consider When Selecting Pain Medication?
Diabetes mellitus (MEL-ih-tus), often referred to as diabetes, is characterized by high blood glucose (sugar) levels that result from the body’s inability to produce enough insulin and/or effectively utilize the insulin. Diabetes is a serious, life-long condition and the sixth leading cause of death in the United States. Diabetes is a disorder of metabolism (the body's way of digesting food and converting it into energy). There are three forms of diabetes. Type 1 diabetes is an autoimmune disease that accounts for five- to 10-percent of all diagnosed cases of diabetes. Type 2 diabetes may account for 90- to 95-percent of all diagnosed cases. The third type of diabetes occurs in pregnancy and is referred to as gestational diabetes. Left untreated, gestational diabetes can cause health issues for pregnant women and their babies. People with diabetes can take preventive steps to control this disease and decrease the risk of further complications. Continue reading >>
Aspirin-like Drug May Help Diabetics Control Blood Sugar
Over the years, I’ve written and edited many articles for medical journals. I have to say I’m now finding it a bit odd to be on the flip side as the subject of such an article (along with 285 other people). A couple years ago, I volunteered to take part in a clinical trial testing whether an old, aspirin-like drug called salsalate could help control blood sugar in people with type 2 diabetes. The results of that trial, called TINSAL-T2D, are reported in the current issue of Annals of Internal Medicine. All 286 volunteers were given blue pills to take every day for nearly a year. Half of us got pills containing salsalate; the others got placebo pills. Over the course of the trial, those in the salsalate group had lower blood sugar levels, and some were even able to reduce dosages of other diabetes medications they were taking. “We were very pleased with the findings of the TINSAL-T2D study,” said lead author Dr. Allison B. Goldfine, associate professor of medicine at Harvard-affiliated Joslin Diabetes Center. “They indicate that salsalate, a drug that has been marketed for over 40 years for the treatment of arthritis, could be an inexpensive additional therapeutic option to treat patients with diabetes.” Inflammation and diabetes Salsalate is an old drug that’s closely related to aspirin. Use of these drugs and their natural precursor use can be traced back at least 3,500 years. Today, salsalate is used to treat arthritis pain. One advantage it has over aspirin and other nonsteroidal anti-inflammatory drugs is that it doesn’t irritate the digestive tract. No one knows exactly how salsalate helps control blood sugar. But its effectiveness supports the idea that inflammation plays a role in type 2 diabetes. In addition to improving blood sugar control, sals Continue reading >>
"anti-inflammatory" Drugs And Their Effects On Type 2 Diabetes.
"Anti-inflammatory" drugs and their effects on type 2 diabetes. University Department of Clinical Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland, United Kingdom. There is a growing body of evidence for the role of inflammation in type 2 diabetes. In addition to the evidence presented elsewhere, evidence is emerging that many drugs that have apparent "anti-inflammatory" properties may reduce the incidence and/or delay the onset of type 2 diabetes. Statins have been found to lower inflammatory markers, and a post hoc analysis of the West of Scotland Coronary Prevention Study (WOSCOPS) suggested that pravastatin may reduce the risk of developing diabetes, although the Lipid Lowering Arm of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) found no statistically significant effect of atorvastatin on risk of developing diabetes. Fibrates have been found to lower some markers of inflammation, and a prospective trial found that bezafibrate reduces risk of developing diabetes. Angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers appear to reduce some markers of inflammation, and a meta-analysis concluded that ACE inhibitors and angiotensin receptor blockers reduce risk of developing type 2 diabetes. Metformin is known to reduce the risk of developing diabetes, and more recent evidence suggests it also lowers C-reactive protein, in part because of its modest weight-reducing effect. Thiazolidinediones reduce risk of developing diabetes, and consistently lower inflammatory markers independent of adiposity effects. High-dose aspirin inhibits cyclooxygenase and IkappaB kinase-beta and reduces fasting plasma glucose concentration, although there has not, as yet, been a large-scale trial to examine the effect of aspirin on the risk of develop Continue reading >>
Anti-inflammatory Diets
Hype or Hope? A quick perusal of the Web or the health and diet section of any bookstore will turn up a number of articles and books with the word “inflammation” in the title. Authors blame the insidious condition for everything from hay fever and depression to crow’s feet; many assure readers that adherence to their specialized, anti-inflammation diet plan will help them shed pounds, banish pain, and reverse the clock. The types of foods common to many of these diets include whole grains, dry beans and legumes, oily fish, nuts and seeds, fruits, vegetables, and certain herbs and spices. These sound like nutritious foods, but is inflammation really the cause of so many ills? And will following a particular diet cure it? We do know that there is an association between chronic inflammation and obesity, diabetes, and heart disease. What’s less clear is how the association works, how concerned you should be about it, and what, if anything, you can do about it. But first, a little background on inflammation is needed. What is inflammation? We’re all familiar with acute inflammation, which you can feel and often see quite distinctly. Inflammation is the body’s natural response to injury and the first step in healing; in its acute form, it can be quite dramatic. Whether you have a virus or a cut, the body sends white blood cells to the site of infection or injury, where they release chemicals to protect you. The most obvious sign of acute inflammation is pain, such as when you have a sore throat; you may also experience fever in the case of an infection, or swelling as your body deals with a traumatic injury. Chronic inflammation is not so easy to identify. “What we’re talking about here is low-grade inflammation that you don’t see or feel easily,” says Viv Continue reading >>
Nsaids (anti-inflammatory Pain Relievers) Safety
Other NSAIDs available by prescription include Daypro , Indocin , Lodine , Naprosyn , Relafen , and Voltaren . Cox-2 inhibitors are a newer form of prescription NSAID. Two of them -- Bextra and Vioxx -- are no longer sold because of concerns about their side effects. The third, Celebrex, is still available. How Anti-Inflammatory Pain Relievers Work While the details are different, all of these medicines work in more or less the same way. They block the effects of chemicals that increase the feeling of pain. Unlike many other painkillers, they also help by reducing swelling, which can further reduce pain. Sometimes swelling is a key cause of pain . But the problem with NSAIDs -- or any systemic drug -- is that they can affect the entire body, not just the part that hurts. "If you use a drug to ease one problem, like an achy joint," Goldberg tells WebMD, "it's likely to cause a different reaction somewhere else too." Anti-Inflammatory Pain Relievers: The Risks For most people, taking an over-the-counter NSAID for the occasional headache or backache is very safe. "The bigger risks are for people who have chronic pain and take NSAIDs in the long-term," says Goldberg. The most common side effect from all NSAIDs is damage to the gastrointestinal tract, which includes your esophagus , stomach, and small intestine. More than half of all bleeding ulcers are caused by NSAIDs, says gastroenterologist Byron Cryer, MD, a spokesperson for the American Gastroenterological Association. "Gastrointestinal bleeding is a serious issue," says Cryer. "But we've seen in many surveys that people really underestimate this risk." Most ulcers caused by NSAIDs will heal once you stop taking the drug, according to the American College of Gastroenterology. Researchers developed Cox-2 inhibitors -- Continue reading >>
Choosing A Pain Reliever
Choosing Wisely is an initiative by the ABIM Foundation to identify commonly-used tests or procedures whose necessity should be questioned and discussed. This information was developed by Consumer Reports in cooperation with the American Society of Nephrology. If you need a painkiller but suffer from high blood pressure, heart failure, or kidney disease, it’s best to steer clear of some commonly used pain relievers. Those include: Ibuprofen, which is sold under the brand names Advil and Motrin, and also as a generic or store brand. You can buy it without a prescription at the drug store. It’s sometimes combined with other drugs in other over-the-counter products, such as certain cold remedies. Naproxen, sold under the brand name Aleve and as a generic or store brand. It doesn’t need a prescription, either. Celecoxib, a prescription drug sold as Celebrex. All three of those drugs, which are called nonsteroidal anti-inflammatory drugs, or NSAIDs, can ease pain and inflammation. But they are too risky if you have any of those health problems. Here’s why. They’re bad for high blood pressure. All NSAIDs can cause or worsen high blood pressure. That increases your chance of having a heart attack or stroke. The drugs can also make some blood pressure drugs less effective. That includes diuretics such as hydrochlorothiazide (Hydrodiuril and generic), ACE inhibitors such as lisinopril (Prinivil, Zestril, and generic) and ARBs such as losartan (Cozaar and generic). They’re bad for the heart and kidneys. Long-term use of NSAIDs can make your body hold onto fluid, which can worsen heart failure symptoms, such as shortness of breath, swollen ankles, and a rapid or irregular heartbeat. They can also reduce kidney function. That makes the drugs risky for people who already Continue reading >>
Anti-inflammatory Foods Help Reverse Type 2 Diabetes
Inflammation is a process by which the body’s white blood cells and chemicals protect us from infection and foreign substances such as bacteria and viruses. Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli and to initiate the healing process. Inflammation is not a synonym for infection, even in cases where inflammation is caused by infection. Although infection is caused by a microorganism, inflammation is one of the responses of the organism to the pathogen. Without inflammation, wounds and infections would never heal, causing cell and tissue damage. But, chronic inflammation fuels ongoing cell/tissue damage, leading to progressive destruction of the tissue, which could compromise the survival of the organism. In addition, chronic inflammation can lead to a variety of diseases, such as hay fever, periodontitis, atherosclerosis, rheumatoid arthritis, and even cancer (e.g., gallbladder carcinoma). It is for that reason that inflammation is normally closely regulated by the body and must be addressed if it is out of control. Normally, inflammation is helpful in assisting the body in healing cuts and bruises and occurs in the body when there is cell/tissue damage that needs to be repaired. Consequently, inflammation is good when you have a cut or injury because it is the body's natural defense in fighting off bad bacteria and promoting healing. However, cellular or chronic inflammation is a condition that happens when the body is in a continuous cycle of inflammation (without healing) or is trying to repair cells that are not damaged. Chronic inflammation is a long lasting inflammation (months Continue reading >>
Other Dangerous Drugs For People With Diabetes
A major problem with all drugs is that busy doctors often ignore potentially damaging drug side effects. Often they aren't even aware that these side effects are listed in the drug's official FDA-required label (called the "Prescribing Information" online.). That is because most doctors get their information about drugs from reps sent out by pharmaceutical companies or doctors who are well-compensated by these companies to promote the latest, most expensive drugs to their peers. Unfortunately, all the major drug companies have a long record of suppressing information about damaging side effects of all their drugs. Periodically, one of these drugs will kill or injure enough people that it comes to the attention of the FDA and the media. Even then, the FDA will usually only post an "alert" and will allow the drug to continue to be sold. Busy doctors apparently don't read these alerts, as they continue to prescribe drugs that have generated serious alerts in quantities that result in billions of dollars of drug company revenue each year. Proof that doctors are woefully ignorant of the side effects of even the most heavily prescribed drugs was provided by this study: Physician Response to Patient Reports of Adverse Drug Effects: Implications For Patient-Targeted Adverse Effect Surveillance.Golomb, Beatrice A, et al. Drug Safety. 30(8):669-675, 2007. TIt was a study of a group of patients prescribed a statin drug that verified that doctors ignore patients' reports of even the most significant side effects. As reported, it found that Eighty-seven percent of patients reportedly spoke to their physician about the possible connection between statin use and their symptom....Physicians were reportedly more likely to deny than affirm the possibility of a connection. Rejection of a Continue reading >>
Anti-inflammatory Drug, Used For Decades, Now Found To Lower Blood Glucose Levels In People With Type 2 Diabetes
Anti-Inflammatory Drug, Used for Decades, Now Found to Lower Blood Glucose Levels in People with Type 2 Diabetes In a modern-day clinical trial of a medicine belonging to one of the worlds oldest classes of drugs, researchers have found that a drug related to aspirin and salicylate, which was first used by ancient Egyptians and Greeks to ease pain caused by inflammation, also has glucose-lowering properties and may be a potential treatment for people with type 2 diabetes, according to results presented at the American Diabetes Associations 72nd Scientific Sessions. Salsalate, a pain medication used for decades as a treatment for rheumatoid arthritis, is notable for lacking many of the side effects of aspirin and is available as an inexpensive, generic prescription drug. Small, preliminary trials of salsalate indicated that it may be effective as a treatment for type 2 diabetes. The exciting thing here is that this drug is relatively inexpensive and has a long safety record for other uses, such as treating joint pain, said Steven Shoelson, MD, PhD, Associate Director of Research at the Joslin Diabetes Center and Principal Investigator for the study. We now have to determine whether the degree to which this drug lowers blood glucose levels is large enough to warrant using it as an addition to the diabetes drug armamentarium. In a year-long trial sponsored by the National Institutes of Health, researchers compared use of salsalate to placebo in 286 patients with type 2 diabetes and found that it reduced A1C levels (a measure of average blood glucose levels over time) by 0.24 percent and fasting blood glucose levels by 11 mg/dl over 48 weeks. Although these improvements may seem modest, the group taking salsalate achieved them while requiring lower doses of other diabetes Continue reading >>
Medications - Non-steroidal Anti-inflammatory Drugs
Medications - non-steroidal anti-inflammatory drugs NSAIDs are commonly used to manage the pain and inflammation associated with arthritis and other musculoskeletal disorders. NSAIDs can cause serious side effects, some of which may be life-threatening. NSAIDs should always be used cautiously and for the shortest time possible. Always talk to your doctor or pharmacist before buying or taking an NSAID to ensure its safe for you to take. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to manage the pain and inflammation (swelling and redness) associated with some types of arthritis (such as rheumatoid arthritis) and other musculoskeletal disorders. NSAIDs are also used to treat non-inflammatory conditions such as migraine, period pain and postoperative pain, and to reduce fever. Aspirin is an NSAID with blood-thinning properties. It can be used in low doses to reduce the risk of heart attack and stroke in high-risk patients. Prostaglandins are hormone-like chemicals in the body that contribute to inflammation, pain and fever by raising temperature and dilating blood vessels, which causes redness and swelling in the place they are released. NSAIDs block a specific enzyme called cyclooxygenase (or COX) used by the body to make prostaglandins. By reducing production of prostaglandins, NSAIDs help relieve the discomfort of fever and reduce inflammation and the associated pain. While NSAIDs are effective in relieving pain, fever and inflammation, they can cause unwanted side effects. Gastrointestinal side effects such as indigestion, stomach upset (including nausea or feeling sick) or stomach pain are commonly caused by NSAIDs. Use of NSAIDs can also cause ulcers and bleeding in the stomach and other parts of the gastrointestinal tract (gut). Other common sid Continue reading >>
