Israeli Device Banishes Finger-pricking For Sugar Levels In Diabetes Patients
Diabetes patients know that one of the greatest challenges in managing the ailment is tracking their blood sugar, or glucose, levels. To do that the only option available today is through the use of standard glucose meters — devices that require multiple finger pricks each day, a painful process. For years, researchers have been trying to find a noninvasive, quicker and easier way to monitor blood glucose. Even the most advanced devices in use today, like needle sensors, which can track glucose continuously, need to be inserted under the skin every one to two weeks. Free Sign Up Now, Caesarea-based startup Cnoga Medical Ltd. says it has come up with a way to track blood glucose levels without pricking or pain. Its glucose meter, already approved for use in numerous countries worldwide, uses a camera to provide a diagnosis of blood glucose levels by observing the changing colors of the user’s finger. During a short training period, the device learns to correlate the user’s skin tone with previous glucose level readings. The technology got the green light on Monday from one of the world’s leading diabetes specialists, Prof. Andreas Pfützner, MD, PhD, who came to Israel to present the company with his findings after having tested the technology in two clinical studies in Germany. “The results were surprising,” he told The Times of Israel in a phone interview. Pfützner held two clinical trials at his institute to validate the performance of the technology, and in both studies he found that the medical device performed “with a surprising level of accuracy,” the same as that of needle sensors. “Cnoga achieved the same level of monitoring as the invasive devices,” he said. “I have not seen this before,” he said. “It is a wonderful device” and a Continue reading >>
Non-invasive Blood Glucose Monitoring Devices Market: Global Industry Analysis And Opportunity Assessment 2017-2027
Diabetes has evolved as one of the primary healthcare epidemic characterized by high sugar levels and principle cause of mortality worldwide. In 2014, World Health Organization (WHO) estimated 8.5% of adults living with diabetes. A diabetic person cannot either synthesize enough insulin (type 1 diabetes) or either does not make enough insulin or cannot effectively use the insulin produced by the body (type 2 diabetes). Another type of diabetes that occur in women during her pregnancy is gestational diabetes. However, gestational diabetes is usually resolved after delivery but can precede towards type 2 diabetes later in a women’s life. Most of the continuous glucose monitoring devices are invasive and involves use of needles leading to increased chance of infection. Furthermore, the invasive glucose monitoring device is considered to be discrete glucose measurement system which cannot be practically used for continuous monitoring of blood glucose. Certain evidences of hyperglycemia between measurements are however not recorded thus resulting in false or no representation of the blood glucose pattern. Noninvasive monitoring of glucose levels eliminates the need of painful pricking with increased risk of infection, and amount of damage caused to the finger tissue. Therefore, non-invasive continuous glucose monitoring devices are being widely investigated and studied over the past few years for their ability to monitor glucose continuously under highly controlled (e.g. in-clinic) conditions. Various techniques that involves measurement of blood glucose levels non-invasively includes, Near Infrared Spectroscopy (NIRS), Mid -Infrared Spectroscopy (Mid-IRS), Raman Spectroscopy, Photo-acoustic Spectroscopy (PA), Optical Coherence Tomography (OCT) and many more. Non- Continue reading >>
A Portable Non-invasive Blood Glucose Monitoring Device
Abstract: Diabetes is known as one of the life threatening diseases in the world that occurs not only among adults and elderly, but also among infants and children. Blood glucose measurements are essential for diabetes patients to determine their insulin dose intake and continuous monitoring is vital to ensure that glucose level is always within the normal range. The commonly used methods to measure glucose level in blood are invasive which are high in accuracy but are usually painful and has higher risk of infections. As an alternative, non-invasive techniques are introduced to develop pain free glucose measuring methods. In this paper, a portable non-invasive blood glucose monitoring device is developed using near infrared sensors. Besides being able to detect glucose concentration in blood, the device is also able to display the glucose level and the required insulin dose, corresponding to the body mass index (BMI) of the user. Several in vitro and in vivo experiments proved the reliability of the device. Results of the experiments proved that the device is reliable in glucose detection with 4% - 16% accuracy compared to the common invasive finger-prick method. Continue reading >>
Apple Is Testing A Noninvasive Blood Glucose Monitor: Cnbc
Apple has tasked a team of 30 engineers with developing a continuous noninvasive blood sugar monitoring technology, according to CNBC. The initiative pits Apple against a technical challenge that has thwarted researchers for years—plus competitors including Alphabet’s Verily—in a push to create a device that frees diabetics from finger-prick blood glucose readings. Work is reportedly fairly advanced. Apple is said to be running the effort from an offsite location in Palo Alto, California. From there, a team of engineers, thought to number 30 as of last year, is working on optical sensors to measure blood glucose noninvasively through the skin. The nature of glucose and other factors means it is tough to accurately record levels using light, but Apple has reportedly advanced to the point that it is running feasibility trials and assessing its regulatory options. With Apple already using an optical sensor in its Watch to measure heart rate, the interest in using light to track glucose suggests that technology developed in the diabetes project has a natural home in its wrist-worn device. However, Apple CEO Tim Cook told The Telegraph in 2015 the timelines for FDA clearance would deter the company from making a regulated Watch. That said, as a continuous noninvasive blood sugar device is likely to appeal to all Type 1 diabetics, some of the 29 million Type 2 diabetics in the U.S. and proponents of the quantified-self movement, the market opportunity is large enough that Apple would have to find a path to market. The bigger question is whether Apple can buck the trend and develop a device that delivers accurate data while meeting consumer usability expectations. Apple is the latest in a line of companies going back years that have tried to crack the challenge. The FDA Continue reading >>
(pdf) A Portable Non-invasive Glucose Monitoring Device
All content in this area was uploaded by Mitra Mohd Addi on Sep 29, 2016 Abstract Diabetes is known as one of the life threatening diseases in the world that occurs not only among adults and elderly, but also among infants and children. Blood glucose measurements are essential for diabetes patients to determine their insulin dose intake and continuous monitoring is vital to ensure that glucose level is always within the normal range. The commonly used methods to measure glucose level in blood are invasive which are high in accuracy but are usually painful and has higher risk of infections. As an alternative, non-invasive techniques are introduced to develop pain free glucose measuring methods. In this paper, a portable non-invasive blood glucose monitoring device is developed using near infrared sensors. Besides being able to detect glucose concentration in blood, the device is also able to display the glucose level and the required insulin dose, corresponding to the body mass index (BMI) of the user. Several in vitro and in vivo experiments proved the reliability of the device. Results of the experiments proved that the device is reliable in glucose detection with 4% - 16% accuracy compared to the common Diabetes Mellitus is one of the common life threatening diseases in the world. Malaysia is ranked 10th in the world with the highest number of population with diabetes (World Health Organization, (WHO), 2013). The number prevalence increases every year due to the changes of humans lifestyles. The main cause of diabetes mellitus is still unrevealed, but it is closely related to body weight, gender, diet, genetic and physical activities[1]. There are many known factors that can develop complications in diabetic patients The effects of diabetes can only be seen between s Continue reading >>
Abbott Wins Fda Approval For Diabetes Device That Doesn't Require Routine Finger Pricks
Abbott wins FDA approval for diabetes device that doesn't require routine finger pricks October 4, 2017 by Lisa Schencker, Chicago Tribune Abbott Laboratories has gained clearance to start selling in the U.S. the first continuous glucose monitor that does not require people with diabetes to routinely prick their fingers. The U.S. Food and Drug Administration recently approved Abbott's FreeStyle Libre Flash Glucose Monitoring System for adults, which already is sold in 41 other countries. The device consists of a small sensor, about the size of a quarter, that's worn on the back of the upper arm to continuously track glucose levels. The sensor, unlike other wearable sensors, does not require patients to prick their fingers for calibration. Patients can place a hand-held reader near the device to see their current glucose levels, trends, patterns and where those levels might be headed. They can then use those readings to figure out how much insulin to take to manage their diabetes. The device has not yet been approved for use by children in the U.S. but Abbott hopes to gain approval from the FDA. The company is not disclosing pricing information until it gets closer to launching the product in the U.S., which will likely be before the end of the year, said Abbott spokeswoman Vicky Assardo. But she said in an email the price will be "very similar" to the price in Europe, where the reader costs about $69, and each sensor, which lasts about 14 days, also costs about $69, before insurance. In the U.S., the sensor will last about 10 days. "We intentionally designed the product to make it as affordable as possible," said Jared Watkin, Abbott senior vice president of diabetes care. In the U.S., continuous glucose monitors are often covered by insurance, Watkin said. He said Abb Continue reading >>
A Truly Non-invasive Glucose Monitoring Device That May Improve Diabetes Management In Patients With Type 2 Diabetes Or Prediabetes
WILMINGTON, Del. and ASHDOD, Israel, Sept. 7, 2017 /PRNewswire/ -- Integrity Applications, Inc. (OTCQB: IGAP), innovator of GlucoTrack®, a non-invasive device for measuring glucose levels in people with type 2 diabetes, presents Data Demonstrating that the performance of GlucoTrack is comparable among patients with prediabetes, newly diagnosed type 2 diabetes and long duration of type 2 diabetes, at the 53rd EASD Annual Meeting in Lisbon, Portugal. The study evaluated the performance of GlucoTrack, a non-invasive glucose monitoring device, in all diabetes populations: patients with prediabetes (N=7), newly diagnosed patients with type 2 diabetes (diabetes duration ≤ 5 years; N=9) and individuals with a long-duration of type 2 diabetes (diabetes duration >5 years; N=16). All participants underwent a calibration day and a trial day that included a pre-prandial measurement and a standardized breakfast followed by six additional measurements over 30-minute intervals. In all groups, 100% of the measurements were in the clinically acceptable A and B zones of the Consensus error grid, with more than 92.5% in the clinically accurate zone A. Mean and median absolute relative difference (ARD) values ranged from 15.6% to 18.3% and from 12.7% to 13.9%, respectively. "The finding of comparable clinical and numerical accuracies across all groups indicates that the device is suitable for people with long and short durations of type 2 diabetes as well as for people with prediabetes, signifying that many patients worldwide may benefit from GlucoTrack," says Dr. Tamar Lin, Lead Research Scientist at Integrity Applications. Non-invasive glucose monitoring devices for home use aim to overcome the barriers of current invasive glucose monitoring methods by offering a simple, painless and Continue reading >>
The Accuracy Of A Non-invasive Glucose Monitoring Device Does Not Depend On Clinical Characteristics Of People With Type 2 Diabetes Mellitus
The accuracy of a non-invasive glucose monitoring device does not depend on clinical characteristics of people with type 2 diabetes mellitus We are experimenting with display styles that make it easier to read articles in PMC. The ePub format uses eBook readers, which have several "ease of reading" features already built in. The ePub format is best viewed in the iBooks reader. You may notice problems with the display of certain parts of an article in other eReaders. Generating an ePub file may take a long time, please be patient. The accuracy of a non-invasive glucose monitoring device does not depend on clinical characteristics of people with type 2 diabetes mellitus Tamar Lin, Yulia Mayzel, and Karnit Bahartan Objective: GlucoTrack is a non-invasive device that indirectly measures glucose fluctuation in the earlobe tissue. Thus, its accuracy may be subjected to a time lag between glucose concentration in blood and tissue. This time lag was shown to depend on individual characteristics related to microvascular complications, such as diabetes duration, HbA1c level, and smoking history. Therefore, the current study investigated the effects of these factors on GlucoTrack performance. Research design and methods: Clinical trials were conducted on 114 people with type 2 diabetes. Device performance was clinically evaluated using Clarke error grid (CEG) analysis and numerically evaluated using the distribution of absolute relative difference (ARD) values. Results: CEG analysis revealed that 98.0% of glucose readings were within the clinically acceptable CEG A + B zones. Total mean ARD was 22.7%. Clinical and numerical accuracies were comparable between never smokers and former/current smokers, but slightly reduced in the HbA1c 7.5% group and in the diabetes duration 15 year Continue reading >>
- Apple reportedly working on noninvasive diabetes sensors
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Diamontech And The Development Of Non-invasive Blood Glucose Monitoring
DiaMonTech and the development of non-invasive blood glucose monitoring DiaMonTech and the development of non-invasive blood glucose monitoring Professor Werner Mntele has considerable experience as a physicist and a physical chemist, and is now Head of Research and Development for DiaMonTech, which has developed technology to revolutionise monitoring glucose levels for diabetics, using molecular spectroscopy the study of the absorption of light by molecules. Mntele has a broad history in analytics and medical issues, in particular molecular analytics. For the past 40 years there has been work on molecular spectroscopy, which he is now using to benefit diabetes patients by offering a non-invasive way to keep track of glucose levels. Diabetes is not only becoming a wider issue among the worlds population, but billions every year are being spent on controlling the disease. According to a study by BCC Research, the global market for diabetes therapeutics and diagnostics was valued at $110bn in 2011 and was set to reach $118.7bn the following year. 2017s market value was expected to reach nearly $157bn after increasing at a five-year CAGR of 5.7%. Grand View Research has also predicted that the global market for devices alone that is, diagnostic, monitoring and insulin delivery products will reach $35.5bn by 2024. Grand View cited major drivers of the market as the growing number of diabetic patients owing to sedentary lifestyles and unhealthy food habits. The report also stated that the growing demand for advances and minimally invasive diagnostic, as well as monitoring, devices is expected to propel the market growth. Theres certainly a demand for a new type of diagnostic product, since Grand View has found that in 2015, the test-strips sub-segment captured the largest m Continue reading >>
Multisensor Noninvasive Blood Glucose Monitoring System
A Thesis by Soumyashree Samadarsinee Bachelor of Technology, Siksha O Anusandhan (SOA) University, 2011 Submitted to the Department of Electrical Engineering and Computer Science and the faculty of the Graduate School of Wichita State University in partial fulfillment of the requirements for the degree of Master of Science All Rights Reserved MULTISENSOR NONINVASIVE BLOOD GLUCOSE MONITORING SYSTEM The following faculty members have examined the final copy of this thesis for form and content, and recommend that it be accepted in partial fulfillment of the requirement for the degree of Master of Science with a major in Computer Networking. _______________________________________ Dr. Abu Asaduzzaman, Committee Chair _______________________________________ Dr. Deepak Gupta, Committee Member _______________________________________ Dr. Yi Song, Committee Member iii DEDICATION To the Almighty, my family for their ultimate encouragement throughout my education and for incomparable advice throughout my life and my gems Ishanee, Tisya, Adrisha, Swaraj, Swayum and Aayana who always find a way to cheer me up. iv ACKNOWLEDGMENTS I am very thankful to my thesis advisor Dr. Abu Asaduzzaman for his continuous encouragement and support throughout my research work. His timely supervision of my work and guidance allowed this research work to be completed on time. He always had time and patience to guide me in accomplishing this work in spite of his busy schedule and offered me assistance from time to time. It has been an honor to work for him as a graduate research assistant. I express my sincere gratitude and thanks towards Dr. Deepak Gupta (Engineering Technology Program) and Dr. Yi Song (EECS Department) for taking time from their busy schedules and serve in my thesis committee. I take Continue reading >>
- Apple reportedly working on noninvasive diabetes sensors
- Abbott's Revolutionary Continuous Glucose Monitoring System, FreeStyle Libre, Now Available To Medicare Patients - Jan 4, 2018
- Exercise and Glucose Metabolism in Persons with Diabetes Mellitus: Perspectives on the Role for Continuous Glucose Monitoring
Fda Approves First Blood Sugar Monitor Without Finger Pricks
FDA approves first blood sugar monitor without finger pricks The FDA has approved a device from Abbott that continuously monitors diabetics’ blood sugar levels without requiring backup finger prick tests. .S. regulators have approved the first continuous blood sugar monitor for diabetics that doesn’t need backup finger prick tests. Current models require users to test a drop of blood twice daily to calibrate, or adjust, the monitor. The pain of finger sticks and the cost of testing supplies discourage many people from keeping close tabs on their blood sugar, which is needed to manage insulin use and adjust what they eat. Abbott’s new FreeStyle Libre Flash Glucose Monitoring System , approved Wednesday by the Food and Drug Administration, uses a small sensor attached to the upper arm. Patients wave a reader device over it to see the current blood sugar level and changes over the past eight hours. Most of the 30 million Americans with diabetes use standard glucose meters, which require multiple finger pricks each day and only show current sugar level. More-accurate continuous glucose monitoring devices are used by about 345,000 Americans. Sign up for our Morning Rounds newsletter But most don’t do the finger pricks to calibrate them and may get inaccurate readings, said Dr. Timothy Bailey, who helped test FreeStyle Libre. “We’re able to lower blood sugar safely” with this technology, said Bailey, director of the Advanced Metabolic Care and Research Institute in California. He receives consulting fees from various diabetes device makers. Too-high blood sugar levels can damage organs and lead to heart attacks, strokes, blindness and amputations. Very low blood sugar can cause seizures, confusion and loss of consciousness. Abbott’s device was approved for ad Continue reading >>
Skin-like Biosensor Offers Needle-free Blood Sugar Monitoring
For people with diabetes, the need to prick fingertips with a lancet every few hours is now over. The advent of sensors for continuous glucose monitoring (CGM) means that patients can read their blood sugar levels in real-time, without the pain and hassles of repeated finger sticks. The latest CGM device, approved in September, doesn’t even require a finger stick for calibration, as other technologies do. But all existing systems are still invasive, expensive and unsightly—involving a clearly visible sensor worn on the arm or abdomen with a tiny needle that enters the skin. And what the community really needs, says Daniel Finan, a research director at JDRF, the non-profit organization formerly known as the Juvenile Diabetes Research Foundation, is a glucose tester that’s cheap, accurate, non-invasive and inconspicuous. Enter the new skin-like biosensor system reported today in the journal Science Advances. It involves first attaching a paper battery to the skin surface to create an electrochemical gradient in the tissue below. The wearer then applies hyaluronic acid—a common ingredient in skin-care products—to the battery’s anode, which pushes the positively charged molecule into the subcutaneous fluid. This changes the osmotic pressure encountered by the blood vessels that run through the skin, causing them to release more glucose that flows to the battery’s cathode at the skin surface. After 20 minutes, the battery is then removed and the biosensor stuck on. It might look like just a tiny square of gold foil, but packed into the gossamer-thin film are five different layers that help convert the sugar molecules into electrical signals that can be read by standard laboratory equipment—or perhaps one day by a small and wearable circuit board. The manufact Continue reading >>
Imagine Living A Healthier Life With Glucowise™
We are developing a new non-invasive glucose monitor that will help you take control of your life. (Caution: GlucoWise is still under development and not available for public testing. If you are interested please use the "Get involved" signup form on this page. Due to the overwhelming demand we are unable to respond to individual emails - we are focused on getting the device to the market quickly). Glucowise™ is a non-invasive, 100% pain-free device that makes traditional blood sampling a thing of the past. Our unique sensor technology will allow you to monitor blood glucose levels without the need to pierce your skin. Simple yet highly reliable, Glucowise™ will exceed industry standards for self-monitoring blood glucose accuracy. You will be able to sample as often as you like and wherever you like, ensuring you avoid sudden hypoglycemic events. Our App and Smart Cloud technology delivers personalised advice and alerts, helping you to fully manage your condition. Intelligent analytics will use your current and historical data to calculate and forecast immediate trends in your blood glucose levels, allowing you to adjust your food or medication intake according to your activities or how you are feeling. Glucowise™ will offer unlimited testing without the need for costly consumables, so you can test as often as you like without having to worry about the cost or pain. The compact design will offer you high levels of privacy. It will take no more than 10 seconds to provide a simple, fast and highly discrete testing experience – anytime, anywhere. The data can then sent wirelessly and securely to your smartphone or tablet. Take control There are many situations whereby conventional testing is challenging. Often people with diabetes will unnecessarily expose themselv Continue reading >>
Noninvasive Blood Glucose Monitoring Device For People With Diabetes In Development
Noninvasive Blood Glucose Monitoring Device For People With Diabetes In Development Novel breathalyzer offers alternative to finger stick testing for people with type 1 and 2 diabetes People with diabetes are one step closer to more easily checking their blood glucose levels with a non-invasive device for detecting and monitoring blood glucose levels, which is currently in development. The hand-held breathalyzer device detects acetone, which has been linked to high blood glucose levels in the breath. The research is being presented at the 2016 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting. The meeting is taking place in Denver Nov. 13-17. Although testing technology has improved in recent decades, with the finger stick testing, as many as 67 percent of people with diabetes may not comply because it is invasive and somewhat painful. Yet, lack of blood-glucose monitoring can result in serious diabetes-related complications. For example, if a person's blood glucose is too low, complications can include seizures, loss of consciousness, and even death. If a person's blood glucose is too high, complications can include infections, cardiovascular disease and nerve and kidney damage. "We believe this technology will be a great improvement in the lives of people with diabetes," said Priefer. "It is the first non-invasive medical device for detecting and monitoring diabetes by connecting one's acetone levels with their blood glucose. We believe it is a necessary alternative to the finger-prick approach for people living with type 1 and type 2 diabetes." Ronny Priefer, Ph.D. and his colleague, Michael Rust, Ph.D., both out of Western New England University in Springfield, Mass., have dev Continue reading >>
Will The Noninvasive Glucose Monitoring Revolution Ever Arrive?
A needle-free alternative to the finger-prick test would be a godsend for many sufferers of diabetes, but the industry has yet to clear the technological hurdles. In the early 2000s, a long-standing problem affecting diabetes sufferers around the world seemed on the brink of being solved. After years of research and development, a needle-free device to measure a person’s blood glucose levels was coming to market—a game-changer for patients fed up with the messy and painful procedure of the blood-drawing finger-prick test. Worn like a wristwatch, Cygnus Incorporated’s GlucoWatch G2 Biographer used weak electric currents to draw glucose from interstitial fluid just under the surface of the skin into an “autosensor.” There, the sugar was oxidized by an enzyme, resulting in the release of hydrogen peroxide that was detected by a metal biosensor. The signal produced by this biosensor could be used, the company claimed, to infer how much glucose was in the fluid, and therefore, after a bit more analysis, in the blood. Approved by the US Food and Drug Administration (FDA) in 2002, the device was intended to provide regular, painless measurements and, at least initially, complement, rather than entirely replace, the finger-prick test used by both type 1 and type 2 diabetics. Nevertheless, the excitement was tangible. The Daily Mail labeled the device “a wristwatch to ease diabetes.” The acting principal deputy commissioner of the FDA called the technology “one of the first steps in developing new products that may one day completely eliminate the need for daily finger-prick tests.” Within months of its release, however, the GlucoWatch gained a bad reputation. Patients reported painful rashes where electrical currents irritated the skin, and the device’s thre Continue reading >>
