Alpha-lipoic Acid (ala) And Diabetes
Exciting new research! Science has linked alpha-lipoic acid (ALA) to increasing our mitochondrial energy production and helping prevent diabetes. At first, medical researchers initially classified alpha-lipoic acid as a new vitamin but then recognized it as an essential coenzyme. Then, they found that alpha-lipoic acid was a powerful biological antioxidant, quenching free radicals, as well as coenzyme Q10 (CoQ10) and vitamins C and E.. Researchers also found that alpha-lipoic acid is unique in being the only antioxidant known to work in both fat and water-soluble tissues. (Vitamin C only works in watery tissues and vitamin E is restricted to fatty tissues.) Antioxidants are known to play a vital role in preventing many of the health disorders associated with aging, including degenerative diseases such as diabetes. Now, a vitamin-like substance known as alpha-lipoic acid is now at the forefront of antioxidant research. This dual ability allows alpha-lipoic acid to easily neutralize free radicals in both interior and exterior cellular structures. Now, it is called the “universal antioxidant.” More importantly, ALA recycles vitamins C, E, CoQ10, and glutathione! This antioxidant could have far-reaching consequences in the search for prevention and therapy of diabetes. And, because it’s the only antioxidant that can easily get into the brain, it could be useful in preventing damage from a stroke! Nature Knows How to do Things! Continue reading >>
Alpha Lipoic Acid: Improve Insulin Sensitivity & Fight Diabetes!
What is it about foods like broccoli and spinach that make them so healthy? There’s the fiber, vitamins and minerals, of course, but then there’s other important chemical compounds we call “antioxidants” too — like alpha lipoic acid (ALA). Chances are you’ve heard a lot about the many benefits of various antioxidants and high-antioxidant foods — fighting inflammation, helping beat cancer or heart disease, warding off depression and cognitive decline, and so much more — but have you ever wondered what exactly antioxidants are and how they work in the body? Alpha lipoic acid — one kind of antioxidant — is a type of compound found in plant foods we commonly eat that scavenges free radicals, fights inflammation and slows the aging process. But perhaps its most famous use is in treating diabetes naturally. Humans also make a small amount of ALA on their own, although the concentration in our bloodstreams goes up substantially when we eat a healthy diet. Naturally abundant in foods like green veggies, potatoes and certain types of yeast, lipoic acid is similar to a vitamin in that it can also be man-made in a lab so it can be taken as an anti-inflammatory supplement (which is then called alpha lipoic acid). How Alpha Lipoic Acid Works Lipoic acid is found in the body and also synthesized by plants and animals. It’s present in every cell inside the body and helps turn glucose into “fuel” for the body to run off of. Is it “essential” that you consume a certain doseage of alpha lipoic acid every day? Not exactly. Even though we can make some of it on our own without supplements or outside food sources (which is why it’s not considered an “essential nutrient”), eating an antioxidant-packed diet plus potentially using ALA supplements can increas Continue reading >>
Alpha-lipoic Acid Information | Evidenced-based Supplement Guide On Medicinenet.com
Dosing considerations for Alpha-lipoic Acid. What other names is Alpha-lipoic Acid known by? Acetate Replacing Factor, A-Lipoic Acid, Acide Alpha-Lipoque, Acide Alpha-Lipoque R, Acide DL-Alpha-Lipoque, Acide Lipoque, Acide Thioctique, Acide 1,2-dithiolane-3-pentanoque, Acide 1,2-dithiolane-3-valrique, Acide 5 Valrique (1,2-dithiolan-3-yl), Acide 6,8-dithiooctanoque, Acide 6,8-Thioctique, Acido Alfa Lipoico, Alpha-Lipoic Acid Extract, ALA, Biletan, Extrait d'acide Alpha-Lipoque, Lipoic Acid, Lipoicin, R-ALA, R-Alpha-Lipoic Acid R, S-Alpha Lipoic Acid, (R)-Lipoic Acid, R-Lipoic Acid, RS-Alpha-Lipoic Acid Thioctacid, Thioctan, Thioctic Acid, 1,2-dithiolane-3-pentanoic acid, 1,2-dithiolane-3-valeric acid, 6,8-dithiooctanoic acid, 6,8-thioctic acid, 5-(1,2-dithiolan-3-yl) valeric acid. Alpha-lipoic acid is a vitamin-like chemical called an antioxidant. Yeast, liver , kidney, spinach, broccoli, and potatoes are good sources of alpha-lipoic acid. It is also made in the laboratory for use as medicine. Alpha-lipoic acid is used for diabetes and nerve-related symptoms of diabetes including burning, pain , and numbness in the legs and arms. High doses of alpha-lipoic acid are approved in Germany for the treatment of these symptoms. Some people use alpha-lipoic acid for memory loss , chronic fatigue syndrome ( CFS ), HIV/AIDS , cancer , liver disease , diseases of the heart and blood vessels (including a disorder called cardiac autonomic neuropathy) and Lyme disease . Alpha-lipoic acid is also used to treat eye-related disorders, such as damage to the retina, cataracts , glaucoma , and an eye disease called Wilson's disease. Coronary artery bypass graft ( CABG ) surgery. Research suggests that taking a product containing alpha-lipoic acid, CoQ10, magnesium, omega-3 fatty acids and Continue reading >>
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Alpha Lipoic Acid: This Antioxidant Can Smash Insulin Resistance And Autoimmune Disease
I first became aware of the alpha lipoic regimen by Dr. Burt Berkson in the late 90’s. Early on in his career, while an internist, he was given several patients who were expected to die from hepatitis C. His job was more or less to simply baby sit them in the ICU and watch them die. But Dr. Berkson was a rebel at heart and he simply couldn’t do that. Instead he called an associate at the National Institutes of Health and found out how he could treat them. He learned that alpha lipoic acid had some impressive experimental support. Remarkably, although these patients were expected to die within a few weeks, they all completely recovered! However not all went well for Dr. Berkson as he made his superiors look foolish and they simply could not tolerate that so rather than embrace his findings, they actively suppressed the results and made his life miserable for showing them up. This was a pivotal moment in Dr. Berskson’s career and caused him to make choices that eventually led to where he is at now. Since then, Dr. Berkson has lectured all over the world on this topic, and published a study on the use of antioxidants for the treatment of hepatitis C. His first book, The Alpha-Lipoic Acid Breakthrough was published in 1998. As many of you already know, I am not fond of recommending many supplements, but I do believe that antioxidants make sense for many of us. Why You Need Antioxidants Your entire body, including your DNA, is under endless, daily assault from a variety of sources, from poor diets to pollution. Think of your cells, including your brain cells, each getting hit by free-radicals thousands of times a day. This violent process is called "oxidation,” which damages your cells. Enter antioxidants. They include vitamins and other nutrients that target free ra Continue reading >>
Given the rising epidemic of diabetes and its devastating complications, natural strategies that support healthy blood sugar (glucose) and protect against oxidative stress offer hope for many individuals. Metabolic syndrome—a combination of risk factors such as insulin resistance, high blood pressure, high triglycerides, and low high-density lipoprotein (HDL)—increases one’s risk for diabetes and cardiovascular disease. Widely known as a potent and effective antioxidant, lipoic acid demonstrates a multitude of unique properties. Regulated as a drug in several European countries (where it is approved for the treatment of diabetes-related complications, certain complications of alcoholism, and a variety of liver conditions),1,2 lipoic acid is an important component of every informed individual’s health maintenance regime. In emerging research, lipoic acid has shown impressive benefits in the context of glaucoma, migraine, stroke, as well as bone health. Protection Against Oxidative Stress One of the underlying problems in diabetes is oxidative stress and the production of free radicals. These free radicals circulate in the body, attacking and damaging tissues. Since people with diabetes have high glucose levels, they are more prone to oxidative stress, which may contribute to the long-term complications of the disease. Antioxidants such as lipoic acid prevent this damage by neutralizing free radicals and reducing oxidative stress.3,4 Lipoic acid is an unusual antioxidant because it can act in both water-soluble and fat-soluble domains in cells and tissues. Thanks to these qualities, it is easily absorbed and transported into many organs and systems within the body, for example, the brain, liver, and nerves. Contrast this with antioxidants such as vitamin C, which Continue reading >>
Diabetic Neuropathy: Can Dietary Supplements Help?
A healthy diet is a critical factor in controlling blood sugar, which is key in managing diabetes and preventing or slowing the progression of diabetes complications such as diabetic neuropathy. Dietary supplements also may play a role. Diabetic neuropathy is damage to nerves caused by excess blood sugar, inflammation and blocked small blood vessels associated with diabetes. Left unchecked, diabetic neuropathy can cause complications such as pain and tingling in the hands and feet; it can also result in digestive difficulties and sexual problems. Advanced neuropathy in the feet can lead to the need for amputation of a toe, foot or lower leg. Eating a healthy diet is an important part of managing your diabetes and may help prevent its complications, including diabetic neuropathy. Tight blood sugar management might also help slow the progression of nerve damage. Dietary supplements also may play a role in managing diabetic neuropathy, although more research is needed. Talk to your doctor before adding a dietary supplement because some may interfere with certain diabetes medications, and some can increase the risk of kidney problems. How dietary supplements might help Various nutrients in food play a role in the protection, repair and function of tissues affected by diabetic neuropathy. So, researchers are interested in nutrition and nutritional supplements to help prevent and manage diabetic neuropathy. Research in this field is still relatively new, and the results of clinical studies have yielded mixed results. However, the following dietary supplements may have some limited benefit in preventing and managing diabetic neuropathy. Vitamin B-12 Vitamin B-12 is present naturally in some foods. It plays a number of roles in the body, including helping with proper nerve func Continue reading >>
Alpha-lipoic Acid (ala) And Diabetic Neuropathy
Alpha-lipoic acid (ALA) is a possible alternative remedy to treat the pain associated with diabetic polyneuropathy. Neuropathy, or nerve damage, is a common and potentially serious complication of diabetes. Nerve damage is permanent, and its symptoms can be difficult to alleviate. Polyneuropathy involves the peripheral nerves of the body. It’s the most common form of neuropathy in people who have diabetes, and it causes foot and leg pain. ALA is also called lipoic acid. It’s an antioxidant found in trace amounts in some foods including: liver red meat broccoli brewer’s yeast spinach The body also makes it in small amounts. Experts think antioxidants protect against cell damage. ALA helps fight free radicals, which are the substances that cause cell damage. ALA may also help the body be more sensitive to insulin. People with diabetes might use ALA in supplemental form to help neuropathy. This supplement is promising, but you should still address risks and certain questions before you take ALA. Neuropathy can develop in people with diabetes as a result of high blood glucose, or hyperglycemia. People with diabetes are at a high risk of nerve damage when blood glucose levels are poorly controlled over many years. Your symptoms may vary depending on the type of neuropathy you have and which nerves are affected. Diabetes can lead to several different types of neuropathy, each with different symptoms. ALA may help ease the symptoms of peripheral and autonomic neuropathy. Peripheral neuropathy The symptoms of nerve damage in people with diabetes most commonly occur in the feet and legs, but they can also occur in the hands and arms. Peripheral neuropathy can cause pain in these areas. It can also cause: numbness or an inability to feel changes in temperature a tingling or Continue reading >>
Alpha Lipoic Acid: How To Treat The Real Cause Of Type 2 Diabetes
There are no miracle cure-alls, silver bullets, or magic pills that will get you trim, fit and healthy, but after an exhaustive search and rigorous testing , The Sherpa has pinpointed a few natural health therapies that DO help and ferreted out the scams to avoid...you may be shocked by what we've discovered. Alpha Lipoic Acid: How to Treat the REAL Cause of Type 2 Diabetes Ask someone what disease they fear the most and many will answer type 2 diabetesand for good reason. One out of every 10 Americans has been diagnosed with type 2 diabetes, and millions more are walking around undiagnosed every day. And if the disease isnt bad enough, there are the terrifying complications, including: The only thing more frightening than what can happen once you get type 2 diabetes is the startling ineffectiveness of the treatments that are most often recommended. While doctors will tell you, often offhandedly, to lose weight and exercise, they are more likely to prescribe a drug or even insulin, which is a HUGE mistake. If you have type 2 diabetes, you already have too much insulin in your system. So adding more insulin is like adding gasoline to a fire. Its the LAST thing you need and it can have serious consequences.1 For example, too much insulin has been shown to: Elevate blood pressure, LDL cholesterol, and triglyceride levels; Increase your risk for Alzheimers and cancer.2 Ultimately, the single most effect thing you can do if you have type 2 diabetes is to modify your diet to include only nutrient-dense, low-glycemic load whole foods and to get moderate daily exercise. But that requires fundamental changes to your lifestyle, which can take time; so in addition to that, you may consider using a treatment that helps your cells become more sensitive to the insulin thats already Continue reading >>
The Emerging Role Of Alpha-lipoic Acid For Diabetic Neuropathy
Neuropathy is a common and well-known complication of chronic hyperglycemia due to diabetes mellitus. Distal symmetric polyneuropathy, a form frequently affecting patients with diabetes, characteristically begins in the toes and traverses proximally in symmetric fashion. Symptoms of this late complication include loss of sensation, vibration sense, temperature sensation and muscle weakness. Often, these patients will describe hot, burning, tingling or throbbing pain that accompanies these symptoms. Those with distal symmetric polyneuropathy also have nighttime pain, which imposes a substantially detrimental effect on their quality of life.1 Researchers have also found increasing age, obesity and peripheral arterial disease to be risk factors for the eventual development of neuropathy.2 There are several strategies for alleviating neuropathic pain. Current mainstays include providing symptomatic treatment with anticonvulsants, such as pregabalin (Lyrica, Pfizer) and gabapentin (Neurontin, Pfizer), or tricyclic antidepressants. However, these medications merely relieve the symptoms and do not alter the actual pathogenetic mechanism of the disease. Furthermore, these medications are associated with adverse effects and contraindications that limit the utility of these drugs.3 Medications that modify disease progression by addressing the underlying cause of symptoms would be useful in providing long-term care for our patients, ideally without side effects. Oxidative stress and free radical generation are deeply implicated in the development of late diabetic complications. Host antioxidant defenses act to reduce reactive oxygen species that oxidative phosphorylation in the mitochondria normally produce. Excessive glucose metabolism increases production of these free radicals Continue reading >>
Diabetes And Alpha Lipoic Acid
Go to: Introduction Lipoic acid (LA) or α-lipoic acid (ALA) is a naturally occurring compound that is also known as 1,2-dithiolane-3-pentanoic acid or thioctic acid (Busby et al., 1999). It is synthesized enzymatically in plant and animal mitochondria from octanoic acid and cysteine (as a sulfur source). ALA acts as a cofactor for pyruvate dehydrogenase and α-keto-glutarate dehydrogenase activity (Schmidt et al., 1994), and is also required for the oxidative decarboxylation of pyruvate to acetyl-CoA, a critical step bridging glycolysis and the citric acid cycle (Reed, 1998). The presence of an asymmetric carbon produces two optical isomers R-LA and S-LA. Only the naturally occurring R isomer is bound to protein and acts as an essential cofactor in biological systems (Reed, 1998). However, synthetic LA is a racemic mixture of R and S isoforms, where S-LA can prevent the polymerization of R-LA to enhance its bioavailability (Shay et al., 2009). In cells containing mitochondria, ALA is reduced in an NADH-dependent reaction with lipoamide dehydrogenase to form dihydrolipoic acid (DHLA), whereas in cells that lack mitochondria, ALA can instead be reduced to DHLA via NADPH with glutathione (GSH) and thioredoxin reductases (Jones et al., 2002). Unlike GSH, for which only the reduced form is an antioxidant, both the oxidized and reduced forms of LA are powerful antioxidants whose functions include: (1) quenching of reactive oxygen species (ROS), (2) regeneration of exogenous and endogenous antioxidants such as vitamins C and E, and GSH, (3) chelation of metal ions, and (4) reparation of oxidized proteins (5) regulation of gene transcription (6) inhibition of the activation of nuclear factor kapp B (NF-κB; Biewenga et al., 1997; Packer, 1998; Zhang and Frei, 2001; Figure 1). Continue reading >>
Alpha-lipoic Acid For Diabetic Peripheral Neuropathy
Alpha-lipoic acid for diabetic peripheral neuropathy Carol Davila University of Medicine and Pharmacy, Internal Medicine, Colentina University Hospital, Bucharest, Romania Cristian Baicus, Internal Medicine, Colentina University Hospital, Carol Davila University of Medicine and Pharmacy, Sos. Stefan cel Mare 19-21, sect. 2, Bucharest, Romania. [email protected] . Cited by (CrossRef): 0 articles Check for updates This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of ALA as a disease-modifying agent in DPN, looking at clinical indicators and biomarkers of disease (symptoms, neuropathy scores, ulceration, quality of life, and neurophysiological parameters), and adverse events. Epidemiology of diabetes mellitus and diabetic polyneuropathy Diabetes mellitus is one of the most common noncommunicable diseases and a leading public health concern. Chronic hyperglycaemia results from insufficient insulin production (type 1 diabetes, formerly called insulin-dependent diabetes) or insulin resistance (type 2 diabetes, formerly non-insulin dependent) ( WHO 1999 ). According to World Health Organization (WHO) estimates, the number of adults living with diabetes has quadrupled between 1980 and 2014 ( NCD 2016 ). People with both types of diabetes develop multisystem complications ( WHO 2016 ), one of the most frequent being diabetic peripheral neuropathy (DPN). DPN has an estimated prevalence in the diabetic population of between 10% and 100% depending upon the data source and ascertainment methodology ( Feldman 2016 ). DPN can be classified clinically as either focal or diffuse. Diffuse disease can affect the sensorimotor or the autonomic nervous systems or both. Sensorimotor disease can involve large or small nerve fibres ( Continue reading >>
Alpha Lipoic Acid And Glycaemic Control In Diabetic Neuropathies At Type 2 Diabetes Treatment.
Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment. Department of Internal Medicine, Cantonal Hospital "Dr. Irfan Ljubijankic", Bihac, Bosnia and Herzegovina. [email protected] INTRODUCTION: Diabetes mellitus is a metabolic, chronic and incurable disease which reduces span and quality of life. Over 50% of diabetic patients have clinical manifestations of diabetic neuropathy. AIM: To show a positive influence of alpha lipoic acid on clinically manifested diabetic neuropathy symptoms as well as the effect of alpha lipoic acid in patients glycaemic control. MATERIAL AND METHODS: Testing has been conducted in Cantonal Hospital"Irfan Ljubijankic MD" in Bihac and included 20 diabetes type 2 patients who were diagnosed with clinically manifested diabetic neuropathy. All the patients' conditions were evaluated by: medical history, clinical parameters, detailed internal examination, laboratory analyses for glycaemic control assessment and mono filament test. They were treated with oral anti-diabetics and insulin as well as with alpha lipoic acid preparation in duration of four months. They were divided into two groups, with good (HbA1c < 7%) and poor (HbAc > or = 7%) glycaemic control. Medical control has been conducted four months after the research started. RESULTS: Twenty patients took part in the research, 7 male and 13 female. The average age of the patients was 58.6 in the first and 55.6 years in the second group. The average patients' disease duration was 13.4 +/- 6.6 years in the first and 11.2 +/- 5.4 years in the second group. The difference in gender, average age and disease duration in both groups statistically is not significant (p < or = 0.05). The number of negative points after the therapy has been reduced for 56.4% i Continue reading >>
- Alpha Lipoic Acid: Improve Insulin Sensitivity & Fight Diabetes!
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Alpha Lipoic Acid | Peacehealth
Alpha lipoic acid (ALA) is a vitamin-like antioxidant , sometimes referred toas the "universal antioxidant" because it is soluble in both fat andwater.1 ALA is manufactured in the body and is found in some foods, particularly liver and yeast. Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people. For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being. 3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit. 2 Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. 1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement,little scientific support. This supplement has been used in connection with the following health conditions: Taking alpha lipoic acid may improve insulin sensitivity and help protect against diabetic complications such as nerve damage. Alpha lipoic acid is a powerful natural antioxidant . Preliminary and double-blind trials have found that sup Continue reading >>
Alpha Lipoic Acid - How Much Do You Take?
Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community alpha lipoic acid - how much do you take? Over the past year I've increased my intake from 300,mg of ala to 600mg of r-ala a day, all in one morning dose. My sense is it's working well on my neuropathy but I realise this is an increase in the active ingredient of four times. Just wondered how much others find to be effective and if anyone has read of problems from over use? I believe there was a short term trial based on 600mg of r-ala and this is what I've based my own dosage decision on. I believe in some countries it is now a prescribed remedy for neuropathy but I can't find any reference to prescribed dosage. Just occurs to me if it is excessive I'm either just excreting expensive material or worse still causing some harm. Really welcome any experiences or thoughts please? I have read that when it is prescribed in Europe it is given by intravenous infusions in large doses, but have no idea how often the infusions are given, or for how long. I have read that when it is prescribed in Europe it is given by intravenous infusions in large doses, but have no idea how often the infusions are given, or for how long. Thank you that's helpful. Just wondering how did you settle on that dosage and have you experimented with others? Thank you that's helpful. Just wondering how did you settle on that dosage and have you experimented with others? I am so sorry, I was mistaken. I take 200mg of it per day. I just checked the bottle. Each capsule is 100mg. It is the Swanson Ultra Double Strength R-Fraction ALA. Sorry to mislead you. The bottle instructions say to take 1 or 2 capsules per day if used as a dietary supplement. I am so sorry, I was mistaken. I take 200 Continue reading >>
Good News For Diabetics
Alpha-Lipoic Acid: Alpha-lipoic acid can slow or even prevent nerve damage in diabetics.1 Speaking before the American Diabetes Association's annual meeting in San Diego in June, Professor Lester Packer, a molecular and cell biologist, delivered a hopeful message regarding a problem that 70% of all diabetics have been unable to escape. The vibrant, 70-year-old, Dr Packer of the University of California at Berkeley, recommended alpha-lipoic acid not only to diabetics but to everyone. "This is a treatment that can't do any damage, and there is even evidence that it can slow down the aging process," he said. A powerful antioxidant, alpha-lipoic acid combats cellular injuries caused by free radicals, those unstable, highly reactive molecules that are byproducts of both normal and stressed cell activity. Our bodies manufacture antioxidant enzymes, such as catalase, that disarm and neutralize free radicals, but only to a certain extent. They are not able to adequately handle the continuous barrage of stressors we are subject to, such as ultraviolet radiation, cosmic rays, smoke, industrial toxins, and even natural components or metabolic products of food. Thus, without additional protection by supplemental antioxidants, excessive free radicals can damage vital cell structures and eventually initiate most chronic and degenerative diseases. The Toll of Diabetes As many as 200,000 deaths are attributable to diabetes every year in the United States, and nerve damage is the complication most directly implicated. When blood glucose levels are continuously elevated, as is often the case in diabetes, nerve damage can affect the heart, eyes, kidneys, sex organs, and legs and feet, the most severe consequence of which can be amputation of the feet. Statistics from the American Diabetes Continue reading >>