The Use Of Berberine For Women With Polycystic Ovary Syndrome Undergoing Ivf Treatment
Previous studies have indicated that berberine is an effective insulin sensitizer with comparable activity to metformin.(1) Reduced insulin sensitivity is reportedly a factor adversely affecting the outcome of IVF in patients with polycystic ovary syndrome (PCOS).(2) Our objective was to evaluate the clinical, metabolic and endocrine effects of berberine versus metformin in PCOS women scheduled for IVF treatment, and to explore the potential benefits to the IVF process.We performed a prospective study in 150 infertile women with PCOS undergoing IVF treatment. Patients were randomized to receive berberine, metformin, or placebo tablets for 3 months before ovarian stimulation.The clinical, endocrine, metabolic parameters, and the outcome of IVF.Compared to placebo, greater reductions in total testosterone, free androgen index, fasting glucose, fasting insulin and HOMA-IR, and increases of SHBG, were observed in the berberine and metformin groups. Three months of treatment with berberine or metformin before the IVF cycle increased the pregnancy rate and reduced the incidence of severe ovarian hyperstimulation syndrome. Furthermore, treatment with berberine, in comparison to metformin, was associated with decreases in BMI, lipid parameters and total FSH requirement, and an increase in live birth rate with fewer gastrointestinal adverse events.Berberine and metformin treatment prior to IVF improved the pregnancy outcome by normalizing the clinical, endocrine and metabolic parameters in PCOS women. Berberine has a more pronounced therapeutic effect and achieved more live births with fewer side effects than metformin. This article is protected by copyright. All rights reserved. Do you want to read the rest of this article? ... The isoquinoline alkaloid and the major constitue Continue reading >>
The Top 10 Supplements You Can Use To Reverse Polycystic Ovary Syndrome
Nut Butter The Bad, The Good, and How to Make it Better Many studies suggest that cinnamon helps reduce insulin resistance and restore ovarian function in women with PCOS. To get these benefits, to 1 teaspoon per day is all you need. Cinnamon Ceylon Vs Cassia, Health Benefits, and Other Interesting Facts For women who want to get pregnant, vitamin b9 is essential. To improve fertility, researchers suggest that women who are at a healthy weight should take 400 micrograms of folic acid (one of the many forms of vitamin b9), and obese or overweight women should take 5 mg of folic acid. However, it is best to supplement with a b-complex that contains all of the b vitamins. You may also feel better by supplementing with b complex that has a more natural form of Vitamin B9 (folic acid isnt and 12234erdx543ewef65may cause problems for some). L-methylfolate and 5-methyltetrahydrofolate (5-MTHF) are the most effective form of the vitamin. Apple cider vinegar has been shown to increase insulin sensitivity in several studies, including a trial in women with PCOS. In this trial, seven women with PCOS took one tablespoon of apple cider vinegar per day. After 40 days, four of the women resumed ovulating, and six experienced a measurable reduction in insulin resistance. For best results, consume 1-2 tablespoons per day. However, this doesnt mean you have to take shots of pure vinegar. Use apple cider vinegar as the vinegar for your salad dressings instead. Health Benefits of Apple Cider Vinegar & How to Make Your Own Magnesium deficiencies are the second most common deficiency in developed countries. Magnesium is important for women with PCOS because it improves insulin sensitivity and decreases nerve excitability, leading to less stress, tension, and PCOS symptoms. When it comes to Continue reading >>
Berberine: Helps Most Pcos Issues. Acne, Insulin Resistance, Hormonal Imbalances, Etc
BERBERINE: Helps MOST PCOS Issues. Acne, Insulin Resistance, Hormonal Imbalances, etc If this is your first visit, be sure tocheck out the FAQ by clicking thelink above. You may have to register before you can post: click the register link above to proceed. To start viewing messages,select the forum that you want to visit from the selection below. BERBERINE: Helps MOST PCOS Issues. Acne, Insulin Resistance, Hormonal Imbalances, etc Berberine is a supplement I recently discovered while actually trying to alleviate some digestive symptoms. However, I am so thankful that I came upon this wonderful herb. I've suffered from moderate acne (scarring), hormonal issues, irregular cycles and more for 12 years now, and everything I've tried has either not worked or given me side effects, in some cases worse than PCOS. I had resigned myself to being a person who depended on the pill to regulate my entire system, and life. However, trying to lead a more natural lifestyle not being dependent on prescription drugs, I am so glad that I believe I've finally found my solution. I'll start by giving you some facts about the herb: Berberine is an alkaloid that is found in and/or also known as: Goldenseal, Oregon Grape, Barberry, Yellow Root etc. It has been used in Japanese Kampo and other traditional natural medicine to treat skin conditions characterized by pus-filled lesions. Common homeopathic uses for barberry include both orally and topically for infection and psoriasis. Native Americans made extracts and herbal teas from barberry root to treat fever, diarrhea, acne, eczema, and cold sores. [source] Berberine: An Alkaloid with Anti-Inflammatory, Antibacterial, and Hormonal Effects: Barberrys main bioactive constituent is the alkaloid berberine. Berberine exhibits anti-inflammatory, a Continue reading >>
6 Reasons Why Metformin Might Not Be Safe For Pcos
Have you been prescribed metformin for PCOS and are wondering what the side affects are? Metformin is often described as a ‘safe’ drug, but read on to find out why this might not be the case. When I was diagnosed with PCOS, the first thing I asked my GP was what I could take to ‘fix’ it. She gently explained that there was no pill or surgery that could cure my condition. However, there was a drug that could help with the elevated insulin levels caused by it. Metformin, she claimed, was a safe drug with no major side effects that would help with insulin resistance and weight loss. Sign me up. At first, I thought metformin was the wonder drug. I lost about 5kg in 4 months, more than I had ever been able to lose previously. I was ecstatic. I had a quick look online to see whether there were any side effects and initially found that diarrhea, loose stools, fatigue, and muscle soreness were commonly experienced. But I thought that it was small price to pay for finally being able to lose some weight. However, when I investigated further I found that that there are some much more sinister side effects of metformin that aren’t so widely publicised. These include: – Depleting our bodies of essential nutrients. – Increasing the risk of having a baby with a neural tube defect by up to 9 times. – Reducing energy levels by almost 50%. – Killing beneficial gut bacteria. This article is not intended to be a case against metformin for PCOS. There is no doubt that metformin helps to reduce weight, lowers blood glucose levels, and promotes ovulation. My concern is the lack of studies about the safety of long-term use of metformin for PCOS, especially in utero. Drugs can help with the associated symptoms of a disease, but they cannot fix the root cause of it. Metformin i Continue reading >>
Berberine Improves Polycystic Ovary Syndrome
You are here: Home > January 2012 Magazine > Berberine Improves Polycystic Ovary Syndrome Berberine Improves Polycystic Ovary Syndrome Polycystic ovary syndrome (PCOS) is a frequent reproductive and metabolic disorder associated with insulin resistance. Berberine is an isoquinoline derivative alkaloid extracted from Coptis chinensis (goldenthread), Berberis aquifolium (Oregon grape), and Hydrastis canadensis (goldenseal), among other plants. These plants have been used for more than 2500 years in both Ayurvedic and Chinese medicine, and in the last decade there has been increased scientific interest in berberines effects for metabolic and cardiovascular disease in the Western world. Although berberine has a wide range of healthful applications, its most important use to date is as an insulin sensitizer. A new study conducted at the First Affiliated Hospital of Harbin Medical University in China has found that berberine may have a potential therapeutic value for PCOS.1 What the researchers set out to do was to evaluate effects of berberine in comparison to metformin on the metabolic features of women with PCOS. Metformin is the first-line drug of choice for the treatment of type 2 diabetes and has been used in PCOS because of its insulin resistance component. In the new study, 89 women with PCOS and insulin resistance were randomized into one of three treatment groups: berberine + cyproterone acetate (n = 31), metformin + cyproterone acetate (n = 30) and placebo + cyproterone acetate (n = 28) for three months. Cyproterone is an antiandrogen, which suppresses the actions of testosterone and its metabolite dihydrotestosterone on tissues. At the beginning of the study, metabolic and hormonal parameters were assessed in the women, and also after the period of treatment. In Continue reading >>
14 Amazing Research Backed Berberine Benefits!
14 Amazing Research Backed Berberine Benefits! The buzz is starting to get out about Berberine . There are not many supplements that have the ability to act as a pharmaceutical drug, but Berberine can, and has been shown to be just as effective as drugs like Metformin. But unlike pharmaceutical drugs that normally can only work to improve one aspect of our health, Berberine can act in multiple ways to produce multiple health benefits. Its also safe with few side effects, and its cheap! So lets take a closer look at what Berberine is and what it can do for you. Berberine is an alkaloid compound thats found in a number of different plants including Goldenseal, European barberry, Goldthread, Oregon grape, Tree Turmeric and Phellodendron. It comes originally from China and India where is has been used in Chinese and Ayurverdic medicine for centuries. Its early uses were primarily for fighting infection and against diarrhea. However, as our health problems have developed to reflect modern lifestyles of high stress, poor diets and little exercise, Berberines amazing properties have been shown to have a significant impact on a number of modern diseases, with none of the side effects of pharmaceutical drugs. It anti-bacterial, anti-fungal, balances blood sugar and other hormones, helps with weight loss and boosts the immune system and thats just for starters. So get ready for 14 amazing research backed benefits of Berberine! With the worlds population growing ever fatter, there have long been efforts to create anti-obesity drugs. However, with little success in recent years, the search is now focused on natural alternatives to chemically created drugs. The key to Berberines effect on weight is its ability to activate AMPK (Adenosine MonoPhosphate-Activated Protein Kinase). AMP Continue reading >>
Pcos Treatment? Metformin For Pcos? There May Be Something Better
The Latest, Science-Based Information In Health, Fitness & Fat Loss PCOS Treatment? Metformin For PCOS? There May Be Something Better by Jade Teta on August 20, 2015 in ME Females I hope you have been enjoying the last few blogs on PCOS. If you missed the first two, you can check them out HERE and HERE . On the last blog I promised I was going to give you the supplement that outperforms Metformin for PCOS. That supplement is called berberine. The study was published in 2012 in the European Journal of Endocrinology (2012;166:99-105). It followed 89 Chinese women who received one of the following: Berberine hydrochloride, 500 mg 3 times/day (n=31) Metformin, 500 mg 2 times/day for the first week, then 3 times/day for the remainder of the study (n=30) All the study participants were also educated in nutrition and instructed to eat a lower fat and lower carbohydrate diet. They were also advised to do 30 minutes of moderate to intense exercise each day, but this was not monitored. The results showed that berberine, Metformin and placebo (an inert sugar pill) all came out about the same in terms of weight loss. What this tells us is that the diet and exercise changes make the biggest differences in weight, NOT drugs and supplements. But it also tells us some other interesting things. Both Metformin and berberine performed equally in their ability to improve blood sugar tolerance and insulin levels. Think about that for a second, a natural herbal compound did as well as Metformin at fixing one of the major causes/contributing factors in PCOS. The biggest difference came in key metabolic parameters like SHBG levels (a key hormonal marker of PCOS), cholesterol, and triglycerides. Berberine out-shined Metformin in this area. Also, while weight loss was the same in the Metformin Continue reading >>
Effect Of Berberine On Insulin Resistance In Women With Polycystic Ovary Syndrome: Study Protocol For A Randomized Multicenter Controlled Trial
Published online 2013 Jul 18. doi: 10.1186/1745-6215-14-226 Effect of berberine on insulin resistance in women with polycystic ovary syndrome: study protocol for a randomized multicenter controlled trial 1Department of Obstetrics and Gynecology, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China 2Department of Obstetrics and Gynecology, University of Hong Kong, Hong Kong, China Yan Li: [email protected] ; Hongli Ma: [email protected] ; Yuehui Zhang: [email protected] ; Hongying Kuang: [email protected] ; Ernest Hung Yu Ng: [email protected] ; Lihui Hou: [email protected] ; Xiaoke Wu: [email protected] Received 2013 Jan 29; Accepted 2013 Jun 28. Copyright © 2013 Li et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This article has been cited by other articles in PMC. Insulin resistance and hyperinsulinemia play a key role in the pathogenesis of polycystic ovary syndrome (PCOS), which is characterized by hyperandrogenism, ovulatory dysfunction, and presence of polycystic ovaries on pelvic scanning. Insulin resistance is significantly associated with the long-term risks of metabolic syndrome and cardiovascular disease. Berberine has effects on insulin resistance but its use in women with PCOS has not been fully investigated. In this paper, we present a research design evaluating the effects of berberine on insulin resistance in women with PCOS. This is a multicenter, randomized, placebo-controlled and double-blind trial. A total of 120 patients will be enrolled in this study and will be randomized i Continue reading >>
Berberine Or Metformin: Which Is The Better Choice For Pcos?
PCOS has affected many women around the world and has often times damaged paths toward motherhood drawing people further into the trap of infertility. But is there a way to get out? And do it naturally? Well, what is it I always say always! There are two treatments, in particular, that catch the attention of many women suffering with PCOS. I say let's get to it and get you back to where you are in control, and not your PCOS! Berberine- This herbal supplement consists of a bioactive compound, of alkaline-class, that is yellow in color and presented of having a very bitter flavor. This supplement is natural and has been used in Traditional Chinese Medicine for over 5,000 years; it is prescribed by Medical and Naturopathic Doctors alike. Metformin- A medical drug derived mainly from the French Lilac (also called "Goat's Rue" as its blood-sugar- lowering properties makes the flower undesirable for goats). Because of this Lilac's medicinal effects, Metformin has been used for centuries in the use of managing diabetes and lowering blood sugar levels. Both medications have shown to regulate blood sugar and androgens (testosterone) and increase insulin sensitivity within the body. Origin- Perhaps the largest difference between these two drugs is this. Despite the fact that Metformin has a natural history (regarding to the lilac) it is in fact a synthetic drug. Metformin is said to be the most used and prescribed medication on the entire globe. But this topic has raised the question: can Berberine, a natural alternative, be just as impactful and beneficial? Berberine, as said before and in contrast to Metformin, is an *herbal* supplement containing a chemical derived from multiple herbs including the European Barberry, Goldenseal, Oregon Grape, Tree Turmeric, and Goldthread. Wh Continue reading >>
Positive Pcos The Benefits Of Taking Berberine
The Benefits of Berberine for Women with PCOS PCOS is one of the most common endocrine disorders affecting women of reproductive age. Increased insulin resistance and hyperinsulinemia are believed to play a key role in the pathogenesis of the condition. Insulin-sensitising medications, such as metformin, have traditionally been used to treat the metabolic and reproductive imbalances in women with PCOS. In addition to conventional medicine, lifestyle changes, such as diet and exercise , have been shown to also improve insulin resistance (1). Now an increasing body of evidence has found that supplements, such as inositol and berberine, can improve some PCOS symptoms. Berberine is a natural plant alkaloid isolated from a number of Chinese herbs, such as Coptidis Rhizoma (Huanglian), Hydrastis Canadensis (goldenseal), and Cortex Phellodendri (Huangbai). It has traditionally been used in Chinese herbal medicine for its anti-diabetic and anti-inflammatory properties (1). There is some encouraging research looking at the effects of berberine on PCOS however, it is limited and further studies are needed. A randomised control trial was completed in 2012 (1) looking at the effects of berberine compared with metformin in 83 Chinese women with PCOS over a three month period. The participants were randomised into three different groups: 1) 500mg of berberine three times daily and compound cyproterone acetate (CPA), a combined birth control pill 2) metformin and CPA 3) placebo and CPA. The study found that both berberine and metformin decreased androgen concentrations similarly. Compared with metformin, participants taking berberine showed reduced total cholesterol levels, waist-to-hip ratio and waist circumference. In comparison to the placebo group, the women taking berberine had Continue reading >>
Berberine Reduces Pcos Problems In A Multiple Ways
Berberine Reduces PCOS Problems in a Multiple Ways Have you heard of berberine? We've just had a look at some medical studies and I have to say we're impressed. Berberine extract is a compound that has been shown to help individuals who have PCOS. Herbs containing berberine have been used in Chinese medicine to treat diabetes for thousands of years. It is found in a handful of plants widely used in botanical medical practice including Goldenseal, Oregon grape, Barberry, and Chinese Goldthread. This extract has value for dealing with a number of chronic disorders, including polycystic ovarian syndrome. Berberine Relieves PCOS, Just As Effective as Metformin In a study at Harbin Medical University in China, of 109 women with polycystic ovary syndrome were given berberine. The researchers discovered that it was as effective as the drug metformin for improvement of insulin sensitivity, weight loss, and reduction of testosterone and blood sugar levels. However, berberine was superior to metformin in several respects: Reduction of total cholesterol and "bad" LDL cholesterol Increasing beneficial sex hormone binding globulin (SHBG). SHBG is very important for properly managing your hormones. Reduction of triglycerides, a fat found in the blood. The women in this study took 500 mg. of berberine extract three times a day. Berberine Reduces Ovarian Testosterone Production Another medical study suggested that taking this extract reduced testosterone production in ovarian cells. If you can't tolerate the side effects of metformin, or don't wish to be on a medication for years and years, berberine may be a good alternative for you. Plus, it doesn't have side effect like metformin has. It has been also used for centuries to support healthy bowel function. Why might this be of intere Continue reading >>
Natural Pcos Treatment | Alternatives To Metformin And The Ocp
Its funny how some assume drugs are stronger, better, more awesome than some woosy natural medicine. But thanks to research, theres some great news on the PCOS treatment front using natural medicine equal if not better efficacy than generally prescribed medications with the added bonus of fewer side effects. For the 20% of women diagnosed with polycystic ovarian syndrome (PCOS), most will have heard of Metformin, the insulin-sensitising drug most commonly prescribed for PCOS treatment. For women suffering PCOS, it can be a rocky road of irregular cycles, infertility, acne and increased facial/body hair, weight gain and insulin resistance. And the standard drugs of choice for PCOS treatment are Metformin and the oral contraceptive pill (OCP). Metformin is effective, but can cause digestive issues such as diarrhoea, reflux/heartburn, nausea and a change in healthy gut flora that can have longer-term health ramifications. The Pill: Theres some fuzzy logic surrounding the recommendation for women with PCOS to take the OCP. Well that sucks! So whos up for some natural wonderment instead? First up, in insulin-resistant PCOS, reducing fructose is key. Note, there are several forms of PCOS as Lara Briden explains in her blog post Treatment for 4 Types of PCOS so make sure you familiarise yourself with them. I adhere to the belief that 1-2 pieces of whole fruit per day is fine but what is not as fine are all those healthy or raw food treats based on copious amounts of dates and dried fruit, honey, agave etc. Processed sugars need to be reduced, along with their inflammatory effects on the body, but so do those high-fructose dried fruits along with hidden sugars in sauces, mayonnaise, take away foods, juices and breakfast cereals. But this is the exciting bit. In addition to die Continue reading >>
Berberine Compared To Metformin In Women With Pcos
Wei W, Zhao H, Wang A, et al. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome. Eur J Endocrinol. 2012;166:99-105. Participants One hundred Chinese women of reproductive age who met diagnostic criteria for polycystic ovarian syndrome (PCOS) and insulin resistance were randomized to the study; 89 completed the study. All subjects received advice from a nutritionist and were instructed to limit dietary fat and carbohydrates without restricting calories. Thirty minutes of moderate to intense exercise per day was recommended but not monitored. All subjects also received the antiandrogen compound cyproterone acetate (2.0 mg/day) in a combined oral contraceptive pill with 35 mcg ethinyl estradiol, taken in a cyclic fashion. Berberine hydrochloride, 500 mg 3 times/day (n=31) Metformin, 500 mg 2 times/day for the first week, then 3 times/day for the remainder of the study (n=30) Placebo tablet 2 times/day (n=28) Study parameters assessed Clinical, hormonal and metabolic assessments were made at baseline and repeated after 3 months of treatment. Clinical assessment included height, weight, body mass index (BMI), waist circumference, and waist-to-hip ratio. Reproductive hormone parameters assessed were total testosterone, sex hormone–binding globulin, and free androgen index. Carbohydrate metabolic parameters included fasting plasma glucose, fasting insulin, and 2-hour oral glucose tolerance test. The degree of insulin resistance was then estimated using various methods, including fasting glucose/insulin ratio, homeostasis model assessment for insulin resistance, and area under the curve for insulin. Lipid profile parameters included triglycerides, total cholesterol, low-de Continue reading >>
Berberine = Pcos Treatment?
Polycystic Ovarian Syndrome, or PCOS, is an abnormality of young womens hormonal balances linking insulin resistance to relatively high androgens (male hormones) and menstrual irregularities plus subsequent infertility. The prevalence of PCOS has increased over recent years possibly due to the obesity epidemic and the consequence of obesity and insulin resistance. Approximately 7% of women within reproductive age suffer from PCOS. The syndrome has traditionally been defined by Rotterdam Criteria, meaning two of three abnormalities including menstrual irregularities (decreased frequency or absent periods), excess androgens (or clinical evidence by facial hair, acne, etc), or polycystic ovaries found on imaging. The recent consensus, however, is that all three should be identified and actual biochemical evidence of androgens be documented instead of just clinical evidence. Since PCOS has a strong correlation to obesity and insulin resistance, treatment has focused on weight loss via improved diet/exercise with metformin treatment to combat the metabolic syndrome which is common place for these women. Oral contraceptives and anti-androgens are used to control the symptoms overall. Polycystic Ovarian Syndrome can be a very physically and emotionally taxing problem to many people. It is important to understand and know all methods of fighting this disease. Berberine has been successfully used and studied in the treatment of obesity-related insulin resistance and diabetes plus the dyslipidemia (bad cholesterol) which accompanies metabolic syndrome. What is interesting is that this potent natural plant alkaloid is revered in traditional Chinese and Ayurvedic medicine, but not really anywhere else. With such a powerful potential, it is a shame more clinicians have not heard of Continue reading >>
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How To Use Berberine To Boost Weight Loss, Lower Blood Sugar & More
Berberine might just be one of the best supplements you've never heard of. Through it's powerful effects on insulin and muscle mass berberine can help lower blood sugar levels and reduce insulin levels. This effect is so strong that it has been compared to pharmaceutical medications (we will go over that below). Beyond its effects on blood sugar and insulin berberine also shows promise in several other areas. Among these conditions include: Is berberine right for you? Let's talk about how to determine if you should take it, how much you should take and how long you should be taking it for: How Berberine helps with Weight Loss Like other supplements that may help with weight loss the mechanism of action of berberine alters many different pathways and has multiple benefits. By now you should be aware that there is no "magical cure" for weight loss, or that one simple supplement or medication will result in significant weight loss by itself. Instead, if weight loss is your goal, your focus should be on targeting specific hormonal pathways that are out of balance in YOUR body. Berberine happens to impact several of these hormonal pathways and this is probably one of the main reasons that berberine has been shown to help with weight loss. Before we begin I want to point out that berberine is best used if it is part of a comprehensive weight loss plan that includes other targeted supplements, hormones (as necessary), dietary changes and other lifestyle changes. So now that that is out of the way, let's talk about the many ways that berberine may help with weight loss. #1. Targets insulin resistance and helps treat Diabetes One of the most important effects of berberine is how it interacts with the hormone insulin. Insulin levels drive weight gain and many dise Continue reading >>
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