Diabetes And Hypertension Linked To Colon Cancer Recurrence And Survival
Diabetes and hypertension linked to colon cancer recurrence and survival Diabetes and hypertension linked to colon cancer recurrence and survival By all accounts, combining colon cancer, diabetes, and high blood pressure can be a recipe for medical disaster. A new study has shown just how deadly this mix can be. This retrospective analysis of more than 36,000 patients with colon cancer found that those with early stage disease and diabetes or high blood pressuretwo components of metabolic syndromehave a greater risk for recurrence after treatment and of dying compared with patients with colon cancer who do not have either condition. Metabolic syndrome is a cluster of conditions that affects one in five American adults. It can include diabetes, obesity, high blood pressure, low levels of good cholesterol, and high amounts of lipid in the blood. Although metabolic syndrome has been linked to colon cancer, the third leading cause of cancer death in the United States, previous work looking at its effect on mortality has not adequately accounted for cancer stage or treatment, said senior author Nestor Esnaola, MD, MPH, MBA, of Temple University School of Medicine. Our results suggest that patients with early stage colon cancer who also have diabetes or hypertension may need to be followed more closely for recurrence and could potentially benefit from broader use of adjuvant chemotherapy. To better understand the effect of metabolic syndrome on colon cancer outcomes, Esnaola and his team linked data from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) program, a large population-based database, to Medicare data from 1998 to 2006 on 36,079 patients with colon cancer, including 7,024 patients (19.5%) who were identified as having metabolic syn Continue reading >>
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The Deadly Link Between Colon Cancer, Diabetes And High Blood Pressure
The Deadly Link Between Colon Cancer, Diabetes and High Blood Pressure If youre among the nearly 26 million Americans with diabetes or the 68 million with high blood pressure, then listen up, especially if you have been diagnosed with colon cancer. A recent study reveals that patients with both colon cancer and diabetes or high blood pressure are at a greater risk for recurrence after treatment and of dying compared with patients with colon cancer who do not have either condition. In this study published in Cancer, of the more than 36,000 patients with colon cancer, 47.7 percent of patients who did not have diabetes were still alive five years after diagnosis compared to only 41.3 percent of patients with diabetes. Researchers also found that at five years, the cancer recurrence rate was almost eight percent higher in patients with diabetes or hypertension. Diabetes and high blood pressure are just two of five conditions comprising metabolic syndrome , a medical disorder that makes people more susceptible to serious disease. Previous research has linked metabolic syndrome to colon cancer, but this study shows a direct relationship between cancer stages and treatment. If you have or have had colon cancer and diabetes or high blood pressure, then you may need to be more closely monitored by your health care provider in order to prevent possible cancer recurrence. Your doctor may also recommend a broader use of adjuvant chemotherapy , additional treatment to destroy cells that may still be present after the cancer has been surgically removed. Colon cancer is the third leading cause of cancer death in the United States, but add a condition like diabetes or hypertension into the mix and the odds may really be stacked against you. Talk to your doctor today for more informati Continue reading >>
The Relationship Between Diabetes And Colorectal Cancer Prognosis: A Meta-analysis Based On The Cohort Studies
The relationship between diabetes and colorectal cancer prognosis: A meta-analysis based on the cohort studies Affiliation: Department of Cancer Prevention and Treatment, Cancer Hospital of China Medical University/ Liaoning Cancer Hospital & Institute, Dadong District, Shenyang, Peoples Republic of China Affiliation: Department of Clinical Epidemiology and Evidence Medicine, The First Hospital of China Medical University, Heping District, Shenyang, Peoples Republic of China Affiliation: Department of Anus and Intestine Surgery, The First Hospital of China Medical University, Heping District, Shenyang, Peoples Republic of China Affiliation: Department of Occupational health, Liaohe Petrochemical Company of China National Petroleum Corporation, Xinglongtai District, Panjin, Peoples Republic of China Affiliation: Department of Cancer Prevention and Treatment, Cancer Hospital of China Medical University/ Liaoning Cancer Hospital & Institute, Dadong District, Shenyang, Peoples Republic of China Affiliation: Department of Cancer Prevention and Treatment, Cancer Hospital of China Medical University/ Liaoning Cancer Hospital & Institute, Dadong District, Shenyang, Peoples Republic of China Though a meta-analysis reported the effect of diabetes on colorectal prognosis in 2013, a series of large-scale long-term cohort studies has comprehensively reported the outcome effect estimates on the relationship between diabetes and colorectal prognosis, and their results were still consistent. We carried out an extensive search strategy in multiple databases and conducted a meta-analysis on the effect of diabetes on colorectal prognosis, based on the included 36 cohort studies, which contained 2,299,012 subjects. In order to collect more data, besides conventional methods, we used the p Continue reading >>
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Preventing Colorectal Cancer
Colorectal cancer is the third most common type of cancer in both men and women. It is also the second most common cause of cancer death in the United States. About 57,000 Americans die from this disease each year, and 145,000 new cases are diagnosed. Only lung cancer leads colorectal cancer in cancer deaths. All Americans should take steps to reduce their risk of colorectal cancer and be screened for it regularly, but people with Type 2 diabetes have even more reason to educate themselves about this deadly disease. Thats because they are at greater risk of developing it than the rest of the population. This article offers some suggestions for lowering your risk as well as guidelines for screening for early detection. Colorectal cancer is a cancer, or tumor, that forms in the colon (the large intestine) and/or rectum (the last 8 to 10 inches of the colon). The colon is where water and nutrients are reabsorbed into the bloodstream as the last stage of digestion. At this point only waste remains. The waste is then eliminated through the rectum and anus. Symptoms of colorectal cancer can include a change in bowel habits, blood in the stool, lower abdominal pain or cramping, fatigue, and vomiting. In the early stages, however, there are no symptoms. The early stages are also the time when it is easiest to cure. Thats why regular screening is so important. However, because so many Americans do not get screened according to the schedule recommended by the American Cancer Society, only about 39% of cases of colorectal cancer are found in the early stages. Most cases of colorectal cancer develop from precancerous polyps, or adenomas. Polyps are growths in the colon that occur frequently in people over 50. Although most polyps are benign, or noncancerous, they can become malign Continue reading >>
Diabetes Status And Being Up-to-date On Colorectal Cancer Screening, 2012 Behavioral Risk Factor Surveillance System
Diabetes Status and Being Up-to-Date on Colorectal Cancer Screening, 2012 Behavioral Risk Factor Surveillance System ORIGINAL RESEARCH Volume 13 February 4, 2016 Nancy R. Porter, MS; Jan M. Eberth, PhD; Marsha E. Samson, MSPH; Oralia Garcia-Dominic, PhD, MS, MA; Eugene J. Lengerich, VMD, MS; Mario Schootman, PhD Suggested citation for this article: Porter NR, Eberth JM, Samson ME, Garcia-Dominic O, Lengerich EJ, Schootman M. Diabetes Status and Being Up-to-Date on Colorectal Cancer Screening, 2012 Behavioral Risk Factor Surveillance System. Prev Chronic Dis 2016;13:150391. DOI: . Although screening rates for colorectal cancer are increasing, 22 million Americans are not up-to-date with recommendations. People with diabetes are an important and rapidly growing group at increased risk for colorectal cancer. Screening status and predictors of being up-to-date on screening are largely unknown in this population. This study used logistic regression modeling and data from the 2012 Behavioral Risk Factor Surveillance System to examine the association between diabetes and colorectal cancer screening predictors with being up-to-date on colorectal cancer screening according to criteria of the US Preventive Services Task Force for adults aged 50 or older. State prevalence rates of up-to-date colorectal cancer screening were also calculated and mapped. The prevalence of being up-to-date with colorectal cancer screening for all respondents aged 50 or older was 65.6%; for respondents with diabetes, the rate was 69.2%. Respondents with diabetes were 22% more likely to be up-to-date on colorectal cancer screening than those without diabetes. Among those with diabetes, having a routine checkup within the previous year significantly increased the odds of being up-to-date on colorectal c Continue reading >>
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Cancer And Diabetes: Managing A Dual Diagnosis
Benefits of good nutrition Nutritional support at CTCA Preventing malnutrition Cancer and diabetes Managing side effects with nutrition What to eat Nutrition tips If you are managing cancer and diabetes, you understand how difficult it can be to eat right and stay strong. Each of these diseases can be frustrating enough to deal with on their own. When battling them at the same time, it can take your stress to new levels. Regardless of which disease came first, know you are not the only one dealing with this situation. Cancer and diabetes often co-exist. And, while managing both diseases simultaneously can be difficult, it can be done. The first step is understanding. Understanding diabetes Diabetes is a disease in which the body does not produce or properly use insulin. Insulin is a hormone secreted by the pancreas (the large gland behind the stomach). Insulin is needed to convert sugar, starches and other carbohydrates into energy needed for daily life. Much of the food you eat is broken down into glucose (sugar), which is the main source of fuel for the body. After digestion, glucose passes into the bloodstream and, with the help of insulin, it moves into the body’s cells where it provides fuel for metabolic processes. If the pancreas produces little or no insulin, or if the body’s cells do not respond appropriately to the insulin that is produced, glucose accumulates in the blood. Thus, the body’s cells lose their main source of fuel. Also, when there is too much sugar in the blood for long periods of time, other cells become damaged. While an estimated 14.6 million Americans (about 7 percent of the U.S. population) have been diagnosed with diabetes, about 6.2 million people have the disease and don’t even realize it. Types of diabetes There are two main type Continue reading >>
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Diabetes And Colon Cancer: An Emerging Link
More than 25 million adults aged 20 and older in the United States have diabetes. That figure has more than tripled since 1980. That is bad news for a number of reasons. Not only can diabetes cause heart disease, stroke, nerve damage, and eye issues, but recent research now shows there is also a clear link between type 2 diabetes and colon cancer. Colon cancer is one of the most preventable types of cancer, yet it is still the third most common cancer among both men and women in the U.S. And, many of the ways people can lower their risk for colon cancer are actually the same as how they can avoid developing type 2 diabetes. These include: Staying away from a diet high in red and processed meats Keeping physically active Maintaining a healthy weight Staying away from tobacco Avoiding heavy alcohol use Even though the two diseases share several common risk factors, research shows that type 2 diabetes itself is indeed linked to increased risk of developing colon cancer. Studies also show that among patients diagnosed with colorectal cancer, those with diabetes were more likely than those without it to die – even after controlling for other factors such as disease stage, body weight, and smoking habits. There are a few major hypotheses for the link, according to Peter Campbell, Ph.D., an American Cancer Society researcher who has been studying the connection between diabetes and colon cancer for a number of years. One idea has to do with a condition that causes the amount of insulin in a person’s blood to be higher than normal, called hyperinsulinemia. Insulin is the body’s way of regulating the amount of sugar – or glucose – in the blood. Hyperinsulinemia can lead to the development of type 2 diabetes. The thought, says Campbell, is that the abnormally high level Continue reading >>
Colon Cancer Prognosis Worse For The Obese, Type 2 Diabetics
home / cancer center / cancer a-z list / colon cancer worse for obese, type 2 diabetics article Colon Cancer Prognosis Worse for the Obese, Type 2 Diabetics FRIDAY, Dec. 2 (HealthDay News) -- People who have been diagnosed with colon cancer have a poorer prognosis if they're obese or have type 2 diabetes , new research suggests. Want More News? Sign Up for MedicineNet Newsletters! Two new studies that looked at the impact that body-mass index (BMI) and a diagnosis of type 2 diabetes had on survival rates after a colon cancer diagnosis found that both factors influence whether or not someone survives colorectal cancer. In addition, both studies found that deaths from any cause, including heart disease , were also increased in those who were obese or had type 2 diabetes. Results of the studies were published online in the Journal of Clinical Oncology. "The message here is to avoid obesity and type 2 diabetes because they have negative health outcomes. We don't know for sure that losing weight or increasing physical activity will help, but we know they're good for trying to avoid other diseases, like cardiovascular disease, that can come up down the road," said Dr. Jeffrey Meyerhardt, author of an accompanying editorial in the same journal, and an associate professor of medicine at the Dana-Farber Cancer Institute and Harvard Medical School in Boston. There are more than 1 million people who've survived a colon cancer diagnosis living in the United States, and mortality from colorectal cancer has gone down over the past two decades, according to background information in the studies. And, while previous research has linked a higher BMI and type 2 diabetes to the development of colorectal cancer in the first place, it hasn't been clear how these factors influence the cours Continue reading >>
Diabetes Mellitus And Risk Of Colorectal Cancer: A Meta-analysis
Diabetes Mellitus and Risk of Colorectal Cancer: A Meta-Analysis Affiliation of authors: Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Correspondence to: Susanna C. Larsson, LicMSc, Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, P.O. Box 210, SE-171 77 Stockholm, Sweden (e-mail: [email protected] ). Search for other works by this author on: Affiliation of authors: Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Search for other works by this author on: Affiliation of authors: Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Search for other works by this author on: JNCI: Journal of the National Cancer Institute, Volume 97, Issue 22, 16 November 2005, Pages 16791687, Susanna C. Larsson, Nicola Orsini, Alicja Wolk; Diabetes Mellitus and Risk of Colorectal Cancer: A Meta-Analysis, JNCI: Journal of the National Cancer Institute, Volume 97, Issue 22, 16 November 2005, Pages 16791687, Background: Diabetes has been associated with an increased risk of colorectal cancer in most, but not all, studies. Findings have also been inconclusive with regard to sex and subsite in the colorectum. To resolve these inconsistencies, we conducted a meta-analysis of published data on the association between diabetes and the incidence and mortality of colorectal cancer. Methods: We identified studies by a literature search of Medline from January 1, 1966, through July 31, 2005, and by searching the reference lists of pertinent articles. Summary relative risks (RRs) with 95% confidence in Continue reading >>
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Management Of Colorectal Cancer And Diabetes
Management of colorectal cancer and diabetes We are experimenting with display styles that make it easier to read articles in PMC. The ePub format uses eBook readers, which have several "ease of reading" features already built in. The ePub format is best viewed in the iBooks reader. You may notice problems with the display of certain parts of an article in other eReaders. Generating an ePub file may take a long time, please be patient. Management of colorectal cancer and diabetes Caroline Yao, Guy F Nash, and Tamas Hickish Colorectal cancer is associated with diabetes mellitus and both of these common conditions are often managed together by a surgeon. The surgical focus is usually upon cancer treatment rather than diabetes management. The relationship between colorectal cancer and diabetes is a complex one and can raise problems in both diagnosis and the management of patients with both conditions. This literature review explores the relationship between diabetes, diabetic treatment and colorectal cancer and addresses the issues that arise in diagnosing and treating this patient group. By highlighting these difficulties, this review aims to improve understanding and to provide clearer insight into both surgical and non-surgical management. Keywords: colorectal cancer, diabetes mellitus, colon cancer, rectal cancer, surgery Colorectal cancer is associated with diabetes mellitus and both of these common conditions are often managed together by a surgeon. The surgical focus is usually upon cancer treatment rather than diabetes management. Type II (non-insulin dependent) diabetes seems to increase colorectal cancer incidence 1 , 2 and certainly the incidences of both seem to increase with age. There are factors that surgeons should be aware of in the perioperative period Continue reading >>
Incidence Of Diabetes In Colorectal Cancer Survivors
Incidence of Diabetes in Colorectal Cancer Survivors Odette Cancer Centre, Sunnybrook Health Sciences Centre Institute for Clinical Evaluative Sciences Institute of Health Policy, Management and Evaluation Womens College Research Institute, Womens College Hospital Odette Cancer Centre, Sunnybrook Health Sciences Centre Institute for Clinical Evaluative Sciences Institute of Health Policy, Management and Evaluation Womens College Research Institute, Womens College Hospital Odette Cancer Centre, Sunnybrook Health Sciences Centre Institute for Clinical Evaluative Sciences Institute of Health Policy, Management and Evaluation Womens College Research Institute, Womens College Hospital Odette Cancer Centre, Sunnybrook Health Sciences Centre Institute for Clinical Evaluative Sciences Institute of Health Policy, Management and Evaluation Womens College Research Institute, Womens College Hospital Odette Cancer Centre, Sunnybrook Health Sciences Centre Institute for Clinical Evaluative Sciences Institute of Health Policy, Management and Evaluation Womens College Research Institute, Womens College Hospital Odette Cancer Centre, Sunnybrook Health Sciences Centre Institute for Clinical Evaluative Sciences Institute of Health Policy, Management and Evaluation Womens College Research Institute, Womens College Hospital Odette Cancer Centre, Sunnybrook Health Sciences Centre Institute for Clinical Evaluative Sciences Institute of Health Policy, Management and Evaluation Womens College Research Institute, Womens College Hospital Odette Cancer Centre, Sunnybrook Health Sciences Centre Institute for Clinical Evaluative Sciences Institute of Health Policy, Management and Evaluation Womens College Research Institute, Womens College Hospital Odette Cancer Centre, Sunnybrook Health Sciences C Continue reading >>
Type Two Diabetes Linked To Increase Colon Cancer Risk
Type Two Diabetes Linked to Increase Colon Cancer Risk Type Two Diabetes Linked to Increase Colon Cancer Risk Type Two Diabetes Linked to Increase Colon Cancer Risk If you have diabetes, you know its about more than just managing your blood sugar. Diabetics have an increased risk of many serious health complications like nerve damage, stroke, kidney disease and vision problems. And now, new research shows that type 2 diabetes is clearly linked to an increased risk of colon cancer. Paul J.H.L. Peeters of the Utrecht University in the Netherlands led a team of researchers in an observational population-based cohort study to assess the risk of colon cancer among nearly 300,000 patients on antidiabetic medications. The diabetic patients were matched with a comparison cohort of individuals without diabetes. After a median follow-up of 4.5 years, researchers found 2,759 cases of colon cancer among the group of diabetic patients. The authors concluded that type two diabetes was associated with a 1.3-fold increased risk of colon cancer, with the greatest risk seen among patients who had been obese for 4-8 years and longer than 8 years (Source: Diabetes Care ). In addition to an increased risk of developing colon cancer, diabetics also have an increased risk of colon cancer morbidity. Studies show that colon cancer patients with diabetes are more likely to die than patients without diabetes, even after accounting for other factors like disease stage, smoking and obesity. The reason behind this risk is still unknown, but Peter Campbell, Ph.D., of the American Cancer Society offers a few theories. The first is hyperinsulinemia, a condition which causes a persons insulin levels to be higher than normal. These high levels of insulin are thought to promote the growth and development Continue reading >>
Diabetes And Colon Cancer - Symptoms, Stages, Diagnosis, Treatment
Colon cancer is also known as bowel cancer Colon cancer, also known as bowel cancer or colorectal cancer, is the third most common form of cancer. Colon cancer is linked with diet factors and obesity and people with type 2 diabetes have been found to have a higher chance of developing it. Colon cancer is most commonly diagnosed in older people as the risks increase with age. The colon is the large intestine which is the last part of the digestive system and ends at the rectum. Colon cancer occurs when cells of the glands in the colon start to grow in an uncontrolled fashion, and therefore tumours develop. If untreated, the cancer will grow into the muscle wall of the colon and can spread to neighbouring organs. The risk of developing bowel cancer is increased for people who: Have a related bowel condition - such as Crohns disease or ulcerative colitis The risk of bowel cancer increases with age. People with type 2 diabetes have also been shown to be at a greater risk of developing bowel cancer although the reasons why are not yet understood well enough to say why. Large scale research study published in 2011 indicated that people with type 2 diabetes had a 38% higher risk of developing colon cancer than those without diabetes. The earliest stages of bowel cancer present no symptoms and so people are strongly encouraged to respond to bowel cancer screenings. The sooner bowel cancer can be spotted, the easier it is to treat and the less chance it has to spread to neighbouring parts of the body. Bleeding in the bowel can cause anaemia, which in turn can lead to persistent tiredness. Diagnosis of colon cancer involve your doctor feeling your abdomen for signs of the cancer. Your doctor will perform a rectal examination which will involve putting on a rubber glove and feeli Continue reading >>
Diabetes And Colon Cancer: An Emerging Link
see more news Want to hear some sobering news? Over 25 million American adults over the age of 20 have diabetes, and the number of cases has tripled since 1980. Although diabetes can be linked to age, ethnicity and family history, life choices are most likely responsible for the dramatic increase of new cases of type 2 diabetes. You may already know that diabetes is linked to many other conditions such as heart disease, nerve damage, vascular damage, stroke and eye issues. Recent studies have found a new and surprising discovery: there is a clear link between diabetes and colon cancer. Even though these two diseases share many of the same risk factors, type 2 diabetes itself is associated with an increased risk of developing colorectal cancer. Furthermore, diabetic patients who develop colon cancer are more likely to die from the disease, even when controlling other risk factors such as body weight, smoking habits and disease stage. What is the nature of this connection? Peter Campbell, Ph.D., an American Cancer Society researcher, has been studying the diabetes-colon cancer connection for several years and has developed a few theories. One theory has to do with hyperinsulinemia, a condition in which blood insulin levels are higher than normal and can lead to type 2 diabetes. Campbell suggests that high levels of insulin and glucose could create an environment in the colon that facilitates the development of tumors. Another theory has to do with hyperglycemia, or too much sugar in the blood. Untreated hyperglycemia, which can cause diabetes, can cause inflammation in the colon, which can lead to cancer. Previous research caused scientists to speculate whether injected insulin increased risk for colon cancer, but now it seems that the elevated risk has to do with type 2 Continue reading >>
Oncotarget | 2017 Update On The Relationship Between Diabetes And Colorectal Cancer: Epidemiology, Potential Molecular Mechanisms And Therapeutic Implications
Published in Oncotarget V8N11 , Mar 14, 2017 2017 update on the relationship between diabetes and colorectal cancer: epidemiology, potential molecular mechanisms and therapeutic implications Nieves Gonzlez, Isabel Prieto, Laura del Puerto-Nevado, Sergio Portal-Nuez, Juan Antonio Ardura, Marta Corton, Beatriz Fernndez-Fernndez, Oscar Aguilera, Carmen Gomez-Guerrero, Sebastin Mas, Juan Antonio Moreno, Marta Ruiz-Ortega, Ana Belen Sanz, Maria Dolores Sanchez-Nio, Federico Rojo, Fernando Vivanco, Pedro Esbrit, Carmen Ayuso, Gloria Alvarez-Llamas, Jess Egido, Jess Garca-Foncillas, Alberto Ortiz, _ Diabetes Cancer Connect Consortium Metrics: PDF 1362 views | HTML 521 views | ? Nieves Gonzlez1,*, Isabel Prieto2,*, Laura del Puerto-Nevado3,*, Sergio Portal-Nuez4,*, Juan Antonio Ardura4, Marta Corton5, Beatriz Fernndez-Fernndez6,7, Oscar Aguilera3, Carmen Gomez-Guerrero6, Sebastin Mas6, Juan Antonio Moreno6, Marta Ruiz-Ortega6, Ana Belen Sanz6,7, Maria Dolores Sanchez-Nio6,7, Federico Rojo8, Fernando Vivanco9, Pedro Esbrit4, Carmen Ayuso5, Gloria Alvarez-Llamas7,9, Jess Egido1,6, Jess Garca-Foncillas3, Alberto Ortiz6,7 and Diabetes Cancer Connect Consortium10 1 Renal, Vascular and Diabetes Research Laboratory, IIS-Fundacion Jimenez Diaz-UAM, Spanish Biomedical Research Network in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain 2 Radiation Oncology, Oncohealth Institute, IIS-Fundacion Jimenez Diaz-UAM, Madrid, Spain 3 Translational Oncology Division, Oncohealth Institute, IIS-Fundacion Jimenez Diaz-UAM, Madrid, Spain 4 Bone and Mineral Metabolism laboratory, IIS-Fundacion Jimenez Diaz-UAM, Madrid, Spain 5 Genetics, IIS-Fundacion Jimenez Diaz-UAM, Madrid, Spain 6 Nephrology, IIS-Fundacion Jimenez Diaz-UAM, Madrid, Spain 8 Pathology, IIS-Fundacion Jimenez Dia Continue reading >>
