Amylin Analogues

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Amylin Analogues In The Treatment Of Diabetes Mellitus: Medicinal Chemistry And Structural Basis Of Its Function.

Open Med Chem J. 2011;5(Suppl 2):78-81. doi: 10.2174/1874104501105010078. Epub 2011 Sep 9. Amylin analogues in the treatment of diabetes mellitus: medicinal chemistry and structural basis of its function. Department of Anatomy, Faculty of Medicine & Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. Amylin, (islet amyloid polypeptide) or diabetes-associated peptide is co-secreted with insulin in the islet of Langerhans of diabetic patients in approximately 1:100, amylin-insulin ratio. The soluble form of amylin, an analogue of amylin, is used as a supplement to insulin in the treatment of type 1 diabetes. Co-administration of amylin analogue with insulin to patients with type 1 diabetes induced a larger reduction in proprandial hyperglycemia, with a concomitant reduction in the level of glucagon when compared to insulin monotherapy. The actions of amylin analogues appear to be synergistic to insulin, with which it is co-released from insulin-producing beta cells after a meal. Amylin analogues such as pramlintide has been shown to significantly reduce body weight, HbA1c values and even the dosage of insulin. A moderate weight loss can also be achieved i Continue reading >>

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Popular Questions

  1. Andrcom

    More of a question. Anybody know how to book only a A1C blood test?

  2. Tim35

    For us, any testing requires a physician order as a first step.

    Which usually is as simple as asking the physician (via email even) to provide said order.

  3. Eddie2

    Anybody know how to book only a A1C blood test?
    You can ask the endo to write it out for you on the lab form, but the home tests are reasonably accurate, very easy, and are only about $30-$40 for 2 tests. It takes only 5 minutes. I do those all the time, and they are close to the lab results.
    Walmart and CVS sell them, or you can get them on Amazon.

    Amazon.com: A1CNOW SELFCHECK 2 TEST 1EA CHEK DIAGNOSTICS (DIABETES): Health & Personal Care
    This test is for home use monitoring of glycemic control in patients with diabetes. What does your A1C number tell you? A1C is an indication of your average blood glucose level over the past 2-3 month ...

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