Evaluation Of Diphenhydramine In Talc Induced Type 2 Diabetes Mellitus In Wistar Rats.
1. Biomed Pharmacother. 2018 Jan;97:652-655. doi: 10.1016/j.biopha.2017.10.085. Epub2017 Nov 6. Evaluation of diphenhydramine in talc induced type 2 diabetes mellitus in Wistar rats. Afzal M(1), Saleem S(2), Singh N(2), Kazmi I(3), Khan R(2), Nadeem MS(4), ZamzamiMA(4), Al-Abbasi FA(5), Anwar F(6). (1)Department of Pharmacology, College of Pharmacy, Aljouf University, Sakaka, KSA. (2)Siddhartha Institute of Pharmacy, Dehradun, Uttarakhand, India. (3)Glocal School of Pharmacy, Glocal University, Saharanpur, Uttar Pradesh 247121, India. Electronic address: [email protected] (4)Department of Biochemistry, Faculty of Science, King Abdul Azeez University, Kingdom of Saudi Arabia. (5)Department of Biochemistry, Faculty of Science, King Abdul Azeez University, Kingdom of Saudi Arabia. Electronic address: [email protected] (6)Department of Biochemistry, Faculty of Science, King Abdul Azeez University, Kingdom of Saudi Arabia. Electronic address: [email protected] Evaluation of diphenhydramine in talc induced type 2 diabetes mellitus was donein Wistar rats. Oral administration of Talc (10mg/kg)carried out for 21daysincreased the levels of serum glutamate pyruvate transaminase (SGPT), glutamateoxaloacetate transaminase (SGOT), serum creatinine, blood glucose, urea, uricacid and triglycerides (TGs), but when the animals were treated withdiphenhydramine (DPH), the levels of the aforementioned biochemical parametersdecreased significantly (p<0.0001). The level of serum cholesterol and highdensity lipoprotein (HDL) was found to be reduced in Diabetes Mellitus (DM)control and when it was treated with DPH control animals, these makers increased significantly. The study done on DM and Diphenhydramine suggests that Talcincreases the blood glucose level at a dose of Continue reading >>
Benadryl (diphenhydramine) Drug Overview And Uses For Patients And Caregivers At Rxlist
Nasal Allergy Relief Products Slideshow Pictures Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor. Seek emergency medical attention if an overdose is suspected. Symptoms of a diphenhydramine overdose include extreme sleepiness, confusion, weakness, ringing in the ears, blurred vision, large pupils, dry mouth, flushing, fever, shaking, insomnia, hallucinations, and possibly seizures. What should I avoid while taking diphenhydramine? Use caution when driving, operating machinery, or performing other hazardous activities. Diphenhydramine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking diphenhydramine. What other drugs will affect diphenhydramine? Do not take diphenhydramine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects. Talk to your pharmacist before taking other over-the-counter cough, cold, allergy, or insomnia medications. These products may contain medicines similar to diphenhydramine, which could lead to an antihistamine overdose. Before taking this medication, tell your doctor if you are taking any of the following medicines: anxiety or sleep medicines such as alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), temazepam (Restoril), or triazolam (Halcion); medications for depression such as amitriptyline (Elavil), doxepin (Sinequa Continue reading >>
What Medicines Can Make Your Blood Sugar Spike?
If you have diabetes or high blood sugar, you probably know some of the things that cause your glucose (another name for blood sugar) to go up. Like a meal with too many carbohydrates, or not enough exercise. But other medicines you might take to keep yourself healthy can cause a spike, too. Know Your Meds Medicines you get with a prescription and some that you buy over the counter (OTC) can be a problem for people who need to control their blood sugar. Prescription medicines that can raise your glucose include: Steroids (also called corticosteroids). They treat diseases caused by inflammation, like rheumatoid arthritis, lupus, and allergies. Common steroids include hydrocortisone and prednisone. But steroid creams (for a rash) or inhalers (for asthma) aren’t a problem. Drugs that treat high blood pressure, such as beta-blockers and thiazide diuretics High doses of asthma medicines, or drugs that you inject for asthma treatment OTC medicines that can raise your blood sugar include: Cough syrup. Ask your doctor if you should take regular or sugar-free. How Do You Decide What to Take? Even though these medicines can raise your blood sugar, it doesn’t mean that you shouldn’t take them if you need them. The most important thing is to work with your doctor on the right way to use them. If you have diabetes or you’re watching your blood sugar, ask your doctor before you take new medicines or change any medicines, even if it’s just something for a cough or cold. (Remember, just being sick can raise your blood sugar.) Make sure your doctor knows all the medicines you take -- for diabetes or any other reason. If one of them may affect your blood sugar, she may prescribe a lower dose or tell you to take the medicine for a shorter time. You may need to check your blood s Continue reading >>
Sleeping Aids And Diabetes
People with diabetes certainly aren't immune to issues with insomnia or other sleeping problems that occur with age, jet lag or seasonal affective disorder. When that happens, sometimes counting sheep just doesn't cut it. But there has been concern discussed recently in the D-OC about using sleep aids with diabetes. A thread on TuDiabetes starts off with the notion that "any kind of sleep aid is taboo for an insulin-dependent diabetic." So we decided to put on our Mythbusters hat and investigate whether this claim is true or false... Although there aren't any recommended sleep aids specifically for people with diabetes, Kelley Champ Crumpler, a diabetes nurse educator and the wife of an endocrinologist, primarily recommends melatonin to treat sleeping problems. Melatonin is a naturally occurring hormone in your system that helps to control your sleep and wake cycles. Unlike insulin, melatonin is a hormone that is synthetically made and can be ingested, so a natural supplement is available over-the-counter (usually found in the vitamin section of your grocery store). "We have them start with a small, 1 mg tablet before bed, and can taper up as needed," Kelley says. "Melatonin won't render you useless like other sleep aid/hypnotics will. It's even safe for children to use." If that doesn't work, Kelley says that using an antihistamine that contains either diphenhydramine (found in Benadryl or nighttime pain relievers like Tylenol PM or Advil PM) or doxyalimine (found in the over-the-counter sleep-aid tablets Unisom). Anecdotal evidence on some of the diabetes forums shows that melatonin and antihistamines are the most popular way of treating insomnia. These meds are also "light" enough that they won't knock you out so much that you won't wake up naturally in an emergency Continue reading >>
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Certain veterinary medications for other conditions may seriously affect diabetic patients. Always check with your nurse before taking. This list is provided because some of these medications don't mention their side effects on diabetics in their literature. Many drugs used in veterinary medicine are also used in human medicine under a differently-trademarked name. Learning the human pharma name (if applicable) or generic name of the drug (same in veterinary & human medicine) can often give you additional information regarding possible side effects and how the drug may affect patients with diabetes. Human pharma drugs provide this information--for some reason, veterinary drugs don't always. If you are considering alternative or herbal medicine for your diabetic pet, see also Alternative medication warnings. Xylitol, a common artificial sweetener, lowers blood sugar dangerously in dogs and sometimes humans, possibly also cats. Some prescription and over-the counter medications, including vitamins and supplements which are made for human use contain Xylitol. Reading labels thoroughly and asking your vet can prevent needless tragedies. Heartworm  is a global problem, with areas on all continents except Antarctica affected and is a disease that is far easier to prevent than to cure. It can affect both cats and dogs. Should your pet be affected by this, a talk with your vet is in order. Increasing insulin doses to counter this temporary situation may cause hypoglycemia once the systemic medication level has lowered. The phenomenon also does not mean your pet has ceased to respond to the insulin you currently use. Since there are no formal label warnings, he/she needs to be aware that there are temporary side effects for these drugs which apply to some d Continue reading >>
Benadryl Archives - Dr. John Day
Real Food. Real Living. Real Happiness. Subscribe: Apple Podcasts | Android | RSS Cindy could not remember where she put her keys. The night before she forgot the name of someone she knew. When she shared these experiences with her friends over lunchthey alllaughed it off as senior moments. Was it really a senior moment? Cindy is just 55. Could her forgetfulness be a sign of early dementia? What is normal brain aging and what is early dementia? How can you tell? In this article, I will share with you the recent three recommendations from the Institute of Medicine on how to protect your brain from aging. When it comes to brain health and preventing dementia, it is never too late to start. Even if you are still in your 20s or 30s, now is the time to protectyour brain! The key factor determining your ability to live an independent, meaningful life is your cognitive function. Is it any wonder that in the 2015 survey of retired people, the top concern of 93% of people was staying mentally sharp . The problem is how do you protect your brain? When further asked in this survey, most retired people felt that brain games (crossword puzzles, sudoku, etc.) were the key to healthy brain function. Few had any idea that physical activity played a role in brain health. Contrary to conventional wisdom, crossword puzzles or sudoku generally do not protect your brain. Yes, it is true your brain is stimulated when you first start doing crossword puzzles or sudoku but this is quickly lost once you have developed some degree of proficiency. In other words, crosswords and sudoku only make you better at doing crosswords and sudoku. To stimulate the brain, you need a lifetime of always learning new things. In a fascinating study , Dr. Richard Haier wanted to study the effects of brain puzzles Continue reading >>
Sneezes And Wheezes: Seasonal Allergies And Diabetes
Spring is really starting to burst out here in Massachusetts. The tulips are blooming and leaves and buds are popping out on the trees. As pretty and welcoming as this is, many of you (about 50 million!) are probably bracing yourself for all of the pollen that is soon to follow, and suffering through the misery that it can bring. Thanks to the mild winter that we had in the Northeast, plants are pollinating earlier than usual. As if that weren’t bad enough, having seasonal allergies can also affect your blood sugar control. Seasonal allergies: do you have them? Seasonal allergies are sometimes called hay fever or, more technically, seasonal allergic rhinitis. You might be wondering if your symptoms are due to a cold, flu, or allergies. While there can be some overlap, the following symptoms are usually indicative of allergies: • Itchy eyes • Watery eyes • Dark circles under the eyes • Sneezing • Runny nose • Stuffy nose • Sore throat You might also feel a little bit tired. You won’t get a fever from allergies, however. These symptoms can linger for weeks unless they’re treated. Treating allergies There are a number of remedies for seasonal allergies, including oral medications, nasal sprays, and eye drops. It’s important that you not only choose the right one for your symptoms, but that you also are aware of how these medicines might affect your blood sugars. The following types of allergy medicines may affect your blood glucose levels or how you manage them: Antihistamines. These medicines can reduce sneezing, runny nose, and itchy and watery eyes. Common antihistamines include diphenhydramine (Benadryl), loratidine (Alavert, Claritin), cetirizine (Zyrtec Allergy), and fexofenadine (Allegra Allergy). Antihistamines might be combined with a deconge Continue reading >>
Medications And Supplements That Can Raise Your Blood Pressure
From pain medications to stimulants, know which drugs and supplements can affect your blood pressure. Some prescription and over-the-counter medications, as well as supplements and other substances, can raise your blood pressure. These substances also can interfere with medications intended to lower your blood pressure. Here are some medications, supplements and other substances that can increase your blood pressure. If you're using any of these substances and are worried about the effect it could have on your blood pressure, talk to your doctor. Pain medications Certain pain and anti-inflammatory medications can cause you to retain water, creating kidney problems and increasing your blood pressure. Examples include: Indomethacin (Indocin, others) Nonsteroidal anti-inflammatory drugs (NSAIDs), including naproxen sodium (Aleve, Anaprox) and ibuprofen (Advil, Motrin IB, others) Piroxicam (Feldene) Have your blood pressure checked regularly. Talk to your doctor about which pain medication is best for you. If you must continue taking a pain medication that increases your blood pressure, your doctor may recommend lifestyle changes or additional medication to control your blood pressure. Antidepressants Antidepressants work by changing your body's response to brain chemicals, including serotonin, norepinephrine and dopamine, that affect your mood. These chemicals may also cause your blood pressure to increase. Examples of antidepressants that can raise your blood pressure include: Venlafaxine (Effexor XR) Monoamine oxidase inhibitors Tricyclic antidepressants Fluoxetine (Prozac, Sarafem, others) If you take antidepressants, have your blood pressure checked regularly. If your blood pressure increases or isn't well-controlled, ask your doctor about alternatives to these medicat Continue reading >>
Diphenhydramine - Oral (benadryl, Genahist, Sominex, Unisom) Side Effects, Medical Uses, And Drug Interactions.
GENERIC NAME: DIPHENHYDRAMINE - ORAL (DYE-fen-HYE-dra-meen) BRAND NAME(S): Benadryl, Genahist, Sominex, Unisom Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage USES: Diphenhydramine is an antihistamine used to relieve symptoms of allergy , hay fever , and the common cold . These symptoms include rash , itching , watery eyes, itchy eyes/nose/throat, cough , runny nose , and sneezing . It is also used to prevent and treat nausea , vomiting and dizziness caused by motion sickness . Diphenhydramine can also be used to help you relax and fall asleep.This medication works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction . Its drying effects on such symptoms as watery eyes and runny nose are caused by blocking another natural substance made by your body (acetylcholine). Cough -and- cold products have not been shown to be safe or effective in children younger than 6 years. Therefore, do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. Some products (such as long-acting tablets/capsules) are not recommended for use in children younger than 12 years. Ask your doctor or pharmacist for more details about using your product safely.These products do not cure or shorten the length of the common cold and may cause serious side effects. To decrease the risk for serious side effects, carefully follow all dosage directions. Do not use this product to make a child sleepy. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drink Continue reading >>
Do Allergy Medications And Diabetes Medications Interact?
I heard people with diabetes need to be careful with allergy medications. Are there allergy medications I cannot take with my diabetes medication? Zyrtec® (cetirizine), Claritin® (loratadine), Allegra® (fexofenadine), and Benadryl® (diphenhydramine) are all allergy medications that should not affect your blood sugar when used by themselves. However, these antihistamines are often paired with pseudoephedrine or phenylephrine. Pseudoephedrine and phenylephrine are both decongestants. These two medications can cause an increase in blood sugar when taken with diabetes medication and should be avoided, if possible, in people with diabetes. Be sure to read labels on cold and allergy medications, and be careful when the letter D is added to a medication name, such as Zyrtec-D or Claritin-D. This means that it contains pseudoephedrine. Continue reading >>
Can Benadryl Raise Your Blood Sugar 426100
Medications That Raise Blood Glucose: Diabetes Forecast almost always increase blood glucose, she says, because this type of administration affects the whole body what doctors If you need to use a steroid inhaler for asthma or hydrocortisone cream for a rash, the risk of increased blood glucose is minimal. How Allergies Can Affect Your Blood Sugar WebMD directly, but some medications may. Benadryl Allergy Does benedryl have any effect on blood sugar not mention this however it mention stomach upset and vomiting in some people I have taken it and am diabetic but your daughter and I are two different people if it should make her sick (just for some reason) then her blood sugar would naturally drop at least nbsp; Do Allergy Medications and Diabetes Medications Interact? (diphenhydramine) are all allergy medications that should not affect your blood sugar when used by themselves. However, these antihistamines are often paired with pseudoephedrine or phenylephrine. Pseudoephedrine and phenylephrine nbsp; Sleeping Aids and Diabetes Healthline Find out the dangers of sleeping aids for people with diabetes, how they might affect their medication, and suggested pills from experts. If your blood sugar drops at night and you can 39;t produce enough cortisol, your body will produce adrenalin instead. This will wake you up and cause your blood sugar nbsp; Sneezes and Wheezes: Seasonal Allergies and Diabetes Diabetes The following types of allergy medicines may affect your blood glucose levels or how you manage them: Antihistamines. These medicines can reduce sneezing, runny nose, and itchy and watery eyes. Common antihistamines include diphenhydramine (Benadryl), loratidine (Alavert, Claritin), cetirizine nbsp; Voice of the Diabetic sugar control. They can increase blo Continue reading >>
Voice Of The Diabetic
by Sarah Johnston Miller, Pharm.D., BCNSP (Note from Dr. Wes Wilson: Looking at this question, I felt it would be wise to refer it to a pharmacist who is actively involved in both patient care and in teaching students about such problems. Dr. Sarah Miller is Professor of Clinical Pharmacy at the University of Montana, and is also a consultant at St. Patrick Hospital in Missoula, Montana. Her answer should be helpful.) Q: Which nonprescription drug products for treatment of common cold symptoms should a person with diabetes avoid? A: There is some concern about the effect some nonprescription (over-the-counter) medications may have on blood sugar control. The diabetic patient should always remember that, in general, "sick days" may be associated with fluctuations in blood sugar. This may be related to the stress of being sick, or to changes in dietary intake during illness. Your nonprescription medications may not be at fault at all--but it pays to know. A severe bout of the common cold (a viral illness) could certainly produce "sick days," elevated blood sugars--without any effects from your nonprescription or other medications. When you're sick, test your blood more often. Textbooks may list quite a few classes of potentially-problematic medications, though many of these are in reality not very significant. Regardless, the diabetic patient should always contact their health care provider (physician, diabetes educator, or pharmacist) prior to taking any new nonprescription medication. This includes "lternative"remedies purchased at the health food store or elsewhere; "natural" does not mean "safe from interactions!" You should be cautious that many nonprescription medications, including those targeting symptoms of the common cold, contain multiple ingredients. Another Continue reading >>
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Choosing A Antihistamine For Diabetics
Choosing the Right Antihistamine as a Diabetic written by: AngelicaMD edited by: Diana Cooper updated: 5/6/2011 Diabetics who suffer from allergies, flu, colds and cough sometimes take over-the-counter (OTC) drugs such as antihistamines. Choosing the right antihistamine as a diabetic is important because many OTC drugs may affect blood sugar levels and cause other undesired side effects. Many diabetic people who experience symptoms of flu, colds, cough and allergies are often not sure if they are suffering from infection or allergies. The symptoms may be similar and so people often buy over-the-counter drugs (OTC) that contain combinations of ingredients which target these symptoms all at once. These symptoms may include headache, fever, runny nose and weakness, for which OTC drugs combining pain relievers, antihistamines, nasal decongestants, cough suppressants and other ingredients are sold. Antihistamines block the action of histamines which are produced by normal cells in reaction to allergens, thus preventing symptoms like runny nose, excessive tearing, itchiness and other allergic reactions. OTC antihistamines are usually combined with other drugs such as nasal decongestants, cough suppressants, expectorants, pain relievers, etc to relieve cough, colds and other flu symptoms. First generation or older preparations of antihistamines often cause drowsiness. Examples of these are diphenhydramine (Benadryl) and chlorpheniramine (Chlortrimeton). These are usually taken when one is expected to rest in bed and contraindicated for persons who are driving vehicles or heavy equipment. Second generation antihistamines are the newer class of drugs which are non-sedating and are taken by people who work or go to school. They include certirizine (Zyrtec) and loratadine (Clarit Continue reading >>
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