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Ibuprofen And A1c

Dear Dr. Roach: Is Inflammation To Blame For Nightly Bathroom Trips?

Dear Dr. Roach: Is Inflammation To Blame For Nightly Bathroom Trips?

Dear Dr. Roach: Is inflammation to blame for nightly bathroom trips? Dear Dr. Roach: I am 80 years old and have had problems with a slightly enlarged prostate for years. This, of course, means frequent nightly trips to the bathroom every one and a half to two hours. I stumbled upon the fact that if I take two ibuprofen (400 mg) at bedtime, I seldom have to go to the bathroom before my normal 6:50 a.m. wake-up time. This has been wonderful, and I wonder if there might be some good medical reasoning here, or if it is just dumb luck on my part. I'm sure many of your readers would be interested in this bedtime subject. A: There have been a few small trials showing that some people's symptoms get better with an anti-inflammatory medicine like ibuprofen. This seems to be the case with both men and women, so it clearly isn't working solely on the prostate. Some authors have speculated that inflammation of the bladder might be the underlying cause for nocturia ("noct" for "nighttime," and "uria" for "urinating"), which is how ibuprofen might work. Small doses are unlikely to cause harm; however, some people with sensitive stomachs might have problems, and people with kidney disease need to be very careful with any anti-inflammatory. Dear Dr. Roach: I am in my 70s, and overweight by 25 pounds. My average sugar level is still around 160. I read that metformin will drop your glucose level by only 20 percent. Will that percentage increase if I take more? If so, by how much? Do I have to take metformin for the rest of my life? Will my body ever correct itself? A: Average sugar level, also called estimated average glucose, is a way to describe blood sugar control in people with diabetes or prediabetes. A level of 160 is equivalent to an A1c level (a more commonly used measure of blo Continue reading >>

Over-the-counter Meds That Raise Blood Glucose

Over-the-counter Meds That Raise Blood Glucose

From cough syrup to decongestants, here are the over-the-counter drugs that may affect your blood glucose Continue reading >>

How To Manage Diabetes While On Oxycodone

How To Manage Diabetes While On Oxycodone

What happens to a person’s blood sugar when they are under stress due to pain, and must take a narcotic pain reliever such as oxycodone? In this article, we will explore what happens to a person with diabetes who is taking long term pain medication. We will look at whether it raises or lowers blood glucose. We will look at how taking oxycodone affects blood glucose levels, activity levels and appetite, and how that could influence the self-management of diabetes. We will look at ways that you can maintain blood glucose in target ranges while taking a narcotic pain reliever such as oxycodone. John’s story As John relayed to me during a phone conversation, he is taking a combination of oxycodone plus acetaminophen for severe pain in his legs related to poor circulation and neuropathy because of his Type 1 diabetes. He has had severe sleep disruption, and was getting no relief on nonsteroidal anti-inflammatory agents. He has been taking oxycodone now for about three months, and has seen a need to increase the basal rate on his insulin pump in order to stay in target range with his blood glucose. He found that once the stress of the pain was gone, his numbers have stayed in range. I suggest reading the following: What is oxycodone? Oxycodone is a narcotic pain reliever that is used to relieve moderate to severe pain. It is in the class of drugs called “opiate analgesics,” and can be found in combination with other nonsteroidal anti-inflammatory medications such as aspirin, acetaminophen, or ibuprofen. Oxycodone can also be found in combination with aspirin and acetaminophen. Each of these components can also have side effects in addition to the oxycodone. Brand names of combination medications include Nortab, Vicodin, and Lortab and Percocet. Precautions for oxycodo Continue reading >>

Non-steroidal Anti-inflammatory Drugs Increase Insulin Release From Beta Cells By Inhibiting Atp-sensitive Potassium Channels

Non-steroidal Anti-inflammatory Drugs Increase Insulin Release From Beta Cells By Inhibiting Atp-sensitive Potassium Channels

Non-steroidal anti-inflammatory drugs increase insulin release from beta cells by inhibiting ATP-sensitive potassium channels We are experimenting with display styles that make it easier to read articles in PMC. The ePub format uses eBook readers, which have several "ease of reading" features already built in. The ePub format is best viewed in the iBooks reader. You may notice problems with the display of certain parts of an article in other eReaders. Generating an ePub file may take a long time, please be patient. Non-steroidal anti-inflammatory drugs increase insulin release from beta cells by inhibiting ATP-sensitive potassium channels Some non-steroidal anti-inflammatory drugs (NSAIDs) incidentally induce hypoglycemia, which is often seen in diabetic patients receiving sulphonylureas. NSAIDs influence various ion channel activities, thus they may cause hypoglycemia by affecting ion channel functions in insulin secreting beta cells. This study investigated the effects of the NSAID meclofenamic acid (MFA) on the electrical excitability and the secretion of insulin from pancreatic beta cells. Using patch clamp techniques and insulin secretion assays, the effects of MFA on the membrane potential and transmembrane current of INS-1 cells, and insulin secretion were studied. Under perforated patch recordings, MFA induced a rapid depolarization in INS-1 cells bathed in low (2.8mM), but not high (28mM) glucose solutions. MFA, as well as acetylsalicylic acid (ASA) and flufenamic acid (FFA), excited the cells by inhibiting ATP-sensitive potassium channels (KATP). In whole cell recordings, KATP conductance consistently appeared when intracellular ATP was diluted. Intracellular glibenclamide prevented the development of KATP activity, whereas intracellular MFA had no effect. At Continue reading >>

Drugs Affecting Hba1c Levels

Drugs Affecting Hba1c Levels

Go to: Diabetes mellitus has assumed epidemic proportions worldwide, causing much morbidity and mortality on account of its various complications. The development of chronic vascular complications of diabetes such as retinopathy, nephropathy and cardiovascular disease is intimately linked to the level of glycemic control attained by the individual with diabetes. Therefore, it is essential to have an index of the long-term glycemic control in diabetes patients, which in turn can be used to guide therapy and predict the likelihood of complications. Glycated hemoglobin (HbA1c) was first described by Rahbar et al. in 1969.[1] Subsequent studies showed that the level of HbA1c correlated well with the glycemic control over a period of 2 to 3 months, leading to the gradual incorporation of the test into clinical practice in the 1980s.[2] With the publication of the Diabetes Control and Complications Trial[3] and the United Kingdom Prospective Diabetes Study,[4] both of which correlated the HbA1c levels to the development of diabetes complications, HbA1c estimation has become established as a cornerstone of diabetes management. Hemoglobin (Hb) is a tetramer formed of two alpha and two beta globin chains. On exposure to high levels of blood glucose, hemoglobin gets non-enzymatically glycated at different sites in the molecule. HbA1c is formed when glucose gets added on to the N-terminal valine residue of the beta chain of Hb.[5] The levels of HbA1c in the blood reflect the glucose levels to which the erythrocyte has been exposed during its lifespan (approximately 117 days in men and 106 days in women). Therefore, the HbA1c is an index of the level of glycemic control over the preceding 2 to 3 months. Of this period, the immediately preceding 30 days contribute 50% to HbA1c.[5] A Continue reading >>

Can Ibuprofen Be Taken Before Or After A A1c?

Can Ibuprofen Be Taken Before Or After A A1c?

My back hurt a bit when I was done, but took some ibuprofen ... "Sounds like so far, so good on all dieting. I am down 2.5 lbs in 2 days, but I am sure most of that is water weight. Still, I'll take it! Norma, I am trying to do the videos too. I did the 1st one the first day. I was able to do the full 30 minutes, mostly doing the adapted exercises. My back hurt a bit when I was done, but took some ibuprofen and all seemed fine. Until the next morning, where again I seemed fine, but must have turned my neck funny and it has been read more... killing me! Don't know if this was the exercising or just a coincidence. Decided not to exercise yesterday--was short on time anyway, as DD2 and I were going to services. Had to get up early this a.m. for more meds, but now it seems much improved. I'll have to see how I am doing later, but would very much like to move on to the 2nd exercise video. DM, So you like the book, it is just different? Ann, The trip sounds like it should be interesting. Good that your friends dropping out does not discourage you from going. The shoes are 3 different styles. I am going to wait and see if they show up today. They said 2 business days, but I don't know if Saturday counts. If not, I will go out tomorrow in search of alternatives (Jan, they are all heels--I am too short to wear flats to an interview :-). All I know about the interview is there are a total of 8 candidates in the 1st round and everyone is being interviewed on Monday or Tuesday. They sent me a bunch of questions I need to be prepared to answer and I have to start with a 5-7 minute presentation on why I want the position and why I think I am qualified. Norma, Work was very quiet for me yesterday too. There were few people in, and everyone pretty much stayed in their offices. I had o Continue reading >>

Go Easy On The Advil, Motrin, Ibuprofen Etc.

Go Easy On The Advil, Motrin, Ibuprofen Etc.

Another study has added to the evidence we already have that suggests that nonsteroidal antinflamatories, the "non-aspirin pain killers" you buy over the counter at the pharmacy are bad for you. The latest study, published in the journal Neurology was hoping to prove that taking these drugs would lower the incidence of dementia. Instead it found the opposite. Here's the study: Risk of dementia and AD with prior exposure to NSAIDs in an elderly community-based cohort. J. C.S. Breitner et al. Neurology 2009, doi:10.1212/WNL.0b013e3181a18691) The researchers "followed 2,736 dementia-free enrollees with extensive prior pharmacy data, following them biennially for up to 12 years to identify dementia and AD." What they found was: Contrary to the hypothesis that NSAIDs protect against AD, pharmacy-defined heavy NSAID users showed increased incidence of dementia and AD, with adjusted hazard ratios of 1.66 (95% confidence interval, 1.24–2.24) and 1.57 (95% confidence interval, 1.10–2.23) This did not surprise me at all, for reasons that were not cited in any discussions of this study. Many people do not realize heavy use of NSAIDs has been linked to high blood pressure and that there appears to be a lifetime dose that dramatically raises the risk of developing end stage kidney disease. I have written about this with appropriate journal citations HERE. One of the studies cited on that page, published in Archives of Internal Medicine , concluded: [Men] who took acetaminophen six or seven days a week had a 34% higher risk of hypertension. Those who took NSAIDs six or seven days a week had a 38% higher risk and those who took aspirin six or seven days a week had a 26% higher risk. High blood pressure is a known cause of vascular dementia, and the older and more fragile people ar Continue reading >>

Ibuprofen Effects On Blood Sugar In Diabetics

Ibuprofen Effects On Blood Sugar In Diabetics

Diabetes is a complex disease, and keeping your blood sugar in control requires more than just counting carbohydrates. Many outside factors, including over-the-counter medications like Ibuprofen, may have an impact on your glucose levels. Diabetes Drug Interactions Ibuprofen may cause an adverse reaction in a diabetic taking oral medication to control his blood sugar, like Diabinase or Orinase. This can lead to unusually high or low blood sugar readings. General Effect on Blood Sugar Readings Aside from the potential diabetes drug interactions mentioned above, Ibuprofen should not cause blood sugar levels to drop or spike noticeably. Frequency Taking Ibuprofen every once in awhile, even if you have diabetes, is generally considered safe. However, regular or prolonged use of Ibuprofen is where problems occur. Discuss diabetes-friendly alternatives with your doctor if you have an ongoing need for NSAIDs (non-steroidal anti-inflammatory drugs). Kidney Complications Multiple studies have linked the regular intake of Ibuprofen with increased chance of kidney failure. Since diabetes already increases your risk for kidney complications, Ibuprofen may worsen these odds. Blood Pressure Drug Complications If you have high blood pressure–a common occurrence among diabetics–you should also be aware that Ibuprofen can negate the effects of many blood pressure medications, including many beta blockers, diuretics, and ACE inhibitors. Continue reading >>

Ibuprofen - Other Medications - Diabetes Forums

Ibuprofen - Other Medications - Diabetes Forums

Registration is fast, simple and absolutely free so please,join our community todayto contribute and support the site. This topic is now archived and is closed to further replies. I stuck this on another thread, and realized it might not get read on a thread about meters, so here it is again. I have had the trouble with my knee hurting for a couple of weeks. My doctor kind of skimmed over it, telling me to just use a little extra aspirin, since I take one daily. But the last few days, my knee hurts so bad it wakes me at night, and my limp is worse. I decided to risk taking a couple of Ibuprofen...I couldn't believe the relief. When I woke in the night and took two more, I actually slept again. But yesterday morning, my BS was 273. Because I was feeling so good, I decided to take the Ibuprofen a couple more days and took 2 about every 6 hours. My knee feels almost normal, but this mornings BS was 350. I took an extra Novolog shot and it is down to 160. Now, do I endure the pain in my knee, or the high BS? The only thing I can think of is the pain itself, my BS has been elevated since the knee started, but just the last two days have I used the Ibuprofen, and had the very high readings. My opinion is that you have hit on the answer yourself. The bad pain is stressing your system you are running adrenaline in response and your liver is responding accordingly - anyway, that's my guess. I hope the pain goes soon - it sounds as bad as toothache. An alternative painkiller that was recommended to me by my pharmacist for when Ibuprofin doesn't work is a mixture of paracetamol and codeine (called Co-codamol in the UK). This works like absolute magic for me. I too have bad knees. The right is notable worse. After the MRI showed I have a problem with the back of the knee cap and a Continue reading >>

Drugs That Can Raise Bg

Drugs That Can Raise Bg

By the dLife Editors Some medicines that are used for treating other medical conditions can cause elevated blood sugar in people with diabetes. You may need to monitor your blood glucose more closely if you take one of the medicines listed below. It’s important to note that just because a medicine has the possibility of raising blood sugar, it does not mean the medicine is unsafe for a person with diabetes. For instance, many people with type 2 diabetes need to take a diuretic and a statin to lower blood pressure and cholesterol. In these and many other cases, the pros will almost always outweigh the cons. Don’t ever take matters of medication into your own hands. Discuss any concerns you have with your healthcare provider. Certain Antibiotics Of all the different antibiotics, the ones known as quinolones are the only ones that may affect blood glucose. They are prescribed for certain types of infection. Levofloxacin (Levaquin) Ofloxacin (Floxin) Moxifloxacin (Avelox) Ciprofloxacin (Cipro, Cipro XR, Proquin XR) Gemifloxacin (Factive) Second Generation Antipsychotics These medicines are used for a variety of mental health conditions. There is a strong association between these medicines and elevated blood sugar, and frequent monitoring is recommended. Clozapine (Clozaril) Olanzapine (Zyprexa) Paliperidone (Invega) Quietiapine (Seroquel, Seroquel XR) Risperidone (Risperdal) Aripiprazole (Abilify) Ziprasidone (Geodon) Iloperidone (Fanapt) Lurasidone (Latuda) Pemavanserin (Nuplazid) Asenapine (Saphris) Beta Blockers Beta blockers are used to treat high blood pressure and certain heart conditions. Not all available beta blockers have been shown to cause high blood sugar. Atenolol Metoprolol Propranolol Corticosteroids Corticosteroids are used to treat conditions where th Continue reading >>

How Pain Relievers Can Affect Blood Sugar Levels

How Pain Relievers Can Affect Blood Sugar Levels

Many of us don’t even think about our blood sugar levels when we’re scrabbling through the medicine cabinet, looking for a pain reliever. We just want to make the pain disappear—stat. But people with diabetes do need to take that matter into consideration when they’re taking any medication. If you have type 2 diabetes, your doctor or diabetes educator has probably warned you to be vigilant about the effects that that your diet, your activity level, and any other medication you take on a regular basis can have on your blood sugar levels. You also need to be careful about any pain relieving medication that you take, even if it’s just on an occasional basis, because certain types of pain killers can lower or raise your blood sugar levels. NSAIDs There are times when you can easily treat pain with an over-the counter pain reliever. You may take a low dose of aspirin or a nonsteroidal anti-inflammatory drug (NSAID) like ibuprofen or naproxen to relieve the occasional headache or muscle pain. A regular dose is unlikely to affect your blood sugar levels, but a higher-than-usual dose may lower your blood sugar level. Talk to your doctor about what’s an appropriate dose for your occasional aches and pains so you don’t accidentally cause an episode of hypoglycemia. Another word of caution. You might have settled on an effective dose of a particular pain reliever that won’t drastically alter your blood sugar levels. But your diabetes puts you at elevated risk for certain other health conditions. So you may have other medical conditions you need to manage—and you will need to watch out for the effect any pain killers you take can have on those. For example, NSAIDS like ibuprofen and naproxen can increase your blood pressure. And they can affect your kidneys, too, Continue reading >>

Ibuprofen?

Ibuprofen?

Member PCOS Type2 since 2003 +/- Insulin Since June 2007 so i usually take aspirin but for really bad muscle pain (as opposed to headaches or whatever) i take ibuprofen. I messed up my back again recently so i've been taking 600 mg of ibuprofen... then someone mentioned something to me and i read the inactive ingrediants which include: cellulose, corn starch, hypormellose, lactose, polydextrose, glycol, stodiaum starch glcolate, stearic acie and titanium dioxide. could this be what's f**king w/my blood sugar? 600 mg is a tiny amount of anything. If anyone of those ingredients were ingested at 600mg they would do nothing to your BG. For example, If the only inactive ingredient in aspirin where sugar and it was present at 600mg, it would be like taking 1/8 of a glucose tablet. Insulin (avg): 19.8 U (35% bolus); CHO (avg): 87g; BG (avg): 97 mg/dl; SD: 31 Tests (avg): 5.1; High: 168; Low: 51; highs>140: 3; lows<70: 10 Member PCOS Type2 since 2003 +/- Insulin Since June 2007 and yeah it's 600 mg of ibuprofen, i'm sure it's trace amounts of the rest of the stuff. I take Ibuprofen when I absolutely need to. For me, and I'm told that we all react differently to different medications, Ibuprofen works very well and doesn't up my B/G levels and BP or upset my stomach, thank heaven! Shaun is very knowledgeable and would know more than I would. I agree with what he shared with us. Aspirin doesn't work for me, nor do any of the other substitutes unless they're prescriptive and I'm on enough prescriptive stuff for my diabetes and high blood pressure now. I'm thinking of opening a pharmacy... :-( Take good care and give the Ibuprofen a try... and maybe take an extra B/G level test or two when you first start taking the Ibuprophen as well... just to see what happens with your particula Continue reading >>

390 Drugs That Can Affect Blood Glucose Levels

390 Drugs That Can Affect Blood Glucose Levels

Knowing the drugs that can affect blood glucose levels is essential in properly caring for your diabetes patients. Some medicines raise blood sugar in patients while others might lower their levels. However, not all drugs affect patients the same way. 390 Drugs that Can Affect Blood Glucose Levels is also available for purchase in ebook format. 390 Drugs that can affect blood glucose Level Table of Contents: Drugs that May Cause Hyper- or Hypoglycemia Drugs That May Cause Hyperglycemia (High Blood Sugar) (GENERIC NAME | BRAND NAME) Abacavir | (Ziagen®) Abacavir + lamivudine,zidovudine | (Trizivir®) Abacavir + dolutegravir + lamivudine | (Triumeq®) Abiraterone | (Zytiga®) Acetazolamide | (Diamox®) Acitretin | (Soriatane®) Aletinib | (Alecensa®) Albuterol | (Ventolin®, Proventil®) Albuterol + ipratropium | (Combivent®) Aliskiren + amlodipine + hydrochlorothiazide | (Amturnide®) Aliskiren + amlodipine | (Tekamlo®) Ammonium chloride Amphotericin B | (Amphocin®, Fungizone®) Amphotericin B lipid formulations IV | (Abelcet®) Amprenavir | (Agenerase®) Anidulafungin | (Eraxis®) Aripiprazole | (Abilify®) Arsenic trioxide | (Trisenox®) Asparaginase | (Elspar®, Erwinaze®) Atazanavir | (Reyataz ®) Atazanavir + cobistat | (Evotaz®) Atenolol + chlorthalidone | (Tenoretic®) Atorvastatin | (Lipitor®) Atovaquone | (Mepron®) Baclofen | (Lioresal®) Belatacept | (Nulojix®) Benazepril + hydrochlorothiazide | (Lotension®) Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued (GENERIC NAME | BRAND NAME) Betamethasone topical | (Alphatrex®, Betatrex®, Beta-Val®, Diprolene®, Diprolene® AF, Diprolene® Lotion, Luxiq®, Maxivate®) Betamethasone +clotrimazole | (Lotrisone® topical) Betaxolol Betoptic® eyedrops, | (Kerlone® oral) Bexarotene | (Targ Continue reading >>

Ibuprofen And Blood Sugar

Ibuprofen And Blood Sugar

Diabetes Forum The Global Diabetes Community Find support, ask questions and share your experiences. Join the community Does anyone know if anti-inflammatories have a side effect of reducing blood sugar levels? I have been taking Ibuprofen for a couple of weeks for a painful tooth, and have noticed that my fasting blood sugar levels are down considerable, and consistently. Is this coincidence? Or is there another explanation? Welcome to the forums. Yes it is possible for NSAID's to lower a1c levels in T2's. Here's a reference study................. Welcome to the forums. Yes it is possible for NSAID's to lower a1c levels in T2's. Here's a reference study................. Welcome to the forums. Yes it is possible for NSAID's to lower a1c levels in T2's. Here's a reference study................. Thank you so much, Urbanracer. I wonder if we should all start taking small doses of anti-inflammatories?! tina_marie Don't have diabetes Well-Known Member My husband is taking them and since he started on them his readings have been low . This morning he was 4.8 and yesterday morning he was 4.5. Thank you, all of you. I understand that anti-inflammatories do indeed reduce blood sugar levels. It is thought that high BS could be caused by inflammation, so logically anti-inflammatories woud be the right treatment. But, as you have warned, these could have a bad effect on the kidneys. I am so disappointed - thought I had stumbled upon a cure of Type ! Where do we go from here? Is there any research going on? Any trials? Continue reading >>

Effort To Lower A1c Levels With Drugs Increases Death Rate In Diabetics

Effort To Lower A1c Levels With Drugs Increases Death Rate In Diabetics

By Jim English While diabetes is the leading cause of kidney failure, blindness and lower limb amputations not caused by accidents or trauma, the most serious threat facing diabetic patients is death from heart attack or stroke. Eighty percent of hospitalizations for patients with diabetes are for macrovascular disorders, such as coronary disease, cerebrovascular disease and peripheral vascular disease, and 75 percent of deaths in diabetics are cardiovascular death, mostly in patients with Type 2 diabetes. To put these numbers in perspective, while a 50-year-old patient with “average” blood pressure and cholesterol levels has a 7 percent chance of experiencing a heart attack in the next 10 years, a 50-year-old diabetic patient faces up to a 50 percent chance of having a heart attack in the next ten years. ACCORD Trial Fails to Protect Diabetic Patients In 2001, the National Institutes of Health (NIH) launched a trial to lower blood glucose levels in diabetic patients to reduce their risk for heart attack, stroke, or death from cardiovascular disease. The trial, called Action to Control Cardiovascular Risk in Diabetes, or ACCORD, involved over 10,000 Type 2 diabetic patients who had either been previously diagnosed with heart disease or had two or more risk factors for heart disease when they entered the study. Participants were randomly assigned to one of two treatment groups. The first group of 5,123 participants was treated with standard drugs and insulin at levels generally approved as the standard for Type 2 diabetes. The second group, consisting of 5,128 participants, was assigned to receive a much more aggressive form of treatment involving higher doses of the standard therapy. For both groups, study clinicians were permitted to use all major classes of FDA-ap Continue reading >>

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