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Actos And Metformin Taken Together

Compare Actos Vs Metformin - Iodine.com

Compare Actos Vs Metformin - Iodine.com

Head-to-head comparisons of medication uses, side effects, ratings, and more. Actos (pioglitazone) can improve blood sugar control but is not a top choice since it has a lot of side effects. 3.1/ 5 average rating with 175 reviewsforActos Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects. 3.7/ 5 average rating with 938 reviewsformetformin Improves sugar control and lowers A1c levels by around 1%. Easily taken by mouth as a once a day pill. Prevents the harmful effects of high sugar levels on your organs. Lower the risk of heart attack or stroke. Improves sugar control and lowers A1c levels as much as 2%. One of the few diabetes medicines that lowers the risk of death from diabetes-related complications. May take several weeks to lower blood sugar. People with heart failure or history of bladder cancer shouldn't use this medicine. Some people might get fluid accumulation (edema), from minor ankle swelling to fluid in lungs that makes it hard to breathe. Raises the risk of bone fractures, especially for people who already have a risk for fractures. Often causes stomach upset, like diarrhea, nausea, gas, or stomach cramping. Usually not a good choice for people with kidney problems. Your doctor will tell you if Glucophage (metformin) is right for you to take. Excessive or chronic alcohol use can increase the risk of a dangerous side effect. Continue reading >>

My Negative Actos Experience

My Negative Actos Experience

Admin Update: Click here to read more actos experiences ! My doctor gave me a combination of Glipizide and Actose. I was overweight at that time, as the months went by on the two drugs I kept gaining weight and gaining weight, as my diabetes doctor noted every time I visited him for my check up. My appetite increased and I knew that Id soon be 300 lbs if something werent done. Finally the doctor admitted that Actose does make you gain weight. I went to the library and read in the Physicians Desk Reference (PDR) that Actose makes the body retain water and fat so I knew what had to be done. I stopped taking the Actose but continued with the Glipizide, taking 2 pills instead of one during the first meal each day. Immediately after I stopped taking Actose I started losing weight and my appetite decreased. Not only did I lose weight and stop eating, but also my sugar levels went down. I started to have, with only the two Glipizides, normal sugar levels due to the fact that I was eating a lot less. When the doctor first gave me Actose it had not been on the market very long. When he realized I was continuously gaining weight from it he wanted me quit. He adamantly insisted that I switch to a new, injectable drug that just came out on the market. Because of the fact that the drug was injectable and new to the market I refused to take it. The fact that he was so adamant that I stop using Actose and switch to the new drug confirmed my belief that I was right that Actose was not a good drug for me to use. Still, he refused to admit that I gained more than 5 lbs from the Actose, yet now three months after not using Actose Ive lost close to 30 lbs. If theres any similar stories about Actose, please let me know. What dosage of Actos are you on? I take Actos 45mgs. I've put on some Continue reading >>

Metformin, Glipizide, Januvia, And Actos Related Questions

Metformin, Glipizide, Januvia, And Actos Related Questions

Metformin, Glipizide, Januvia, and Actos Related Questions Metformin, Glipizide, Januvia, and Actos Related Questions A friend's father (age 70+) is taking all of those drugs, and I wonder if that's a dangerous mix. I read about them today, and it seems Actos is the worst, followed by Glipizide. I also read in an older thread here that it's dangerous to take Actos and Januvia together. Why is that? Is that an unwelcome combination only for causing weight gain? He thinks one of these drugs is raising his cholesterol levels, but I didn't find it mentioned among the side-effects of any of them. I think only Actos could be a potential suspect, although some studies show it may lower cholesterol. What do you think? He is mildly anemic with no apparent reason. I've seen it mentioned many times here that Metformin depletes vitamin B12, but his B12 is within the lab ranges. I don't really trust many of those ranges, so I think he could still be B12 deficient with a result of 432 (211 - 946). Need to ask if he is supplementing with B12. Continue reading >>

Actos And Metformin Combination: Dosage And Side Effects

Actos And Metformin Combination: Dosage And Side Effects

Actos and Metformin Combination: Dosage and Side Effects Actos and Metformin Combination: Dosage and Side Effects What is an Actos and Metformin combination? Actos and metformin is a combination of two oral diabetes drugs that are taken together to help reduce high blood sugar in patients with type 2 diabetes . Type 2 diabetes is a medical condition where the body cells become resistant to insulin. Insulin is the hormone that helps to convert glucose into energy. Without insulin, glucose will build up in the bloodstream and cause a spike in blood sugar levels. To prevent the risk of long-term health complications associated with high blood sugar, type 2 diabetes patients may be prescribed to take Actos and Metformin .The drugs are commonly prescribed together with a proper diet and exercise program. However,they should not be used to treat patients with type 1 diabetes. This is because these drugs work by helping the body cells respond better to the insulin it already produces. People with type 1 diabetes do not produce insulin naturally. Because of this, they require to take insulin medication . Actos and Metformin are prescription medications available in both immediate and extended-release tablets. Your dosage and the form you take will be based on different factors, including your age, severity of your condition, other drugs you are taking, and how your body responds to the initial dose. The initial dose is 500850 mg of Metformin and 15 mg of Actos, and should be taken every day with meals. If your initial dose is 500mg of Metformin to 15mg of Actos, this is typically taken twice a day. If you are given an initial dose of 850mg Metformin and 15mg Actos, you will only need to take it once a day, unless specified otherwise. The maximum daily dose is 2550 mg of Metfor Continue reading >>

Actos

Actos

Actos (pioglitazone) is an oral Type 2 diabetes drug that lowers blood sugar by decreasing insulin resistance and reducing the amount of glucose made in the liver. This allows the body to better dispose of excess blood sugar. Typically, the dose starts at 15 or 30 mg and is taken once a day, but some people may require a stronger dose. Doctors can increase the strength of the medicine by 15 mg increments to a maximum of 45 mg daily. However, numerous studies and a review by the U.S. Food and Drug Administration (FDA) link higher dosages and prolonged use to an increased risk of bladder cancer and other serious conditions. Actos is not intended to treat Type 1 diabetes or diabetic ketoacidosis. The drug can be used alone or with other Type 2 diabetes medicines such as metformin. There are two additional types of Actos that combine pioglitazone and metformin: Actoplus Met and Actoplus Met XR (extended release). What Does Actos Treat? Actos is approved to treat Type 2 diabetes in adults by improving glycemic (defined as causing glucose – sugar – in the blood) control. The drug comes in a tablet form to be taken by mouth daily and should be used in combination with diet and exercise. People with Type 2 diabetes do not make or use insulin well. Insulin is a hormone produced by the pancreas that regulates the amount of glucose in the blood. It moves blood sugar into cells where it is stored for later use as energy. Type 2 diabetes results in higher than normal levels of glucose because glucose does not enter cells. The body is then unable to use the glucose for energy. Type 2 diabetes is a lifelong (chronic) disease that can develop at any age, including during childhood. However, it mostly occurs in middle-aged and older people. The condition often develops slowly over t Continue reading >>

Actos Side Effects | Diabetic Connect

Actos Side Effects | Diabetic Connect

Good Morning, I have had no trouble with my sugar till the doctor took me off Actos. He was afraid it would cause bladder cancer. I take Mediform 500mg in morning and Lantus 20 units in morning. Sugar is running 120-140 in the mornings and by noon back to 100 after noon the 2 hours it may be 152+. I have to cover if over 152 with novolog pin. By bedtime it is 120's if I don't eat. The doctor told me to start taking mediform at nite with my other pills. I have but it hasn't helped yet. A1c was under 6 now is 6.5. Any help or options would be helpful. I'm very aggressive with everything so I'm very disappointed that its not working. I refuse to let this get me down. Help. I was on Actos for 3 years and swollen ankles became away of life. I finally had my DR. take me off after reading all the negative press about Actos..Right now I am on metformin HCL and a once daily shot of lantus Insulin..This seems to working real well for me and no more swollen ankles I was on it and glypizide ER for quite a while and yes, it did a job on my ankles and weight gain. I just started Januvia this friday and hope it helps me. I was on 45mgs of Actos per day for 8 months from July 2010 to February 2011. The other name for it is Piaglitazone and I never suffered from weight gain or swollen ankles or feet but I had massive hair loss. I am now getting back most of my hair loss but still have a way to go to get back to normal. I checked this out on the internet and hair loss is one of the major side effect of this drug. was just recently taken of actos for the possilbe hazrds it can cause and has given to replace gliipizide I don't use but just yesterday I saw a tv ad stating that Actos has been linked to bladder cancerthere is an on-going lawsuityou are to contact the said Lawyer if you use t Continue reading >>

Actos And Metformin Drug Interactions - Drugs.com

Actos And Metformin Drug Interactions - Drugs.com

Do not stop taking any medications without consulting your healthcare provider. Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist. Some mixtures of medications can lead to serious and even fatal consequences. Continue reading >>

Metformin And Pioglitazone

Metformin And Pioglitazone

Metformin and pioglitazone is a combination of two oral diabetes medicines that help control blood sugar levels. Metformin and pioglitazone is for people with type 2 diabetes who do not use daily insulin injections. This medication is not for treating type 1 diabetes . Metformin and pioglitazone may also be used for purposes not listed in this medication guide. Lifestyle Lessons - 9 Tips For Managing Type 2 Diabetes You should not use this medicine if you have severe or uncontrolled heart failure , kidney problems, active bladder cancer , metabolic acidosis , or diabetic ketoacidosis (call your doctor for treatment with insulin ). Metformin and pioglitazone is not for treating type 1 diabetes. Metformin and pioglitazone can cause or worsen congestive heart failure. Call your doctor at once if you have shortness of breath (even with mild exertion), swelling, or rapid weight gain . If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking metformin and pioglitazone. Some people develop lactic acidosis while taking metformin. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain , nausea with vomiting , slow or uneven heart rate, dizziness , or feeling very weak or tired. You should not use this medicine if you are allergic to metformin or pioglitazone, or if you have: diabetic ketoacidosis (call your doctor for treatment with insulin). If you need to have any type of x-ray or CT scan using a dye that is injected into your veins, you will need to temporarily stop taking metformin and pioglitazone. Be sure your caregivers know ahead of time that you are using this medication. Some peo Continue reading >>

Actoplus Met, Actoplus Met Xr Drug Imprint

Actoplus Met, Actoplus Met Xr Drug Imprint

(pioglitazone and metformin hydrochloride) Tablets CONGESTIVE HEART FAILURE AND LACTIC ACIDOSIS Thiazolidinediones, including pioglitazone, which is a component of ACTOPLUS MET, cause or exacerbate congestive heart failure in some patients [see WARNINGS AND PRECAUTIONS ]. After initiation of ACTOPLUS MET, and after dose increases, monitor patients carefully for signs and symptoms of heart failure (e.g., excessive, rapid weight gain, dyspnea, and/or edema). If heart failure develops, it should be managed according to current standards of care and discontinuation or dose reduction of ACTOPLUS MET must be considered [see WARNINGS AND PRECAUTIONS ]. ACTOPLUS MET is not recommended in patients with symptomatic heart failure. Initiation of ACTOPLUS MET in patients with established New York Heart Association (NYHA) Class III or IV heart failure is contraindicated [see CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS ]. Lactic acidosis is a rare but serious complication that can occur due to metformin accumulation. The risk increases with conditions such as sepsis, dehydration, excess alcohol intake, hepatic impairment, renal impairment, and acute congestive heart failure [see WARNINGS AND PRECAUTIONS ]. The onset is often subtle, accompanied only by nonspecific symptoms such as malaise, myalgias, respiratory distress, increasing somnolence, and nonspecific abdominal distress. Laboratory abnormalities include low pH, increased anion gap, and elevated blood lactate [see WARNINGS AND PRECAUTIONS ]. If acidosis is suspected, ACTOPLUS MET should be discontinued and the patient hospitalized immediately [see WARNINGS AND PRECAUTIONS ]. ACTOPLUS MET tablets are a thiazolidinediones andbiguanide combination product that contains two oral antidiabetic medications:pioglitazone hydrochlori Continue reading >>

Pioglitazone And Metformin Fixed-dose Combination In Type 2 Diabetes Mellitus: An Evidence-based Review Of Its Place In Therapy

Pioglitazone And Metformin Fixed-dose Combination In Type 2 Diabetes Mellitus: An Evidence-based Review Of Its Place In Therapy

Pioglitazone and metformin fixed-dose combination in type 2 diabetes mellitus: an evidence-based review of its place in therapy We are experimenting with display styles that make it easier to read articles in PMC. The ePub format uses eBook readers, which have several "ease of reading" features already built in. The ePub format is best viewed in the iBooks reader. You may notice problems with the display of certain parts of an article in other eReaders. Generating an ePub file may take a long time, please be patient. Pioglitazone and metformin fixed-dose combination in type 2 diabetes mellitus: an evidence-based review of its place in therapy Giuseppe Derosa and Sibilla Anna Teresa Salvadeo Type 2 diabetes mellitus, a metabolic disease with increasing incidence, is one of the most important cardiovascular risk factors. Insulin resistance represents the common mechanism that leads to type 2 diabetes in obese subjects. Metformin and the thiazolidinediones, pioglitazone and rosiglitazone, are insulin-sensitizing agents available for treatment of type 2 diabetes. Large clinical trials have demonstrated the effectiveness of both metformin and pioglitazone in reducing cardiovascular morbidity and mortality. The fixed-dose combination of metformin and pioglitazone appears to be a good option for treating diabetes in insulin-resistant patients. The purpose of this article is to review the place in therapy of a fixed-dose combination of pioglitazone and metformin in the management of patients with type 2 diabetes. The current evidence suggests that combined therapy may help to achieve the recommended goals in the management of diabetes. A fixed-dose formulation of pioglitazone and metformin may provide advantages in terms of glycemic control and other cardiovascular risk factor Continue reading >>

Actos Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - Webmd

Actos Oral : Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - Webmd

Sore throat , muscle pain , weight gain, or tooth problems may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: new/worsening vision problems (such as blurred vision ), bone fracture, reddish-colored urine, urgent need to urinate, pain while urinating. Pioglitazone may rarely cause liver disease. Tell your doctor right away if you develop symptoms of liver disease, including: dark urine, yellowing of eyes / skin , persistent nausea / vomiting , stomach / abdominal pain . Pioglitazone does not usually cause low blood sugar ( hypoglycemia ). Low blood sugar may occur if this drug is prescribed with other diabetes medications (such as insulin or a sulfonylurea). Low blood sugar is more likely if you drink large amounts of alcohol, do unusually heavy exercise , or do not consume enough calories from food. To help prevent low blood sugar , eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal. Symptoms of low blood sugar include sudden sweating , shaking, fast heartbeat, hunger , blurred vision , dizziness , or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar . If you don't have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the Continue reading >>

Actoplus Met, Actoplus Met Xr (metformin And Pioglitazone) Drug Side Effects, Interactions, And Medication Information On Emedicinehealth.

Actoplus Met, Actoplus Met Xr (metformin And Pioglitazone) Drug Side Effects, Interactions, And Medication Information On Emedicinehealth.

oval, white, imprinted with 4833M, 15/850 What are the possible side effects of metformin and pioglitazone (Actoplus Met, Actoplus Met XR)? This medication may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, slow or irregular heart rate, dizziness , or feeling very weak or tired. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any other serious side effects, such as: stomach pain, blood in your urine, painful urination; feeling short of breath, especially when lying down; pale skin, feeling light-headed, rapid heart rate, trouble concentrating; sudden unusual pain in your hand, arm, or foot; or nausea, stomach pain, low fever , loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). sneezing, runny nose, cough or other signs of a cold. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about metformin and pioglitazone (Actoplus Met, Actoplus Met XR)? You should not use this medication if you are allergic to metformin (Glucophage) or pioglitazone (Actos), or if you have kidney problems, severe heart failure, active bladder cancer , or metabolic acidosis. Do not use metformin and pioglitazone if you are in a state o Continue reading >>

Efficacy Of Pioglitazone/metformin Combination Therapy In Subjects With Type 2 Diabetes Mellitus And Dyslipidemia.

Efficacy Of Pioglitazone/metformin Combination Therapy In Subjects With Type 2 Diabetes Mellitus And Dyslipidemia.

You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Efficacy of Pioglitazone/Metformin Combination Therapy in Subjects With Type 2 Diabetes Mellitus and Dyslipidemia. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. ClinicalTrials.gov Identifier: NCT00770653 Study Description Study Design Arms and Interventions Outcome Measures Eligibility Criteria Contacts and Locations More Information The purpose of this study is to compare pioglitazone and metformin combination therapy, twice daily (BID), to glimepiride and metformin combination therapy for treating diabetic subjects with dyslipidemia. Drug: Pioglitazone and Metformin Drug: Glimepiride and Metformin Insulin resistance is a major endocrinopathy preceding the development of hyperglycemia, diabetic dyslipidemia and cardiovascular disease in type 2 diabetes. The most common pattern of dyslipidemia in patients with type 2 diabetes are elevated triglyceride levels, decreased hih-density lipoprotein cholesterol and a predominance of small dense low-density lipoprotein particles. Each of these dyslipidemia features is associated with an increased risk of cardiovascular events. Pioglitazone and Metformin are established drugs which can be used for the treatment of type 2 diabetes. This study will investigate the effects of treatment with fixed Pioglitazone/Metformin combination therapy of Metformin and Glimepiride in Metformin-pretreated type 2 diabetic patients with dyslipidemia. Total participation time in this study is anticipated to be approximately 24 weeks. Quadruple (Participant, Continue reading >>

Are Your Meds Making You Fat?

Are Your Meds Making You Fat?

One of the frustrations of diabetes is the way everyone tells you to lose weight. Then they give you medicine that makes you gain weight. Some of the worst offenders are insulin and the thiazolidinedione drugs, pioglitazone (brand name Actos) and rosiglitazone (Avandia). Why do these drugs cause weight gain, and what can you do about it? To recap: As you know, Type 2 diabetes is a disease of insulin resistance. Your muscle and brain cells don’t want the glucose that the insulin is trying to bring, so they resist. The glucose stays in the bloodstream. At first, the beta cells in the pancreas try to compensate by pumping out extra insulin to overcome the resistance. When the beta cells can’t keep up, or when the resistance gets too severe, you start running high blood sugar and developing symptoms of diabetes. When Insulin is Low People with Type 1 diabetes don’t make enough insulin, period, and people with Type 2 develop a low-insulin situation over time. What does that do to you? With insufficient insulin, glucose can’t get into your muscle and brain cells to be burned as fuel. It can’t get into the liver to be stored as starch, and it can’t get converted into fat. Why not? Because insulin does all those things. So, when you don’t have enough insulin, you won’t gain weight, because your body can’t do anything with the glucose, and you wind up urinating it away. That’s why weight loss is a classic symptom of Type 1. Then You Inject Now this is the tricky part—if you have Type 2, and you are given insulin, the fat storage will resume full speed. Insulin resistance doesn’t affect fat storage. But because of insulin resistance, you will get only a partial improvement in glucose uptake by your muscle and brain cells. So the glucose starts to get store Continue reading >>

Metformin And Pioglitazone Overview

Metformin And Pioglitazone Overview

Metformin/pioglitazone is a prescription medication used to treat type 2 diabetes. It is a single product containing 2 medications: pioglitazone and metformin. Pioglitazone belongs to a group of drugs called thiazolidinediones. These work by increasing the body’s sensitivity to insulin. Metformin belongs to a group of drugs called biguanides. These work by decreasing the amount of glucose absorbed from food and decreasing the amount of glucose that is produced by the liver. This medication comes in tablet form and is taken one or two times a day, with food. Common side effects of metformin/pioglitazone include upper respiratory tract infection, edema, diarrhea, headache, muscle pain, and weight gain. In combination with other medications to treat diabetes, metformin/pioglitazone can also cause hypoglycemia (low blood sugar), which can cause blurred vision and dizziness. Do not drive or operate heavy machinery until you know how metformin/pioglitazone affects you. Continue reading >>

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