Timing Your Metformin Dose
The biggest problem many people have with Metformin is that it causes such misery when it hits their stomachs that they can't keep taking it even though they know it is the safest and most effective of all the oral diabetes drugs. In many cases all that is needed is some patience. After a rocky first few days many people's bodies calm down and metformin becomes quite tolerable. If you are taking the regular form of Metformin with meals and still having serious stomach issues after a week of taking metformin, ask your doctor to prescribe the extended release form--metformin ER or Glucophage XR. The extended release form is much gentler in its action. If that still doesn't solve your problem, there is one last strategy that quite a few of us have found helpful. It is to take your metformin later in the day, after you have eaten a meal or two. My experience with metformin--and this has been confirmed by other people--is that it can irritate an empty stomach, but if you take it when the stomach contains food it will behave. There are some drugs where it matters greatly what time of day you take the drug. Metformin in its extended release form is not one of them. As the name suggests, the ER version of the pill slowly releases the drug into your body over a period that, from my observations, appears to last 8 to 12 hours. Though it is supposed to release over a full 24 hours, this does not appear to be the case, at least not with the generic forms my insurer will pay for. Because there seems to be a span of hours when these extended release forms of metformin release the most drug into your blood stream, when you take your dose may affect how much impact the drug has on your blood sugars after meals or when you wake up. For example, the version I take, made by Teva, releases Continue reading >>
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Metformin ? - March 2015 Babies | Forums | What To Expect
See active discussions on March 2015 Babies Is anyone on metformin because of pcos pregnancy? How much dose? What did your doctor say about whether to continue or stop midway? I am on 850 mg and have a history of high testosterone and DHT because of pcos. I want to continue it throughout my pregnancy. Is it safe? This is my second pregnancy on Metformin for PCOS. I took it my entire pregnancy last time & will this time. I take 2000mgs a day. Last time it was fine until the last 3 weeks when I needed to switch to glyburide do to increasing blood sugar. I've always been told it's safer to take it throughout pregnancy than it is not to. I actually conceived via fertility treatments and I have PCOS. My last pregnancy I was on 850mg until I hit 12 weeks and then my doctor told me to stop. This pregnancy I'm doing the same thing. So far everything is fine. Just ask your doctor and see what he thinks. I've read a lot of PCOS women stay on it. Talk to your doctor about it. With my first pregnancy, I was told to stop at 12w (was on 1500mg). And I weaned myself off until 14w when I stopped completely. Everything was fine after that. I did get gestational diabetes but I think I would've gotten that anyway. This time, my doctor didn't mention anything at my 12w appointment so I've continued taking it. I think she may have just overlooked it though *shrugs* I'm currently on 2000mg a day. I'm sure I'll be told to stop it at my next appointment though next week. My dr stops metformin at 12 weeks. I was on 2000 mg a day and dr said it was fine to stop, there was no need to wean off of it. Both my reproductive endocrinologist and ob/gyn agreed with stopping it at 12 weeks after I conceived through ivf My doctor wants me to continue taking 1500mg throughout my pregnancy which is fine by Continue reading >>
Metformin, Oral Tablet
Metformin oral tablet is available as both a generic and brand-name drug. Brand names: Glucophage, Glucophage XR, Fortamet, and Glumetza. Metformin is also available as an oral solution but only in the brand-name drug Riomet. Metformin is used to treat high blood sugar levels caused by type 2 diabetes. FDA warning: Lactic acidosis warning This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects. Lactic acidosis is a rare but serious side effect of this drug. In this condition, lactic acid builds up in your blood. This is a medical emergency that requires treatment in the hospital. Lactic acidosis is fatal in about half of people who develop it. You should stop taking this drug and call your doctor right away or go to the emergency room if you have signs of lactic acidosis. Symptoms include tiredness, weakness, unusual muscle pain, trouble breathing, unusual sleepiness, stomach pains, nausea (or vomiting), dizziness (or lightheadedness), and slow or irregular heart rate. Alcohol use warning: You shouldn’t drink alcohol while taking this drug. Alcohol can affect your blood sugar levels unpredictably and increase your risk of lactic acidosis. Kidney problems warning: If you have moderate to severe kidney problems, you have a higher risk of lactic acidosis. You shouldn’t take this drug. Liver problems warning: Liver disease is a risk factor for lactic acidosis. You shouldn’t take this drug if you have liver problems. Metformin oral tablet is a prescription drug that’s available as the brand name drugs Glucophage, Glucophage XR, Fortamet, and Glumetza. Glucophage is an immediate-release tablet. All of the other brands are extended-r Continue reading >>
Metformin, Weight Loss & Pcos – Does It Actually Work?
Did you know that one of the main reasons you can't lose weight with PCOS is because of your hormones? It's true, and that's why many women (and physicians) turn to using Metformin to try and help with weight loss. But just because it works for some people doesn't mean it will necessarily work for YOU. Find out why metformin helps with weight loss, but more important what works better and how to finally lose weight if you have PCOS. Insulin & PCOS: Why It's so Important One of the most common medications prescribed for PCOS is metformin. But, PCOS is a hormonal condition which results in weight gain, hair growth on the face, infertility, acne and estrogen/progesterone imbalances. So why is metformin, a medication used to lower blood sugar and treat insulin resistance, used to treat estrogen/progesterone imbalances in women? The logic is quite simple: Most of the symptoms of PCOS (all those listed above) stem from insulin resistanc e! In fact many physicians recommend that ALL women with PCOS should be treated for insulin resistance regardless of what their fasting insulin and fasting blood sugar levels are. This means that the root cause of PCOS (at least the majority of it) is insulin resistance, and this is why metformin is so commonly used to treat. Insulin resistance causes a block of glucose uptake in your skeletal muscles which results in a lower metabolism (and weight gain), insulin also directly acts on your ovaries and adrenals increasing androgens like testosterone and DHEA. It's also the action of insulin on your pituitary that results in increased LH production which over stimulates your ovaries resulting in the characteristic "cysts" of PCOS. High levels of DHEA and testosterone lead to acne and hair growth (hirsutism). But one simple question r Continue reading >>
2000mg Of Metformin???
Well I went to see the new endocrinologist today. This is what he had to say. He upped my dosage from 500mg to 2000mg a day! I will start the increase of 1000 this week, 1500 next week and 2000 the third week. He said I will have GI issues, but after a month my body should get used to it? He also told me its great that I walk 2 mi a day on treadmill, but that will not help me lose weight. He said calorie intake is the only way to lose weight. He said to stay at my current weight, I need 1800 calories a day, if I cut that to 1000-1200 a day, I WILL lose weight. He suggested I do a low gi diet (which I just started) and he suggests to all PCOS patients to either buy shakes for those meals, and then a low gi dinner. He said when you control your calorie intake, you see major difference! So I left there somewhat upset about the 2000 mg of metformin. I have a weak GI to begin with, I dont like using any restroom but my own when I have GI Issues, so it looks like I will be HOUSEBOUND for the next month and half until my body adjusts....lets hope it adjusts sooner rather than later. Anyone else on 2000mg of metformin? Have you lost weight? I am just so discouraged, I feel this PCOS has taken over my life. 10 more lbs and I will weigh as much as I did when I delivered my TWINS!!! Thats nuts. Since my check up at my 6 week appt after giving birth in 2004, I have gained 35 lbs! It is so depressing! I took 2000 mg of Metformin.... I love Metformin!!!! I was on 1000 mg and nothing was happening. My RE switched me to 2000 mg and in two months my cycle started and came both months on the same date and that hasn't happened in over 10 years. I lost 23 lbs in those two months and I wasn't even trying to loose weight and I also FINALLY ovulated and got pregnant with my daughter. While I Continue reading >>
Lowest Price | Metformin 2000 Mg Day
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Metformin Wonder Drug
A while back I wrote about why metformin is the number one treatment for Type 2 diabetes. Now new research finds metformin prevents cancer and heart disease and may actually slow aging! Where can I get this stuff? A study from Scotland found that people on metformin had only roughly half the cancer rate of people with diabetes who weren’t on the drug. This is important, because diabetes is associated with higher risks of liver, pancreas, endometrial, colon and rectum, breast, and bladder cancer. Nobody could explain how metformin helped, but then Canadian researchers showed that metformin reduces cell mutations and DNA damage. Since mutations and DNA damage promote both cancer and aging, this is striking news. No one thought we could limit mutations before, but perhaps metformin can do it. A study on mice exposed to cigarette smoke showed that those given metformin had 70% less tumor growth. A small study of humans in Japan showed similar improvements in colorectal cancer outcomes. Metformin is now being studied in clinical trials for breast cancer. The researchers write, “Women with early-stage breast cancer taking metformin for diabetes have higher response rates to [presurgical cancer therapies] than diabetic patients not taking metformin.” They also had better results than people without diabetes. How Does It Work? According to Michael Pollak, MD, professor in McGill’s Medicine and Oncology Departments, metformin is a powerful antioxidant. It slows DNA damage by reducing levels of “reactive oxygen species” (ROS). ROS are produced as byproducts when cells burn glucose. Just as oxygen helps fires burn or metals rust, ROS will oxidize (“burn” or “rust”) the nuclei or other parts of cells. ROS are what the antioxidant vitamins are supposed to block. Continue reading >>
Whats The Most Metformin You Can Take?
Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. Been type 2 for about a year now. First a1c results were ove 11 and now down around 6.1. Last six months I was having morning fasting numbers between 100-125. However the last month my fasting numbers in the morning are averaging around 150.. There has been no major changes in my diet or excercise progam. I take metformin (1000) twice a day. Exercise regulary and am not overweight. Do you think it may be time to go with more metformin? I see my MD again next month. What is the highest amount of metformin you can take? I did a search, and on medicinenet.com as well as some others, the maximum dosage for metformin is 2550 mg/day, generally divided into 3 doses. I don't think i've ever typed any dication on anyone taking over 1000 mg twice a day (at least in the 3 years i've been on it...probably didn't pay attention before then). Have you experimented with taking your dinner dose at bedtime to see if it will help the a.m. numbers? I take my metformin around 10 pm....just not on an empty stomach. I take 3 mets a day breakfast lunch Dinner. for a total of 1500 I tried moving my dinner metformin to when i go to bed seemed to help me this morning. might have been a fluke I take 1000 met in the morning and 1500 with dinner in the evening I took 850MG 3 x day for a year before I switched to ER version. I was told ER version is only 750MG. I have taken 750mg 3 x day for over a year. I take 1000mg 3 times a day and have done so for about 15 years with no problems. Have you experimented with taking your dinner dose at bedtime to see if it will help the a.m. numbers? I take my metformin around 10 pm....j Continue reading >>
Efficacy, Tolerability, And Safety Of A Novel Once-daily Extended-release Metformin In Patients With Type 2 Diabetes
OBJECTIVE—The purpose of this study was to determine the efficacy and safety of a novel extended-release metformin in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS—Adults with type 2 diabetes (newly diagnosed, treated with diet and exercise only, or previously treated with oral diabetic medications) were randomly assigned to receive one of three extended-release metformin treatment regimens (1,500 mg/day q.d., 1,500 mg/day twice daily, or 2,000 mg/day q.d.) or immediate-release metformin (1,500 mg/day twice daily) in a double-blind 24-week trial. RESULTS—Significant decreases (P < 0.001) in mean HbA1c (A1C) levels were observed by week 12 in all treatment groups. The mean changes from baseline to end point in the two groups given 1,500 mg extended-release metformin (−0.73 and −0.74%) were not significantly different from the change in the immediate-release metformin group (−0.70%), whereas the 2,000-mg extended-release metformin group showed a greater decrease in A1C levels (−1.06%; mean difference [2,000 mg extended-release metformin − immediate-release metformin]: −0.36 [98.4% CI −0.65 to −0.06]). Rapid decreases in fasting plasma glucose levels were observed by week 1, which continued until week 8, and were maintained for the duration of the study. The overall incidence of adverse events was similar for all treatment groups, but fewer patients in the extended-release metformin groups discontinued treatment due to nausea during the initial dosing period than in the immediate-release metformin group. CONCLUSIONS—Once- or twice-daily extended-release metformin was as safe and effective as twice-daily immediate-release metformin and provided continued glycemic control for up to 24 weeks of treatment. Metformin hydrochloride has been w Continue reading >>
- A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes
- A Novel Intervention Including Individualized Nutritional Recommendations Reduces Hemoglobin A1c Level, Medication Use, and Weight in Type 2 Diabetes
- Identification of novel biomarkers to monitor β-cell function and enable early detection of type 2 diabetes risk
Drug information provided by: Micromedex This medicine usually comes with a patient information insert. Read the information carefully and make sure you understand it before taking this medicine. If you have any questions, ask your doctor. Carefully follow the special meal plan your doctor gave you. This is a very important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed. Metformin should be taken with meals to help reduce stomach or bowel side effects that may occur during the first few weeks of treatment. Swallow the extended-release tablet whole with a full glass of water. Do not crush, break, or chew it. While taking the extended-release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about. Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way. You may notice improvement in your blood glucose control in 1 to 2 weeks, but the full effect of blood glucose control may take up to 2 to 3 months. Ask your doctor if you have any questions about this. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the Continue reading >>
High-dose Metformin Safe, Effective In Japanese Adults With Type 2 Diabetes
In Japanese adults with poorly controlled type 2 diabetes, high doses of metformin administered twice or three times daily improved fasting plasma glucose and 24-hour glycemic profile in a dose-dependent fashion, according to findings reported in the Journal of Diabetes Investigation. “While the usual dosage of metformin is over 2,000 mg per day in Europe and the USA, the maximum dose allowed for clinical use in Japan has long been limited to 750 mg per day, which is less than half that of Western countries,” Hiroshi Ikegami, MD, PhD, of the department of endocrinology, metabolism and diabetes at Kindai University in Osaka, Japan, and colleagues wrote. “In addition, the recommended prescription of the maximum dose of metformin in Japan (750 mg per day) has been via 250-mg tablets administered three times per day. ... These differences in dosage and dosing frequency of metformin between Japan and Western countries have made it difficult to translate the results of clinical trials in Western countries to Japanese patients.” In two prospective studies, Ikegami and colleagues analyzed data from 71 Japanese patients with type 2 diabetes recruited between August 2011 and October 2016 from Kindai University Hospital (39 men; mean age, 61 years; mean BMI, 27 kg/m²; mean diabetes duration, 8.4 years; mean FPG, 7.5 mmol/L). All patients were provided standard meals recommended by the Japan Diabetes Society, and treatment with metformin was not initiated until patient FPG reached 11 mmol/L or less, to minimize the confounding effect of an initial improvement in glycemic control due to hospitalization. In the total cohort, 14 patients were treated with metformin monotherapy, whereas 54 patients were prescribed metformin as an add-on therapy to other antidiabetes medication Continue reading >>
The Slower The Better
Endocrine Unit, Careggi University Hospital, Florence, Italy Department of Biomedical Experimental and Clinical Sciences, University of Florence, Obesity Agency, Careggi University Hospital, Viale Pieraccini 6, 50134 Florence, Italy C. M. Rotella, Email: [email protected] . Received 2014 Jan 20; Accepted 2014 Feb 27. This article has been cited by other articles in PMC. A new formulation of metformin: metformin extended-release (ER) is now available, with different formulations in each country and it appears relevant to discuss the management of this drug in clinical practice. Metformin, an oral biguanide hypoglycemic agent, is an efficacious tool in the treatment of type 2 diabetes mellitus. Metformin’s efficacy, security profile, benefic cardiovascular and metabolic effects make this drug as the first agent of choice in the treatment of type 2 diabetes, together with lifestyle modifications [ 1 ]. Type 2 diabetes is characterized by impaired insulin secretion and insulin resistance. Insulin resistance in the fasting state induces an increase in hepatic gluconeogenesis and induces hyperglycemia in the early morning. Metformin, as its major effect, decreases hepatic glucose output lowering fasting glycaemia and, secondarily, it increases glucose uptake in peripheral tissues. It is generally well tolerated, despite the fact that the most common adverse effects are gastrointestinal ones, which may be tampered by dose titration. In monotherapy metformin decreases HbA1c levels by 0.6–1.0 % and this is not accompanied by hypoglycemia in the large majority of patients. Metformin is neutral with respect to weight or, possibly, induces a modest weight loss. The UKPDS has demonstrated a beneficial effect of metformin therapy on CVD outcomes [ 2 ]. Severe renal dysfunc Continue reading >>
Metformin Weight Loss – Does It Work?
Metformin weight loss claims are something that are often talked about by health professionals to be one of the benefits of commencing metformin therapy, but are they true? At myheart.net we’ve helped millions of people through our articles and answers. Now our authors are keeping readers up to date with cutting edge heart disease information through twitter. Follow Dr Ahmed on Twitter @MustafaAhmedMD Metformin is possibly one of the most important treatments in Type II Diabetes, so the question of metformin weight loss is of the utmost importance, as if true it could provide a means to lose weight as well as control high sugar levels found in diabetes. What is Metformin? Metformin is an oral hypoglycemic medication – meaning it reduces levels of sugar, or more specifically glucose in the blood. It is so effective that the American Diabetes Association says that unless there is a strong reason not to, metformin should be commenced at the onset of Type II Diabetes. Metformin comes in tablet form and the dose is gradually increased until the maximum dose required is achieved. How Does Metformin Work & Why Would it Cause Weight Loss? Metformin works by three major mechanisms – each of which could explain the “metformin weight loss” claims. These are: Decrease sugar production by the liver – the liver can actually make sugars from other substances, but metformin inhibits an enzyme in the pathway resulting in less sugar being released into the blood. Increase in the amount of sugar utilization in the muscles and the liver – Given that the muscles are a major “sink” for excess sugar, by driving sugar into them metformin is able to reduce the amount of sugar in the blood. Preventing the breakdown of fats (lipolysis) – this in turn reduces the amount of fatt Continue reading >>
Metformin (glucophage) For Pcos
Metformin (or Glucophage) for polycystic ovararian symdrome (PCOS) by Kelly Why would you be taking metformin or glucophage (metformin is the generic for glucophage) Metformin is a diabetes medicine used for lowering insulin and blood sugar levels in women with polycystic ovary syndrome (PCOS). This helps regulate menstrual cycles, start ovulation, and lower the risk of miscarriage in women with PCOS. It is generally used in conjuction with clomid. The most common side effects of metformin Nausea. Loss of appetite. Diarrhea. Increased abdominal gas. A metallic taste. Tiredness. Problems that might arise and ways to troubleshoot I have always had pretty strong side effects (lots of nausea and always very tired) while taking metformin. It does get better as time goes on but working myself up to the maximum dosage has always been hard. I’ve been to a number of different doctors who have all suggested different ways to work up to my maximum dosage (1500 mg). It is generally suggested that you start with the lowest dose and keep increasing it as you get used to it (or as the side effects start to go away). The first time I took it, I took 500 mg for about three weeks (1 pill in the morning). Then added a second pill at lunch time (so I took 1000 mg for 3 weeks). And, then I added a third pill at dinner time. The second time that I took metformin, I increased the dosage from 500 mg to 1500 mg over the course of three weeks. I was sick a lot but I feel like I got the worst part over with faster. My personal experience has been that it usually takes me about 1 month for the side effects to start to lessen. I will still have bouts of nausea, but after about 2 months that starts to happen less often. My personal tips Always take with food or a glass of milk – I always take my Continue reading >>
Characteristics Of Trials In The Meta-analysis.
NumberPopulationInterventionComparisonRelevant outcomes 22313 singleton pregnancies in women aged 18–45 years with PCOS (Rotterdam criteria). Metformin (850 mg twice daily or 1000 mg twice daily), n = 153. Age 29.5 ± 4.4, BMI 29.8 ± 7160 PCOS. Age 29.1 ± 4.3, BMI 28.6 ± 7.3.Second-trimester miscarriage, preterm delivery, preeclampsia, and gestational diabetes. 25360 nondiabetic PCOS patients (Egypt) (Rotterdam criteria) included were taking metformin for 3–6 months before they became pregnant.200 pregnant women continued on metformin at a dose of 1000–2000 mg daily throughout pregnancy. Age 30.8 ± 2.2, BMI 30.1 ± 1.5.160 women discontinued metformin use at the time of conception. Age 31.5 ± 2.4, BMI 29.6 ± 1.6.Gestational diabetes, preeclampsia, and caesarean section rate. 26274 pregnancies were randomly assigned to either metformin or placebo treatment. Criteria were (1) PCOS diagnosed according to the Rotterdam criteria, (2) age 18–45 yr, (3) gestational age between 5 and 12 wk, and (4) a singleton viable fetus shown on ultrasonography.The metformin (2000 mg daily) treatment in pregnant PCOS women (n = 135). Age 29.6 ± 4.4, BMI 29.5 ± 7.0.Placebo in pregnant PCOS women (n = 138). Age 29.2 ± 4.4, BMI 28.5 ± 7.2.Preeclampsia, preterm delivery, GDM weight, blood pressure, heart rate, and mode and length of delivery. 27197 infertile obese Pakistani women with PCOS (Rotterdam 2003 consensus)119 (cases) were taking metformin 500 mg three times a day and continued throughout pregnancy. 70 conceived while on metformin only. 49 needed additional medications. Age 29 ± 4.1, BMI 32 ± 4.6. In 78 cases, metformin was stopped in first trimester or they conceived without metformin. 21 conceived without medication, 13 conceived on metformin, and 44 required induc Continue reading >>