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Metformin And Thyroid Disease

Metformin And Thyroid Disease

X Meng, Endocrinology, Chinese Medicine Hospital in Linyi City, Linyi, China S Xu, Endocrinology, Jiangsu Province Hospital of Integration on Chinese and Western Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, China G Chen, Endocrinology, Jiangsu Province Hospital of Integration on Chinese and Western Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, China M Derwahl, Department of Medicine, St Hedwig Hospital and Charite, University Medicine of Berlin, Berlin, D-10115 , Germany C Liu, Endocrinology, Jiangsu Province Hospital of Integration on Chinese and Western Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, China Correspondence: Chao Liu, Email: liuchao{at}nfmcn.com An intriguing area of research in thyroidology is the recently discovered association of insulin resistance with thyroid functional and morphological abnormalities. Individuals with hyperinsulinemia have larger thyroid gland and a higher prevalence of thyroid nodules and cancer. Accordingly, patients treated with metformin have a smaller thyroid volume and a lower risk of incident goiter, thyroid nodule and cancer. Multiple studies in vitro and in vivo have demonstrated that metformin can inhibit the growth of thyroid cells and different types of thyroid cancer cells by affecting the insulin/IGF-1 and mTOR pathways. Besides, metformin treatment was associated with a decrease in the levels of serum thyroid stimulating hormone (TSH) in diabetic patients possibly by enhancing the effects of thyroid hormones in the pituitary and activating the adenosine monophosphate-activ Continue reading >>

Reddit: Iama Grad Student Who Has Tried Nearly Every

Reddit: Iama Grad Student Who Has Tried Nearly Every "study"/"smart" Drug | Hacker News

It is a bit weird that doctors are only supposed to prescribe these drugs for medical conditions and not enhancement. If the effects are beneficial and the drug is safe, why not allow healthy people to take it? Of course, it's not hard to get a prescription if you want one. I just wish everyone didn't have to play this game of off-label prescriptions and lying to doctors. Edit: Disclaimer: I take modafinil and I find it very useful. Because our society has not debated the consequences of cognitive enhancement, and we are worse off for it. There are moral arguments for and against enhancement, but the way it currently is prohibited, yet tolerated (nearly everyone who really wants to can game the prescription requirement), is the worst way to handle it. So why not allow healthy people to take it? Because it distorts the competition - not who studied the most wins, but he who enhanced himself best. If you allow some enhancement, why not others forms? What about artificial limbs for athletes? Where does enhancement stop? What about everyone then feeling pressured to enhance themselves to still be able to compete, if they want to or not? I'd say the status quo is bad but not the worst. It would be better if cognitive-enhancing drugs were available for anyone who wanted them. It would be worse if using drugs for cognitive enhancement was illegal. I don't think the sports analogy maps. Sports are artificial competitions and usually zero-sum. Commerce is cooperative. Intelligent individuals often benefit the less lucky. They invent new technologies that end up helping everyone. If you allow some enhancement, why not others forms? What about artificial limbs for athletes? I guess that would be the Paralympics, but I don't have a problem with it. Cyborg kickboxing sounds more in Continue reading >>

Bia: Once Flawed, Not Anymore

Bia: Once Flawed, Not Anymore

In the world of body composition analysis, bioelectrical impedance analysis (BIA) is almost a dirty word. Although well-known and popularly used in consumer home/fitness equipment, BIA technology has been disregarded for yearswhen it comes to medical or professional purposes. And for good reason:many early BIA devices had serious design flaws. Even today, many people immediately dismiss BIA technology as technology that can only give ballpark estimations, even in the best of circumstances. However, BIA has come a very long way over the past few decades. So far, in fact, that some bioelectrical impedance devices are now producing results that nearlymirror results generated by DEXA, an industry-regarded gold standard. Imagine if you could determine body composition with a device that used technology whichhad all the convenience of traditional BIA, but combined it with the precision and reproducibility of a gold standard procedure. Imagine if that device was small enough to be placed anywhere: a doctors office, a gym, even a bedroom. Imagine if that device could track your results forever and illustrate your progress over time. If you havent interacted with BIA technology recently, or the last time you encountered it was in a Fitness Science textbook in a college class years ago, consider this your crash course update on modern, 21stcentury, BIA technology. Many of the valid concerns people have about using BIA technology stem from outdated, older technology. If youre concerned about the accuracy of BIA devices, you probably have very legitimate reasons. These devices fall into three general groups: Lets look at each one to see what the concerns are and where they come from. When people think about BIA devices that measure body fat, many of them think about something that Continue reading >>

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Bigcommerce V6 Shopping Carts For Websites

Bigcommerce V6 Shopping Carts For Websites

Posted by Daniel O. on May 16, 2011 at 10:16 am Affecting ONLY BigCommerce 6 users. BigCommerce decided to temporarily pause software upgrades to existing BigCommerce 6 users. They found that some stores had their inventory levels wiped out after the upgrade to Version 7. This problem did not affect ALL customers but it did make some red flags come up and the people from BigCommerce [] Posted by Daniel O. on March 1, 2011 at 1:02 pm Would you like a drop down Category Menu with Columns for your BigCommerce store? Then this is the tutorial for you. This tutorial will guide you through the steps to create a drop-down category menu with columns for your BigCommerce store. The links to your Categories will need to be hand-coded and keeping it updated [] Posted by Daniel O. on January 27, 2011 at 9:31 pm It is OFFICIAL, BigCommerce IS PCI COMPLIANT! As stated by Mitchell Harper (BigCommerces Founder and CEO) on their Blog, Home Page, and GetSatisfaction forum; today BigCommerce received their PCI DSS Compliance badge and should only be matter of weeks before they make it into VISAs list of PCI Certified providers. This is a HUGE deal [] Posted by Daniel O. on January 13, 2011 at 3:43 pm Is the BigCommerce link getting in the way of you signing up for service? Dont let that happen! I am glad to inform you that it is possible to customize a few things on the BigCommerce template. Besides removing the BigCommerce link from the footer of your store you can Enable and Disable a few [] Avoiding 15 Minute Log Out in BigCommerce Posted by Daniel O. on December 8, 2010 at 10:32 pm Since I work in BigCommerce most of the day I find it irritating that now there is a 15 minute inactivity log out. It may very well be for PCI compliance and security purposes but it sure is annoying. This Continue reading >>

Many Psychiatric Drugs Have Serious Effects On Body Weight

Many Psychiatric Drugs Have Serious Effects On Body Weight

Unexpectedly losing a loved one launched 18-year-old Debra* into an episode of major depression, triggering dangerous delusions that landed her in a hospital. Her doctor immediately started her on an antidepressant and on risperidone (Risperdal), an antipsychotic. In little more than a month, her weight shot up by 15 pounds. “Gaining weight made it even more difficult for me to want to leave my house because I felt self-conscious,” Debra says. In the medical community, antipsychotics are well known to cause significant weight gain. Gains of 20 to 35 pounds or more over the course of a year or two are not unusual. Debra's doctor never warned her, though, leaving her feeling like she was losing herself both mentally and physically. The situation is not uncommon, according to psychiatrist Matthew Rudorfer, chief of the somatic treatments program at the National Institute of Mental Health, who points out that although the U.S. Food and Drug Administration carefully tracks acute side effects such as seizures, it pays less attention to longer-term complications such as weight change. Perhaps taking their cue from the FDA, doctors tend to downplay weight-related risks that accompany many psychiatric drugs, Rudorfer says. But for Debra and many others, these side effects are not trivial. The three types of psychiatric drugs that can seriously affect body weight are reviewed below. Antipsychotics According to a 2014 review of eight studies, as many as 55 percent of patients who take modern antipsychotics experience weight gain—a side effect that appears to be caused by a disruption of the chemical signals controlling appetite. Olanzapine (Zyprexa) and clozapine (Clozaril) are the top two offenders; studies have shown that on average these drugs cause patients to gain more Continue reading >>

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Beef Tenderloin Steak

Beef Tenderloin Steak

Beef tenderloin, and most cuts of meat for that matter, is a muscle. It likes to be relaxed when you cook it. It's more relaxed when it's warm, than freezing cold, straight from the refrigerator. It'll also cook more evenly, if it's warm. If you haven't done so, already, place your covered raw steaks on the countertop for about 30 minutes to an hour, prior to cooking them. This isn't long enough for them to pick up any bacteria, so provided your kitchen is clean ... not to worry. Optional: Some people tie a string around the steak, at this point. They tighten it, nice and tight. They remove it, when the steak is cooked and rested. This will create a more perfectly circular or "round" steak. I like my steak to be in the shape it came in, but if you want a round steak ... go for it! Pre-heat an oven proof saut pan, over medium-high heat. Be sure to select a pan that is wide enough to allow for all 4 steaks, and allow space between them. They should not touch one another in the pan. This will help with heat distribution. Season your beef with salt and freshly cracked pepper. Your beef can likely handle more salt than you might think. Really coat your beef with a nice dusting of salt (don't go crazy, though ... that's a nice piece of meat!). Look at your steaks and make a decision about which side of each steak is the most attractive. This will be the presentation side. Make a mental note. Add your olive oil (light olive oil, or another flavorless, high smoke point oil, is recommended) to the pan. Quickly swirl the oil around the pan. The oil should ripple, but shouldn't burn or smoke. Once you see nice rippling of the oil, add the butter to the pan. Give the pan a quick twirl, then place the attractive "presentation side" of the steaks face DOWN in the saut pan. Allow the Continue reading >>

Effect Of Metformin On Metabolic Improvement And Gut Microbiota

Effect Of Metformin On Metabolic Improvement And Gut Microbiota

Effect of Metformin on Metabolic Improvement and Gut Microbiota aCenter for Human and Environmental Microbiome, School of Public Health, Seoul National University, Seoul, South Korea bN-Bio, Seoul National University, Seoul, South Korea Metformin is commonly used as the first line of medication for the treatment of metabolic syndromes, such as obesity and type 2 diabetes (T2D). Recently, metformin-induced changes in the gut microbiota have been reported; however, the relationship between metformin treatment and the gut microbiota remains unclear. In this study, the composition of the gut microbiota was investigated using a mouse model of high-fat-diet (HFD)-induced obesity with and without metformin treatment. As expected, metformin treatment improved markers of metabolic disorders, including serum glucose levels, body weight, and total cholesterol levels. Moreover, Akkermansia muciniphila (12.44% 5.26%) and Clostridium cocleatum (0.10% 0.09%) abundances increased significantly after metformin treatment of mice on the HFD. The relative abundance of A. muciniphila in the fecal microbiota was also found to increase in brain heart infusion (BHI) medium supplemented with metformin in vitro. In addition to the changes in the microbiota associated with metformin treatment, when other influences were controlled for, a total of 18 KEGG metabolic pathways (including those for sphingolipid and fatty acid metabolism) were significantly upregulated in the gut microbiota during metformin treatment of mice on an HFD. Our results demonstrate that the gut microbiota and their metabolic pathways are influenced by metformin treatment. Continue reading >>

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Comparison Of Two Insulin Sensitizers, Metformin And Myo-inositol, In Women With Polycystic Ovary Syndrome (pcos).

Comparison Of Two Insulin Sensitizers, Metformin And Myo-inositol, In Women With Polycystic Ovary Syndrome (pcos).

Abstract Insulin resistance (IR) plays a pivotal role in PCOS. Insulin-sensitizer agents such as metformin and inositols have been shown to improve the endocrine and metabolic aspects of PCOS. The purpose of this study is to compare their effects on the clinical and metabolic features of the women with PCOS. Fifty PCOS women with IR and/or hyperinsulinemia were randomized to treatment with metformin (1500 mg/day) or myo-inositol (4 g/day). IR was defined as HOMA-IR >2.5, while hyperinsulinemia was defined as a value of AUC for insulin after a glucose load over the cutoff of our laboratory obtained in normal women. The Matsusa Index has been calculated. The women have been evaluated for insulin secretion, BMI, menstrual cycle length, acne and hirsutism, at baseline and after 6 months of therapy. The results obtained in both groups were similar. The insulin sensitivity improved in both treatment groups. The BMI significantly decreased and the menstrual cycle was normalized in about 50% of the women. No significant changes in acne and hirsutism were observed. The two insulin-sensitizers, metformin and myo-inositol, show to be useful in PCOS women in lowering BMI and ameliorating insulin sensitivity, and improving menstrual cycle without significant differences between the two treatments. KEYWORDS: Androgens; amenorrhea; insulin resistance; insulin sensitizer; polycystic ovary syndrome Continue reading >>

Reversing Type 2 Diabetes In Only 2.5 Months With Keto And Fasting

Reversing Type 2 Diabetes In Only 2.5 Months With Keto And Fasting

With a combination of keto, fasting and exercise, Osvaldo has been able to reverse his type 2 diabetes in only 2.5 months! It’s very impressive. Here’s exactly how he did it: The email Hello Andreas, I want to thank you for the advice at Diet Doctor, as it helped me reverse my type 2 diabetes in only one and a half months. On the 1st of June 2017, I went to a scheduled appointment at my doctor’s office and he stated that my blood sugar had risen to an HbA1c of 73 mmol/mol (8.8%), and he thought that I should start taking insulin. I had, since I was diagnosed in 2012, taken Metformin (850 mg) three times daily and Glimeperid 4 mg in the morning. I told him that I didn’t want to take insulin and so he prescribed Januvia instead, with the intention of strengthening the blood-sugar lowering power of the medication, but he said that we needed to book another appointment within three months to see whether the blood sugar (as measured by HbA1c) had been lowered to approximately 52 mmol/mol (6.9%) which is what they recommend for people with the diagnosis of type 2 diabetes and if that didn’t happen he would have to prescribe insulin. When I went home I felt both disappointed and angry as I hadn’t worked out during the last couple of months and it hadn’t affected the result in any significant way, but at the same time I refused to accept that type 2 diabetes is a chronic and incurable disease which worsens no matter what. My older brother died from the disease in the beginning of May and my father in law passed away from it three years ago. I refused to see a dark future in front of me. I started to search for alternative treatments and found a YouTube clip by Dr. Jason Fung about reversing type 2 diabetes and I started to collect information by looking on other p Continue reading >>

Metformin Stock Could Be Wise Investment: Malcolm Berko

Metformin Stock Could Be Wise Investment: Malcolm Berko

Metformin stock could be wise investment: Malcolm Berko Dear Mr. Berko: Our neighbor is an engineer. He's a bright, well-read 76-year-old, and he's nobody's fool. He was telling us about a drug called metformin, which he says delays the aches and pains of advancing age and postpones many of the devastating diseases that can come with age, such as heart disease, arthritis and cognitive decline. My wife and I don't need the drug (yet), but I'd like to know what pharmaceutical company makes metformin and whether you'd buy the stock. -- MB, Vancouver, Wash. Dear MB: I may have a little bit more luck than the average investor picking drug stocks because there are some very wise medicine men in my circle of acquaintances. So every once in a while, I'll get a firsthand update on a certain drug, the effectiveness of which fails, matches or exceeds expectations. Metformin, first approved by the U.K. in 1957, is an oral diabetes medicine that helps diabetics control their blood sugar levels. It took our dismal Food and Drug Administration only 37 more years to approve metformin in the U.S. Resultantly, Bristol-Myers Squibb (BMY-$72) began producing and marketing metformin in 1994. It's prescribed primarily for patients with Type 2 diabetes and sometimes used in combination with insulin or other medications. When I asked about metformin, two of those esteemed sources chuckled and suggested that your neighbor has fallen for the old Fountain of Youth scheme. This was the dream of Juan Ponce de Leon, the 4-foot-11-inch first governor of Puerto Rico, who believed it would bring him enormous wealth. And Ponce de Leon was a real ponce, too. However, there are numerous early indications that your neighbor knows what he's talking about. Metformin has demonstrated impressive efficacy in m Continue reading >>

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