diabetestalk.net

Best Nitric Oxide Supplement For Diabetics

Nitric Oxide Synthesis Is Reduced In Subjects With Type 2 Diabetes And Nephropathy

Nitric Oxide Synthesis Is Reduced In Subjects With Type 2 Diabetes And Nephropathy

Nitric Oxide Synthesis Is Reduced in Subjects With Type 2 Diabetes and Nephropathy From the Department of Clinical and Experimental Medicine, Metabolism Division, University of Padova, Italy. Corresponding author: Paolo Tessari, [email protected]p . Received 2009 Dec 3; Accepted 2010 May 11. Copyright 2010 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See for details. This article has been cited by other articles in PMC. Nitric oxide (NO) is a key metabolic and vascular regulator. Its production is stimulated by insulin. A reduced urinary excretion of NO products (NOx) is frequently found in type 2 diabetes, particularly in association with nephropathy. However, whether the decreased NOx excretion in type 2 diabetes is caused by a defective NOx production from arginine in response to hyperinsulinemia has never been studied. We measured NOx fractional (FSR) and absolute (ASR) synthesis rates in type 2 diabetic patients with diabetic nephropathy and in control subjects, after l-[15N2-guanidino]-arginine infusion, and use of precursorproduct relationships. The study was conducted both before and after an euglycemic hyperinsulinemic (1,0001,200 pmol/l) clamp. In type 2 diabetes, NOx FSR was reduced both under basal (19.3 3.9% per day, vs. 22.9 4.5% per day in control subjects) and hyperinsulinemic states (24.0 5.6% per day, vs. 37.9 6.4% per day in control subjects; P < 0.03 by ANOVA). Similarly, in type 2 diabetes, NOx ASR was lower than in control subjects under both conditions (basal, 0.32 0.06 vs. 0.89 0.34 mol per day; hyperinsulinemia, 0.35 0.07 vs. 1.15 0.38 mol per day; P = 0.01 by ANOVA). In type 2 diabetes, the ability of insulin Continue reading >>

Nitric Oxide Holds Promise For Diabetes Cell Repair

Nitric Oxide Holds Promise For Diabetes Cell Repair

University of Florida researchers say primitive cells that act like molecular maintenance men—traveling throughout the body to repair damaged blood vessels—become too rigid in patients with diabetes, fueling the disease’s vascular complications. But they have found a way to restore the cells’ flexibility, at least in the laboratory, according to findings published in the January 2006 issue of the journal Diabetes. Many complications of diabetes, such as heart disease, stroke, blindness, and kidney failure, arise after blood vessels suffer damage, spurring the accumulation of fatty deposits in the arteries, or an overgrowth of new capillaries in the eye. “We’re interested in what happens in the body at the molecular level to cause these life-threatening problems,” says Mark S. Segal, PhD, an assistant professor of nephrology, hypertension, and transplantation at UF’s College of Medicine. “Our work is focused on understanding why diabetic patients are at increased risk for these other diseases.” CELLS FAIL TO REPAIR The problem is rooted in the body’s response to vascular injury. The bone marrow churns out cells crucial to repairing the damaged lining of blood vessels. But sometimes these cells fail to report for duty. “Part of the defect we think is occurring in diabetic patients is that these cells do not carry out appropriate repair,” Segal said. The inability of these cells to repair the large blood vessels of the body is similar to their inability to repair the small vessels within the eye, he added. “In the vasculature, it leads to atherosclerosis, and within the eye, the same process leads to diabetic retinopathy,” he said. “So the link is we have one defect in these cells that can lead to both of these problems.” NITRIC OXIDE IS K Continue reading >>

L-arginine In Diabetics

L-arginine In Diabetics

Angela Ogunjimi has been a prize-winning writer and editor since 1994. She was a general assignment reporter at two newspapers and a business writer at two magazines. She writes on nutrition, obesity, diabetes and weight control for a project of the National Institutes of Health. Ogunjimi holds a master's degree in sociology from George Washington University and a bachelor's in journalism from New York University. One of the most helpful ways L-arginine acts with diabetics is lowering blood pressure.Photo Credit: sanchairat/iStock/Getty Images L-arginine can help diabetics through a number of mechanisms. For example, it may aid in reducing the risk of cardiovascular-related complications such as high blood pressure, high cholesterol and heart disease. This is because L-arginine creates a chemical in your body that works to relax your blood vessels. Diabetes can complicate this process, however, so it's important to seek treatment from your doctor rather than attempt to self-medicate with L-arginine supplements. Another way L-arginine may help diabetics is by boosting athletic performance, which can aid in building muscle and losing fat. L-arginine, sometimes simply called arginine, is an amino acid with numerous functions. It helps to make urea, a chemical waste material that helps your body shed ammonia. As an amino acid, it's a building block of protein, so it assists in protein-related functions, such as wound healing and tissue repair. In clinical settings, L-arginine has been used to prevent wasting, or rapid weight and strength loss, in seriously ill patients, and to enhance sperm production as part of fertility treatments. By making nitric oxide in your body, L-arginine helps vasodilation, and could have important implications for diabetes treatment. Vasodilatio Continue reading >>

Blood Sugar Level

Blood Sugar Level

Three-pronged approach to diabetes A healthy diet, sufficient exercise, and avoidance of nicotine and alcohol can significantly reduce the risk of developing type 2 diabetes. Even elevated blood sugar levels and limited insulin sensitivity can often be improved with specific measures. In many cases, long term insulin administration can thus be avoided altogether, or at least meaningfully reduced. In order to reduce possible damage from elevated blood sugar levels, nutrition experts recommend supporting your metabolism with the following three-pronged approach: Losing weight and exercising: Those who exercise strengthen their heart, circulation, blood vessels, and joints. Slightly elevated blood sugar levels can often be brought down to normal levels through a healthy diet, weight loss, and exercise alone. Insulin resistance and the flexibility of blood vessels can be improved through diet, and antioxidants can help protect cells from the damage caused by high blood sugar. The amino acids, vitamins, and trace elements highlighted in the following section are therefore of particular importance to the body’s own regulation of blood sugar levels. Amino acids and the regulation of blood sugar levels L-arginine L-arginine improves circulation plays a role in your cardiovascular health (blood pressure, particularly circulation in fine blood vessels). L-arginine forms the molecule, NO (nitric oxide), which signals in the relaxation and dilation of blood vessels. Many studies have confirmed that taking L-arginine can result in improved circulation and blood pressure. Endothelial dysfunction (dysfunction of the interior wall of blood vessels) is usually first observed in the smallest blood vessels, for example those found in the retina of the eye or a man’s penis. In studies, Continue reading >>

Nitric Oxide Supplements

Nitric Oxide Supplements

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community I'd like some advice on Nitric Oxide Suppliments. I'm looking for one that focuses just on Nitric Oxide and doesnt contain any thing else eg cafine, creatine, no sugar and preferebly no carbs either! Can anyone recomend a good brand? I've searched google but it's hard to tell the quality of some suppliments shown... Nitric oxide is an air pollutant produced by combustion of substances in air, like in automobile engines Just walk next to a main road for half an hour a day, you should be fine :wink: Just walk next to a main road for half an hour a day, you should be fine :wink: Ahh thats great, just let me know once you've extracted all the other harmful pollutents from the air and I'll come collect it from you?..... Just as a matter of interest.....what is this stuff for ? Nitric Oxide, a key molecule manufacturered by the body, causes vasodilation (an expansion of the internal diameter of blood vessels), which in turn leads to increased blood flow, oxygen transport, delivery of nutrients to skeletal muscle and a reduction in blood pressure. It's therfore marketed mainly as a body building suppliment (whixh is what I intend to use it for) but it is also thought to help with the damage that highblood sugars can cause to the cardiovascular and nervous system, studies have shown.. So it'd be great if anyone that has had experience with NO suppliments, or body building could recomend any. It is one of the effects of viagra, nitric oxide enters the blood stream when you take one, increasing blood flow to the pelvic area. We thought it might be for Body building, hopefully if the few Members we have that do that are around they will answer you in due course. Continue reading >>

Amino Acids And Their Significance For Diabetes

Amino Acids And Their Significance For Diabetes

Arginine can reduce insulin resistance Diabetics cannot sufficiently utilise carbohydrates such as sugar, which is an important energy source. Insulin plays a significant role here as it is a blood-sugar reducing endogenous hormone and the production of insulin is lower in those affected. Furthermore, the cells in their bodies are not able to properly absorb the insulin that is available. The reason for this is the highly diminished sensitivity of the cells towards insulin. The cell membranes are unable to recognise the hormone and therefore do not absorb enough of it. The consequence of this so-called insulin resistance is that not enough energy is produced in the cells. Moreover, sugar cannot properly be degraded in the blood and therefore accumulates so that the blood sugar level increases. Over the long-term, a constantly elevated blood sugar level can damage the vessels and lead to calcification and typical resulting illnesses such as stroke or heart attack. Diabetes mellitus type 2 is mostly associated with older people, as the insulin sensitivity in the cells decreases with age. A well-received study from 1998 showed that arginine can reduce insulin resistance, meaning in turn that insulin sensitivity can be increased.1 Arginine - an important amino acid for insulin absorption Another study by European researchers showed that the amino acid arginine is of great importance for the sensitivity of the body’s cells towards insulin. Arginine is a precursor of nitrogen oxide, a transmitting substance which has a direct influence on insulin sensitivity. For the study, six type two diabetes patients were split into two groups. Both groups consumed a normal diabetic diet. One of the groups was administered a placebo to be taken three times daily for one month. The other Continue reading >>

Nitric Oxide - Diabetes Self-management

Nitric Oxide - Diabetes Self-management

A clear, colorless gas that performs a number of important functions in the body. It seems to play a role in several medical conditions, including septic shock, dementia, and impotence, and it may partially account for the high rate of heart disease seen in people with diabetes. Nitric oxide is considered such an important chemical in the body that the journal Science named it the Molecule of the Year in 1992, and in 1998 three scientists won the Nobel Prize in Medicine for researching its role in the body. Scientists have long been familiar with nitric oxide as a component of car exhaust, cigarette smoke, and air pollution, but it wasnt until the late 1980s that researchers discovered that mammal cells also produce the gas and use it to communicate with other cells. Abnormalities in the bodys production of nitric oxide have been implicated in high blood pressure, atherosclerosis (narrowing of the arteries), diabetes, erectile dysfunction, and stroke. Scientists are furthest along in their understanding of nitric oxide in the area of heart disease. Normally, cells lining the inner wall of blood vessels secrete nitric oxide, which travels to the muscle cells around the blood vessels and causes them to widen, allowing easier blood flow. Impaired nitric oxide production may contribute to constricted blood vessels, high blood pressure (especially in the 90% of cases with no identifiable cause), and atherosclerosis. Scientists now know that nitroglycerin and similar drugs dilate blood vessels and help alleviate angina temporary chest pain resulting from insufficient oxygen to the heart because the drugs release nitric oxide. Nitric oxide also keeps blood platelets from clumping together and sticking to the inner walls of arteries, protecting the body from blood clots and at Continue reading >>

Nitric Oxide Supplement Side Effects - Should You Be Worried?

Nitric Oxide Supplement Side Effects - Should You Be Worried?

Nitric oxide supplements have played an integral role in bodybuilding since 1996. These supplements help athletes and fitness enthusiasts alike improve circulation, build muscle, and boost immunity. Interestingly enough, nitric oxide supplements dont actually contain nitric oxide (NO), which is a gas produced naturally by the body. Rather, these supplements provide various amino acids and other ingredients to spur nitric oxide production. RELATED: 10 Best Nitric Oxide Supplements of 2018! To make nitric oxide, enzymes in the body break down the amino acid, arginine, explains Jim White, spokesperson for the American Dietetic Association. Then, nitric oxide dilates blood vessels, increasing blood flow and circulation. Improved circulation increases the maximum amount of nutrients and oxygen available to the muscles. More nutrients and oxygen enables the muscles to work harder and longer with reduced fatigue and recovery time. Nitric oxide supplementation can offer amazing results when the right ingredients are used. Arginine and citrulline (which converts into arginine) are some of the most effective ingredients in the industry. However, using nitric oxide supplements is a double-edged sword. On one side, you have increased performance and enhanced results, but on the other, you have the risk of negative side effects. Most Common Nitric Oxide Supplement Side Effects The most common nitric oxide supplement side effects are primarily minor and include nausea, diarrhea, headaches and stomach problems but there are other potential side effects to be aware of before taking a nitric oxide supplement with some less concerning than others. As mentioned earlier, the amino acid arginine is essential for nitric oxide production. However, consuming excess amounts of arginine often r Continue reading >>

Nitric Oxide And Diabetes!

Nitric Oxide And Diabetes!

Diabetes has become a national health problem. Fortunately, there are clinical studies to show that nitric oxide can positively affect the complications of diabetes. This blog will help you understand the hard facts, complications, and the potential of a proper nitric oxide / l-arginine protocol to help with this devastating disease. Now before we start you might be wondering why an endocrine disease is showing up on a web site focused on cardiovascular health. The answer is that diabetes directly affects the vascular system giving rise to most of the complications. One noted clinical expert in this area, Dr. J. Joseph Prendergast says, “Many people still think diabetes is a disease about sugar. It’s not the sugar! It’s the complications!” Dr. Prendergast is not discounting the need to control your blood sugar. That’s extremely important. What he’s trying to get people to understand is that unregulated glucose (blood sugar) causes high levels of oxidative stress which damages the endothelial cells and their ability to properly produce nitric oxide – the master signaling molecule for your cardiovascular system. To prevent the complications you also need to repair the damage to the endothelium. The Hard Facts! Diabetes is a disease in which the body does not produce insulin (Type 1) or does not properly respond to insulin (Type 2). According to the most recent statistics from the Diabetes Association of Greater Cleveland (updated in February of 2009)17.9 million American have been diagnosed with diabetes. What makes this “America’s largest healthcare epidemic” is that 57 million Americans are in a pre-diabetic condition where their blood glucose levels are higher than normal but not high enough to be diagnosed with type 2 diabetes. Almost 25% of the Am Continue reading >>

Using Nitric Oxide To Help Treat Diabetes

Using Nitric Oxide To Help Treat Diabetes

We're sorry, an error occurred. We are unable to collect your feedback at this time. However, your feedback is important to us. Please try again later. Further to my query on natural substances that help diabetes, have you heard of Nitric Oxide (NO)? Sounds toxic, ay? It is in fact a "free radical gas that is a powerful regulator of circulation (it is an endogenous vasodilator) and a neurotransmitter (it helps in the processing of nerve signals as they cross synapses)." Read all about it at DiabetesInControl . Apparently NO is impaired in people with both Type 1 and Type 2 diabetes, and this deficiency may play an important role in the poor circulation in diabetic patients that leads to high incidence of ulcers. Some researchers also believe the NO shortage is one cause of peripheral neuropathy (diabetic nerve damage). In short, impaired circulation is indeed the root of most diabetic complicaitons, and NO seems to have a powerful effect in improving this problem. So where can I get me some NO?! The January issue of the medical journal Diabetes features a paper by several doctors proposing NO as a potential new diabetes treatment. The authors experimented with adding "physiologic concentrations" of NO to the CD34+cells, which repair blood vessels throughout the body -- working with cells taken from diabetic patients in a lab setting. According to the experts, this work takes "groundbreaking" strides towards halting diabetic complications. We're talking fully regenerated cell repair . Too late for my father, but here's an advancement that Our D-Generation might actually benefit from. Disclaimer: Content created by the Diabetes Mine team. For more details click here. This content is created for Diabetes Mine, a consumer health blog focused on the diabetes community. The Continue reading >>

Diabetes Makes It Hard For Blood Vessels To Relax

Diabetes Makes It Hard For Blood Vessels To Relax

Follow all of ScienceDaily's latest research news and top science headlines ! Diabetes Makes It Hard For Blood Vessels To Relax One way diabetes is bad for your blood vessels is by creating too much competition for an amino acid that helps blood vessels relax, researchers say. That amino acid, L-arginine, is broken down by the enzyme arginase to urea, which helps the body eliminate toxins resulting from the proteins we eat. Arginase also is associated with vascular problems related to aging, hypertension, sickle cell disease, atherosclerosis and erectile dysfunction. One way diabetes is bad for your blood vessels is by creating too much competition for an amino acid that helps blood vessels relax, researchers say. Credit: Image courtesy of Medical College of Georgia One way diabetes is bad for your blood vessels is by creating too much competition for an amino acid that helps blood vessels relax, researchers say. Credit: Image courtesy of Medical College of Georgia One way diabetes is bad for your blood vessels is by creating too much competition for an amino acid that helps blood vessels relax, researchers say. That amino acid, L-arginine, is broken down by the enzyme arginase to urea, which helps the body eliminate toxins resulting from the proteins we eat. Diabetics have a lot of arginase activity, which means they use a lot more L-arginine, says Dr. Maritza Romero, postdoctoral fellow at the Medical College of Georgia and lead author of the paper published in the current issue of Circulation Research. It also means too little L-arginine is available to help nitric oxide synthase make nitric oxide, the powerful vasodilator that helps blood vessels relax, says Dr. Romero, who works in the lab of Dr. R. William Caldwell, chair of the MCG Department of Pharmacology and Continue reading >>

Blood Sugar And Nitric Oxide

Blood Sugar And Nitric Oxide

That may seem great to some people, but it can be devastating. The internal organs and brain are largely made of fats as well as become a food source in this desperate situation. Without having insulin, regardless of what the body breaks apart to use for fuel, it cannot get glucose into the cells. Nonetheless, the glucose, or sugar doesnt only disappear, it remains inside the blood. The body does attempt to excrete the excess sugar through the urine, nonetheless, it ends up becoming dehydrated as a result of reverse osmosis which draws water out of the cells to cope with all the surplus sugar. This state of Diabetic Keto-Acidosis or DKA can be very hazardous. Apart from vomiting, dehydration, blurred eyesight, elevated blood pressure, and headaches, a person battling DKA can experience precipitous declines in potassium levels ultimately causing all kinds of difficulties, as well as cerebral edema, coma and death. Even when effectively maintained, both type 1 and type 2 diabetes possess important long-term complications, most of which are linked to the cardiovascular system. Diabetics have a higher prevalence of high blood pressure levels and atherosclerosis (cardiovascular disease) than the normal populace as well as additional blood circulation problems. Besides these problems, diabetics also have increased incidences of circulatory associated disorders like retinopathy and reduced renal function. The Unfortunate Specifics Regarding Diabetes Besides the approximately 18 million Americans having either type 1 or type 2 diabetes, Fifty seven million Americans are in a pre-diabetic situation where their blood sugar levels tend to be strangely elevated however, not quite high enough to be diagnosed with type 2 diabetes. According to the Diabetes Association of Greater Cle Continue reading >>

Is It Safe To Take Supplements If You Have Diabetes?

Is It Safe To Take Supplements If You Have Diabetes?

You will find supplements for anything and everything these days. Even when you do not suffer from an ailment, supplements are suggested to keep you healthy and ailment-free. According to CDC, use of supplements is common among US adult population – over 50% adults used supplements during 2003-2006, with multivitamins/multiminerals being the most commonly used. So when you are a diabetic, especially if you have prediabetes and type-2 diabetes, you may find yourself confronting a large number of options for supplements that claim to support, reduce and even cure your diabetes. Diabetes is quite a frustrating disorder and you may find yourself tempted to try out these supplements one after another. But is it really safe to take supplements when you are a diabetic? Let us find out. But before that you need to understand what exactly supplements are. Defining Supplements As the name suggests, a supplement is anything that adds on to something. A dietary supplement is therefore something that one takes in addition to one’s diet to get proper nutrition. US Congress in the Dietary Supplement Health and Education Act defines dietary supplements as having the following characteristics: It is a product that is intended to supplement the diet; It contains one or more dietary ingredients (including vitamins, minerals, herbs and other botanicals, amino acids, and other substances) or their constituents; It is intended to be taken by mouth as a pill, capsule, tablet, or liquid; It is not represented for use as a conventional food or as sole item of a mean or a diet; and, It is labeled on the front panel as being a dietary supplement. Now let us look at some general benefits and risks of taking supplements. We will discuss these in context of diabetes later in the article. Benefit Continue reading >>

Supplements For Diabetics

Supplements For Diabetics

Diabetes is a condition people face when the body goes throughan abnormally high blood glucose levels. This is caused by a person having a difficult time producing or making use of insulin. The American Diabetes Association shows that you should keep the amount of sugar and saturated fat rather low in you diet. If you are diabetic and also weight lifting, you need to choose the right supplements that fit your dietary needs. Many people take pre-workouts before a workout in order toincreaseenergy and strength. For diabetics, you should choose a pre-workout that is caffeine free. Caffeine may interfere with glucose levels in the body and makes it hard for people to control their blood sugar.You can Build Your Own Stim-Free Pre-Workout on Campusprotein.com to take your workouts to the next level, minusthe added caffeine and stimulants. There are many more benefits for diabetics when it comes to adding protein powder to your diet. Although protein is a great wayto build and maintain muscle, it can also help lower blood glucose levels.Choosing the right protein powder is very important, you want to stay away from oneswith added sugars or fat. Whey isolates will be your best choice, they contain minimal fats and easily digestible protein.Wheyhas theability to boost metabolic rate, improve insulin and blood sugar metabolism, and help maintain appetite that maybenefit many people. Here are some of the best protein options: Continue reading >>

"no" News Is Good News: Nitric Oxide For Cvd & Diabetes

"NO" News is Good News: Nitric Oxide for CVD & Diabetes "From diabetes to hypertension, cancer to drug addiction, stroke to intestinal motility, memory and learning disorders to septic shock, sunburn to anorexia, male impotence to tuberculosis, there is probably no pathological condition where nitric oxide does not play an important role."homepage of the Nitric Oxide Society, www.nitricoxide.ws With over 82,000 recent studies to its credit, Nitric Oxide (NO), has become something of a biochemical superstar since the discovery of its vascular effects in the 1990s. The more researchers study it, the more clinical implications they find. We now recognize that many widespread diseases like cardiovascular disease, hypertension, dyslipidemia, diabetes, erectile dysfunction and sickle cell anemia involve, to varying degrees, abnormalities of NO production. Is there a common connectionand perhaps a common correctionfor these various conditions? Ever heard of Viagra? Nitroglycerine? Few people haven't. But most people, even many physicians, don't realize these are nitric oxide therapies. They increase NO production and release in the vasculature of specific tissues and blood vessels. In humans and other animals NO is internally produced from precursors like arginine, which are converted by enzymes called NO synthases into NO. The three synthases known at this time are Endothelial (think cardiovascular), Neuronal (think brainnervous system), and Inducible (think immune system). At this point, there are two basic therapeutic approaches to increasing NO: arginine-derived nitric oxide therapies (ADNO) in which arginine is delivered orally or intravenously and then converted internally into NO; and administration of NO gas via mask inhalation. The latter is standard for premature in Continue reading >>

More in diabetes