Type 2 Diabetes: Medication Side Effects Stops A Third Of Patients From Taking Drugs
Almost a third of diabetes patients aren’t taking their prescribed medication, metformin, due to its side effects, researchers have revealed. Metformin, the most commonly prescribed drug to treat type 2 diabetes, can lead to gastrointestinal side effects, including diarrhoea and flatulence, said scientists from the University of Surrey. The drug had the lowest level of patient compliance of all diabetes medication studied, with 30 per cent of diabetics choosing to not take their medication. Patients not taking their medication because of side effects should speak to their GP or nurse, to discuss changing to different drugs, they urged. “The importance of diabetes patients taking their prescribed medication cannot be underestimated,” said Clinical Researcher Dr Andy McGovern. “A failure to do so can lead to complications in their condition including eye disease and kidney damage. “Medication which is not taken does no good for the patient but still costs the NHS money, so this is an important issue. "We have known for a long time that a lot of medication prescribed for chronic diseases never actually get taken. What this latest research suggests is that patients find some of these medication classes much easier to take than others.” Fri, August 19, 2016 Diabetes is a common life-long health condition. There are 3.5 million people diagnosed with diabetes in the UK and an estimated 500,000 who are living undiagnosed with the condition. The scientists compared patient adherence of the most common type 2 diabetes medication. While diabetes patients were most likely to avoid metformin, 23 per cent of sulfonylureas and 20 per cent of pioglitazone weren’t taken, the researchers claimed. A relatively newer type of drug, DPP4 inhibitors, had one of the highest level Continue reading >>
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Quiz - As Diabetes Increases Worldwide, A Vegetable Could Help
From VOA Learning English, this is the Health & Lifestyle report. Diabetes is a serious, chronic disease on the rise around the world. And, not everyone can take the medication that treats it. However, researchers have discovered that a compound found in a common vegetable might help treat diabetes. In 2016 the World Health Organization published its Global Report on Diabetes. It says the number of diabetic adults rose from 108 million in 1980 to 422 million in 2014. Diabetes happens in two ways. If the body does not produce enough of a hormone called insulin it is called Type 1. Type 2 diabetes is when the body cannot effectively use the insulin it produces. Insulin controls levels of sugar in the blood. Over time, diabetes can damage the heart, blood vessels, eyes, kidneys and nerves. Diabetes is a major cause of blindness, kidney failure, heart attacks, stroke and lower limb amputation. It can lead to an early death. India is one of the countries that could be facing a public health crisis as cases of diabetes increase. Amit Jain is a children's doctor in that country. He says obesity is one of the main reasons people get Type 2 diabetes. However, children who are not obese can also get diabetes. Rohin Sarin is a regular 15-year old kid. He goes to school. He likes sports. But unlike most children, four times a day he has to take a shot of insulin. Rohin has type 2 diabetes. "Sometimes it affects me negatively like if I just play a lot and I don't eat my food properly; then my sugar goes down. So, then I feel dizzy and I am not able to play the sport properly." About 300 million people around the world have type-2 diabetics. A large percentage of these people cannot take a drug used to treat this disease. The drug metformin is a first-line therapy. This means it is o Continue reading >>
Metformin Makes Headline News
Metformin is the first-line drug of choice in the treatment of type II diabetes. It was first approved in Europe in 1958.1 Americans had to wait until 1994 to legally obtain metformin.1 The holdup in approving metformin goes beyond the FDA. It is an indictment of a political/legal system that will forever cause needless suffering and death unless substantively changed. When Life Extension® informed Americans about drugs like metformin in the 1980s, the FDA did everything in its power to incarcerate me and shut down our Foundation.2 FDA propaganda at the time was that consumers needed to be "protected" against "unproven" therapies. As history has since proven, the result of the FDA's embargo has been unparalleled human carnage. So called "consumer protection" translated into ailing Americans being denied access to therapies that the FDA now claims are essential to saving lives. Today's major problem is not drugs available in other countries that Americans can't access. Instead, it is a political/legal system that suffocates medical innovation. Headline news stories earlier this year touted the anti-cancer effects of metformin, data that Foundation members were alerted to long ago.3 The problem is that it is illegal for metformin manufacturers to promote this drug to cancer patients or oncologists. It's also illegal to promote metformin to healthy people who want to reduce their risk of cancer, diabetes, vascular occlusion, and obesity. This fatal departure from reality continues unabated, as our dysfunctional political/legal system denies information about metformin that could spare countless numbers of lives. Type II diabetics suffer sharply higher rates of cancer4-7and vascular disease.8-11 The anti-diabetic drug metformin has been shown in numerous scientific studies Continue reading >>
Breaking Down Diabetes: Drugs For Diabetes, Starting With The Best Metformin
Stanford University School of Medicine blog Breaking down diabetes: Drugs for diabetes, starting with the best metformin Metformin is physician-researcher Randall Stafford's go-to drug for diabetes. He explains why in this installment in the series, Breaking down diabetes. A huge assortment of 100 medications are available to treat high blood sugar in Type 2 diabetes, including two historical breakthrough drugs, insulin and metformin . The pharmaceutical industry has successfully added a few new, innovative drugs, but the most effective drugs remain the older, less expensive medications. Let's make some sense out of this mess of medications. Most are given by mouth (oral), but injected insulin, which I'll address in a future blog post, remains a key medication. In addition, oral drugs have limited impact, so they are often used in combinations (including tablets containing two drugs). Patients frequently try multiple oral drugs before starting insulin. With very few exceptions, I start patients on metformin first. To illustrate a patient's experience with diabetes drugs, let's check in on with Mrs. R., a 70-year-old with diabetes: When she was first diagnosed 19 years ago, she started on metformin at 500 mg twice per day. These large tablets initially caused intestinal discomfort (a common side effect). Over time, the mild abdominal pain went away. This drug worked well for a few years, but Mrs. R gained some additional weight and the metformin was no longer adequate. The drug, glipizide was added. This also worked for many years, but in 2012, she needed a third drug, sitagliptin . Eventually, she would need insulin. To understand Mrs. R's experience, or the medications taken by you or a friend or family member, lets start with the best medication, metformin. Approved Continue reading >>
Diabetes Drug Takes Aim At Cancer's Fuel Source
Follow all of ScienceDaily's latest research news and top science headlines ! Diabetes drug takes aim at cancer's fuel source Shuts down cancer cell's primary way of making energy in patients with head and neck cancer To understand how metformin changes the biology of cancer cells, researchers have tested tumor cells before and after metformin treatment in non-diabetic cancer patients. In the last three years, researchers have shown that diabetic patients with head and neck cancer, may have better outcomes than non-diabetic patients when they are taking the drug metformin for their diabetes. In order to examine this relationship further and understand how metformin changes the biology of cancer cells, researchers at the Sidney Kimmel Cancer Center at Thomas Jefferson University tested tumor cells before and after metformin treatment in non-diabetic cancer patients. The pilot clinical trial results were published today in the journal The Laryngoscope. "This study is the first step in showing how metformin acts on head-and-neck tumors, and we are excited that it could eventually offer patients a method of improving their outcomes with few side effects," says senior author Ubaldo Martinez-Outschoorn, M.D., Assistant Professor in the Department of Medical Oncology at Thomas Jefferson University and researcher at the Sidney Kimmel Cancer Center. Dr. Martinez-Outschoorn and colleagues showed that metformin not only changes the pathways that cancer cells rely on to make fuel for growth, but also alters the cancer microenvironment -- the cells that surround and support the tumor. "Because tumors need a lot of energy to grow quickly, throwing a wrench in their energy-production pathway makes this kind of cancer more susceptible to standard therapies," says first author Joseph C Continue reading >>
Herbal And Fruit Supplement Found To Be More Effective At Managing Diabetes Than Metformin Drug
Monday, April 02, 2018 by: Isabelle Z. Tags: alternative diabetes treatment, diabetes, diabetes prevention, disease treatments, fruits, herbal medicine, herbal remedies, Herbs, metformin, natural medicine, natural remedies, Ojamin, prevention, superfoods, supplements, turmeric, Type 2 Diabetes (Natural News) Type 2 diabetes can be a tricky illness to manage. In many cases, it is entirely possible to keep it under control with proper diet and regular exercise, and the lack of side effects makes this the most prudent approach for many people. However, others turn to diabetes drugs like Metformin to manage their condition, many times at the behest of their doctor, without realizing there are other options. The repercussions of poorly managed diabetes are very serious, but those who take Metformin often pay the price in terms of side effects and the higher risk of mortality that comes from taking it alongside insulin. Moreover, one out of every seven patients is unable to tolerate this medication due to its effects on the kidneys. Thankfully, researchers have recently found a few good natural options for managing diabetes when lifestyle changes alone arent cutting it. One recent study shows that an Indian herb and fruit supplement is not only effective at managing type 2 diabetes, but it actually works better when used alone than in combination with Metformin. Known as Ojamin, this supplement is widely used in India for diabetes because of its few side effects and lower cost than synthetic drugs. It contains the aqueous extracts of 14 different herbs, which include [Read full story] Continue reading >>
- KINGS Herbal | REH KINGS Herbal Official website | Ka Rey Herrera KINGS Herbal - one of leading herbal food supplement in the Philippines | Herbal supplement best for diabetes, hypertension, cancer, kidney stone and various diseases and illnesses
- KINGS Herbal | REH KINGS Herbal Official website | Ka Rey Herrera KINGS Herbal - one of leading herbal food supplement in the Philippines | Herbal supplement best for diabetes, hypertension, cancer, kidney stone and various diseases and illnesses
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Diabetes Drug Metformin 'may Help Reverse Breast Cancer Drug Resistance'
Research shows that metformin can boost cancer survival rates and prevent new tumours developing This may be the first indication of a clinical role for metformin in the long-term management of cancer Previous work has shown that metformin has an anti-proliferative effect on many kinds of cancer cell, they added. Multiple-study analyses of diabetic cancer patients treated with metformin have hinted at the drug boosting survival and preventing new tumours. The team led by Dr Terra Arnason, from the University of Saskatchewan, Canada, wrote in the journal Public Library of Science One: "Our demonstration that metformin can prevent MDR development and re-sensitise MDR cells to chemotherapy in vitro (in the laboratory) provides important medical relevance towards metformin's potential clinical use against MDR cancers. "This may be the first indication of a clinical role for metformin in the long-term management of cancer, where individuals may be maintained on oral metformin to extend remission times, or prevent drug resistance from developing." The drug is thought to act through a number of pathways involving histones, proteins that package DNA and also play a role in gene regulation. Medical breakthroughs: Nine of the most modern miracles Incredible medical breakthroughs leading to promising new treatments are just around the corner. Take a look at some of the most recent discoveries. Continue reading >>
Stopping Metformin: When Is It Ok?
The most common medication worldwide for treating diabetes is metformin (Glumetza, Riomet, Glucophage, Fortamet). It can help control high blood sugar in people with type 2 diabetes. It’s available in tablet form or a clear liquid you take by mouth before meals. Metformin doesn’t treat the underlying cause of diabetes. It treats the symptoms of diabetes by lowering blood sugar. It also increases the use of glucose in peripheral muscles and the liver. Metformin also helps with other things in addition to improving blood sugar. These include: lowering lipids, resulting in a decrease in blood triglyceride levels decreasing “bad” cholesterol, or low-density lipoprotein (LDL) increasing “good” cholesterol, or high-density lipoprotein (HDL) If you’re taking metformin for the treatment of type 2 diabetes, it may be possible to stop. Instead, you may be able to manage your condition by making certain lifestyle changes, like losing weight and getting more exercise. Read on to learn more about metformin and whether or not it’s possible to stop taking it. However, before you stop taking metformin consult your doctor to ensure this is the right step to take in managing your diabetes. Before you start taking metformin, your doctor will want to discuss your medical history. You won’t be able to take this medication if you have a history of any of the following: alcohol abuse liver disease kidney issues certain heart problems If you are currently taking metformin, you may have encountered some side effects. If you’ve just started treatment with this drug, it’s important to know some of the side effects you may encounter. Most common side effects The most common side effects are digestive issues and may include: diarrhea vomiting nausea heartburn abdominal cramps Continue reading >>
Forget The Blood Of Teens. This Pill Promises To Extend Life For A Nickel A Pop
Nir Barzilai has a plan. It’s a really big plan that might one day change medicine and health care as we know it. Its promise: extending our years of healthy, disease-free living by decades. And Barzilai knows about the science of aging. He is, after all, the director of the Institute for Aging Research at the Albert Einstein College of Medicine in the Bronx. And, as such, he usually talks about his plan with the caution of a seasoned researcher. Usually. Truth is, Barzilai is known among his colleagues for his excitability—one author says he could pass as the older brother of Austin Powers—and sometimes he can’t help himself. Like the time he referred to his plan—which, among other things, would demonstrate that human aging can be slowed with a cheap pill—as “history-making.” In 2015, he stood outside of the offices of the Food and Drug Administration, flanked by a number of distinguished researchers on aging, and likened the plan to a journey to “the promised land.” Last spring, Barzilai traveled to the Vatican to discuss the plan at a conference on cellular therapies. It was the second time he’d been invited to the conference, which is a pretty big deal in the medical world. At the last one, in 2013, he appeared alongside a dwarf from Ecuador, a member of a community of dwarfs whose near immunity to diabetes and cancer has attracted the keen interest of researchers. The 2016 conference featured a number of the world’s top cancer scientists and included addresses from Pope Francis and Joe Biden. That Barzilai was invited was a sign not only of his prominence in his field but also of how far aging research, once relegated to the periphery of mainstream science, has come in recent years. That progress has been spurred by huge investments from Sil Continue reading >>
An Old-line Diabetes Drug May Have New Uses Against Diseases Of Aging
Just over a year ago, Catherine Price decided to start taking one of the cheapest, safest, oldest, most widely prescribed drugs for Type 2 diabetes. So much metformin is taken in the United States — some 72 million prescriptions were written for it in 2013 — that a recent study found higher trace levels of it (presumably from the urine of people taking it) in Lake Michigan than of any other drug, including caffeine. But Price, a science and medical reporter in Oakland, Calif., doesn’t have Type 2 diabetes. She has Type 1, the far less common form of the disease, which requires lifelong treatment with insulin, to compensate for her body’s failure to produce enough of the hormone. However, she had read studies indicating that metformin combined with insulin might help Type 1 diabetics, too. Moreover, the drug was being studied in clinical trials as a way to lower the risk of cancer, heart disease and dementia — not just for diabetics, but for everyone. For Price, there was yet another possible benefit — as a treatment for polycystic ovary syndrome, an endocrine disorder that doctors thought might explain the difficulty she and her husband had had conceiving. Sure enough, a month and a half after she had started taking metformin pills and even as she was enjoying the benefits of better blood-sugar control, Price became pregnant, eventually giving birth to a girl. “I’m still taking metformin along with my insulin,” said Price, 36, who was diagnosed with Type 1 diabetes 14 years ago. “I remember eating Mexican food one night, which can be a potential disaster for people with diabetes because of the carbs, but I noticed I needed only two-thirds to a half of the insulin I normally needed.” Synthesized in the 1920s, metformin was first approved for treatme Continue reading >>
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How Much Do You Know About Metformin?
Metformin is a drug commonly used in the treatment of Type 2 diabetes. It is sold as a generic and under several brand names, including Glucophage, Glumetza, Riomet, and Fortamet. Both the American Diabetes Association (ADA) and the American Association of Clinical Endocrinologists (AACE) recommend metformin as a cornerstone of therapy for Type 2 diabetes when exercise and dietary changes aren’t enough to keep blood glucose levels in target range. The low cost of the generic forms along with a long history of use make it a good choice for many individuals with Type 2 diabetes. Although metformin has helped many people lower their blood glucose levels, it does have some potential side effects that are worth knowing about. Understanding the risks and benefits of metformin is key to using it successfully. Take this quiz to test your knowledge of this popular diabetes medicine. (You can find the answers later in the article.) Q 1. How does metformin work to lower blood glucose levels? A. It stimulates the pancreas to make more insulin. B. It decreases the amount of glucose produced by the liver and makes it easier for cells to accept glucose from the bloodstream. C. It slows the digestive system’s breakdown of carbohydrates into glucose, allowing more time for insulin to work. D. It suppresses appetite, slows stomach emptying, and inhibits the release of glucagon (a hormone that raises blood glucose levels). 2. In addition to lowering blood glucose, metformin sometimes causes moderate weight loss. TRUE FALSE 3. In research studies, metformin use was associated with which of the following benefits in people with Type 2 diabetes? A. Reduced risk of morning high blood glucose. B. Reduced neuropathy (nerve damage). C. Reduced retinopathy (damage to the retina, a membrane in Continue reading >>
Whats The Story On Metformin For Diabetes?
Whats the Story on Metformin for Diabetes? Have you had your blood sugar checked lately. Millions of American have elevated blood glucose levels and don't realize it. Doctors prescribe metformin for diabetes. What are the pros and cons? Metformin has become the go-to drug for type 2 diabetes. Its easy to understand why. The drug works to control blood sugar and it is incredibly inexpensive compared to many of the newer diabetes drugs. Of course lifestyle remains the number one most important way to manage this metabolic disease. Metformin for diabetes can enhance the benefit of diet, exercise and other lifestyle changes. Q. I have been diagnosed with type 2 diabetes. Ive been trying to control my blood sugar levels with the help of a nutritionist for about a year now. I am thin, work out regularly and eat really well. Its not enough. My doctor has now prescribed metformin. What are your thoughts on this drug? And do you know of anything else I could try? I am still asymptomatic and feel great. I wish I could help myself through diet and exercise. Q. Dont give up on your good diet and exercise habits! They will help with the effectiveness of your treatment, even if you havent been able to control your blood sugar with them alone. Metformin is a first-line drug for type 2 diabetes, as well as one of the oldest and best-studied. It improves the bodys response to insulin and can be quite effective. In addition to its ability to keep blood sugar down, metformin has also shown promise for its anti-cancer activity ( Acta Biochimica et Biophysica Sinica, online Oct. 7, 2017 ). Metformin Side Effects Can Be Hard to Handle: There are potential side effects, however. The most common are digestive: nausea, stomach ache, indigestion, loss of appetite, diarrhea and flatulence. The m Continue reading >>
Worlds First Anti-ageing Drug Could See Humans Live To 120
Worlds first anti-ageing drug could see humans live to 120 Pensioners could be as healthy as 50 year olds in the future if tests on metformin perform as well as expectedCredit:ALAMY The worlds first anti-ageing drug will be tested on humans next year in trials which could see diseases like Alzheimers and Parkinsons consigned to distant memory. Scientists now believe that it is possible to actually stop people growing old as quickly and help them live in good health well into their 110s and 120s. Although it might seem like science fiction, researchers have already proven that the diabetes drug metformin extends the life of animals, and the Food and Drug Administration in the US has now given the go ahead for a trial to see if the same effects can be replicated in humans. This would be the most important medical intervention in the modern era, an ability to slow ageing Dr Jay Olshansky, University of Illinois Chicago If successful it will mean that a person in their 70s would be as biologically healthy as a 50 year old. It could usher in a new era of geroscience where doctors would no longer fight individual conditions like cancer, diabetes and dementia, but instead treat the underlying mechanism ageing. Scottish ageing expert Professor Gordon Lithgow of the Buck Institute for Research on Ageing in California, is one of the study advisors. If you target an ageing process and you slow down ageing then you slow down all the diseases and pathology of ageing as well, he said Thats revolutionary. Thats never happened before. I have been doing research into ageing for 25 years and the idea that we would be talking about a clinical trial in humans for an anti-ageing drug would have been though inconceivable. But there is every reason to believe its possible. The future is taki Continue reading >>
Metformin | Latest & Breaking News On Metformin | Photos, Videos, Breaking Stories And Articles On Metformin - Moneycontrol.com
Metformin is the most widely prescribed drug for the treatment of type 2 diabetes. Besides its blood sugar lowering effect, it also displays anti-cancer properties. The usual therapeutic dose is too low to effectively fight cancer. "The company's US subsidiary Lupin Pharmaceuticals Inc has launched its Metformin HCl extended release tablets in the strengths of 500 mg and 1,000 mg," Lupin said in a BSE filing. "The decision to import and the country of origin for such imports are based on economic considerations, Kumar said. However, the higher dose of metformin was toxic and reduced the lifespan of mice Aurobindo gets USFDA nod for a copy of diabetes drug Actos Drug maker Aurobindo Pharma has got final approval from US Food and Drugs Administration (FDA) to manufacture and market Pioglitazone tablets in 15mg, 30mg and 45mg strength, and its earlier tentatively approved Pioglitazone Hydrochloride + Metformin Hydrochloride tablets in 15mg (base)/500mg and 15mg (base)/850mg strengths. Generics drugs maker Aurobindo Pharma has received final approval from US Food and Drugs Administration (FDA) to manufacture and market Metformin Hydrochloride extended-release tablets in 500mg and 750mg strength. Drug maker Lupin said on Thursday that it has resumed US sales of its copy of Shionogi Inc's Fortamet tablets, a type 2 diabetes treatment drug. A US district court in New Jersey has granted motion for a preliminary injunction against Lupin's generic version of anti-diabetes drug Fortamet. Continue reading >>
Scientists Find Natural Mimetics Of Anti-cancer & Anti-aging Drugs Metformin And Rapamycin
Scientists find natural mimetics of anti-cancer & anti-aging drugs metformin and rapamycin Scientists at the Biogerontology Research Foundation, Insilico Medicine and Life Extension use Deep Learning-based Artificial Intelligence to Score natural compounds according to safety and gene- and pathway-level similarity to metformin and rapamycin IMAGE:This figure depicts an AI-driven drug discovery workflow schematic. view more Wednesday, Nov. 29, 2017, London, UK: Researchers from the Biogerontology Research Foundation , Insilico Medicine , Life Extension and other institutions announce the publication of a landmark study in the journal Aging on the identification of natural mimetics of metformin and rapamycin. Metformin, a common type 2 diabetes drug, and rapamycin, a common anti-rejection drug, have both been shown to have substantial anti-aging and anti-cancer effects in a variety of model organisms. However, both compounds have known side effects and are regulated drugs for existing disease indications, factors that problematize their off-label use as healthspan extending drugs. In this study, the researchers applied deep-learned neural networks to profile the safety and gene- and pathway-level similarity of more than 800 natural compounds to metformin and rapamycin, in an effort to identify natural compounds that can mimic the effects of these anti-cancer and anti-aging drugs while remaining free of the adverse effects associated with them. "Earlier this year we launched Young.AI, a comprehensive system utilizing the recent advances in deep learning for tracking a variety of aging biomarkers. I hope that the consumers using the Longevity A.I. will start using it. One of the goals of our group is to identify the combinations of molecules that achieve the desired effect Continue reading >>