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Diabetes Mellitus Articles 2016

Management Of Diabetes Mellitus In Older People With Comorbidities

Management Of Diabetes Mellitus In Older People With Comorbidities

Abstract Diabetes mellitus is a chronic disease of aging that affects more than 20% of people over 65. In older patients with diabetes, comorbidities are highly prevalent and their presence may alter the relative importance, effectiveness, and safety of treatments for diabetes. Randomized controlled trials have shown that intensive glucose control produces microvascular and cardiovascular benefits but typically after extended treatment periods (five to nine years) and with exposure to short term risks such as mortality (in one trial) and hypoglycemia. Decision analysis, health economics, and observational studies have helped to illustrate the importance of acknowledging life expectancy, hypoglycemia, and treatment burden when setting goals in diabetes. Guidelines recommend that physicians individualize the intensity of glucose control and treatments on the basis of the prognosis (for example, three tiers based on comorbidities and functional impairments) and preferences of individual patients. Very few studies have attempted to formally implement and study these concepts in clinical practice. To better meet the treatment needs of older patients with diabetes and comorbidities, more research is needed to determine the risks and benefits of intensifying, maintaining, or de-intensifying treatments in this population. This research effort should extend to the development and study of decision support tools as well as targeted care management. Continue reading >>

 Bonus Article Medical Treatment Of Diabetes Mellitus

Bonus Article Medical Treatment Of Diabetes Mellitus

Mitka M. Report quantifies diabetes complications. JAMA 2007; 297:23372338. Welschen LM, Bloemendal E, Nijpels G, et al. Self-monitoring of blood glucose in patients with type 2 diabetes who are not using insulin: a systematic review. Diabetes Care 2005; 28:15101517. UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34) [published erratum appears in Lancet 1998; 352:1558]. Lancet 1998; 352:854865. Chase HP, Jackson WE, Hoops SL, Cockerham RS, Archer PG, OBrien D. Glucose control and the renal and retinal complications of insulin-dependent diabetes. JAMA 1989; 261:11551160. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329:977986. Evans JM, Newton RW, Ruta DA, MacDonald TM, Stevenson RJ, Morris AD. Frequency of blood glucose monitoring in relation to glycaemic control: observational study with diabetes database. BMJ 1999; 319:8386. Bergenstal, RM, James GR III; Global Consensus Conference on Glucose Monitoring Panel. The role of self-monitoring of blood glucose in the care of people with diabetes: report of a global consensus conference. Am J Med 2005; 118(suppl 9A):1S6S. American Diabetes Association. Standards of medical care in diabetes2017: summary of revisions. Diabetes Care 2017; 40(suppl 1):S1S135. Schwedes U, Siebolds M, Mertes G; for the SMBG Study Group. Meal-related structured self-monitoring of blood glucose: effect on diabetes control in non-insulin-treated type 2 diabetic patients. Diabetes Care 2002; 25:19281932. Saudek CD, Derr RL, Kalyani RR. Assessing glyc Continue reading >>

Prevalence, Awareness, Treatment, Control Of Type 2 Diabetes Mellitus And Risk Factors In Chinese Rural Population: The Ruraldiab Study

Prevalence, Awareness, Treatment, Control Of Type 2 Diabetes Mellitus And Risk Factors In Chinese Rural Population: The Ruraldiab Study

Article | Open Prevalence, awareness, treatment, control of type 2 diabetes mellitus and risk factors in Chinese rural population: the RuralDiab study Scientific Reports volume 6, Articlenumber:31426 (2016) The study aimed to investigate prevalence, awareness, treatment and control of type 2 diabetes mellitus (T2DM), and to explore potential risk factors in rural areas of China. A total of 16413 individuals aged 1874 years in rural districts were recruited from the Rural Diabetes, Obesity and Lifestyle (RuralDiab) study for the epidemiological research. Meanwhile, a meta-analysis including 7 published studies was conducted to validate the result of the cross-sectional study. The rates of crude and age-standardized prevalence, awareness, treatment and control of T2DM were 12.19%, 67.00%, 62.35%, 22.20% and 6.98%, 60.11%, 54.85%, 18.77%, respectively. The prevalence, awareness, treatment and control of T2DM displayed increased trends with age (Ptrend < 0.01) and were strongly associated with education, drinking, more vegetable and fruit intake, physical activity, family history of diabetes, body mass index (BMI). The results of this meta-analysis showed that the pooled prevalence, awareness, treatment and control of T2DM in China countryside were 7.3% (5.39.4%), 57.3% (36.977.6%), 48.4% (32.464.5%) and 21.0% (9.932.1%), respectively. The prevalence of T2DM was high with inadequate awareness, treatment and control of T2DM in China rural areas. Healthy lifestyles should be advocated to reduce prevalence and improve awareness, treatment, and control of T2DM in Chinese rural residents. As the third leading cause of mortality, diabetes seriously threatens to human health worldwide 1 , 2 , and it has caused large disease burden to the patients, their families and the society, Continue reading >>

Management Of Hypertension And Diabetes Mellitus By Cardiovascular And Endocrine Physicians: A China Registry

Management Of Hypertension And Diabetes Mellitus By Cardiovascular And Endocrine Physicians: A China Registry

Current hypertension guidelines provide recommendations specifically for patients with diabetes mellitus, such as, for instance, intensive target of blood pressure (BP) control and initial use of inhibitors of the reninangiotensin system [1,2] . Current diabetes guidelines provide similar recommendations for the management of hypertension, although there is not much guidance on the management of diabetes mellitus in the presence of hypertension [3,4] . The presence of both hypertension and diabetes mellitus confers a higher risk of cardiovascularrenal disease than the presence of either condition alone [5] . In addition, the presence of both hypertension and diabetes mellitus makes the management of both diseases difficult and complicated [6] . In a recent Chinese registry, the control rate of hypertension in patients with both hypertension and diabetes mellitus was only 14.9%, being much lower than in those patients without diabetes mellitus (45.9%) [7] . In spite of low control rate of hypertension, physicians are often hesitating to add more antihypertensive drugs, such as diuretics [8] , because of the concerns for side effects, such as hypokalaemia, and potential negative effects on insulin release. In China, diabetes mellitus is managed by endocrine physicians and hypertension mainly by cardiovascular physicians. Although patients may move between the two departments and physicians may exchange ideas and views on the management of both diseases, comparative information is scarce. We therefore performed a multicentre registry across the two departments to investigate the prevalence and management of the presence of both hypertension and diabetes mellitus and the association of albuminuria with both diseases. The present study was designed as a cross-sectional, mul Continue reading >>

Trends In Diabetes: Sounding The Alarm

Trends In Diabetes: Sounding The Alarm

Diabetes is a major cause of death and disability worldwide. In 2012 it caused as many deaths as HIV/AIDS (1·5 million).1 Disability resulting from diabetes has grown substantially since 1990, with particularly large increases among people aged 15–69 years.2 People with all types of diabetes are at risk of developing a range of complications that can endanger their health and survival, and the high costs of care increase the risk of catastrophic medical expenditure.3 Diabetes is the theme of this year's World Health Day on April 7, and WHO has published the Global Report on Diabetes to raise awareness and spark momentum for action at the necessary scale. In The Lancet, the NCD Risk Factor Collaboration (NCD-RisC)4 presents a robust and timely analysis of trends in diabetes prevalence. They provide updated, consistent, and comparable estimates of age-standardised prevalence of diabetes since 1980, derived from 751 population-based measurement studies involving nearly 4·4 million participants. These are the first global estimates and trend analyses published since adoption of the voluntary target to halt the rise in diabetes and obesity (against the 2010 baseline) by 2025. The news is not good. NCD-RisC estimates that the number of people with diabetes quadrupled between 1980 and 2014. Age-standardised prevalence among adult men doubled during that time (from 4·3% [95% credible interval 2·4–7·0] to 9·0% [7·2–11·1]), and age-standardised prevalence among adult women increased by 60% (5·0% [2·9–7·9] to 7·9% [6·4–9·7]). Diabetes prevalence either increased or remained the same in every country. Given these trends, the authors calculate that only a few countries, mostly in western Europe, have even a chance of meeting the target to halt the rise in dia Continue reading >>

Complications Of Diabetes 2016

Complications Of Diabetes 2016

Journal of Diabetes Research Volume 2016 (2016), Article ID 6989453, 3 pages 1Diabetes Clinic, Second Department of Internal Medicine, Democritus University of Thrace, 68100 Alexandroupolis, Greece 2Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland 3Diabetic Foot Clinic, King’s College Hospital, London, UK Copyright © 2016 Konstantinos Papatheodorou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The prevalence of diabetes (DM) is constantly increasing worldwide at an alarming rate. According to the International Diabetes Federation in 2015, an estimated 415 million people globally were suffering from this condition [1]. Complications of DM account for increased morbidity, disability, and mortality and represent a threat for the economies of all countries, especially the developing ones [2]. The present special issue has been devoted to the recent progress in our understanding of diabetic complications, including the underlying molecular mechanisms, new diagnostic tools that facilitate early diagnosis, and novel treatment options. It consists of 20 articles covering 5 thematic areas: (a) epidemiology and pathogenesis of diabetic complications, (b) microvascular complications, (c) macrovascular complications, (d) miscellaneous complications, and (e) treatment options. (a) Epidemiology and Pathogenesis of Diabetic Complications. There is growing evidence that the underlying mechanisms in the pathogenesis of diabetic complications include certain genetic and epigenetic modifications, nutritional factors, and sedentary lifestyle [3]. In a pa Continue reading >>

Management Of Diabetes Mellitus In Older People With Comorbidities

Management Of Diabetes Mellitus In Older People With Comorbidities

Management of diabetes mellitus in older people with comorbidities Management of diabetes mellitus in older people with comorbidities BMJ 2016; 353 doi: (Published 15 June 2016) Cite this as: BMJ 2016;353:i2200 Elbert S Huang, associate professor of medicine Department of Medicine, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA Diabetes mellitus is a chronic disease of aging that affects more than 20% of people over 65. In older patients with diabetes, comorbidities are highly prevalent and their presence may alter the relative importance, effectiveness, and safety of treatments for diabetes. Randomized controlled trials have shown that intensive glucose control produces microvascular and cardiovascular benefits but typically after extended treatment periods (five to nine years) and with exposure to short term risks such as mortality (in one trial) and hypoglycemia. Decision analysis, health economics, and observational studies have helped to illustrate the importance of acknowledging life expectancy, hypoglycemia, and treatment burden when setting goals in diabetes. Guidelines recommend that physicians individualize the intensity of glucose control and treatments on the basis of the prognosis (for example, three tiers based on comorbidities and functional impairments) and preferences of individual patients. Very few studies have attempted to formally implement and study these concepts in clinical practice. To better meet the treatment needs of older patients with diabetes and comorbidities, more research is needed to determine the risks and benefits of intensifying, maintaining, or de-intensifying treatments in this population. This research effort should extend to the development and study of decision support tools as well as targeted care managem Continue reading >>

World Journal Of Diabetes - Baishideng Publishing Group

World Journal Of Diabetes - Baishideng Publishing Group

High impact papers are those to which special attention is paid by experts in the given field, with a large number of visitors, frequent downloads and higher citation rates. The research must be creative, with high academic standards and have a wide influence, if it is to become a high impact paper. They are ranked by the number of downloads. Update on the treatment of type 2 diabetes mellitus Juan Jos Marn-Pealver, Iciar Martn-Timn, Cristina Sevillano-Collantes, Francisco Javier del Caizo-Gmez World J Diabetes 7(17):354-395. Published online Sep 15, 2016. doi: 10.4239/wjd.v7.i17.354 Short acting insulin analogues in intensive care unit patients Federico Bilotta, Carolina Guerra, Rafael Badenes, Simona Lolli, Giovanni Rosa World J Diabetes 5(3):230-234. Published online Jun 15, 2014. doi: 10.4239/wjd.v5.i3.230 Literature review on the management of diabetic foot ulcer Leila Yazdanpanah, Morteza Nasiri, Sara Adarvishi World J Diabetes 6(1):37-53. Published online Feb 15, 2015. doi: 10.4239/wjd.v6.i1.37 Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus World J Diabetes 6(3):456-480. Published online Apr 15, 2015. doi: 10.4239/wjd.v6.i3.456 Adiponectin: Probe of the molecular paradigm associating diabetes and obesity World J Diabetes 6(1):151-166. Published online Feb 15, 2015. doi: 10.4239/wjd.v6.i1.151 Role of vitamin D in diabetes mellitus and chronic kidney disease Akio Nakashima, Keitaro Yokoyama, Takashi Yokoo, Mitsuyoshi Urashima World J Diabetes 7(5):89-100. Published online Mar 10, 2016. doi: 10.4239/wjd.v7.i5.89 Abstract (454) | Core Tip (367) | Full Article (HTML) (3442) | Full Article (PDF)-1055K (1753) | Full Article (Word)-393K (131) | Audio-2465K (17) | Peer-Review Report-133K (88) | Answering Reviewers-96K (74) | PubMed Centra Continue reading >>

Diagnosis And Management Of Diabetes: Synopsis Of The 2016 American Diabetes Association Standards Of Medical Care In Diabetes Free

Diagnosis And Management Of Diabetes: Synopsis Of The 2016 American Diabetes Association Standards Of Medical Care In Diabetes Free

Description: The American Diabetes Association (ADA) published the 2016 Standards of Medical Care in Diabetes (Standards) to provide clinicians, patients, researchers, payers, and other interested parties with the components of diabetes care, general treatment goals, and tools to evaluate the quality of care. Methods: The ADA Professional Practice Committee performed a systematic search on MEDLINE to revise or clarify recommendations based on new evidence. The committee assigns the recommendations a rating of A, B, or C, depending on the quality of evidence. The E rating for expert opinion is assigned to recommendations based on expert consensus or clinical experience. The Standards were reviewed and approved by the Executive Committee of the ADA Board of Directors, which includes health care professionals, scientists, and laypersons. Feedback from the larger clinical community was incorporated into the 2016 revision. Recommendations: The synopsis focuses on 8 key areas that are important to primary care providers. The recommendations highlight individualized care to manage the disease, prevent or delay complications, and improve outcomes. Since 1989, the American Diabetes Association (ADA) Standards of Medical Care in Diabetes (Standards) have provided the framework for evidence-based recommendations to treat patients with diabetes. This synopsis of the 2016 ADA Standards highlights 8 areas that are important to primary care providers: diagnosis, glycemic targets, medical management, hypoglycemia, cardiovascular risk factor management, microvascular disease screening and management, and inpatient diabetes management. Guideline Development and Evidence Grading Recommendations for Glycemic Targets Medical Management of Diabetes Type 1 Diabetes Type 2 Diabetes Cardiovascu Continue reading >>

Diabetes Mellitus

Diabetes Mellitus

Since 1998 the Diabetes Mellitus (or Sakharni Diabet) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of diabetology. The Journal is aimed to provide a forum to discuss etiology and pathogenesis, clinical features, modern diagnostic and treatment approaches to diabetes mellitus and its complications, as well as associated conditions. features original national and foreign research articles, reflecting world diabetology development issues thematic editions on specific areas (diabetic nephropathy, diabetic neuropathy, diabetic retinopathy, etc.); publishes chronicle of major international congress sessions and workshops on diabetes mellitus, as well as state-of-the-art guidelines; is intended for scientists, diabetologists, endocrinologists and specialists of allied trade, general practitioners, family physicians and pediatricians. The Diabetes Mellitus Journal is included into the List of leading scientific peer-reviewed journals, where principal data of applicants for scientific degree has to be published, as decreed by State Commission for Academic Degrees and Titles in Bulletin 2 of 2003 and revised in 2010. The Diabetes Mellitus journal is currently indexed in Scopus (Elsevier), Emerging Sources Citation Index (Web of Science, Thomson Reuters), Google Scholar and Russian Science Citation Index . All articles in the Diabetes Mellitus journal are published in Open Access (Gold) format with Free Full-text access to all articles via several websites ( dia.endojournals.ru , www.elibrary.ru , www.cyberleninka.ru ) and mobile applications for iOS (available in AppStore ). The journal is open for Russian and English language manuscripts. All English language manuscripts are publish Continue reading >>

Dentistry Journal | Free Full-text | Diabetes Mellitus And Its Association To The Occurrence Of Medication-related Osteonecrosis Of The Jaw

Dentistry Journal | Free Full-text | Diabetes Mellitus And Its Association To The Occurrence Of Medication-related Osteonecrosis Of The Jaw

Dent. J. 2016, 4(2), 17; Diabetes Mellitus and Its Association to the Occurrence of Medication-Related Osteonecrosis of the Jaw Department of Oral and Maxillofacial Surgery of the University Medical Center of the Johannes Gutenberg-University, Augustusplatz 2, 55131 Mainz, Germany Author to whom correspondence should be addressed. Received: 17 April 2016 / Revised: 22 May 2016 / Accepted: 24 May 2016 / Published: 31 May 2016 View Full-Text | Download PDF [192 KB, uploaded 31 May 2016] To date there is no consensus on the role of diabetes in the development of medication-related osteonecrosis of the jaws (MR-ONJ). Therefore, this study aimed to investigate the prevalence of diabetes and pathological glucose metabolism in patients with MR-ONJ compared to the general population. All maxillofacial surgery inpatients in one year at our department were investigated regarding diagnosis, anamnesis, medication, and blood glucose readings. 1374 records were analyzed. 35 patients with MR-ONJ were identified. Diabetics accounted for 14.3%. No significant difference in the prevalence of known diabetes was found, except for pathological glucose metabolism in patients with MR-ONJ (p < 0.001). Diabetes does not necessarily promote the onset of MR-ONJ. Therefore, diabetes should not be considered as a standalone risk factor. On the contrary, hyperglycemia as a possible indicator for poorly managed or yet undetected diabetes is associated with MR-ONJ. View Full-Text Continue reading >>

International Journal Of Diabetes And Clinical Research | Clinmed International Library

International Journal Of Diabetes And Clinical Research | Clinmed International Library

International Journal of Diabetes and Clinical Research is a global peer reviewed open access journal that emphasis on the different aspects of clinical diabetes. It highlights the investigative reports focusing on areas such as the pathogenesis of diabetes and its complications, normal and pathologic pancreatic islet function and intermediary metabolism, pharmacological mechanisms of drug and hormone action, and biochemical and molecular aspects of normal and abnormal biological processes. Clinical Diabetes acts as platform for the diabetes health care practitioners and clinicians to represent their original work, reviews, commentaries, shorts communications, letters, oral presentations and case studies. The classification terms include but not limited to Type 1 Diabetes, Type 2 diabetes, Diabetes care, Insulin Resistance, Insulinotherapy, Endocrinology, Gestational diabetes, Prediabetes, Metabolic Syndrome, Diabetic risk factors, Blood glucose dynamics and Diabetes- Therapeutic approaches. International Journal of Diabetes and Clinical Research ensures the faster publication of high quality articles with the support of its eminent Editorial board members. Two independent review comments followed by editor's decision will be considered to publish the article. IJDCR is a permanent archive of Diabetes information which under open access category provides its global readers with free access to its content, thus serving the scientific community. Continue reading >>

Journal Of Diabetes Mellitus (jdm)

Journal Of Diabetes Mellitus (jdm)

Although abnormalities in the fatty acid composition of serum and red cell membrane phospholipids of patients with type 2 diabetes are well-documented, lacking are studies of this issue in prediabetic individuals.For this cross-sectional study, we recruited 180 subjects (30-80 years), 56 of whom were normal with regard to glucose control (HbA1c, <5.7%), 61 who had prediabetes (HbA1c, 5.7%-6.4%) and 59 who had type 2 diabetes (HbA1c, >6.5%). Serum phospholipids were isolated and analyzed for fatty acids.Most importantly, the fatty acid compositions of the controls and prediabetic subjects were not different for 19 fatty acids. However, the fatty acid profile of the phospholipids of the patients with diabetes differed from the other two groups; the 14 to 18-carbon saturated fatty acids were decreased by 12%-26% whereas the unsaturated fatty acids 16:1n-7, 18:1n-9, 18:2n-6, 20:3n-6 and 20:4n-6 were increased by 45%-64%. Of note, the docosahexaenoic acid (DHA) status of individuals in all three study groups was remarkably low compared with international values, as indicated by DHA proportions in the 1.62%-2.07% range, and there were no differences between groups. The mean melting point of the phospholipid fatty acids of the diabetic patients (32.2C) was significantly lower (p < 0.001) than that of the prediabetic subjects (38.1C) and the controls (39.9C) which were not different from each other.These observations indicate that the fatty acid changes associated with type 2 diabetes follow the onset of the disease as opposed to being a causative factor of poor glucose control and insulin insensitivity. This study was done to assess whether self monitoring of blood glucose is associated with better glycaemic control in type 2 diabetic Trinidadians. Data was collected from 146 Continue reading >>

Journal Of Diabetes & Metabolic Disorders

Journal Of Diabetes & Metabolic Disorders

Journal of Diabetes & Metabolic Disorders The prevalence of diabetes mellitus is increasing in Indonesia due to population growth, urbanization, and lifestyle. Diabetes mellitus (DM) is the leading cause of chronic kidney disease that escalates mortal... Authors: Laurentia Mihardja, Delima Delima, Roy G. A. Massie, Muhammad Karyana, Pringgodigdo Nugroho and Em Yunir Citation: Journal of Diabetes & Metabolic Disorders 2018 :338 Increased serum complement C3 has been related to body fat mass, metabolic syndrome and chronic diseases. The purpose of this study was to evaluate the levels of C3 in the subjects of normal weight obese (here... Authors: Maryam Karkhaneh, Mostafa Qorbani, Mohamad Reza Mohajeri-Tehrani and Saeed Hoseini Citation: Journal of Diabetes & Metabolic Disorders 2017 16:49 Iranian university students lifestyle and health status survey: study profile The physical health assessment of university students in Iran is a national large scale assessment examining health behaviors among tertiary education students. Understanding risky health behaviors which are t... Authors: Masoume Mansouri, Farshad Sharifi, Mehdi Varmaghani, Hamid Yaghubi, Yousef Moghadas Tabrizi, Maede Raznahan, Alireza Khajavi, Maryam Ghodsi, Payam Roshanfekr, Gita Shafiee, Abasali Keshtkar and Mahdi Ebrahimi Citation: Journal of Diabetes & Metabolic Disorders 2017 16:48 Carbohydrate restricted diet regimen is widely accepted as therapeutic approach for the treatment of kidney disease associated with type-2 diabetes, obesity and hypertensive disorders. The present study tested... Authors: Pawan Krishan, Gaaminepreet Singh and Onkar Bedi Citation: Journal of Diabetes & Metabolic Disorders 2017 16:47 We had earlier reported that the extract of Pueraria tuberosa significantly inhibits DPP-IV en Continue reading >>

Publication Trends Of Research On Diabetes Mellitus And T Cells (19972016): A 20-year Bibliometric Study

Publication Trends Of Research On Diabetes Mellitus And T Cells (19972016): A 20-year Bibliometric Study

Publication trends of research on diabetes mellitus and T cells (19972016): A 20-year bibliometric study Contributed equally to this work with: Ye Gao, Yiran Wang, Xiao Zhai Roles Investigation, Methodology, Writing original draft Affiliation Graduate Management Unit, Changhai Hospital Affiliated to theSecond Military Medical University, Shanghai, China Contributed equally to this work with: Ye Gao, Yiran Wang, Xiao Zhai Roles Data curation, Software, Writing original draft Affiliations Graduate Management Unit, Changhai Hospital Affiliated to theSecond Military Medical University, Shanghai, China, Department of Oncology, Changhai Hospital Affiliated to the SecondMilitary Medical University, Shanghai, China Contributed equally to this work with: Ye Gao, Yiran Wang, Xiao Zhai Roles Formal analysis, Resources, Software Affiliation Department of Orthopedics, Changhai Hospital Affiliated to the SecondMilitary Medical University, Shanghai, China Continue reading >>

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