What Is The Difference Between Glucose And Triglycerides

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The Role Of Insulin And Glucose In Goose Primary Hepatocyte Triglyceride Accumulation

In order to obtain some information on how fatty liver arises in geese, we investigated the role of insulin and glucose in triglyceride (TG) accumulation in goose primary hepatocytes. Goose primary hepatocytes were isolated and treated with insulin and glucose. Compared with the control group, 100 and 150 nmol l–1 insulin increased TG accumulation, acetyl-CoA carboxylase-α (ACCα) and fatty acid synthase (FAS) activity, and the mRNA levels of sterol regulatory element-binding protein-1 (SREBP-1), FAS and ACCα genes. Insulin at 200 nmol l–1 had an inhibiting effect on TG accumulation and the activity of ACC and FAS, but increased the gene expression of SREBP-1, FAS and ACCα. We also found that high glucose (30 mmol l–1) increased the TG level, ACC and FAS activity, and the mRNA levels of SREBP-1 and FAS. However, there was no effect of high glucose on ACCα mRNA level. In addition, the interaction between insulin and glucose was observed to induce TG accumulation, ACC and FAS activity, and gene expression of SREBP-1, FAS and ACCα, and increase SREBP-1 nuclear protein level and binding of nuclear SREBP-1 and the SRE response element of the ACC gene. The result also indicate Continue reading >>

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Popular Questions

  1. Franksta1118

    Triacylglycerol vs. Glucose

    Can somebody provide an explanation of why Triacylglycerols provide more ATP per carbon when fully oxidized to ATP than does Glucose. I'm thinking along the lines of B-Oxidation and such but I'm not too sure how the numbers work out. Thanks a lot!

  2. BloodySurgeon

    In order for a n-carbon fatty acid to be completely oxidized, (n/2)-1 turns of B-oxidation cycles must be completed, which produces (n/2)-1 FADH2, (n/2)-1 NADH, and n/2 acetyl-CoA. Each acetyle-CoA then goes through the citric acid cycle and produces the same amount of ATP as half a glucose. So as long as a fatty acid is 4 carbons or longer, it will produce more ATP than glucose.
    Also remember a triglyceride has three fatty acid chains and have chains usually around 16 carbons long in humans. So if you do the math, there are usually around 9x more ATP in triglycerides.

  3. BloodySurgeon

    This of course is unless information for the mcat... all you need to know is that triglycerides have more energy, but ATP are more usable energy sources by breaking the high energy phosphate bonds.

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