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Can Cancer Cause Diabetes Symptoms

Diabetes May Be Warning Sign Of Pancreatic Cancer

Diabetes May Be Warning Sign Of Pancreatic Cancer

A presentation to the European Cancer Congress in Amsterdam reports that 50% of people in two sample groups who had been diagnosed with pancreatic cancer had been diagnosed with type 2 diabetes in the previous year and been given their first medication to control it. Fewer than 5 out of 100 people can expect to be alive 5 years after being diagnosed with pancreatic cancer. Survival rates are poor because the cancer doesn't usually cause any symptoms until late in the disease. The American Cancer Society estimates more than 53,000 people will be diagnosed with pancreatic cancer in 2017. "Although it has been known for some time that there is an association between type 2 diabetes and pancreatic cancer, the relationship between the two conditions is complex," Alice Koechlin, from the International Prevention Research Institute in Lyon, France, told the conference. The pancreas contains cells that make insulin. Type 2 diabetes happens when these cells are unable to make enough insulin or the insulin doesn't work properly. The study involved 368,377 people with type 2 diabetes in Belgium and 456,311 in Italy. Among these patients over a 5-year period, there were 885 and 1,872 cases of pancreatic cancer diagnosed respectively. The researchers found that patients had a 3.5 times higher risk of being diagnosed with pancreatic cancer compared to those on other non-insulin, non-incretin diabetes treatments in the first 3 months after their first prescription for a class of diabetes medications known as incretins. The risks decreased with time. These are hormones that stimulate the pancreas to produce more insulin. Among patients who already had type 2 diabetes, the need to switch to injecting insulin because their condition got worse was associated with a seven-times-higher risk Continue reading >>

Pancreatic Cancer Symptoms

Pancreatic Cancer Symptoms

Pancreatic cancer often goes undetected until it's advanced and difficult to treat. In the vast majority of cases, symptoms only develop after pancreatic cancer has grown and begun to spread. Because more than 95% of pancreatic cancer is the adenocarcinoma type, we'll describe those symptoms first, followed by symptoms of rare forms of pancreatic cancer. Initially, pancreatic cancer tends to be silent and painless as it grows. By the time it's large enough to cause symptoms, pancreatic cancer has generally grown outside the pancreas. At this point, symptoms depend on the cancer's location within the pancreas: Pancreatic cancer in the head of the pancreas tends to cause symptoms such as weight loss, jaundice (yellow skin), dark urine, light stool color, itching, nausea, vomiting, abdominal pain, back pain, and enlarged lymph nodes in the neck. Pancreatic cancer in the body or tail of the pancreas usually causes belly and/or back pain and weight loss. In general, symptoms appear earlier from cancers in the head of the pancreas, compared to those in the body and tail. Because pancreatic cancer grows around important areas of the digestive system, gastrointestinal symptoms often predominate: Abdominal pain. More than 80% of people with pancreatic cancer eventually experience some abdominal pain as the tumor grows. Pancreatic cancer can cause a dull ache in the upper abdomen radiating to the back. The pain may come and go. Bloating. Some people with pancreatic cancer have a sense of early fullness with meals (satiety) or an uncomfortable swelling in the abdomen. Nausea Pale-colored stools. If the duct draining bile into the intestine is blocked by pancreatic cancer, the stools may lose their brown color and become pale or clay-colored. Urine may become darker. As it grows an Continue reading >>

Other Symptoms Of Pancreatic Cancer

Other Symptoms Of Pancreatic Cancer

Pancreatic cancer often doesn’t cause any signs or symptoms in the early stages. This can make it hard to diagnose early. But as the cancer grows, it may start to cause symptoms. These will depend on the type of pancreatic cancer and where it is in the pancreas. The symptoms and how bad they are can vary for each person. It’s important to remember that symptoms described here can be caused by more common things, such as indigestion or heartburn. They can also be caused by conditions such as pancreatitis (inflammation of the pancreas), gallstones, irritable bowel syndrome, or hepatitis (inflammation of the liver). These symptoms don’t necessarily mean that someone has pancreatic cancer. But if you have any symptoms that you’re worried about it’s important that you see your GP. What are the symptoms of pancreatic cancer? The most common type of pancreatic cancer is called pancreatic ductal adenocarcinoma (PDAC). The information here is about the symptoms of PDAC. There are also rare types of pancreatic cancer called pancreatic neuroendocrine tumours (PNETs) of pancreatic cancer. They may cause some of the symptoms here, as well as some different symptoms. Read more about the symptoms of PNETs. The symptoms of PDAC can be quite vague and may come and go to begin with. Common symptoms include abdominal (tummy) and back pain, unexplained weight loss, and indigestion. Other symptoms include: changes to bowel habits – including steatorrhoea (pale, smelly stools (poo) that may float), diarrhoea (loose watery stools) or constipation (problems opening your bowels) jaundice (yellow skin and eyes, and itching) nausea and vomiting (feeling and being sick) You may find it helpful to have a look at our diagram of the pancreas and surrounding organs when reading the informa Continue reading >>

Pancreatic Cancer Symptoms: Diabetes Could Be A Warning Sign For Deadly Disease

Pancreatic Cancer Symptoms: Diabetes Could Be A Warning Sign For Deadly Disease

Pancreatic cancer is hard to diagnose in its early stages as the tumour doesn't usually cause any symptoms. The disease affects around 8,800 people every year in the UK. Diabetic have an increased risk of pancreatic cancer - however now experts have suggested cancer can cause some cases of diabetes. Experts have revealed the onset of diabetes, or existing diabetes getting much worse could be a sign of hidden pancreatic cancer. Medical records and the type of diabetic medicines they are prescribed could be a tool in identifying those at risk, scientists from the International Prevention Research Institute in Lyon said. An analysis of nearly a million patients with type 2 diabetes in Italy and Belgium with pancreatic cancer found half were diagnosed within one year of being found to have type 2 diabetes and being given their first prescription to control it. Experts said they had a 3.5 times greater risk of being diagnosed with the disease in the first three months after their first prescription for incretins, hormones which stimulate the pancreas to produce more insulin to lower blood sugar levels. Injecting insulin was associated with a seven-fold increased risk of being diagnosed with pancreatic cancer. Professor Philippe Autier said: "Although it has been known for some time that there is an association between type 2 diabetes and pancreatic cancer, the relationship between the two conditions is complex. "Incretin therapies reduce diabetic hyperglycemia through stimulating the release of insulin by the pancreas. "These drugs are typically prescribed when the oral anti-diabetic drugs can no longer control blood glucose levels. "Because of their stimulating effects on the pancreas, it has long been thought that the incretin therapies could promote the occurrence of panc Continue reading >>

Diabetes And Cancer: What's The Connection?

Diabetes And Cancer: What's The Connection?

When Michelle Hall was diagnosed with breast cancer two years ago, she was shocked. "The standing joke in the family was that I came from a long line of stocky French women who lived forever," says Hall, 62, of Salem, N.H. "We had no breast cancer in the family." Hall had been diagnosed with type 2 diabetes in 2001, so she would have special challenges while facing down cancer. As diseases, cancer and diabetes seem a world away from each other. Yet, numerous studies suggest the conditions are linked. People with diabetes are more likely to be diagnosed with cancer than those without diabetes, but why remains unclear. Scientists are still trying to answer even the most basic questions: Does diabetes cause cancer? If so, what kinds of cancer and how? As the interplay between diabetes and cancer becomes clearer, researchers hope to gain an edge against both diseases. The link between diabetes and cancer may be partially explained by risk factors that underlie and raise the risk of both diseases. Sex: Overall, men are more likely to develop both cancer and type 2 diabetes than women. Weight: Overweight and obese people are more likely to develop cancer than lean people. The association between type 2 diabetes and weight is also well established. While it's clear that losing weight reduces the risk for type 2 diabetes, less is known about whether weight loss combats cancer. Diet: Eating patterns that are thought to help prevent and treat type 2 diabeteslimited red and processed meats and abundant vegetables, fruits, and whole grainsare also associated with a lower risk for many types of cancer. Exercise: Studies show that regular physical activity lowers the risk of developing several types of cancer. Likewise, 30 minutes of moderate-intensity exercise per day can reduce th Continue reading >>

Pancreatic Cancer - Symptoms And Causes - Mayo Clinic

Pancreatic Cancer - Symptoms And Causes - Mayo Clinic

Pancreatic cancer is cancer that forms in the cells of the pancreas. Pancreatic cancer begins in the tissues of your pancreas an organ in your abdomen that lies horizontally behind the lower part of your stomach. Your pancreas releases enzymes that aid digestion and hormones that help manage your blood sugar. Pancreatic cancer typically spreads rapidly to nearby organs. It is seldom detected in its early stages. But for people with pancreatic cysts or a family history of pancreatic cancer, some screening steps might help detect a problem early. One sign of pancreatic cancer is diabetes, especially when it occurs with weight loss, jaundice or pain in the upper abdomen that spreads to the back. Treatment may include surgery, chemotherapy, radiation therapy or a combination of these. Signs and symptoms of pancreatic cancer often don't occur until the disease is advanced. They may include: Pain in the upper abdomen that radiates to your back Loss of appetite or unintended weight loss Yellowing of your skin and the whites of your eyes (jaundice) See your doctor if you experience unexplained weight loss or if you have persistent fatigue, abdominal pain, jaundice, or other signs and symptoms that bother you. Many conditions can cause these symptoms, so your doctor may check for these conditions as well as for pancreatic cancer. It's not clear what causes pancreatic cancer in most cases. Doctors have identified factors, such as smoking, that increase your risk of developing the disease. Your pancreas is about 6 inches (15 centimeters) long and looks something like a pear lying on its side. It releases (secretes) hormones, including insulin, to help your body process sugar in the foods you eat. And it produces digestive juices to help your body digest food. Pancreatic cancer oc Continue reading >>

Diabetes And Pancreatic Cancer

Diabetes And Pancreatic Cancer

Your pancreas produces a hormone called insulin, which helps to control your blood sugar level. When you digest food and drink, carbohydrate is broken down into glucose, which is a type of sugar. This passes into your blood, and is used by the body. Normally, insulin controls the blood sugar level. But if you have pancreatic cancer or you have had all or part of your pancreas removed, your pancreas may not produce enough insulin. This means your blood sugar level may not be properly controlled, and you may develop diabetes. Diabetes is a condition where the amount of sugar in your blood is too high. If your blood sugar level is too high (hyperglycaemia), you may feel very thirsty, pass more urine, get headaches and feel tired. Your pancreas also produces a hormone called glucagon which also helps to control your blood sugar level. If your pancreas doesn’t produce enough glucagon when you need it, your blood sugar level may drop and become too low (hypoglycaemia). You may feel hungry, shaky or sweaty. This is more common if you have had surgery to remove your pancreas, such as a Whipple's operation. Managing diabetes If you are diagnosed with diabetes, you should see specialist diabetes or pancreatic dietitian. You may also see a diabetes nurse for help with managing any medication prescribed. It’s important that you get specialist advice, because managing your diabetes may be more difficult because of your pancreatic cancer. Your dietitian and diabetes nurse should discuss any changes to your diet and treatment with you. You may need to monitor your blood sugar level, and take tablets or have insulin injections to stop your blood sugar level becoming too high or too low. There are different types of diabetes, and information on the internet may not be right for you, Continue reading >>

Pancreatic Cancer Symptoms & Signs

Pancreatic Cancer Symptoms & Signs

Pancreatic cancer is often referred to as a “silent cancer” because it is thought that the early symptoms can be vague and unrecognised. Pancreatic cancer symptoms however can present themselves early in many cases. Here are some of the most common symptoms to look out for: Classic pancreatic cancer symptoms can include: Painless jaundice (yellow skin/eyes, dark urine, itching). Weight loss which is significant and unexplained Abdominal pain or discomfort which is new-onset and significant Other possible symptoms of pancreatic cancer: Pain or discomfort in the upper abdomen which is new, that tends to radiate to the back. This is significant and can be persistent but also intermittent, this pain or discomfort can vary between patients. Back pain Diabetes which is new-onset and not associated with weight gain Vague indigestion (dyspepsia) or abdominal discomfort (not responding to prescribed medication) Loss of appetite Nausea and vomiting Pain when eating Steatorrhea (fatty stools that are often pale and smell foul) Not everyone will have all of these symptoms. For example, those who have a tumour in the body or tail of the pancreas are unlikely to have painless jaundice. All of these symptoms can have other causes, and there is not yet a reliable and easy test for pancreatic cancer. Explanation of the symptoms: Pain or discomfort in the abdomen and upper back Approximately 70 per cent of patients with pancreatic cancer go to the doctor initially due to pain. This pain is often described as beginning in the stomach area and radiating around to the upper back (just above where a woman’s bra strap would be). Generally the reason for the pain is because of the tumour pressing against your abdomen and spine. Jaundice 30% of patients will have yellowing of the skin and Continue reading >>

Cancer And Diabetes: Managing A Dual Diagnosis

Cancer And Diabetes: Managing A Dual Diagnosis

Benefits of good nutrition Nutritional support at CTCA Preventing malnutrition Cancer and diabetes Managing side effects with nutrition What to eat Nutrition tips If you are managing cancer and diabetes, you understand how difficult it can be to eat right and stay strong. Each of these diseases can be frustrating enough to deal with on their own. When battling them at the same time, it can take your stress to new levels. Regardless of which disease came first, know you are not the only one dealing with this situation. Cancer and diabetes often co-exist. And, while managing both diseases simultaneously can be difficult, it can be done. The first step is understanding. Understanding diabetes Diabetes is a disease in which the body does not produce or properly use insulin. Insulin is a hormone secreted by the pancreas (the large gland behind the stomach). Insulin is needed to convert sugar, starches and other carbohydrates into energy needed for daily life. Much of the food you eat is broken down into glucose (sugar), which is the main source of fuel for the body. After digestion, glucose passes into the bloodstream and, with the help of insulin, it moves into the body’s cells where it provides fuel for metabolic processes. If the pancreas produces little or no insulin, or if the body’s cells do not respond appropriately to the insulin that is produced, glucose accumulates in the blood. Thus, the body’s cells lose their main source of fuel. Also, when there is too much sugar in the blood for long periods of time, other cells become damaged. While an estimated 14.6 million Americans (about 7 percent of the U.S. population) have been diagnosed with diabetes, about 6.2 million people have the disease and don’t even realize it. Types of diabetes There are two main type Continue reading >>

Signs And Symptoms Of Exocrine Pancreatic Cancer

Signs And Symptoms Of Exocrine Pancreatic Cancer

The symptoms of exocrine pancreatic cancers and pancreatic neuroendocrine tumors (NETs) are often different, so they are described separately. Having one or more of the symptoms below does not mean you have pancreatic cancer. In fact, many of these symptoms are more likely to be caused by other conditions. Still, if you have any of these symptoms, it’s important to have them checked by a doctor so that the cause can be found and treated, if needed. Early pancreatic cancers often do not cause any signs or symptoms. By the time they do cause symptoms, they have often already spread outside the pancreas. Jaundice and related symptoms Jaundice is yellowing of the eyes and skin. Most people with pancreatic cancer (and nearly all people with ampullary cancer) will have jaundice as one of their first symptoms. Jaundice is caused by the buildup of bilirubin, a dark yellow-brown substance made in the liver. Normally, the liver excretes bilirubin as part of a liquid called bile. Bile goes through the common bile duct into the intestines, where it helps break down fats. It eventually leaves the body in the stool. When the common bile duct becomes blocked, bile can’t reach the intestines, and the level of bilirubin in the body builds up. Cancers that start in the head of the pancreas are near the common bile duct. These cancers can press on the duct and cause jaundice while they are still fairly small, which can sometimes lead to these tumors being found at an early stage. But cancers that start in the body or tail of the pancreas don’t press on the duct until they have spread through the pancreas. By this time, the cancer has often spread beyond the pancreas as well. When pancreatic cancer spreads, it often goes to the liver. This can also lead to jaundice. Dark urine: Somet Continue reading >>

8 Symptoms Of Pancreatic Cancer You're Probably Ignoring | Reader's Digest

8 Symptoms Of Pancreatic Cancer You're Probably Ignoring | Reader's Digest

Over 53,000 people are expected to be diagnosed with pancreatic cancer in 2017, and 43,000 will die from it. Symptoms often arent noticeable until the disease is in the advanced stages, but if you notice any of the following pancreatic cancer signs, talk to your doctor. "Jaundice is one of the clearest symptoms of pancreatic cancer," says Christopher DiMaio, MD, a gastroenterologist at The Mount Sinai Hospital in New York City. "Often, patients feel fine until one day a friend notices their eyes look yellow, then they go to the doctor and find they have advanced pancreatic cancer." Cancers that start near the head of the pancreas can block the bile duct, preventing bile from reaching the intestines, where it helps break down fats and eventually leaves the body in the stool. This bile builds up and causes jaundice, which is yellowing of the skin or eyes. It can also cause your skin to itch, according to the American Cancer Society . These are other cancer symptoms women should never ignore and cancer signs men should never ignore . Place the tip of your finger on the top of your abdomen, just below the breastbone. Then imagine your finger pointing straight back through your body to the spine. That's a common location that pancreatic cancer patients report feeling pain, says Dr. DiMaio. "The pain is hard to describe, but a dull, internal pain in this area, or radiating around the sides of your abdomen to the back, is a tip-off and you should get it checked out," he says. Cancers that start in the body or tail of the pancreas can press on nearby organs, causing pain. If the cancer spreads to the nerves surrounding the pancreas, this can cause back pain. Here are some more reasons your back might be hurting . If your urine starts to look dark (brown or rust colored), this Continue reading >>

Pancreatic Cancer And Diabetes – A Cellular Case Of Chicken And Egg

Pancreatic Cancer And Diabetes – A Cellular Case Of Chicken And Egg

We’ve all heard the age-old question about the chicken and the egg. Well scientists studying the link between diabetes (a condition where the amount of glucose in your blood is too high because the body cannot use it properly) and pancreatic cancer are facing a similar conundrum. It seems there’s a link between the two conditions, but it’s not clear which one comes first. While the majority of people with diabetes will never develop pancreatic cancer, the question of whether diabetes could be a cause or a consequence of pancreatic cancer is an important one. Answering this could help scientists better understand the biology of these two conditions, and might help spot people at higher risk of pancreatic cancer. So, as it’s pancreatic cancer awareness month, we’ve dug into the evidence to see what is known about these links, and which questions remain unanswered. We know there’s a link Doctors first started exploring the possibility of a link between diabetes and pancreatic cancer in the 1940s and 1950s. Several reports had come out saying that patients with pancreatic cancer were more likely to also have diabetes than other people. This has been shown for type 2 diabetes as well as type 1 and young onset diabetes. Since then, many studies have shown a link between the two conditions. Overall, it seems that people with diabetes are around twice as likely to be diagnosed with pancreatic cancer than the general population. And this makes sense, given that diabetes and pancreatic cancer are diseases that both affect the pancreas. The next big question is: how does this work? Does diabetes increase a person’s risk of pancreatic cancer or is it the cancer that causes diabetes? Or is there something else increasing the risk of both conditions? How pancreatic canc Continue reading >>

Rapid Diabetes Deterioration -- Sign Of Pancreatic Cancer?

Rapid Diabetes Deterioration -- Sign Of Pancreatic Cancer?

Rapid Diabetes Deterioration -- Sign of Pancreatic Cancer? AMSTERDAM Patients with type 2 diabetes whose condition deteriorates rapidly soon after diagnosis may have asymptomatic pancreatic cancer, say European investigators. In a study of more than 550,000 diabetes patients, researchers found that patients who received glucagonlike peptide-1 (GLP-1) receptor agonists, or incretin mimetics, were at significantly increased risk of developing pancreatic cancer. However, the researchers observed that the increased risk diminished rapidly after diagnosis. Given that they also found that the risk for pancreatic cancer was markedly increased after starting insulin therapy, they suggested that "reverse causation" may be in play, with asymptomatic pancreatic cancer initially causing diabetes before progressing to a symptomatic stage. The new findings were presented here at the inaugural meeting of the European CanCer Organisation (ECCO) Congress 2017. Alice Koechlin, from the International Prevention Research Institute (IPRI) in Lyon, France, said in a statement: "Doctors and their diabetic patients should be aware that the onset of diabetes or rapidly deteriorating diabetes could be the first sign of hidden pancreatic cancer, and steps should be taken to investigate it." She cautioned that investigating the possibility of undiagnosed pancreatic cancer is "difficult," as there is currently no good, noninvasive method for detecting asymptomatic pancreatic cancer. "We hope that our results will encourage the search for blood markers indicating the presence of pancreatic cancer, which could guide decisions to perform a confirmation examination like endoscopy," she said. Peter Naredi, MD, PhD, chair of the Congress, president of ECCO, and professor of surgery at the Sahlgrenska Ac Continue reading >>

Diabetes And Pancreatic Cancer

Diabetes And Pancreatic Cancer

Approximately 25.8 million people in the United States, approximately 8.3% of the population, have diabetes. It is estimated that 18.8 million have been diagnosed, but unfortunately, 7.0 million people, or over one fourth, are unaware that they have the disease. Diabetes is a disease in which the body does not make or properly use a pancreatic hormone called insulin. Insulin helps the body utilize glucose (sugar) efficiently. Normally, insulin allows glucose to enter cells to be used for energy. In the case of diabetes, either the body does not produce enough insulin or the amount that is produced is not fully effective. Instead of entering cells, the glucose remains in the blood resulting in high blood glucose levels. Diabetes can cause major health problems, such as high-blood pressure, blindness, kidney disease and neuropathy. Long-term high blood glucose levels can lead to cell damage and long-term complications. There are several types of diabetes. Type 1 diabetes results from the bodys inability to produce insulin and accounts for approximately 5% of those diagnosed with the disease. Type 2 diabetes results from the bodys failure to properly use insulin combined with insulin deficiency and accounts for most diagnosed cases of diabetes in the United States. Pre-diabetes occurs when a persons blood glucose levels are higher than normal, but are not high enough to be diagnosed as type 2 diabetes. Approximately 79 million Americans are pre-diabetic. Other types of diabetes result from specific genetic conditions, surgery, medications, infections, pancreatic diseases and other illnesses. How does diabetes relate to pancreatic cancer? Diabetes may be either a risk factor or a symptom of pancreatic cancer. Pancreatic cancer is more likely to occur in people who have lon Continue reading >>

The Relationship Between Diabetes And Pancreatic Cancer

The Relationship Between Diabetes And Pancreatic Cancer

Go to: Review The early symptoms of pancreatic cancer, such as abdominal pain, weight loss, fatigue, jaundice, and nausea, are nonspecific and may occur late in the course of the disease [1,2]. As a result, pancreatic cancer is usually diagnosed at an advanced stage, frequently after the tumor has already metastasized. Pancreatic cancer is insensitive to pharmacological and radiological intervention and often recurs after apparently curative surgery. All these factors contribute to the dismal prognosis of the disease [3]. About 80% of pancreatic cancer patients have glucose intolerance or frank diabetes [4,5]. This observation has led to the following two hypotheses: i. pancreatic cancer causes diabetes and ii. diabetes is a risk factor for the development of pancreatic cancer. Numerous studies have been performed in order to elucidate the relationship between these two diseases. Evidence suggesting that pancreatic cancer causes diabetes The majority of diabetes associated with pancreatic cancer is diagnosed either concomitantly with the cancer or during the two years before the cancer is found [6]; 71% of the glucose intolerance found in pancreatic cancer patients is unknown before the cancer is diagnosed [5]. These suggest that recently-developed glucose intolerance or diabetes may be a consequence of pancreatic cancer and that recent onset of glucose intolerance or diabetes may be an early sign of pancreatic cancer. Several studies have demonstrated that diabetes in pancreatic cancer patients is characterized by peripheral insulin resistance [4,5,7]. Insulin resistance is also found in non-diabetic or glucose intolerant pancreatic cancer patients, though to a lesser degree [7]. Insulin sensitivity and overall diabetic state in pancreatic cancer patients who undergo t Continue reading >>

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