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Abnormal Lipid Metabolism In Diabetes

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Lipid Metabolism In The Etiology Of Type 2 Diabetes Esser, Victoria University Of Texas Sw Medical Center Dallas, Dallas, Tx, United States

Lipid Metabolism in the Etiology of Type 2 Diabetes (Scanned from the applicant's description) Type 2 diabetes mellitus has major clinical and social impact, but its underlying pathophysiology is poorly understood. Since the disease is diagnosed as a disorder of carbohydrate metabolism, i.e., hyperglycemia, the possible contribution of abnormal lipid metabolism to its etiology has been largely overlooked. The predominant, obesity-related form of diabetes is characterized by hyperinsulinemia, resistance to insulin-mediated glucose disposal in skeletal muscle, and elevated plasma free fatty acid and triglyceride levels. It has been suggested that a derangement of lipid metabolism is an early event contributing to the development of both hyperinsulinemia and insulin resistance. Our laboratory has demonstrated the essential role that plasma fatty acids play in sustaining normal glucose-stimulated insulin secretion in fasted subjects, and has also utilized novel 1-H NMR spectroscopic techniques to illustrate the strong correlation between intramyocellular lipid (IMCL) content and skeletal muscle insulin resistance. In the current proposal, we seek to expand on this theme by investigati Continue reading >>

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Popular Questions

  1. laura w

    New sugar substitute, Truvia

    Truvia is now available as a sugar substitute. The consistency is similar to sugar more so than any of the other sugar substitute currently available. It is sweeter than splenda with a more natural taste. I do not use Equal as it is metabolized into formaldehyde. I've looked at informational sites on the safety of truvia, and it comes with toxicity warnings. Any comments?

  2. steamfan

    Originally Posted by laura w
    Truvia is now available as a sugar substitute. The consistency is similar to sugar more so than any of the other sugar substitute currently available. It is sweeter than splenda with a more natural taste. I do not use Equal as it is metabolized into formaldehyde. I've looked at informational sites on the safety of truvia, and it comes with toxicity warnings. Any comments? If you don't use Equal because it metabolizes into formaldehyde, you should probably avoid eating apples as well because they metabolize into formaldehyde as well. Considerably more than a single serving of Equal.

  3. Arky

    My concern/issue about Truvia is that that it has 3 carbs per packet. While that's not alot per packet, if you use more than one it can add up. At the times I do use sweeteners, I tend to use from 2 to 4 packets. That's up to 12 extra grams of carbs just from sweetner. I'd rather it come from something more filling.
    Jason

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