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Can Amlodipine Cause Diabetes

Adht: Amlodipine Diabetic Hypertension Efficacy Response Evaluation Trial

Adht: Amlodipine Diabetic Hypertension Efficacy Response Evaluation Trial

ADHT: Amlodipine Diabetic Hypertension Efficacy Response Evaluation Trial Authors: Linda Brookes, MSc Faculty and Disclosures Presenter: Joel M Neutel, MD (Orange County Heart Institute and Research Center, Orange, California) Diabetic patients have a better chance of controlling their blood pressure with a combination of an angiotensin converting enzyme (ACE) inhibitor or an angiotensin receptor blocker (ARB) and a calcium channel blocker (CCB), according to the results of the Amlodipine Diabetic Hypertension Efficacy Response Evaluation Trial (ADHT). [1] Adding a second drug, in this case the CCB amlodipine, to monotherapy with an ACE inhibitor or an ARB more than doubled the control rate in diabetic hypertensive patients in this study. The study "confirms that the use of combination therapy is critically important in the management of hypertension -- when you do it, you need to do it early and more aggressively," Dr. Neutel said. Diabetic patients with elevated blood pressure are at greater risk of cardiovascular disease than patients without diabetes, yet most diabetic patients treated for hypertension do not achieve blood pressure goals set out by current US guidelines. [2-4] Although tight blood pressure control in diabetic patients confers even more protection than glycemic control, < 20% of these patients achieve blood pressure levels of 130/80 mm Hg. Another factor is "therapeutic inertia," with surveys showing too many physicians accepting inadequate control, even after treatment, in these patients. Aggressive blood pressure treatment is important in these patients, and addition of a second, complementary antihypertensive drug will always be more successful in lowering blood pressure than uptitrating the first drug. "We are dealing with multifactorial disease Continue reading >>

The Effect Of Amlodipine On Blood Glucose Level And Its Interaction With Oral Hypoglycemic Drugs In Albino Rabbits | Prajapat | International Journal Of Basic & Clinical Pharmacology

The Effect Of Amlodipine On Blood Glucose Level And Its Interaction With Oral Hypoglycemic Drugs In Albino Rabbits | Prajapat | International Journal Of Basic & Clinical Pharmacology

The effect of amlodipine on blood glucose level and its interaction with oral hypoglycemic drugs in albino rabbits Rajeev Prajapat, I. P. Jain, S. P. Singh, Suresh Singh, Pooja Agarwal Background: Amlodipine used as many cardiac conditions esp in hypertension. Diabetes affects cardiovascular system adversely. So this study was done to see effect of amlodipine on blood glucose level and its interaction with commonly used oral hypoglycemic agents in diabetic & non diabetic albino rabbits. Methods: Rabbits were divided into nine groups of 6 rabbits in each group. I and II group were non-diabetic given normal saline and amlodipine respectively. Group III to IX were made diabetic by using alloxan monohydrate (150mg/kg i.p.) & given normal saline, glimepiride, metformin, pioglitazone, amlodipine + glimepiride, amlodipine + metformin and amlodipine + pioglitazone respectively. All drugs were given orally once daily for 7 day except group VII, VIII and IX in which glimepiride, metformin and pioglitazone were added on 7th day. After GTT blood glucose level were measured at 0, 1, 2 and 6 hours on 7th day in all groups by using spectrophotometer. Results: After 7 days of treatment the amlodipine produced significant hyperglycemia in normal rabbits. Amlodipine on combination, causes significant decreased in hypoglycemic effect of glimepiride, significant increased the hypoglycemic effect of metformin, while no significant changes in hypoglycemic effects of pioglitazone in diabetic rabbits. Conclusion: The present study shows that amlodipine causes hyperglycemia in normal rabbits. Amlodipine significantly altered hypoglycemic effect of glimepiride and metformin as compared to control group. If these finding are true to human beings then amlodipine should be use cautiously in diabet Continue reading >>

Blood Pressure Drugs Can Boost Blood Sugar

Blood Pressure Drugs Can Boost Blood Sugar

Blood pressure drugs can boost blood sugar Depending on the drug, though, it may not matter. People with high blood pressure can turn to several types of medication when diet and exercise aren't enough to rein in their hypertension (see "So many choices"). Each of them does the job. Yet each has its own quirks and costs. Common side effects range from frequent urination with diuretics to fatigue with beta blockers or a chronic dry cough with ACE inhibitors. While most of the side effects are aggravating or irritating, one that could pose long-term health problems is an increase in blood sugar. Dozens of drugs are available for lowering blood pressure. They work in different ways. Here are the main classes of antihypertension medications and some of their commonly prescribed brands. Diuretics lower blood pressure by causing the body to rid itself of excess fluids and sodium through urination. chlorothiazide (Diuril)chlorthalidone (Hygroton)furosemide (Lasix)hydrochlorothiazide (Esidrix, HydroDIURIL)spironolactone (Aldactone) Beta blockers decrease the heart rate and output of blood from the heart. atenolol (Tenormin)bisoprolol (Zebeta)metoprolol (Lopressor, Toprol XL)nadolol (Corgard)propranolol (Inderal) ACE inhibitors expand blood vessels and decrease resistance to blood flow. captopril (Capoten)enalapril (Vasotec)lisinopril (Prinivil, Zestril)ramipril (Altace)trandolapril (Mavik) Calcium-channel blockers interrupt the movement of calcium into the cells of the heart and blood vessels. amlodipine (Norvasc, Lotrel)diltiazem (Cardizem, Tiazac)nifedipine (Adalat, Procardia)nisoldipine (Sular)verapamil (Calan, Isoptin, Verelan) Angiotensin receptor blockers do what ACE inhibitors do, but via a different mechanism. candesartan (Atacand)eprosartan (Teveten)irbesartan (Avapro Continue reading >>

Antihypertensive Medications And Blood Sugar: Theories And Implications

Antihypertensive Medications And Blood Sugar: Theories And Implications

Go to: MECHANISMS OF ADVERSE GLYCEMIC EFFECTS Various theories about the mechanisms of antihypertensive-induced glycemic defects have been postulated. Few of these theories have been confirmed and some are conflicting. In general, postulated mechanisms can be classified into four categories: effects on peripheral blood flow, effects on the insulin receptor, effects on the liver and effects on insulin release (Figure 1). Improved peripheral blood flow to skeletal muscles is thought to facilitate glucose disposal to the tissues. In this way, medications such as alpha-blockers, which promote peripheral vasodilation, may improve insulin sensitivity and glucose uptake (20). Through the same mechanism, ACEIs or ARBs may improve insulin sensitivity by reducing angiotensin II-mediated vasoconstriction and/or increasing vasodilators such as bradykinin, prostaglandins or nitric oxide (21,22). Conversely, medications that reduce peripheral blood flow could direct blood away from sites of glucose uptake, reducing glucose disposal (20). Nonselective beta-blockers limit peripheral blood flow by reducing cardiac output, a beta-1-mediated effect, and preventing peripheral vasodilation, a beta-2-mediated effect (20,23). Beta-blockers with intrinsic sympathomimetic activity are less likely than nonselective agents to reduce peripheral blood flow because of neutral or stimulatory effects on beta-2 receptors (20,23). Therefore, these agents may have a reduced impact on glucose disposal and insulin sensitivity compared with nonselective beta-blockers. Cardioselective beta-blockers are also less likely to reduce peripheral blood flow than nonselective agents; however, cardioselective beta-blockers still exhibit some glycemic adverse effects (23). In support of the blood flow hypothesis is th Continue reading >>

Can The Drug Amlodipine Besylate 5 Mg Raise Blood Sugar Testing?

Can The Drug Amlodipine Besylate 5 Mg Raise Blood Sugar Testing?

Home Q & A Questions Can the drug AMLODIPINE... Can the drug AMLODIPINE BESYLATE 5 mg raise blood sugar testing? Since taking this drug (about 5 weeks) my blood sugar readings have been rising. Is this a usual side effect? Yes, hypreglycemia (raised blood sugar levels) is a known side effect of amlodipine. If the readings are very high then please see your doctor. Still looking for answers? Try searching for what you seek or ask your own question . Can I take Moringa and Amlodipine Besylate at the same time? The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to receive email notifications whenever new articles are published. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated June 1st, 2018), Cerner Multum (updated June 5th, 2018), Wolters Kluwer (updated June 4th, 2018) and others. To view content sources and attributions, please refer to our editorial policy . Continue reading >>

Effects Of Losartan And Amlodipine On Urinary Albumin Excretion And Ambulatory Blood Pressure In Hypertensive Type 2 Diabetic Patients With Overt Nephropathy

Effects Of Losartan And Amlodipine On Urinary Albumin Excretion And Ambulatory Blood Pressure In Hypertensive Type 2 Diabetic Patients With Overt Nephropathy

Editor’s comment: The editorial committee of Diabetes Care had some ethical concerns about potentially leaving patients for up to 24 weeks with blood pressure between 140/90 and 200/110 mmHg. After careful consideration, we decided to publish this article for the following reasons. First, the scientific information was considered valid and important. Second, the study was passed by the institutional review board (IRB) of the investigators. The study was passed by their institution at a time when perhaps ethical guidelines were not as stringent. Third, in response to queries by the editorial committee, the investigators pointed out that other hypertension studies initiated at around that time also had similar protocols. The editorial committee then dealt with the general issue of different criteria utilized by different IRBs around the world. Although the editorial committee will continue to be sensitive to decisions by various IRBs, investigators should realize that the more recent, stricter guidelines will also be considered by the editorial committee should ethical concerns be raised in the review process. OBJECTIVE—Few studies have assessed whether 24-h blood pressure control induced by antihypertensive agents improves macroalbuminuria in hypertensive type 2 diabetic patients with overt nephropathy. We evaluated the effects of losartan and amlodipine on 24-h blood pressure, autonomic nervous activity, and albuminuria in these patients. RESEARCH DESIGN AND METHODS—In this open-label, parallel-prospective, randomized study, 44 patients were treated with losartan and 43 with amlodipine for a 12-week titration phase and a maintenance phase for a maximum of 12 weeks. Twenty-four–hour blood pressure and urinary albumin excretion were measured before and during trea Continue reading >>

Study Of Effect Of Amlodipine On Blood Sugar Level

Study Of Effect Of Amlodipine On Blood Sugar Level

Nepal Journals OnLine (NepJOL) is a service to provide access to Nepalese published research, and increase worldwide knowledge of indigenous scholarship. Read more . Study of Effect of Amlodipine on Blood Sugar Level Objective: To study the effect of AMLODIPINE on blood sugarlevels in hypertensive patients. Method: It is a prospective study in which patients were selected from Princess Esra hospital, Hyderabad. Results: This study was done on 20 mild to moderate newly detected hypertensive patients. Statistical analysis shows a highly significant rise in blood sugar level with P' value < 0.001 after 2 and 4 weeks of using 2.5 to 5 mgm (once daily) amlodipine. Conclusion: As calcium channels are involved in the release of insulin from the cells of pancreas, calcium channel blockers like amlodipine may cause hyperglycemia when used in hypertensive patients. Further studies are required in this field on a larger number of patients. Keywords: Amlodipine; Calcium channel blockers; Diabetes Mellitus; Hypertension Asian Journal of Medical Sciences Vol.1(1) 2010 p.4-5 Amlodipine; Calcium channel blockers; Diabetes Mellitus; Hypertension Continue reading >>

390 Drugs That Can Affect Blood Glucose Levels

390 Drugs That Can Affect Blood Glucose Levels

Knowing the drugs that can affect blood glucose levels is essential in properly caring for your diabetes patients. Some medicines raise blood sugar in patients while others might lower their levels. However, not all drugs affect patients the same way. 390 Drugs that Can Affect Blood Glucose Levels is also available for purchase in ebook format. 390 Drugs that can affect blood glucose Level Table of Contents: Drugs that May Cause Hyper- or Hypoglycemia Drugs That May Cause Hyperglycemia (High Blood Sugar) (GENERIC NAME | BRAND NAME) Abacavir | (Ziagen®) Abacavir + lamivudine,zidovudine | (Trizivir®) Abacavir + dolutegravir + lamivudine | (Triumeq®) Abiraterone | (Zytiga®) Acetazolamide | (Diamox®) Acitretin | (Soriatane®) Aletinib | (Alecensa®) Albuterol | (Ventolin®, Proventil®) Albuterol + ipratropium | (Combivent®) Aliskiren + amlodipine + hydrochlorothiazide | (Amturnide®) Aliskiren + amlodipine | (Tekamlo®) Ammonium chloride Amphotericin B | (Amphocin®, Fungizone®) Amphotericin B lipid formulations IV | (Abelcet®) Amprenavir | (Agenerase®) Anidulafungin | (Eraxis®) Aripiprazole | (Abilify®) Arsenic trioxide | (Trisenox®) Asparaginase | (Elspar®, Erwinaze®) Atazanavir | (Reyataz ®) Atazanavir + cobistat | (Evotaz®) Atenolol + chlorthalidone | (Tenoretic®) Atorvastatin | (Lipitor®) Atovaquone | (Mepron®) Baclofen | (Lioresal®) Belatacept | (Nulojix®) Benazepril + hydrochlorothiazide | (Lotension®) Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued (GENERIC NAME | BRAND NAME) Betamethasone topical | (Alphatrex®, Betatrex®, Beta-Val®, Diprolene®, Diprolene® AF, Diprolene® Lotion, Luxiq®, Maxivate®) Betamethasone +clotrimazole | (Lotrisone® topical) Betaxolol Betoptic® eyedrops, | (Kerlone® oral) Bexarotene | (Targ Continue reading >>

Long-term Effects Of The Novel [beta]-blocker, Nebivolol, On Blood Glucose In Hypertensive Patients

Long-term Effects Of The Novel [beta]-blocker, Nebivolol, On Blood Glucose In Hypertensive Patients

Long-term Effects of the Novel [beta]-blocker, Nebivolol, on Blood Glucose in Hypertensive Patients Adverse effects on blood gluco Adverse effects on blood glucose (BG) are a concern with conventional [beta]-blockers1. Effects on BG of the novel, vasodilatory, selective [beta]1-blocker2, nebivolol, were evaluated during a long-term extension study in mild-to-moderate hypertensive patients (sitting diastolic blood pressure [SiDBP] [ge]95 and [le]109mmHg). Patients who successfully completed one of three randomized, placebo-controlled, double-blind, 12-week, nebivolol dose-ranging studies entered a 9-month, open-label study, receiving once-daily nebivolol (5, 10 or 20 mg up-titrated to achieve BP goal). After 28 days, non-responders (average SiDBP [ge]90 mmHg and/or heart rate [lt]55 bpm) received nebivolol + open-label adjunct therapy (thiazide diuretic [[plusmn] triamterine] or other anti-hypertensives). BG levels were evaluated at baseline, 3, 6 and 9 months. A total of 845 patients were treated: the majority received nebivolol monotherapy (N=607); nebivolol + diuretics (N=206); nebivolol + other (N=32, mostly amlodipine). Diabetic patients comprised 6.3% of the total, obese patients (BMI [ge]30) 42.0% and black patients 23.3%. Mean changes from baseline in BG (mg/dL) at 3, 6 and 9 months (95% confidence interval) were, respectively: nebivolol monotherapy 2.21 ([minus]0.01, 4.43), 3.26 (0.76, 5.75) and 0.74 ([minus]1.55, 3.03); nebivolol + diuretics 6.05 (2.00, 10.10), 8.27 (4.79, 11.74) and 7.42 (4.20, 10.64). Small sample size in the nebivolol + other group precluded meaningful interpretation of the results. Clinically significant BG increases were seen only in patients treated with adjunctive diuretics, which was likely due to the diuretics3. Long-term nebivolol tr Continue reading >>

Blood Glucose & Amlodipine

Blood Glucose & Amlodipine

Amlodipine, sold under the brand name Norvasc, belongs to a class of medications called calcium channel blockers. Amlodipine is mainly used to treat high blood pressure and angina caused by coronary heart disease. Amlodipine relaxes blood vessels so the heart does not have to pump as hard. Amlodipine also increases blood flow to the heart, which relieves chest pain. Amlodipine might affect blood glucose levels. Video of the Day Amlodipine might cause hyperglycemia, or increased blood glucose levels, according to Drugs.com. Glucose is the main source of energy for the body.The body produces glucose from the breakdown of carbohydrates, fats and proteins. High levels of blood glucose can cause damage to blood vessels and body organs. Insulin, a hormone produced by the pancreas, helps the body control blood glucose levels. Healthy people are able to lower high blood glucose levels caused by amlodipine, but diabetics might have problems. Amlodipine should be used cautiously in patients with diabetes. Symptoms of Hyperglycemia Patients with a blood glucose level higher than 160 mg/dl are considered to have hyperglycemia. Amlodipine causes short-term hyperglycemia. Blood glucose levels return to normal when the drug is discontinued. Symptoms of hyperglycemia caused by amlodipine include increased thirst, frequent urination, increased hunger, blurred vision, fatigue and dry mouth. Chronic hyperglycemia is common in patients with diabetes. Amlodipine is available as an oral tablet that is taken once daily. Amlodipine should be taken around the same time each day. Diabetics should check their blood glucose levels before and after taking amlodipine. Patients taking amlodipine should be aware of the signs of hyperglycemia and report them to their doctor. Patients taking amlodipine Continue reading >>

Do Common Medicines Trigger Diabetes?

Do Common Medicines Trigger Diabetes?

Diabetes is a major health hazard. Not a surprise, right? Everyone should know by now that diabetes increases the risk for heart attacks, strokes, nerve damage, kidney damage, dementia, eye damage, erectile dysfunction and skin problems. But did you know that a surprising number of medications can raise blood sugar and even trigger type 2 diabetes? Here is a story from a reader about her hubby’s problem. Q. My husband was prescribed HCTZ (hydrochlorothiazide) for high blood pressure. At the same time, his blood sugar was tested (HbA1C) and we were told that he was “not diabetic.” Four months later, he ended up in the emergency room with low potassium and his blood sugar was again tested and he “was not diabetic.” Two months after that (6 months on HCTZ), he was in the ER again, this time with diabetic ketoacidosis (DKA). He was in intensive care for 5 days with insulin therapy, during which time I did more intensive research myself. The Doctor refused to acknowledge that the problem was caused by the HCTZ, and insisted that he was an “undiagnosed diabetic,” even though the prior hospital testing proved otherwise. Doctors wanted him back on the HCTZ when discharged, and we refused. Came home from hospital and the next day we were back at the doctors office due to a bad reaction to the insulin. After getting off the hydrochlorothiazide completely he was able to stop all diabetes medication. The doctor still insists that he is diabetic, even though his most recent HbA1C rest results came back: “not diabetic.” A. It is quite surprising to us that your husband’s physicians had such a hard time acknowledging that the diuretic HCTZ (hydrochlorothiazide) could have raised his blood sugar levels high enough to trigger a diagnosis or diabetes. This is a well-k Continue reading >>

What Medicines Can Make Your Blood Sugar Spike?

What Medicines Can Make Your Blood Sugar Spike?

If you have diabetes or high blood sugar, you probably know some of the things that cause your glucose (another name for blood sugar) to go up. Like a meal with too many carbohydrates, or not enough exercise. But other medicines you might take to keep yourself healthy can cause a spike, too. Know Your Meds Medicines you get with a prescription and some that you buy over the counter (OTC) can be a problem for people who need to control their blood sugar. Prescription medicines that can raise your glucose include: Steroids (also called corticosteroids). They treat diseases caused by inflammation, like rheumatoid arthritis, lupus, and allergies. Common steroids include hydrocortisone and prednisone. But steroid creams (for a rash) or inhalers (for asthma) aren’t a problem. Drugs that treat high blood pressure, such as beta-blockers and thiazide diuretics High doses of asthma medicines, or drugs that you inject for asthma treatment OTC medicines that can raise your blood sugar include: Cough syrup. Ask your doctor if you should take regular or sugar-free. How Do You Decide What to Take? Even though these medicines can raise your blood sugar, it doesn’t mean that you shouldn’t take them if you need them. The most important thing is to work with your doctor on the right way to use them. If you have diabetes or you’re watching your blood sugar, ask your doctor before you take new medicines or change any medicines, even if it’s just something for a cough or cold. (Remember, just being sick can raise your blood sugar.) Make sure your doctor knows all the medicines you take -- for diabetes or any other reason. If one of them may affect your blood sugar, she may prescribe a lower dose or tell you to take the medicine for a shorter time. You may need to check your blood s Continue reading >>

Amlodipine And Blood Sugars

Amlodipine And Blood Sugars

Diabetes Forum The Global Diabetes Community This site uses cookies. By continuing to use this site, you are agreeing to our use of cookies. Learn More. Get the Diabetes Forum App for your phone - available on iOS and Android . Find support, ask questions and share your experiences. Join the community Rachox Type 2 (in remission!) Moderator I have been on Amlodipine and Ramipril for a number of years for my blood pressure. Since being diagnosed Type 2, going low carb and loosing a chunk of weight my BP had come down to the point when I was getting dizzy if I stood up quickly. After a week of home monitoring with an average BP of 124/77 my GP agreed I could stop the Amlodipine. That was three weeks ago. I have been monitoring my BP every day and since stopping it my BP is averaging 127/77 so just a tiny rise. However the main point of this post is that Id read that Amlodipine can raise blood sugars in Type 2s. I never knew if that was true for me as I was on Amlodipine before my type 2 diagnosis. That was why I wanted to drop the Amlodipine rather than the Ramipril, plus Ramipril has kidney protecting qualities. Anyway my average blood sugars are down, so far March is showing an average of 5.4 down from Februarys 5.5 and were only half way through March! Several times a week Im getting 4s now in the evenings where before 4s were a rarity! Im seeing my GP next Tuesday and am hoping I can stay off Amlodipine. Im not sure when hell want my next HbA1c but Im hoping May 3 months after my last and if my HbA1c has gone down further Im going to ask to drop one of my Metformin. I think hell agree as he said those immortal words at my last appointment that he didnt want my HbA1c to go much lower! Just thought this might be interesting to any other Type 2s on Amlodipine. Remember Continue reading >>

Controlling Hypertension In Patients With Diabetes

Controlling Hypertension In Patients With Diabetes

Hypertension and diabetes mellitus are common diseases in the United States. Patients with diabetes have a much higher rate of hypertension than would be expected in the general population. Regardless of the antihypertensive agent used, a reduction in blood pressure helps to prevent diabetic complications. Barring contraindications, angiotensin-converting enzyme inhibitors are considered first-line therapy in patients with diabetes and hypertension because of their well-established renal protective effects. Calcium channel blockers, low-dose diuretics, beta blockers, and alpha blockers have also been studied in this group. Most diabetic patients with hypertension require combination therapy to achieve optimal blood pressure goals. Nearly one in four adults in the United States has hypertension, and more than 10 million adults have diabetes.1 Moreover, hypertension is twice as common in persons with diabetes as it is in others.2 Obesity may be a common link between the two disorders, but other factors such as insulin resistance3 and autonomic dysfunction4 may also be involved. Excess weight with truncal obesity, hypertension, impaired glucose tolerance, insulin resistance, and dyslipidemia are among the components of the metabolic syndrome, which has been associated with an increased risk of coronary heart disease.5 In general, only 25 percent of patients with hypertension have adequate control of their blood pressure.6 Blood pressure goals are lower, and thus more difficult to achieve, in patients who also have diabetes. Elevated blood pressure is known to contribute to diabetic microvascular and macrovascular complications (Table 1).4,7,8 Fortunately, reductions in blood pressure can decrease the risk of these complications.8 TABLE 1 Microvascular complications Renal d Continue reading >>

Double Blind Comparison Of The Effects Of Amlodipine And Enalapril On Insulin Sensitivity In Hypertensive Patients1 | American Journal Of Hypertension | Oxford Academic

Double Blind Comparison Of The Effects Of Amlodipine And Enalapril On Insulin Sensitivity In Hypertensive Patients1 | American Journal Of Hypertension | Oxford Academic

This study compares the effects of a calcium channel blocker (amlodipine) and an angiotensin converting enzyme inhibitor (enalapril) on in vivo insulin sensitivity in patients with essential hypertension. Forty-six patients with mild and moderate hypertension were studied. After a 2-week single-blind placebo phase, they were randomly assigned to double-blind therapy with either amlodipine (2.5 to 10 mg/day) or enalapril (5 to 40 mg/day) for 16 weeks. Both groups were comparable in terms of demographic characteristics, degree of obesity, metabolic parameters, and arterial blood pressure. Insulin sensitivity was measured at baseline and at week 16 during the active phase using euglycemic hyperinsulinemic clamps. Arterial blood pressure decreased similarly in both groups. Whole body glucose uptake (M-value) increased with amlodipine from 3.63 0.32 (mean SEM) to 3.97 0.31 mg/kg/min (P= .02). A similar tendency was observed with enalapril: from 3.59 0.32 to 3.94 0.30 mg/kg/min (P= .09). A trend to lower steady-state insulin level during the second clamp (compared to baseline) was observed in both groups. The clamp-derived insulin sensitivity index (that corrects for steady-state insulin levels and glucose levels during the clamp) increased similarly in both groups: from 1.15 0.11 to 1.39 0.13 with amlodipine (P= .03) and from 1.25 0.13 to 1.49 0.16 with enalapril (P= .01). LDL cholesterol decreased with amlodipine (mean change, 11.3 mg/dL, P= .004). Amlodipine and enalapril were associated with increments in insulin sensitivity. Amlodipine provided an additional benefit with decreased low density lipoprotein cholesterol levels.Am J Hypertens 1999;12:298303 1999 American Journal of Hypertension, Ltd. Calcium channel blocker , amlodipine , angiotensin converting enzyme inhibi Continue reading >>

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