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Can Diabetics Take Amlodipine?

Effects Of Losartan And Amlodipine On Urinary Albumin Excretion And Ambulatory Blood Pressure In Hypertensive Type 2 Diabetic Patients With Overt Nephropathy

Effects Of Losartan And Amlodipine On Urinary Albumin Excretion And Ambulatory Blood Pressure In Hypertensive Type 2 Diabetic Patients With Overt Nephropathy

Editor’s comment: The editorial committee of Diabetes Care had some ethical concerns about potentially leaving patients for up to 24 weeks with blood pressure between 140/90 and 200/110 mmHg. After careful consideration, we decided to publish this article for the following reasons. First, the scientific information was considered valid and important. Second, the study was passed by the institutional review board (IRB) of the investigators. The study was passed by their institution at a time when perhaps ethical guidelines were not as stringent. Third, in response to queries by the editorial committee, the investigators pointed out that other hypertension studies initiated at around that time also had similar protocols. The editorial committee then dealt with the general issue of different criteria utilized by different IRBs around the world. Although the editorial committee will continue to be sensitive to decisions by various IRBs, investigators should realize that the more recent, stricter guidelines will also be considered by the editorial committee should ethical concerns be raised in the review process. OBJECTIVE—Few studies have assessed whether 24-h blood pressure control induced by antihypertensive agents improves macroalbuminuria in hypertensive type 2 diabetic patients with overt nephropathy. We evaluated the effects of losartan and amlodipine on 24-h blood pressure, autonomic nervous activity, and albuminuria in these patients. RESEARCH DESIGN AND METHODS—In this open-label, parallel-prospective, randomized study, 44 patients were treated with losartan and 43 with amlodipine for a 12-week titration phase and a maintenance phase for a maximum of 12 weeks. Twenty-four–hour blood pressure and urinary albumin excretion were measured before and during trea Continue reading >>

Study Of Effect Of Amlodipine On Blood Sugar Level

Study Of Effect Of Amlodipine On Blood Sugar Level

Nepal Journals OnLine (NepJOL) is a service to provide access to Nepalese published research, and increase worldwide knowledge of indigenous scholarship. Read more . Study of Effect of Amlodipine on Blood Sugar Level Objective: To study the effect of AMLODIPINE on blood sugarlevels in hypertensive patients. Method: It is a prospective study in which patients were selected from Princess Esra hospital, Hyderabad. Results: This study was done on 20 mild to moderate newly detected hypertensive patients. Statistical analysis shows a highly significant rise in blood sugar level with P' value < 0.001 after 2 and 4 weeks of using 2.5 to 5 mgm (once daily) amlodipine. Conclusion: As calcium channels are involved in the release of insulin from the cells of pancreas, calcium channel blockers like amlodipine may cause hyperglycemia when used in hypertensive patients. Further studies are required in this field on a larger number of patients. Keywords: Amlodipine; Calcium channel blockers; Diabetes Mellitus; Hypertension Asian Journal of Medical Sciences Vol.1(1) 2010 p.4-5 Amlodipine; Calcium channel blockers; Diabetes Mellitus; Hypertension Continue reading >>

Management Of Hypertension In Patients With Diabetes Using An Amlodipine-, Olmesartan Medoxomil-, And Hydrochlorothiazide-based Titration Regimen.

Management Of Hypertension In Patients With Diabetes Using An Amlodipine-, Olmesartan Medoxomil-, And Hydrochlorothiazide-based Titration Regimen.

Abstract The safety and efficacy of an amlodipine/olmesartan medoxomil (OM)-based titration regimen was assessed in patients with type 2 diabetes mellitus and hypertension. After a 2- to 3-week placebo run-in period, 207 patients received amlodipine 5 mg and were uptitrated to amlodipine/OM 5/20, 5/40, and 10/40 mg and then amlodipine/OM 10/40 mg plus hydrochlorothiazide 12.5 and 25 mg in a step-wise manner at 3-week intervals if the seated blood pressure (BP) remained ≥120/70 mm Hg. The primary end point was the change from baseline in the mean 24-hour ambulatory systolic BP after 12 weeks of treatment. The baseline mean ± SD seated cuff systolic/diastolic BP was 158.8 ± 13.1/89.1 ± 10.1 mm Hg and the mean ± SD 24-hour ambulatory systolic/diastolic BP was 144.4 ± 11.7/81.6 ± 9.8 mm Hg. At week 12, the change from baseline in the mean ± SEM 24-hour ambulatory systolic/diastolic BP was -19.9 ± 0.8/-11.2 ± 0.5 mm Hg (p<0.0001 vs baseline), and 70% of patients had achieved a 24-hour ambulatory BP target of <130/80 mm Hg. At the end of 18 weeks of active treatment in patients uptitrated to amlodipine/OM 10/40 mg plus hydrochlorothiazide 25 mg, the change from baseline in the mean ± SEM seated BP was -28.0 ± 1.5/-13.7 ± 1.0 mm Hg (p<0.0001 vs baseline), with 62% of patients reaching the guideline-recommended seated BP goal of <130/80 mm Hg. Drug-related treatment-emergent adverse events occurred in 19.3% of patients. The most frequent events were peripheral edema (6%), dizziness (3%), and hypotension (2%). In conclusion, this amlodipine/OM-based titration regimen was well tolerated and effectively lowered BP throughout the 24-hour dosing interval in patients with hypertension and type 2 diabetes. Continue reading >>

Blood Glucose & Amlodipine

Blood Glucose & Amlodipine

Amlodipine, sold under the brand name Norvasc, belongs to a class of medications called calcium channel blockers. Amlodipine is mainly used to treat high blood pressure and angina caused by coronary heart disease. Amlodipine relaxes blood vessels so the heart does not have to pump as hard. Amlodipine also increases blood flow to the heart, which relieves chest pain. Amlodipine might affect blood glucose levels. Video of the Day Amlodipine might cause hyperglycemia, or increased blood glucose levels, according to Drugs.com. Glucose is the main source of energy for the body.The body produces glucose from the breakdown of carbohydrates, fats and proteins. High levels of blood glucose can cause damage to blood vessels and body organs. Insulin, a hormone produced by the pancreas, helps the body control blood glucose levels. Healthy people are able to lower high blood glucose levels caused by amlodipine, but diabetics might have problems. Amlodipine should be used cautiously in patients with diabetes. Symptoms of Hyperglycemia Patients with a blood glucose level higher than 160 mg/dl are considered to have hyperglycemia. Amlodipine causes short-term hyperglycemia. Blood glucose levels return to normal when the drug is discontinued. Symptoms of hyperglycemia caused by amlodipine include increased thirst, frequent urination, increased hunger, blurred vision, fatigue and dry mouth. Chronic hyperglycemia is common in patients with diabetes. Amlodipine is available as an oral tablet that is taken once daily. Amlodipine should be taken around the same time each day. Diabetics should check their blood glucose levels before and after taking amlodipine. Patients taking amlodipine should be aware of the signs of hyperglycemia and report them to their doctor. Patients taking amlodipine Continue reading >>

Amlodipine - Oral, Norvasc

Amlodipine - Oral, Norvasc

The display and use of drug information on this site is subject to express terms of use. By continuing to view the drug information, you agree to abide by such terms of use. amlodipine - oral, Norvasc GENERIC NAME: AMLODIPINE - ORAL (am-LOE-di-peen) BRAND NAME(S): Norvasc USES: Amlodipine is used with or without other medications to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Amlodipine belongs to a class of drugs known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily.Amlodipine is also used to prevent certain types of chest pain (angina). It may help to increase your ability to exercise and decrease the frequency of angina attacks. It should not be used to treat attacks of chest pain when they occur. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor. How to Lower Blood Pressure: Exercise Tips HOW TO USE: Take this medication by mouth with or without food as directed by your doctor, usually once daily.The dosage is based on your medical condition and response to treatment. Your doctor may gradually increase your dose. Follow your doctor's instructions carefully.Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.If used for angina, this medication must be taken regularly to be effective. It should not be used to treat angina when it occurs. Use other medications (such as sublingual nitroglycerin) to relieve an angina attack as directed by your doctor. Consult your doctor or pharmacist for details.T Continue reading >>

What Medicines Can Make Your Blood Sugar Spike?

What Medicines Can Make Your Blood Sugar Spike?

If you have diabetes or high blood sugar, you probably know some of the things that cause your glucose (another name for blood sugar) to go up. Like a meal with too many carbohydrates, or not enough exercise. But other medicines you might take to keep yourself healthy can cause a spike, too. Know Your Meds Medicines you get with a prescription and some that you buy over the counter (OTC) can be a problem for people who need to control their blood sugar. Prescription medicines that can raise your glucose include: Steroids (also called corticosteroids). They treat diseases caused by inflammation, like rheumatoid arthritis, lupus, and allergies. Common steroids include hydrocortisone and prednisone. But steroid creams (for a rash) or inhalers (for asthma) aren’t a problem. Drugs that treat high blood pressure, such as beta-blockers and thiazide diuretics High doses of asthma medicines, or drugs that you inject for asthma treatment OTC medicines that can raise your blood sugar include: Cough syrup. Ask your doctor if you should take regular or sugar-free. How Do You Decide What to Take? Even though these medicines can raise your blood sugar, it doesn’t mean that you shouldn’t take them if you need them. The most important thing is to work with your doctor on the right way to use them. If you have diabetes or you’re watching your blood sugar, ask your doctor before you take new medicines or change any medicines, even if it’s just something for a cough or cold. (Remember, just being sick can raise your blood sugar.) Make sure your doctor knows all the medicines you take -- for diabetes or any other reason. If one of them may affect your blood sugar, she may prescribe a lower dose or tell you to take the medicine for a shorter time. You may need to check your blood s Continue reading >>

Effects Of Amlodipine Fosinopril Combination On Microalbuminuria In Hypertensive Type 2 Diabetic Patients

Effects Of Amlodipine Fosinopril Combination On Microalbuminuria In Hypertensive Type 2 Diabetic Patients

The aim of this study is to compare the long-term effect of amlodipine and fosinopril in monotherapy or in combination on urinary albumin excretion (UAE) in hypertensive diabetic patients. We selected 453 hypertensive patients with type 2 diabetes and microalbuminuria and randomized them to amlodipine (5 to 15 mg/day), fosinopril (10 to 30 mg/day), or amlodipine plus fosinopril (5/10 to 15/30 mg/day) for a 3-month titration period. The nonresponder patients or those complaining of side effects during the titration period were discontinued (n = 144); the remaining 309 patients were enrolled in the trial and treated with the same therapy for 4 years. Every 6 months, blood pressure (BP), heart rate (HR), UAE, creatinine clearance, and glycosylated hemoglobin (HbA1c) were evaluated. The combination therapy was more effective in reducing BP than either drug alone at any time of the study without affecting glucose homeostasis. All three treatments provided a significant decrease in UAE during the 48-month study period. However, this effect was more pronounced and became evident earlier with fosinopril than with amlodipine monotherapy (after 3 v 18 months of therapy). In addition, the combination therapy provided a greater antialbuminuric effect than the single drugs. This could be due to the greater antihypertensive effects, although other drug-specific effects cannot be excluded. The cardiovascular outcomes were similar in the amlodipine and in the fosinopril group, but they were lower in the combination group. These results strengthen the rationale to use a calcium-antagonist/angiotensin converting enzyme inhibitor combination in the treatment of hypertensive patients with type 2 diabetes. Hypertension , diabetes , microalbuminuria , amlodipine , fosinopril Longitudinal st Continue reading >>

Diabetes Clinic

Diabetes Clinic

Medicines affect different people in different ways. Just because side effects have occurred in other patients does not mean you will get them. Discuss how you feel on Norvasc with your doctor and pharmacist. Do not stop taking Norvasc on your own. A few patients report mild tenderness or swelling of their gums while taking Norvasc. This effect can be prevented with good dental care. Brush your teeth carefully and often with a soft toothbrush, and use dental floss daily. Massaging your gums regularly with a soft toothbrush will also help. If your gums become tender, red or swollen be sure to tell your doctor or dentist. Other side effects have been reported in a few cases. These include tingling in the hands, arms, feet or legs, stomach upset and diarrhea. Again, if any of these effects bother you, be sure to tell your doctor. You should be certain to contact your doctor immediately if you experience anything unusual. Keep Norvasc out of sight and out of the reach of children. Never take medicine in front of small children as they will want to copy you. Unused medicines which you know you will no longer need should be carefully discarded. Small quantities may be disposed of in the toilet or you may wish to seek advice from your pharmacist. The Compliance Pack protects each tablet. When you first open the package, if you find any damage to the plastic seal or foil which exposes the tablet, ask your pharmacist to check the package. Check with your doctor if you want to drink alcohol (including wine with your meals) while you are Norvasc. Drinking alcohol while on Norvasc may make you feel dizzier than usual. Alcohol may also cause an uncomfortable drop in blood pressure. Remember, you may not notice any signs of high blood pressure. Therefore it is important to take Norv Continue reading >>

Uptitrating Amlodipine Significantly Reduces Blood Pressure In Diabetic Patients With Hypertension: A Retrospective, Pooled Analysis

Uptitrating Amlodipine Significantly Reduces Blood Pressure In Diabetic Patients With Hypertension: A Retrospective, Pooled Analysis

Uptitrating amlodipine significantly reduces blood pressure in diabetic patients with hypertension: a retrospective, pooled analysis Correspondence: Barrett W Jeffers, Pfizer Inc., 235 East 42nd Street, New York, NY 10017, USA, Tel +1 908 901 7231, Email [email protected] Author information Copyright and License information Disclaimer Copyright 2014 Jeffers et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution Non Commercial (unported, v3.0) License The full terms of the License are available at . Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Diabetic patients with hypertension are approximately twice as likely to develop cardiovascular disease as non-diabetic patients with hypertension. Given that hypertension affects 60% of patients with diabetes, effective blood pressure (BP) management is important in this high-risk population. This post-hoc analysis pooled data from six clinical studies to quantify additional BP efficacy achieved when titrating hypertensive diabetic patients from amlodipine 5 mg to 10 mg. Approximately half of the diabetic patients were male (44/98; 44.9%) with a mean (standard deviation [SD]) age of 60.6 (9.6) years and a baseline mean (standard error [SE]) systolic blood pressure/diastolic blood pressure (SBP/DBP) of 150.8 (1.30)/87.5 (0.94) mmHg while on amlodipine 5 mg (159.1 [1.40]/92.6 [0.94] mmHg prior to treatment). In comparison, 350/610 (57.4%) non-diabetic patients were male with a mean (SD) age of 58.7 (11.1) years and baseline mean (SE) SBP/DBP of 150.3 (0.62)/90.9 (0.41) mmHg while on amlodipine 5 mg (160.0 [0.67]/96.2 [0.45] mmHg prior to treatment). Increasing amlo Continue reading >>

The Effect Of Amlodipine On Blood Glucose Level And Its Interaction With Oral Hypoglycemic Drugs In Albino Rabbits - Scopemed.org - Deposit For Medical Articles

The Effect Of Amlodipine On Blood Glucose Level And Its Interaction With Oral Hypoglycemic Drugs In Albino Rabbits - Scopemed.org - Deposit For Medical Articles

The effect of amlodipine on blood glucose level and its interaction with oral hypoglycemic drugs in albino rabbits Rajeev Prajapat, I. P. Jain, S. P. Singh, Suresh Singh, Pooja Agarwal. Background: Amlodipine used as many cardiac conditions esp in hypertension. Diabetes affects cardiovascular system adversely. So this study was done to see effect of amlodipine on blood glucose level and its interaction with commonly used oral hypoglycemic agents in diabetic & non diabetic albino rabbits. Methods: Rabbits were divided into nine groups of 6 rabbits in each group. I and II group were non-diabetic given normal saline and amlodipine respectively. Group III to IX were made diabetic by using alloxan monohydrate (150mg/kg i.p.) & given normal saline, glimepiride, metformin, pioglitazone, amlodipine + glimepiride, amlodipine + metformin and amlodipine + pioglitazone respectively. All drugs were given orally once daily for 7 day except group VII, VIII and IX in which glimepiride, metformin and pioglitazone were added on 7th day. After GTT blood glucose level were measured at 0, 1, 2 and 6 hours on 7th day in all groups by using spectrophotometer. Results: After 7 days of treatment the amlodipine produced significant hyperglycemia in normal rabbits. Amlodipine on combination, causes significant decreased in hypoglycemic effect of glimepiride, significant increased the hypoglycemic effect of metformin, while no significant changes in hypoglycemic effects of pioglitazone in diabetic rabbits. Conclusion: The present study shows that amlodipine causes hyperglycemia in normal rabbits. Amlodipine significantly altered hypoglycemic effect of glimepiride and metformin as compared to control group. If these finding are true to human beings then amlodipine should be use cautiously in diabe Continue reading >>

Adht: Amlodipine Diabetic Hypertension Efficacy Response Evaluation Trial

Adht: Amlodipine Diabetic Hypertension Efficacy Response Evaluation Trial

ADHT: Amlodipine Diabetic Hypertension Efficacy Response Evaluation Trial Authors: Linda Brookes, MSc Faculty and Disclosures Presenter: Joel M Neutel, MD (Orange County Heart Institute and Research Center, Orange, California) Diabetic patients have a better chance of controlling their blood pressure with a combination of an angiotensin converting enzyme (ACE) inhibitor or an angiotensin receptor blocker (ARB) and a calcium channel blocker (CCB), according to the results of the Amlodipine Diabetic Hypertension Efficacy Response Evaluation Trial (ADHT). [1] Adding a second drug, in this case the CCB amlodipine, to monotherapy with an ACE inhibitor or an ARB more than doubled the control rate in diabetic hypertensive patients in this study. The study "confirms that the use of combination therapy is critically important in the management of hypertension -- when you do it, you need to do it early and more aggressively," Dr. Neutel said. Diabetic patients with elevated blood pressure are at greater risk of cardiovascular disease than patients without diabetes, yet most diabetic patients treated for hypertension do not achieve blood pressure goals set out by current US guidelines. [2-4] Although tight blood pressure control in diabetic patients confers even more protection than glycemic control, < 20% of these patients achieve blood pressure levels of 130/80 mm Hg. Another factor is "therapeutic inertia," with surveys showing too many physicians accepting inadequate control, even after treatment, in these patients. Aggressive blood pressure treatment is important in these patients, and addition of a second, complementary antihypertensive drug will always be more successful in lowering blood pressure than uptitrating the first drug. "We are dealing with multifactorial disease Continue reading >>

Drugs That Can Worsen Diabetes Control

Drugs That Can Worsen Diabetes Control

One of the main goals of any diabetes control regimen is keeping blood glucose levels in the near-normal range. The cornerstones of most plans to achieve that goal include following a healthy diet, getting regular exercise, and taking insulin or other medicines as necessary. However, it’s not uncommon for people with diabetes to have other medical conditions that also require taking medicines, and sometimes these drugs can interfere with efforts to control blood glucose. A few medicines, including some commonly prescribed to treat high blood pressure and heart disease, have even been implicated as the cause of some cases of diabetes. This article lists some of the medicines that can worsen blood glucose control, the reasons they have that effect, the usual magnitude of the blood glucose changes, as well as the pros and cons of using these drugs in people who have diabetes. Where the problems occur To understand how various medicines can worsen blood glucose control, it helps to understand how insulin, the hormone responsible for lowering blood glucose, works in the body. Insulin is released from the beta cells of the pancreas in response to rising levels of glucose in the bloodstream, rising levels of a hormone called GLP-1 (which is released from the intestines in response to glucose), and signals from the nerve connections to the pancreas. The secretion of insulin occurs in two phases: a rapid first phase and a delayed second phase. Both of these phases are dependent on levels of potassium and calcium in the pancreas. Insulin acts on three major organs: the liver, the muscles, and fat tissue. In the liver, insulin enhances the uptake of glucose and prevents the liver from forming new glucose, which it normally does to maintain fasting glucose levels. In muscle and f Continue reading >>

Amlodipine And Blood Sugars

Amlodipine And Blood Sugars

Diabetes Forum The Global Diabetes Community This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies. Learn More. Get the Diabetes Forum App for your phone - available on iOS and Android . Find support, ask questions and share your experiences. Join the community Rachox Type 2 (in remission!) Moderator I have been on Amlodipine and Ramipril for a number of years for my blood pressure. Since being diagnosed Type 2, going low carb and loosing a chunk of weight my BP had come down to the point when I was getting dizzy if I stood up quickly. After a week of home monitoring with an average BP of 124/77 my GP agreed I could stop the Amlodipine. That was three weeks ago. I have been monitoring my BP every day and since stopping it my BP is averaging 127/77 so just a tiny rise. However the main point of this post is that Id read that Amlodipine can raise blood sugars in Type 2s. I never knew if that was true for me as I was on Amlodipine before my type 2 diagnosis. That was why I wanted to drop the Amlodipine rather than the Ramipril, plus Ramipril has kidney protecting qualities. Anyway my average blood sugars are down, so far March is showing an average of 5.4 down from Februarys 5.5 and were only half way through March! Several times a week Im getting 4s now in the evenings where before 4s were a rarity! Im seeing my GP next Tuesday and am hoping I can stay off Amlodipine. Im not sure when hell want my next HbA1c but Im hoping May 3 months after my last and if my HbA1c has gone down further Im going to ask to drop one of my Metformin. I think hell agree as he said those immortal words at my last appointment that he didnt want my HbA1c to go much lower! Just thought this might be interesting to any other Type 2s on Amlodipine. Remember Continue reading >>

Amlodipine And Death/stroke Incidence

Amlodipine And Death/stroke Incidence

Diabetes & Heart Health There's new information about how to protect your heart. A segment of the Anglo-Scandinavian Cardiac Outcomes Trial looked at the effect of two kinds of antihypertension drugs on the heart health of people with type 2 diabetes.The results were so dramatic that the study was stopped early in order to afford all participants the benefits of what was becoming evident. Comparing the effect of taking a calcium channel blocker (amlodipine) to a beta blocker (atenolol), researchers found that amlodipine reduced the incidence of death and stroke significantly. Fatal and nonfatal strokes were reduced by 25 percent, peripheral arterial disease by 48 percent and noncoronary revascularization procedures (such as angioplasty) by 57 percent in comparison to what happened to those taking atenolol. Further questions about atenolol arose from a review of nine clinical trials on the use of beta blockers for treatment of hypertension published in the Journal of the American College of Cardiology on October 28, 2008. Most of the patients were taking atenolol. The researchers found that even though atenolol or other beta blockers lower the heart rate, they were associated with a greater risk of heart attack, stroke, heart failure and death from all causes. Scientists do stress the need for more studies before this finding is confirmed. Myths about Cholesterol If you are concerned about lowering your cholesterol levels, the first things to give up are faulty beliefs. Myth 1: You should never eat eggs if you have high cholesterol. Reality: It's true that for people with high cholesterol, limiting egg consumption is important. One egg contains 215 mg of cholesterol, and the American Heart Association says that those with heart disease should get only 200 mg a day. But p Continue reading >>

Can The Drug Amlodipine Besylate 5 Mg Raise Blood Sugar Testing?

Can The Drug Amlodipine Besylate 5 Mg Raise Blood Sugar Testing?

Home Q & A Questions Can the drug AMLODIPINE... Can the drug AMLODIPINE BESYLATE 5 mg raise blood sugar testing? Since taking this drug (about 5 weeks) my blood sugar readings have been rising. Is this a usual side effect? Yes, hypreglycemia (raised blood sugar levels) is a known side effect of amlodipine. If the readings are very high then please see your doctor. Still looking for answers? Try searching for what you seek or ask your own question . Can I take Moringa and Amlodipine Besylate at the same time? The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to receive email notifications whenever new articles are published. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated June 1st, 2018), Cerner Multum (updated June 5th, 2018), Wolters Kluwer (updated June 4th, 2018) and others. To view content sources and attributions, please refer to our editorial policy . Continue reading >>

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