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Alpha Lipoic Acid Diabetes

Alpha-lipoic Acid (ala) And Diabetic Neuropathy

Alpha-lipoic Acid (ala) And Diabetic Neuropathy

Alpha-lipoic acid (ALA) is a possible alternative remedy to treat the pain associated with diabetic polyneuropathy. Neuropathy, or nerve damage, is a common and potentially serious complication of diabetes. Nerve damage is permanent, and its symptoms can be difficult to alleviate. Polyneuropathy involves the peripheral nerves of the body. It’s the most common form of neuropathy in people who have diabetes, and it causes foot and leg pain. ALA is also called lipoic acid. It’s an antioxidant found in trace amounts in some foods including: liver red meat broccoli brewer’s yeast spinach The body also makes it in small amounts. Experts think antioxidants protect against cell damage. ALA helps fight free radicals, which are the substances that cause cell damage. ALA may also help the body be more sensitive to insulin. People with diabetes might use ALA in supplemental form to help neuropathy. This supplement is promising, but you should still address risks and certain questions before you take ALA. Neuropathy can develop in people with diabetes as a result of high blood glucose, or hyperglycemia. People with diabetes are at a high risk of nerve damage when blood glucose levels are poorly controlled over many years. Your symptoms may vary depending on the type of neuropathy you have and which nerves are affected. Diabetes can lead to several different types of neuropathy, each with different symptoms. ALA may help ease the symptoms of peripheral and autonomic neuropathy. Peripheral neuropathy The symptoms of nerve damage in people with diabetes most commonly occur in the feet and legs, but they can also occur in the hands and arms. Peripheral neuropathy can cause pain in these areas. It can also cause: numbness or an inability to feel changes in temperature a tingling or Continue reading >>

Lipoic Acid

Lipoic Acid

Given the rising epidemic of diabetes and its devastating complications, natural strategies that support healthy blood sugar (glucose) and protect against oxidative stress offer hope for many individuals. Metabolic syndrome—a combination of risk factors such as insulin resistance, high blood pressure, high triglycerides, and low high-density lipoprotein (HDL)—increases one’s risk for diabetes and cardiovascular disease. Widely known as a potent and effective antioxidant, lipoic acid demonstrates a multitude of unique properties. Regulated as a drug in several European countries (where it is approved for the treatment of diabetes-related complications, certain complications of alcoholism, and a variety of liver conditions),1,2 lipoic acid is an important component of every informed individual’s health maintenance regime. In emerging research, lipoic acid has shown impressive benefits in the context of glaucoma, migraine, stroke, as well as bone health. Protection Against Oxidative Stress One of the underlying problems in diabetes is oxidative stress and the production of free radicals. These free radicals circulate in the body, attacking and damaging tissues. Since people with diabetes have high glucose levels, they are more prone to oxidative stress, which may contribute to the long-term complications of the disease. Antioxidants such as lipoic acid prevent this damage by neutralizing free radicals and reducing oxidative stress.3,4 Lipoic acid is an unusual antioxidant because it can act in both water-soluble and fat-soluble domains in cells and tissues. Thanks to these qualities, it is easily absorbed and transported into many organs and systems within the body, for example, the brain, liver, and nerves. Contrast this with antioxidants such as vitamin C, which Continue reading >>

Alpha-lipoic Acid For Diabetic Peripheral Neuropathy

Alpha-lipoic Acid For Diabetic Peripheral Neuropathy

Alpha-lipoic acid for diabetic peripheral neuropathy Carol Davila University of Medicine and Pharmacy, Internal Medicine, Colentina University Hospital, Bucharest, Romania Cristian Baicus, Internal Medicine, Colentina University Hospital, Carol Davila University of Medicine and Pharmacy, Sos. Stefan cel Mare 19-21, sect. 2, Bucharest, Romania. [email protected] . Cited by (CrossRef): 0 articles Check for updates This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of ALA as a disease-modifying agent in DPN, looking at clinical indicators and biomarkers of disease (symptoms, neuropathy scores, ulceration, quality of life, and neurophysiological parameters), and adverse events. Epidemiology of diabetes mellitus and diabetic polyneuropathy Diabetes mellitus is one of the most common noncommunicable diseases and a leading public health concern. Chronic hyperglycaemia results from insufficient insulin production (type 1 diabetes, formerly called insulin-dependent diabetes) or insulin resistance (type 2 diabetes, formerly non-insulin dependent) ( WHO 1999 ). According to World Health Organization (WHO) estimates, the number of adults living with diabetes has quadrupled between 1980 and 2014 ( NCD 2016 ). People with both types of diabetes develop multisystem complications ( WHO 2016 ), one of the most frequent being diabetic peripheral neuropathy (DPN). DPN has an estimated prevalence in the diabetic population of between 10% and 100% depending upon the data source and ascertainment methodology ( Feldman 2016 ). DPN can be classified clinically as either focal or diffuse. Diffuse disease can affect the sensorimotor or the autonomic nervous systems or both. Sensorimotor disease can involve large or small nerve fibres ( Continue reading >>

Alpha Lipoic Acid | Diabetes Forum The Global Diabetes Community

Alpha Lipoic Acid | Diabetes Forum The Global Diabetes Community

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community With the advice from members here, I bought some alpha lipoic acid 600mg. Been taking them about 3 weeks now, was sceptical. The first two weeks, I took one aday, the past two weeks, one in the morning and one at night. So I would l8ke to say a big thank you for suggesting it. With the advice from members here, I bought some alpha lipoic acid 600mg. Been taking them about 3 weeks now, was sceptical. The first two weeks, I took one aday, the past two weeks, one in the morning and one at night. So I would l8ke to say a big thank you for suggesting it. I'm sure others will also be interested to know, but what differences do you feel so far? I'm really pleased for you Ally. I have noticed a good improvement in my feet, although my neuropathy is very mild and nothing like yours. Have you noticed any changes in your blood sugars? Oh yes bs levels are lower, not a huge difference but are lower though my morning bs lever still varies between 7,s into the 9,s. By the evenings my feet used to throb so much, that is still there but about 50% better. Nerve pain doesn,t seem so bad, the nerve pain was so bad that at one point, I was going to ask my gp about painkillers. Pain is alot more bareable I'm really pleased for you Ally. I have noticed a good improvement in my feet, although my neuropathy is very mild and nothing like yours. Have you noticed any changes in your blood sugars? Yes my levels are lower, not a big difference but noticeable My morning bs readings are still the same I'm sure others will also be interested to know, but what differences do you feel so far? Really pleased for you. I use r-ala too @ 600lmg a day and feel it is really helping my neuro Continue reading >>

Effect Of Α-lipoic Acid On Platelet Reactivity In Type 1 Diabetic Patients

Effect Of Α-lipoic Acid On Platelet Reactivity In Type 1 Diabetic Patients

Abstract OBJECTIVE Type 1 diabetes is associated with increased platelet reactivity. We investigated whether α-lipoic acid (ALA) has any effect on platelet reactivity in these patients. RESEARCH DESIGN AND METHODS We randomly assigned 51 type 1 diabetic patients to ALA (600 mg once daily) or placebo for 5 weeks. Platelet reactivity was evaluated by the PFA-100 method and by measuring CD41 and CD62 platelet expression. C-reactive protein (CRP) and 8-iso-prostaglandin F2α serum levels also were measured. RESULTS Baseline variables were similar in the two groups. After treatment, closure time was longer (P = 0.006) and CD62P platelet expression was lower, both before (P = 0.002) and after (P = 0.009) ADP stimulation in the ALA group compared with the placebo group. CRP and 8-iso-prostaglandin F2α levels showed no differences between the two groups. CONCLUSIONS Our data show that ALA reduces measures of platelet reactivity ex vivo in type 1 diabetic patients, independently of antioxidant or anti-inflammatory effects. Type 1 diabetes is associated with the increased risk of cardiovascular disease (1). Higher platelet reactivity has been reported in diabetic patients (2,3). α-Lipoic acid (ALA) acts as a cofactor in multienzyme complexes, including pyruvate dehydrogenase and branched-chain ketoacid dehydrogenase, and is licensed for treatment of symptomatic diabetic neuropathy (4,5). Recent studies have suggested that ALA has anti-inflammatory and antioxidant proprieties (6–8) that might eventually improve platelet function. RESEARCH DESIGN AND METHODS We performed a randomized, double-blind, placebo-controlled pilot study to assess whether ALA has any effects on platelet reactivity, oxidative stress, and inflammation in type 1 diabetic patients. We enrolled 51 type 1 di Continue reading >>

Alpha Lipoic Acid

Alpha Lipoic Acid

Ryan Bradley, ND, MPH and Bill Walter, ND May, 2012 Whether patient, family member, or health-care provider, we all know caring for diabetes requires more than 'just' keeping blood sugar balanced (which is challenging enough). There are also the associated conditions - e.g., high cholesterol, high blood pressure, neuropathy, etc., requiring time and attention to prevent severe complications which can greatly impair quality of life and rapidly limit functionality. In this month’s 'Complementary Corner' we’re going to shine a spotlight on a natural product with great potential in the care for diabetes called 'alpha-lipoic acid' (or ALA for short). ALA is a sulfur-containing compound present in human cells, where it is required for energy production within the mitochondria. In addition to its critical role in energy production, ALA is known to have antioxidant and anti-inflammatory properties - both of which are useful in managing diabetes and its complications. Research on ALA includes large clinical trials supporting its role in treating neuropathy, but research suggests it may help improve insulin sensitivity, lower blood sugar and cholesterol, improve blood vessel tone, and decrease inflammation and oxidative stress. Use in diabetes: Neuropathy In diabetes, 'neuropathy' typically refers to nerve damage accumulated over years or decades as a result of increased oxidative stress and reductions in blood flow. When occurring in the extremities (typically the legs and feet), neuropathy can lead to pain, tingling, and numbness. This loss of sensation can in turn lead to unnoticed injuries, which is why people with diabetes should have their feet checked by healthcare providers at each visit. In addition to the extremities, however, neuropathy can also develop in the nerv Continue reading >>

Diabetes And Alpha Lipoic Acid

Diabetes And Alpha Lipoic Acid

Go to: Introduction Lipoic acid (LA) or α-lipoic acid (ALA) is a naturally occurring compound that is also known as 1,2-dithiolane-3-pentanoic acid or thioctic acid (Busby et al., 1999). It is synthesized enzymatically in plant and animal mitochondria from octanoic acid and cysteine (as a sulfur source). ALA acts as a cofactor for pyruvate dehydrogenase and α-keto-glutarate dehydrogenase activity (Schmidt et al., 1994), and is also required for the oxidative decarboxylation of pyruvate to acetyl-CoA, a critical step bridging glycolysis and the citric acid cycle (Reed, 1998). The presence of an asymmetric carbon produces two optical isomers R-LA and S-LA. Only the naturally occurring R isomer is bound to protein and acts as an essential cofactor in biological systems (Reed, 1998). However, synthetic LA is a racemic mixture of R and S isoforms, where S-LA can prevent the polymerization of R-LA to enhance its bioavailability (Shay et al., 2009). In cells containing mitochondria, ALA is reduced in an NADH-dependent reaction with lipoamide dehydrogenase to form dihydrolipoic acid (DHLA), whereas in cells that lack mitochondria, ALA can instead be reduced to DHLA via NADPH with glutathione (GSH) and thioredoxin reductases (Jones et al., 2002). Unlike GSH, for which only the reduced form is an antioxidant, both the oxidized and reduced forms of LA are powerful antioxidants whose functions include: (1) quenching of reactive oxygen species (ROS), (2) regeneration of exogenous and endogenous antioxidants such as vitamins C and E, and GSH, (3) chelation of metal ions, and (4) reparation of oxidized proteins (5) regulation of gene transcription (6) inhibition of the activation of nuclear factor kapp B (NF-κB; Biewenga et al., 1997; Packer, 1998; Zhang and Frei, 2001; Figure 1). Continue reading >>

Diabetic Neuropathy: Can Dietary Supplements Help?

Diabetic Neuropathy: Can Dietary Supplements Help?

A healthy diet is a critical factor in controlling blood sugar, which is key in managing diabetes and preventing or slowing the progression of diabetes complications such as diabetic neuropathy. Dietary supplements also may play a role. Diabetic neuropathy is damage to nerves caused by excess blood sugar, inflammation and blocked small blood vessels associated with diabetes. Left unchecked, diabetic neuropathy can cause complications such as pain and tingling in the hands and feet; it can also result in digestive difficulties and sexual problems. Advanced neuropathy in the feet can lead to the need for amputation of a toe, foot or lower leg. Eating a healthy diet is an important part of managing your diabetes and may help prevent its complications, including diabetic neuropathy. Tight blood sugar management might also help slow the progression of nerve damage. Dietary supplements also may play a role in managing diabetic neuropathy, although more research is needed. Talk to your doctor before adding a dietary supplement because some may interfere with certain diabetes medications, and some can increase the risk of kidney problems. How dietary supplements might help Various nutrients in food play a role in the protection, repair and function of tissues affected by diabetic neuropathy. So, researchers are interested in nutrition and nutritional supplements to help prevent and manage diabetic neuropathy. Research in this field is still relatively new, and the results of clinical studies have yielded mixed results. However, the following dietary supplements may have some limited benefit in preventing and managing diabetic neuropathy. Vitamin B-12 Vitamin B-12 is present naturally in some foods. It plays a number of roles in the body, including helping with proper nerve func Continue reading >>

Alpha Lipoic Acid: Improve Insulin Sensitivity & Fight Diabetes!

Alpha Lipoic Acid: Improve Insulin Sensitivity & Fight Diabetes!

What is it about foods like broccoli and spinach that make them so healthy? There’s the fiber, vitamins and minerals, of course, but then there’s other important chemical compounds we call “antioxidants” too — like alpha lipoic acid (ALA). Chances are you’ve heard a lot about the many benefits of various antioxidants and high-antioxidant foods — fighting inflammation, helping beat cancer or heart disease, warding off depression and cognitive decline, and so much more — but have you ever wondered what exactly antioxidants are and how they work in the body? Alpha lipoic acid — one kind of antioxidant — is a type of compound found in plant foods we commonly eat that scavenges free radicals, fights inflammation and slows the aging process. But perhaps its most famous use is in treating diabetes naturally. Humans also make a small amount of ALA on their own, although the concentration in our bloodstreams goes up substantially when we eat a healthy diet. Naturally abundant in foods like green veggies, potatoes and certain types of yeast, lipoic acid is similar to a vitamin in that it can also be man-made in a lab so it can be taken as an anti-inflammatory supplement (which is then called alpha lipoic acid). How Alpha Lipoic Acid Works Lipoic acid is found in the body and also synthesized by plants and animals. It’s present in every cell inside the body and helps turn glucose into “fuel” for the body to run off of. Is it “essential” that you consume a certain doseage of alpha lipoic acid every day? Not exactly. Even though we can make some of it on our own without supplements or outside food sources (which is why it’s not considered an “essential nutrient”), eating an antioxidant-packed diet plus potentially using ALA supplements can increas Continue reading >>

Alpha-lipoic Acid: Uses, Side Effects, Interactions, Dosage, And Warning

Alpha-lipoic Acid: Uses, Side Effects, Interactions, Dosage, And Warning

Alpha-lipoic acid is a vitamin-like chemical called an antioxidant. Yeast, liver, kidney, spinach, broccoli, and potatoes are good sources of alpha-lipoic acid. It is also made in the laboratory for use as medicine. Alpha-lipoic acid is most commonly taken by mouth for diabetes and nerve-related symptoms of diabetes including burning, pain, and numbness in the legs and arms. It is also given as an injection into the vein (by IV) for these same uses. High doses of alpha-lipoic acid are approved in Germany for the treatment of these nerve-related symptoms. Alpha-lipoic acid seems to help prevent certain kinds of cell damage in the body, and also restores vitamin levels such as vitamin E and vitamin C . There is also evidence that alpha-lipoic acid can improve the function and conduction of neurons in diabetes. Alpha-lipoic acid is used in the body to break down carbohydrates and to make energy for the other organs in the body. Alpha-lipoic acid seems to work as an antioxidant, which means that it might provide protection to the brain under conditions of damage or injury. The antioxidant effects might also be helpful in certain liver diseases. Aging skin. Early research suggests that applying cream containing 5% alpha-lipoic acid might reduce fine lines and skin roughness caused by sun damage. Also, taking a specific product containing alpha-lipoic acid and other ingredients seems to improve elasticity and reduce wrinkles and roughness of aging skin. Coronary artery bypass graft (CABG) surgery. Research suggests that taking a product containing alpha-lipoic acid, coenzyme Q10, magnesium, omega-3 fatty acids, and selenium up to 2 months before and 1 month after surgery seems to decrease complications following CABG surgery. Diabetes. Taking alpha-lipoic acid by mouth or in Continue reading >>

Alpha Lipoic Acid: How To Treat The Real Cause Of Type 2 Diabetes

Alpha Lipoic Acid: How To Treat The Real Cause Of Type 2 Diabetes

There are no miracle cure-alls, silver bullets, or magic pills that will get you trim, fit and healthy, but after an exhaustive search and rigorous testing , The Sherpa has pinpointed a few natural health therapies that DO help and ferreted out the scams to avoid...you may be shocked by what we've discovered. Alpha Lipoic Acid: How to Treat the REAL Cause of Type 2 Diabetes Ask someone what disease they fear the most and many will answer type 2 diabetesand for good reason. One out of every 10 Americans has been diagnosed with type 2 diabetes, and millions more are walking around undiagnosed every day. And if the disease isnt bad enough, there are the terrifying complications, including: The only thing more frightening than what can happen once you get type 2 diabetes is the startling ineffectiveness of the treatments that are most often recommended. While doctors will tell you, often offhandedly, to lose weight and exercise, they are more likely to prescribe a drug or even insulin, which is a HUGE mistake. If you have type 2 diabetes, you already have too much insulin in your system. So adding more insulin is like adding gasoline to a fire. Its the LAST thing you need and it can have serious consequences.1 For example, too much insulin has been shown to: Elevate blood pressure, LDL cholesterol, and triglyceride levels; Increase your risk for Alzheimers and cancer.2 Ultimately, the single most effect thing you can do if you have type 2 diabetes is to modify your diet to include only nutrient-dense, low-glycemic load whole foods and to get moderate daily exercise. But that requires fundamental changes to your lifestyle, which can take time; so in addition to that, you may consider using a treatment that helps your cells become more sensitive to the insulin thats already Continue reading >>

Alpha-lipoic Acid (ala) And Diabetes

Alpha-lipoic Acid (ala) And Diabetes

Exciting new research! Science has linked alpha-lipoic acid (ALA) to increasing our mitochondrial energy production and helping prevent diabetes. At first, medical researchers initially classified alpha-lipoic acid as a new vitamin but then recognized it as an essential coenzyme. Then, they found that alpha-lipoic acid was a powerful biological antioxidant, quenching free radicals, as well as coenzyme Q10 (CoQ10) and vitamins C and E.. Researchers also found that alpha-lipoic acid is unique in being the only antioxidant known to work in both fat and water-soluble tissues. (Vitamin C only works in watery tissues and vitamin E is restricted to fatty tissues.) Antioxidants are known to play a vital role in preventing many of the health disorders associated with aging, including degenerative diseases such as diabetes. Now, a vitamin-like substance known as alpha-lipoic acid is now at the forefront of antioxidant research. This dual ability allows alpha-lipoic acid to easily neutralize free radicals in both interior and exterior cellular structures. Now, it is called the “universal antioxidant.” More importantly, ALA recycles vitamins C, E, CoQ10, and glutathione! This antioxidant could have far-reaching consequences in the search for prevention and therapy of diabetes. And, because it’s the only antioxidant that can easily get into the brain, it could be useful in preventing damage from a stroke! Nature Knows How to do Things! Continue reading >>

Alpha Lipoic Acid: This Antioxidant Can Smash Insulin Resistance And Autoimmune Disease

Alpha Lipoic Acid: This Antioxidant Can Smash Insulin Resistance And Autoimmune Disease

I first became aware of the alpha lipoic regimen by Dr. Burt Berkson in the late 90’s. Early on in his career, while an internist, he was given several patients who were expected to die from hepatitis C. His job was more or less to simply baby sit them in the ICU and watch them die. But Dr. Berkson was a rebel at heart and he simply couldn’t do that. Instead he called an associate at the National Institutes of Health and found out how he could treat them. He learned that alpha lipoic acid had some impressive experimental support. Remarkably, although these patients were expected to die within a few weeks, they all completely recovered! However not all went well for Dr. Berkson as he made his superiors look foolish and they simply could not tolerate that so rather than embrace his findings, they actively suppressed the results and made his life miserable for showing them up. This was a pivotal moment in Dr. Berskson’s career and caused him to make choices that eventually led to where he is at now. Since then, Dr. Berkson has lectured all over the world on this topic, and published a study on the use of antioxidants for the treatment of hepatitis C. His first book, The Alpha-Lipoic Acid Breakthrough was published in 1998. As many of you already know, I am not fond of recommending many supplements, but I do believe that antioxidants make sense for many of us. Why You Need Antioxidants Your entire body, including your DNA, is under endless, daily assault from a variety of sources, from poor diets to pollution. Think of your cells, including your brain cells, each getting hit by free-radicals thousands of times a day. This violent process is called "oxidation,” which damages your cells. Enter antioxidants. They include vitamins and other nutrients that target free ra Continue reading >>

The Emerging Role Of Alpha-lipoic Acid For Diabetic Neuropathy

The Emerging Role Of Alpha-lipoic Acid For Diabetic Neuropathy

Neuropathy is a common and well-known complication of chronic hyperglycemia due to diabetes mellitus. Distal symmetric polyneuropathy, a form frequently affecting patients with diabetes, characteristically begins in the toes and traverses proximally in symmetric fashion. Symptoms of this late complication include loss of sensation, vibration sense, temperature sensation and muscle weakness. Often, these patients will describe hot, burning, tingling or throbbing pain that accompanies these symptoms. Those with distal symmetric polyneuropathy also have nighttime pain, which imposes a substantially detrimental effect on their quality of life.1 Researchers have also found increasing age, obesity and peripheral arterial disease to be risk factors for the eventual development of neuropathy.2 There are several strategies for alleviating neuropathic pain. Current mainstays include providing symptomatic treatment with anticonvulsants, such as pregabalin (Lyrica, Pfizer) and gabapentin (Neurontin, Pfizer), or tricyclic antidepressants. However, these medications merely relieve the symptoms and do not alter the actual pathogenetic mechanism of the disease. Furthermore, these medications are associated with adverse effects and contraindications that limit the utility of these drugs.3 Medications that modify disease progression by addressing the underlying cause of symptoms would be useful in providing long-term care for our patients, ideally without side effects. Oxidative stress and free radical generation are deeply implicated in the development of late diabetic complications. Host antioxidant defenses act to reduce reactive oxygen species that oxidative phosphorylation in the mitochondria normally produce. Excessive glucose metabolism increases production of these free radicals Continue reading >>

Alpha Lipoic Acid | Peacehealth

Alpha Lipoic Acid | Peacehealth

Alpha lipoic acid (ALA) is a vitamin-like antioxidant , sometimes referred toas the "universal antioxidant" because it is soluble in both fat andwater.1 ALA is manufactured in the body and is found in some foods, particularly liver and yeast. Our proprietary "Star-Rating" system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people. For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being. 3 Stars Reliable and relatively consistent scientific data showing a substantial health benefit. 2 Stars Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. 1 Star For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement,little scientific support. This supplement has been used in connection with the following health conditions: Taking alpha lipoic acid may improve insulin sensitivity and help protect against diabetic complications such as nerve damage. Alpha lipoic acid is a powerful natural antioxidant . Preliminary and double-blind trials have found that sup Continue reading >>

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