diabetestalk.net

Can Diabetes Be Inherited

Type 1 Diabetes

Type 1 Diabetes

Type 1 diabetes is a disorder characterized by abnormally high blood sugar levels. In this form of diabetes, specialized cells in the pancreas called beta cells stop producing insulin. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy. Lack of insulin results in the inability to use glucose for energy or to control the amount of sugar in the blood. Type 1 diabetes can occur at any age; however, it usually develops by early adulthood, most often starting in adolescence. The first signs and symptoms of the disorder are caused by high blood sugar and may include frequent urination (polyuria), excessive thirst (polydipsia), fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. These symptoms may recur during the course of the disorder if blood sugar is not well controlled by insulin replacement therapy. Improper control can also cause blood sugar levels to become too low (hypoglycemia). This may occur when the body's needs change, such as during exercise or if eating is delayed. Hypoglycemia can cause headache, dizziness, hunger, shaking, sweating, weakness, and agitation. Uncontrolled type 1 diabetes can lead to a life-threatening complication called diabetic ketoacidosis. Without insulin, cells cannot take in glucose. A lack of glucose in cells prompts the liver to try to compensate by releasing more glucose into the blood, and blood sugar can become extremely high. The cells, unable to use the glucose in the blood for energy, respond by using fats instead. Breaking down fats to obtain energy produces waste products called ketones, which can build up to toxic levels in people with type 1 diabetes, resulting in diabetic ketoacidosis. Affected individuals may begin breathin Continue reading >>

Type 2 Diabetes Causes

Type 2 Diabetes Causes

Type 2 diabetes has several causes: genetics and lifestyle are the most important ones. A combination of these factors can cause insulin resistance, when your body doesn’t use insulin as well as it should. Insulin resistance is the most common cause of type 2 diabetes. Genetics Play a Role in Type 2 Diabetes Type 2 diabetes can be hereditary. That doesn’t mean that if your mother or father has (or had) type 2 diabetes, you’re guaranteed to develop it; instead, it means that you have a greater chance of developing type 2. Researchers know that you can inherit a risk for type 2 diabetes, but it’s difficult to pinpoint which genes carry the risk. The medical community is hard at work trying to figure out the certain genetic mutations that lead to a risk of type 2. Lifestyle Is Very Important, Too Genes do play a role in type 2 diabetes, but lifestyle choices are also important. You can, for example, have a genetic mutation that may make you susceptible to type 2, but if you take good care of your body, you may not develop diabetes. Say that two people have the same genetic mutation. One of them eats well, watches their cholesterol, and stays physically fit, and the other is overweight (BMI greater than 25) and inactive. The person who is overweight and inactive is much more likely to develop type 2 diabetes because certain lifestyle choices greatly influence how well your body uses insulin. Lack of exercise: Physical activity has many benefits—one of them being that it can help you avoid type 2 diabetes, if you’re susceptible. Unhealthy meal planning choices: A meal plan filled with high-fat foods and lacking in fiber (which you can get from grains, vegetables, and fruits) increases the likelihood of type 2. Overweight/Obesity: Lack of exercise and unhealthy me Continue reading >>

Which Type Of Diabetes Is More Likely To Be Inherited And Why?

Which Type Of Diabetes Is More Likely To Be Inherited And Why?

Yahoo!-ABC News Network | 2018 ABC News Internet Ventures. All rights reserved. Which Type Of Diabetes Is More Likely To Be Inherited And Why? DIRECTOR OF THE DIVISION OF ENDOCRINOLOGY, UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE Question: Which type of diabetes is more likely to be inherited and why? Answer: Type 1 diabetes typically occurs in childhood, while type 2 diabetes usually develops in adults. However, some adults develop a form of diabetes that looks very similar to type 1 diabetes, and now with the huge increase in obesity, many children and adolescents are getting type 2 diabetes. Now, both type 1 and type 2 diabetes have a genetic component; that means of course, that they tend to run in families. However, we often regard diseases that develop in childhood as being more likely to be due to genetics. But this is not the case for diabetes, and in fact, studies show that type 2, which mostly commonly develops in adulthood, seems to have a greater genetic basis than the childhood form of type 1 diabetes. For example, as you know, identical twins share 100 percent of their genetic material; however, if one twin has type 1 diabetes, the chance of that the other twin will develop it is only 10 to 20 percent. In contrast, if one twin has type 2, or the adult form of diabetes, the other twin has up to a 90 percent chance of developing type 2 diabetes. In type 2 diabetes, we know that overeating and lack of physical activity are very important contributors. Meanwhile, for type 1 diabetes, it's more the exposure to toxins in the environment, possibly viruses, and other external factors that can increase risk to this form of diabetes. Continue reading >>

Is Type 2 Diabetes Caused By Genetics?

Is Type 2 Diabetes Caused By Genetics?

Diabetes is a complex condition. Several factors must come together for you to develop type 2 diabetes. For example, obesity and a sedentary lifestyle play a role. Genetics can also influence whether you’ll get this disease. If you’ve been diagnosed with type 2 diabetes, there’s a good chance that you’re not the first person with diabetes in your family. According to the American Diabetes Association, your risk of developing type 2 diabetes is: 1 in 7 if one of your parents was diagnosed before the age of 50 1 in 13 if one of your parents was diagnosed after the age of 50 1 in 2, or 50 percent, if both your parents have diabetes Several gene mutations have been linked to the development of type 2 diabetes. These gene mutations can interact with the environment and each other to further increase your risk. Type 2 diabetes is caused by both genetic and environmental factors. Scientists have linked several gene mutations to a higher diabetes risk. Not everyone who carries a mutation will get diabetes. But many people with diabetes do have one or more of these mutations. It can be difficult to separate genetic risk from environmental risk. The latter is often influenced by your family members. For example, parents with healthy eating habits are likely to pass them on to the next generation. On the other hand, genetics plays a big part in determining weight. Sometimes behaviors can’t take all the blame. Studies of twins suggest that type 2 diabetes might be linked to genetics. These studies were complicated by the environmental influences that also affect type 2 diabetes risk. To date, numerous mutations have been shown to affect type 2 diabetes risk. The contribution of each gene is generally small. However, each additional mutation you have seems to increase your Continue reading >>

Type 2 Diabetes Is More Common Than Type 1 Diabetes.

Type 2 Diabetes Is More Common Than Type 1 Diabetes.

Whereas type 1 diabetes is characterized by the onset in young persons (average age at diagnosis = 14), type 2 diabetes usually develops in middle age or later. This tendency to develop later in life has given rise to the term "adult onset diabetes," although the prevalence of type 2 diabetes in younger people is rising, making this term somewhat inaccurate and outdated. The typical type 2 diabetes patient is overweight ,although there are exceptions. In contrast to type 1 diabetes, symptoms often have a more gradual onset. Type 2 diabetes is associated with insulin resistance rather than the lack of insulin, as seen in type 1 diabetes. This often is obtained as a hereditary tendency from one's parents. Insulin levels in these patients are usually normal or higher than average but the body's cells are rather sluggish to respond to it. This lack of insulin activity results in higher than normal blood glucose levels. Incidence of Type 2 Diabetes Type 2 diabetes is the most common type of diabetes. This disease exists in all populations, but prevalence varies greatly, ie, 1% in Japan, and greater than 40% in the Pima Indians of Arizona. In Caucasians, the figure is somewhere between 1-2% of the entire population. The high incidence of type 2 diabetes in certain groups such as the Pima Indians appears to be a relatively recent development that followed a change in the type of food intake (from relatively little food to plenty of food). With this came the development of obesity within their culture which results in diabetes developing in those that are genetically predisposed. This "urbanization phenomenon" has been most carefully studied in non-white populations, but is probably ethnically and racially nonspecific. In other words, obesity tends to promote diabetes in those Continue reading >>

Is Diabetes Genetic? Facts About Hereditary Risk

Is Diabetes Genetic? Facts About Hereditary Risk

Diabetes is a complex set of diseases with no single cause. Genetic factors make some people more vulnerable to diabetes, particularly with the right environment. In addition, certain lifestyle factors can cause type 2 diabetes in individuals with no known family history. This complex interaction between genes, lifestyle, and environment points to the importance of taking steps to minimize individual diabetes risk. Is type 1 diabetes hereditary? Type 1 diabetes is an autoimmune disease, which means that it causes the body's immune system to attack healthy cells. It is often called juvenile diabetes because most people are diagnosed in childhood, and the condition then lasts their lifetime. Doctors used to think type 1 diabetes was wholly genetic. Newer studies have shown, however, that children develop type 1 diabetes 3 percent of the time if their mother has the condition, 5 percent of the time if their father has it, or 8 percent if a sibling has type 1 diabetes. Consequently, researchers now believe that something in the environment has to trigger type 1 diabetes. Some risk factors include: Cold weather. People develop type 1 diabetes in winter more frequently than summer. It is also more common in places with cool climates. Viruses. Researchers think some viruses might activate type 1 diabetes in people who are otherwise vulnerable. Measles, mumps, coxsackie B virus, and rotavirus have been linked to type 1 diabetes. Research suggests that people who develop type 1 diabetes may have autoimmune antibodies in their blood for many years before showing symptoms. As a result, the disease may develop over time, or something may have to activate the autoimmune antibodies for symptoms to appear. Is type 2 diabetes hereditary? Type 2 diabetes is the more common form of the d Continue reading >>

Genetics And Type 1 Diabetes

Genetics And Type 1 Diabetes

If you have type 1 diabetes, you might wonder if your child would get it, too. Or if one of your parents has it, what it means for you. Your genes definitely play a role in type 1, a less common form of diabetes that’s often diagnosed in children and young adults. But they’re not the whole story. Like much in life, it’s a mix of nature and nurture. Your environment, from where you grow up to the foods you eat, also matters. Researchers don’t know exactly how -- and how much -- all those things affect your chances of getting the disease. Your genes set the stage, but you can’t be certain how it'll all play out. There’s no diabetes gene that gets turned on or off to give you type 1. Instead, a bunch of them play a role, including a dozen or so that have the biggest say: the HLA genes. They make proteins your immune system uses to keep you healthy. Since type 1 diabetes is an autoimmune disease -- your body destroys the cells that make insulin -- it makes sense that HLA genes are front and center. There are thousands of versions of them in the human gene pool. Which ones you get from your parents affect your chances of diabetes in a big way. Some make you more likely to get it, while others can help protect you from it. You have type 1 if your body makes little or no insulin, a hormone that helps your body turn sugar into energy. Certain genes are more common in one group of people than in another. That’s why race and ethnicity affect things, too. For example, white people are more likely to have type 1 diabetes than others. But even if you have genes that make you more likely to get type 1, that doesn’t mean you definitely will. Even with identical twins -- who have the same exact genes -- sometimes one gets it and the other doesn’t. That’s where the e Continue reading >>

Diabetes And Family History: How Much Risk Is Genetic?

Diabetes And Family History: How Much Risk Is Genetic?

Whether you have Type I or Type II diabetes, there are several factors that could have contributed to the disease. Among these are your family’s lifestyle and your genetic history. By gaining a better understanding of these two issues, you may be able to control your diabetes with more ease, or possibly (in the case of Type II) avoid it altogether. At the very least, understanding the risks created by your genetic and family history will allow you to detect diabetes earlier and avoid the damage it can do if left untreated. How Family Affects Diabetes Risk Your family affects your diabetes risk in two different ways. First, of course, your parents contributed to your genetic heritage. But there’s also the way your parents, your siblings, and your extended family may have influenced the way you eat, exercise, and care for yourself, because these are habits you learn from the people around you as you grow up. Your genetic makeup can play a big role in both Type I and Type II diabetes, while the way a family cares for itself and the habits you’re taught in regard to diet and exercise are generally more related to Type II risk. To help prevent Type II diabetes if you don’t have the disease yet or if you’re prediabetic, there are four questions the NIDDK suggests you ask your family. These are: Does anyone in your family have Type II diabetes and if so, who are they? Has anyone in your family been told they may develop diabetes or are at risk for it? Has anyone in your family been told they need to get more exercise or lose weight in order to prevent diabetes? Did your mother have diabetes when she was pregnant, either with me or with a sibling? Type II diabetes can be greatly affected by the lifestyle a family lives. As you grow up and get older you learn a lot of Continue reading >>

Is Diabetes Genetic?

Is Diabetes Genetic?

Diabetes is a complex disease. Several factors must come together for a person to develop Type 2 Diabetes. While genetics may influence whether you’ll get this disease or not, other factors like environmental risk factors and a sedentary lifestyle also play a huge role. So, is type 2 diabetes genetic? And if not, which type of diabetes is genetic? Those are the questions we are faced with today. And unfortunately, the answer is not that simple. Yes, genetics can play a role in increasing the risk for both Diabetes Type 1 as well as Diabetes Type 2, but genes alone will not determine whether you will develop diabetes or not. Will You Get Diabetes If It Runs In Your Family? If you’ve just been diagnosed with diabetes, chances are that you’re not the first person in your family who has diabetes. The details of whether diabetes can be inherited, and how this occurs, are not clear yet. About 10% of patients diagnosed with insulin-dependent Type 1 diabetes have a first degree relative with this type of diabetes. By first degree relative, we mean father, mother, sibling, twin and child. However, when it comes to the more common type of diabetes, which is Diabetes Type 2, it has a tendency to occur in families, but this is also not very strong and not predictable. A Swedish study on Metabolic Consequences of a Family History of Non-Insulin Dependent Diabetes Mellitus concluded that abdominal obesity, insulin resistance, and decreased resting metabolic rate are characteristic features of first-degree relatives of patients with non-insulin dependent diabetes mellitus (in other words, Diabetes Type 2). And that the decrease in resting metabolic rate is partially related to the degree of abdominal obesity. Many doctors with clinical practice treating diabetes believe that thi Continue reading >>

Genetics & Diabetes : What's Your Risk?

Genetics & Diabetes : What's Your Risk?

A school nurse anxiously wants to know if there is a reason why several children from her small grade school have been diagnosed with type 1 (juvenile onset) diabetes. Is it an epidemic? Will there be more cases? Is a recent chicken pox outbreak to blame? A man in his 50s develops type 2 diabetes. His mother developed diabetes in her 60s. Should this man's brother and sister be concerned, too? What about his children's chances of developing diabetes? A married couple wants to have children, but they are concerned because the husband has type 1 diabetes. They wonder what the risk is that their child would have diabetes. A couple has three young children. One of the children develops type 1 diabetes. There's no history of diabetes anywhere in either parent's families. Is this just a fluke? What are the chances the other children will develop diabetes? Chances are if you or a loved one have diabetes, you may wonder if you inherited it from a family member or you may be concerned that you will pass the disease on to your children. Researchers at Joslin Diabetes Center report that, while much has been learned about what genetic factors make one more susceptible to developing diabetes than another, many questions remain to be answered. While some people are more likely to get diabetes than others, and in some ways type 2 (adult onset diabetes) is simpler to track than type 1 (juvenile onset) diabetes, the pattern is not always clear. For more than 20 years researchers in the Epidemiology and Genetics Section at Joslin in Boston (Section Head Andrzej S. Krolewski, M.D., Ph.D., Senior Investigator James H. Warram, M.D., Sc.D., and colleagues) have been studying diabetes incidence and hereditary factors. They are continuing a scientific journey begun by Elliott P. Joslin, M.D., Continue reading >>

Diabetes In The Family: Is It Inherited?

Diabetes In The Family: Is It Inherited?

Weve updated our Privacy Notice. Take a moment to review it here. Im asking this on behalf of a friend whose grandfather and father have diabetes. Is it more likely that my friend will get it too? Is diabetes... Im asking this on behalf of a friend whose grandfather and father have diabetes . Is it more likely that my friend will get it too? Is diabetes fatal? type 1 diabetes (insulin-dependent diabetes), which occurs in young people and is the more severe form, requiring insulin injections type 2 diabetes (non-insulin dependent diabetes), which is milder and occurs in older people and is usually controlled with diet and tablets. The details of whether diabetes can be inherited, and how this occurs, are not clear. About 10 per cent of people getting the more severe Type 1 diabetes have a close relative with this type of diabetes. That is not the same as saying that 10 per cent of people with affected relatives will get diabetes, but there is an unpredictable association. Type 2 diabetes also has a tendency to occur in families, but this is also not very strong and not predictable. In your friends case, if grandfather and father are affected, they probably have the milder Type 2 form of diabetes, so your friend has little risk of developing diabetes at a young age. It may be there is an increased risk of him developing diabetes in later life, but it would be the milder Type 2 form. I am a little confused that you say, he takes pills and does a blood sugar tes t. If you are referring to your friend then this probably means he has the mild form of diabetes already, and is probably an older person. You ask if you can get very ill with diabetes and die. Diabetes is a serious condition, but these days if patients follow their diet and take their pills or insulin treatment re Continue reading >>

Do Children Always Inherit Type 1 Diabetes? - Watch Webmd Video

Do Children Always Inherit Type 1 Diabetes? - Watch Webmd Video

C. Ronald Kahn, M.D. President and Director, Joslin Diabetes Center: If I am a type 1 diabetic, will my child be? C. Ronald Kahn, M.D. President and Director, Joslin Diabetes Center: We talk about type-one diabetes, which of course the insulin dependant kind, one of the questions I often get from women, especially women in the child bearing age, is, what is the risk that my child will have diabetes? And even sometimes, parents will say, or couples will say, well maybe we shouldn't have children because there's a risk of diabetes. C. Ronald Kahn, M.D. President and Director, Joslin Diabetes Center: So the good news part is first of all, the risk is still very low, that the diabetes won't be passed on to a child, if you have type one diabetes. And the interesting aspect here is, that if the father has type one diabetes the risk of the child having type-one diabetes is about 7%. Not as low as the general population, but still not very high, less than one in ten. Something like one in fourteen. If the mother has type-one diabetes, the risk is only about two or two and a half percent. So the good news is for women with diabetes is A) They can have children and B) if the mother has type one diabetes, her risk of actually having a diabetic child is even lower than if the father has it. C. Ronald Kahn, M.D. President and Director, Joslin Diabetes Center: In both cases what they should have is planned pregnancies. They should try to make sure their diabetes is in good control if the woman has diabetes. Because then you'll have normal healthy children. Normal healthy pregnancies, and have great outcomes. Continue reading >>

Is Diabetes A Hereditary Disease?

Is Diabetes A Hereditary Disease?

The entire approach and foundation of Orthodox Medicine is based on Luis Pasteur's Germ Theory, a flawed concept. A disease condition is viewed by the orthodoxy as an isolated event, confined to the area in which it manifests itself (E.g. an ear infection, eye infection, gum infection, lung cancer, skin cancer, diabetes, heart disease, etc. ). Under this theory, for unknown reasons, microbes or tumors indiscriminately grow in the patient and must be cut (surgery), burned (radiation), or poisoned (drugs) out of the body. In the orthodox model, the solution is sought through mechanical and chemical means. Seeking to understand WHY the infection or disease condition appeared in the first place, is not explored. The quick fix with a prescription for drugs to smother the symptoms is the typical orthodox 'answer'. A contemporary of Pasteur, Antoine Bechamp, had a different opinion as to why disease conditions 'took hold'. Bechamp felt that the ENVIRONMENT, or the ECOLOGY of the blood played the critical role in deciding whether disease conditions would manifest or not. It is important to discover the stressors (environmental, biological, chemical, psychological, and emotional) in a patient's life that cause a weakening of a particular bodily system; which in turn allows the manifestation of a disease condition in a weakened area. In order to maintain a state of health, all systems within the body need to exist in a state of balance or equilibrium. Imbalance leads to conditions of discomfort (dis-ease) which eventually spirals into ill health if not corrected. The Chinese and Indians (Ayurvedic medicine) had worked all of this out thousands of years ago. Doctors at the International Council for Truth in Medicine are revealing the truth about diabetes that has been suppressed f Continue reading >>

The Genetics Of Diabetes

The Genetics Of Diabetes

Why me? How did I deserve this? Am I to blame? These are questions that many people ask when diagnosed with a serious condition or disease. Unfortunately, there’s no clear-cut answer when it comes to diabetes. Unlike some traits, diabetes doesn’t seem to be inherited in a simple pattern, and there is a lot of misinformation out there about its causes. (Have you ever had to explain that diabetes doesn’t happen because someone ate too much sugar?) It’s apparent, though, that some people are born more likely to develop diabetes than others. We know that type 1 and type 2 diabetes have different causes, but genetics plays an important role in both types. People with diabetes inherit a predisposition to the disease, then something in their environment triggers it. Identical twins are proof that genes alone are not enough, however. Identical twins have identical genes; therefore, they should have the same genetic risk for a disease—right? Not necessarily. Research has found that if one identical twin has type 1 diabetes, the other twin will get the disease about 50 percent of the time. For type 2 diabetes, that risk rises to as much as 4 in 5. In both type 1 and type 2, identical twins have a much higher risk of both developing diabetes than non-identical (fraternal) twins, which further supports the fact that genetics is involved. So what are the causes of type 1 diabetes? Again, we know that genetics is involved. We also know that it’s not just one gene responsible, but many different genes, each of which contributes only a small part of the risk. Scientists have identified a few genes responsible for type 1, but the majority of the genetic risk is still unidentified. Because of the data about identical twins, we know that type 1 diabetes doesn’t arise solely Continue reading >>

Diabetes Genetics: How Is Diabetes Inherited?

Diabetes Genetics: How Is Diabetes Inherited?

An estimated 2.5 to 3 million Americans have type 1 diabetes. My father was one of them. Diagnosed around age 10, he spent most of his life injecting insulin into his arms, stomach and legs. Eventually, his eye sight and heart could no longer function properly, and he passed away when I was in high school. Around this time, I was introduced to the subject of genetics. I thought back to all those check-ups at the Joslin clinic (now Joslin Diabetes Center) and realized that genetics was the reason everyone watched me and my sister so closely. Genetics was the reason my family was so scared when I starting gaining too much weight in middle school and freaked out every time my foot fell asleep or I was thirsty. Genetics. The loss of my father and timely introduction to genetics drove my decision to become a genetic counselor. Part of a genetic counselors job is to assess disease risk using what we know about family history, the genes and mutations involved, and sometimes, genetic and non-genetic testing results. We then use that information to help individuals and families make more informed decisions about their health. The Genetics of Diabetes Type 1 and type 2 diabetes are both considered to have multifactorial inheritance — meaning that many factors contribute to the development of these conditions. While the manner of inheritance may be the same for these two conditions, the genetic, lifestyle and environmental risk factors are different. A number of genes associated with immune system function have been linked to type 1 diabetes susceptibility. Many Caucasians with diabetes have specific genetic variations (called 3 and/or 4) in the HLA-DR gene. We also know that different variations, HLA-DR7 and HLA-DR9, play important roles in African-Americans and the Japanese, r Continue reading >>

More in diabetes