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Can Antibiotics Affect Insulin Levels?

Use Of Antibiotics And Risk Of Type 2 Diabetes: A Population-based Case-control Study

Use Of Antibiotics And Risk Of Type 2 Diabetes: A Population-based Case-control Study

Go to: Abstract Context and objective: Evidence that bacteria in the human gut may influence nutrient metabolism is accumulating. We investigated whether use of antibiotics influences the risk of developing type 2 diabetes and whether the effect can be attributed to specific types of antibiotics. We conducted a population-based case-control study of incident type 2 diabetes cases in Denmark (population 5.6 million) between January 1, 2000, and December 31, 2012. Data from the Danish National Registry of Patients, the Danish National Prescription Registry, and the Danish Person Registry were combined. Results: The odds ratio (OR) associating type 2 diabetes with exposure to antibiotics of any type was 1.53 (95% confidence interval 1.50–1.55) with redemption of more than or equal to 5 versus 0–1 prescriptions. Although no individual group of antibiotics was specifically associated with type 2 diabetes risk, slightly higher ORs for type 2 diabetes were seen with narrow-spectrum and bactericidal antibiotics (OR 1.55 and 1.48) compared to broad-spectrum and bacteriostatic types of antibiotics (OR 1.31 and 1.39), respectively. A clear dose-response effect was seen with increasing cumulative load of antibiotics. The increased use of antibiotics in patients with type 2 diabetes was found up to 15 years before diagnosis of type 2 diabetes as well as after the diagnosis. Our results could support the possibility that antibiotics exposure increases type 2 diabetes risk. However, the findings may also represent an increased demand for antibiotics from increased risk of infections in patients with yet-undiagnosed diabetes. Continue reading >>

Amoxicillin & Insulin

Amoxicillin & Insulin

Amoxicillin is an antibiotic used to treat various types of infection. If you are taking insulin for diabetes or other diseases, taking amoxicillin might give you cause for concern. In most cases, amoxicillin does not interact with insulin, although the infection it is treating might cause changes in your blood sugar levels. Consult your doctor if you have any concerns about taking amoxicillin. Video of the Day The drug amoxicillin is a penicillin antibiotic primarily used to treat infections caused by bacteria, such as bladder infections or pneumonia. Amoxicillin does not treat viral infections. According to consumer website Drugs.com, amoxicillin can cause issues if you have asthma, liver disease, kidney disease or mononucleosis. It is not known to cause issues with insulin or in those with diabetes. However, you should not take amoxicillin if you are allergic to penicillin. Insulin is a hormone produced by the pancreas. The primary function of insulin is to control the level of glucose, or blood sugar, in the body. When you consume foods in the form of basic sugars or carbohydrates, your body breaks them down into glucose, which it then absorbs into your bloodstream. If the level of glucose in your blood gets too high, your pancreas secretes insulin, which then prompts cells in your fat tissues, liver and muscle tissues to take up glucose and store it in the form of glycogen for later use. In those with diabetes and other insulin-related diseases, the ability of the body to secrete or take up insulin is impaired, leading to potentially harmful levels of blood glucose. Taking amoxicillin does not directly interfere with the level of insulin in your body, according to Dr. Sheetal Kaul of the Ask Doctor Free website. However, the infection you are treating with the amox Continue reading >>

Do Antibiotics Raise Diabetes Risk Via Gut Microbiota?

Do Antibiotics Raise Diabetes Risk Via Gut Microbiota?

Do Antibiotics Raise Diabetes Risk via Gut Microbiota? People who take multiple courses of antibiotics may face an increased risk of developing both type 1 and type 2 diabetes, potentially through alterations in gut microbiota, conclude US researchers. The team, led by Ben Boursi, MD, a postdoctoral researcher in the department of gastroenterology at the University of Pennsylvania, Philadelphia, found that the risk of diabetes was increased by up to 37%, depending on the type of antibiotic and the number of courses prescribed. "Overprescription of antibiotics is already a problem around the world as bacteria become increasingly resistant to their effects," commented Dr Boursi in a statement. "Our findings are important, not only for understanding how diabetes may develop, but as a warning to reduce unnecessary antibiotic treatments that might do more harm than good." The study was published online ahead of print March 24 in the European Journal of Endocrinology. The More Courses of Antibiotics, the Greater the Risk Dr Boursi explained that studies both in animal models and humans have shown an association between changes in gut microbiota in response to antibiotic exposure and obesity, insulin resistance, and diabetes. Speaking to Medscape Medical News, he noted: "In mice, we know that germ-free mice are lean and, by fecal transplantation, we can transmit obesity to them. We also know that low dose of penicillin may induce obesity in mice models." He added that there have been several studies in humans indicating that exposure to antibiotics in early childhood is associated with an increased risk of obesity in later life, while other investigations have reported differences in gut microbiota between people with and without diabetes. To investigate further, Dr Boursi an Continue reading >>

Effect Of Antibiotics On Gut Microbiota, Gut Hormones And Glucose Metabolism

Effect Of Antibiotics On Gut Microbiota, Gut Hormones And Glucose Metabolism

Effect of Antibiotics on Gut Microbiota, Gut Hormones and Glucose Metabolism 1Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark 2NNF Centre for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 2NNF Centre for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 2NNF Centre for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 3Endocrine Research Unit, University of Southern Denmark, Odense, Denmark 2NNF Centre for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 1Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark 2NNF Centre for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 1Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark 2NNF Centre for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 3Endocrine Research Unit, University of Southern Denmark, Odense, Denmark 4National Food Institute, Technical University of Denmark, Sborg, Denmark 5Department of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark 6Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark 7Department of Clinical Biochemistry, R Continue reading >>

Drugs That Can Worsen Diabetes Control

Drugs That Can Worsen Diabetes Control

One of the main goals of any diabetes control regimen is keeping blood glucose levels in the near-normal range. The cornerstones of most plans to achieve that goal include following a healthy diet, getting regular exercise, and taking insulin or other medicines as necessary. However, it’s not uncommon for people with diabetes to have other medical conditions that also require taking medicines, and sometimes these drugs can interfere with efforts to control blood glucose. A few medicines, including some commonly prescribed to treat high blood pressure and heart disease, have even been implicated as the cause of some cases of diabetes. This article lists some of the medicines that can worsen blood glucose control, the reasons they have that effect, the usual magnitude of the blood glucose changes, as well as the pros and cons of using these drugs in people who have diabetes. Where the problems occur To understand how various medicines can worsen blood glucose control, it helps to understand how insulin, the hormone responsible for lowering blood glucose, works in the body. Insulin is released from the beta cells of the pancreas in response to rising levels of glucose in the bloodstream, rising levels of a hormone called GLP-1 (which is released from the intestines in response to glucose), and signals from the nerve connections to the pancreas. The secretion of insulin occurs in two phases: a rapid first phase and a delayed second phase. Both of these phases are dependent on levels of potassium and calcium in the pancreas. Insulin acts on three major organs: the liver, the muscles, and fat tissue. In the liver, insulin enhances the uptake of glucose and prevents the liver from forming new glucose, which it normally does to maintain fasting glucose levels. In muscle and f Continue reading >>

Drug-induced Low Blood Sugar

Drug-induced Low Blood Sugar

Low blood sugar (hypoglycemia) is common in people with diabetes who are taking insulin or other medicines to control their diabetes. All of the following can cause blood sugar (glucose) level to drop: Drinking alcohol Getting too much activity Intentionally or unintentionally overdosing on the medicines used to treat diabetes Missing meals Even when diabetes is managed very carefully, the medicines used to treat diabetes can result in drug-induced low blood sugar. The condition may also occur when someone without diabetes takes a medicine used to treat diabetes. In rare cases, non-diabetes-related medicines can cause low blood sugar. Medicines that can cause drug-induced low blood sugar include: Bactrim (an antibiotic) Beta-blockers Haloperidol Insulin MAO inhibitors Metformin when used with sulfonylureas Pentamidine Quinidine Quinine SGLT2 inhibitors (such as dapagliflozin and empagliflozin) Sulfonylureas Thiazolidinediones (such as Actos and Avandia) Continue reading >>

Diabetes Case Study: A New Perspective On Type 1 And Type 2

Diabetes Case Study: A New Perspective On Type 1 And Type 2

< PREV HOME NEXT > Antibiotics As I have pointed out before, infections increase blood glucose levels drastically. I have noticed through careful observation that my infections are rather chronic and can be present for a long time before they show any major symptoms. I have occasionally had flair-ups of mouth sores, inflammation and joint pain in various parts of my body. I have for a long time suspected latent infections to be the cause. My infections seem to be curable with heavy duty antibiotics, and the antibiotics lower my blood glucose load, thus requiring an immediate drop in the amount of insulin that I use. Overall, I rarely use antibiotics. Perhaps you have noticed more signs of hypoglycemia than usual when taking antibiotics? In some cases, people are allergic to Penicillin. Could some of these allergic reactions simply be the symptoms of hypoglycemia? Some signs of hypoglycemia include: sweating, dizziness, palpitation, tremor, agitation, hunger, restlessness, headache, seizures, confusion, disorientation, anxiety, fear, death, etc. I have observed rapid hypoglycemic action when using antibiotics. What I observed was not mentioned on the antibiotics warning labels. The labels did warn of “False positive urine glucose test results on urine test strips.” I have observed this phenomenon myself. I have to accept the warning as fact, but it may not be “false” after all. If the antibiotics kill bacteria (which caused the glucose load), and thus rapidly cause hypoglycemia, then where does the glucose load end up? The blood is purged of the excess glucose. Since the blood purge does not occur with insulin by storing it into fat, it may end up in the urine, resulting in a high urine glucose level when using antibiotics. Only after the diet and healthy lifesty Continue reading >>

Drugs That Can Raise Bg

Drugs That Can Raise Bg

By the dLife Editors Some medicines that are used for treating other medical conditions can cause elevated blood sugar in people with diabetes. You may need to monitor your blood glucose more closely if you take one of the medicines listed below. It’s important to note that just because a medicine has the possibility of raising blood sugar, it does not mean the medicine is unsafe for a person with diabetes. For instance, many people with type 2 diabetes need to take a diuretic and a statin to lower blood pressure and cholesterol. In these and many other cases, the pros will almost always outweigh the cons. Don’t ever take matters of medication into your own hands. Discuss any concerns you have with your healthcare provider. Certain Antibiotics Of all the different antibiotics, the ones known as quinolones are the only ones that may affect blood glucose. They are prescribed for certain types of infection. Levofloxacin (Levaquin) Ofloxacin (Floxin) Moxifloxacin (Avelox) Ciprofloxacin (Cipro, Cipro XR, Proquin XR) Gemifloxacin (Factive) Second Generation Antipsychotics These medicines are used for a variety of mental health conditions. There is a strong association between these medicines and elevated blood sugar, and frequent monitoring is recommended. Clozapine (Clozaril) Olanzapine (Zyprexa) Paliperidone (Invega) Quietiapine (Seroquel, Seroquel XR) Risperidone (Risperdal) Aripiprazole (Abilify) Ziprasidone (Geodon) Iloperidone (Fanapt) Lurasidone (Latuda) Pemavanserin (Nuplazid) Asenapine (Saphris) Beta Blockers Beta blockers are used to treat high blood pressure and certain heart conditions. Not all available beta blockers have been shown to cause high blood sugar. Atenolol Metoprolol Propranolol Corticosteroids Corticosteroids are used to treat conditions where th Continue reading >>

[effect Of Certain Antibiotics Of Tetracycline Series On The Level Of Blood Sugarand The Role Of Insulin In The Mechanism Of Its Regulation].

[effect Of Certain Antibiotics Of Tetracycline Series On The Level Of Blood Sugarand The Role Of Insulin In The Mechanism Of Its Regulation].

1. Probl Endokrinol (Mosk). 1976 Nov-Dec;22(6):106-10. [Effect of certain antibiotics of tetracycline series on the level of blood sugarand the role of insulin in the mechanism of its regulation]. Experiments on male rats showed enterally administered tetracycline andchlortetracycline to promote an elevation of the blood sugar level. Theseantibiotics administered once together with glucose retarded the normalization ofthe blood sugar concentration. After 7-day administration of tetracycline andchlortetracycline glucose load caused a stable hyperglycemia. Special experimentswith depancreatization and insulin injection to the animals and also theintravenous injection of glucose and the antibiotic demonstrated that the changesin the blood sugar concentration under the effect of tetracycline were associatedboth with its inhibitory action on the absorbing function of the intestine andwith the retarded glucose utilization in the tissues. Insulin injectedintramuscularly eliminated the hyperglycemic effect caused by the antibiotics. Continue reading >>

About Insulin

About Insulin

What Is Insulin? The human body requires energy to function. We receive energy from the foods we eat in the form of protein, fat and carbohydrates, or "carbs." The food we eat is typically converted to sugars. In order for sugar to enter the cell and provide energy, it must bind to a hormone called insulin (IN-su-lin). Insulin is like a key that "unlocks the door" to enter the cell. If we did not have insulin in our bodies, the sugar could not "unlock the door" to enter the cell. The blood sugar levels would then become very high. When there is not enough insulin to unlock the cell, the sugar stays in the blood and cannot be used to make energy. If we did not have insulin in our bodies, our blood sugar levels would also become too high. If this happens consistently, it will lead to serious health problems, including heart disease and damage to the nerves, eyes and kidney. Insulin is produced and secreted by the pancreas. Some people with diabetes have a condition where the pancreas does not make enough insulin to meet its needs or the body does not properly use the insulin it makes. In this case, a special diet and regular exercise is required to control the blood sugars. If diet and exercise is not enough to control the blood sugars, and if the pancreas is not making insulin as it is supposed to, then insulin from outside the body (external insulin) may be required. Many people with diabetes depend on (external) insulin injections to control their blood sugar. Are there any types of drugs that can interact with or affect insulin? Although insulin does not actually “interact” with any drugs, there are numerous drugs that can have an impact on someone who uses insulin. For instance, certain medications can have an effect on your blood sugar and may contribute to an i Continue reading >>

A Rare But Serious Side Effect Of Levofloxacin

A Rare But Serious Side Effect Of Levofloxacin

Hypoglycemia in a geriatric patient Drugs should always be considered in the differential diagnosis of hypoglycemia. Fluoroquinolones have rarely been associated with hypoglycemia (1,2). Levofloxacine, which belongs to the fluoroquinolone group of antibiotics, has previously been reported to cause hypoglycemia in only one patient who was also receiving oral antidiabetic drugs (2). Herein, we describe an elderly patient with hypoglycemia associated with levofloxacine therapy who did use oral antidiabetic drugs or insulin. A 64-year-old female with type 2 diabetes treated only by diet was interned for urinary infection and pneumonia. She had no history of malabsorbtion or oral intolerance. The patient’s weight was 84 kg, and she was 157 cm tall (corresponding to a BMI of 34.1 kg/m2). Her current medications included coraspin, omeprazole, and atorvastatin. Cefuroxime 3 × 750 mg/day i.v. was started. During cefuroxime therapy, her blood glucose levels were within normal limits with diet. C-reactive protein level was not decreased. On the 3rd day of treatment, cefuroxime was replaced with levofloxacin (500 mg/day) because of unresponsiveness. During treatment with levofloxacin, the symptoms of diseases diminished significantly, but the patient complained of generalized weakness. On the 2nd day of levofloxacin therapy, the patient became lethargic and disoriented. Blood pressure was 126/72 mmHg, heart rate was 82 bpm and regular, and body temperature was normal. Meningial irritation signs were absent, and pupils were intermediate, symmetric, and reactive. Optic fundi were normal, and no focal neurologic deficit was detected. Other physical findings were unremarkable. Her blood glucose level was measured as 32 mg/dl. The simultaneous blood insulin level was 6.7 IU (normal r Continue reading >>

390 Drugs That Can Affect Blood Glucose Levels

390 Drugs That Can Affect Blood Glucose Levels

Knowing the drugs that can affect blood glucose levels is essential in properly caring for your diabetes patients. Some medicines raise blood sugar in patients while others might lower their levels. However, not all drugs affect patients the same way. 390 Drugs that Can Affect Blood Glucose Levels is also available for purchase in ebook format. 390 Drugs that can affect blood glucose Level Table of Contents: Drugs that May Cause Hyper- or Hypoglycemia Drugs That May Cause Hyperglycemia (High Blood Sugar) (GENERIC NAME | BRAND NAME) Abacavir | (Ziagen®) Abacavir + lamivudine,zidovudine | (Trizivir®) Abacavir + dolutegravir + lamivudine | (Triumeq®) Abiraterone | (Zytiga®) Acetazolamide | (Diamox®) Acitretin | (Soriatane®) Aletinib | (Alecensa®) Albuterol | (Ventolin®, Proventil®) Albuterol + ipratropium | (Combivent®) Aliskiren + amlodipine + hydrochlorothiazide | (Amturnide®) Aliskiren + amlodipine | (Tekamlo®) Ammonium chloride Amphotericin B | (Amphocin®, Fungizone®) Amphotericin B lipid formulations IV | (Abelcet®) Amprenavir | (Agenerase®) Anidulafungin | (Eraxis®) Aripiprazole | (Abilify®) Arsenic trioxide | (Trisenox®) Asparaginase | (Elspar®, Erwinaze®) Atazanavir | (Reyataz ®) Atazanavir + cobistat | (Evotaz®) Atenolol + chlorthalidone | (Tenoretic®) Atorvastatin | (Lipitor®) Atovaquone | (Mepron®) Baclofen | (Lioresal®) Belatacept | (Nulojix®) Benazepril + hydrochlorothiazide | (Lotension®) Drugs That May Cause Hyperglycemia (High Blood Sugar) – Continued (GENERIC NAME | BRAND NAME) Betamethasone topical | (Alphatrex®, Betatrex®, Beta-Val®, Diprolene®, Diprolene® AF, Diprolene® Lotion, Luxiq®, Maxivate®) Betamethasone +clotrimazole | (Lotrisone® topical) Betaxolol Betoptic® eyedrops, | (Kerlone® oral) Bexarotene | (Targ Continue reading >>

What Medicines Can Make Your Blood Sugar Spike?

What Medicines Can Make Your Blood Sugar Spike?

If you have diabetes or high blood sugar, you probably know some of the things that cause your glucose (another name for blood sugar) to go up. Like a meal with too many carbohydrates, or not enough exercise. But other medicines you might take to keep yourself healthy can cause a spike, too. Know Your Meds Medicines you get with a prescription and some that you buy over the counter (OTC) can be a problem for people who need to control their blood sugar. Prescription medicines that can raise your glucose include: Steroids (also called corticosteroids). They treat diseases caused by inflammation, like rheumatoid arthritis, lupus, and allergies. Common steroids include hydrocortisone and prednisone. But steroid creams (for a rash) or inhalers (for asthma) aren’t a problem. Drugs that treat high blood pressure, such as beta-blockers and thiazide diuretics High doses of asthma medicines, or drugs that you inject for asthma treatment OTC medicines that can raise your blood sugar include: Cough syrup. Ask your doctor if you should take regular or sugar-free. How Do You Decide What to Take? Even though these medicines can raise your blood sugar, it doesn’t mean that you shouldn’t take them if you need them. The most important thing is to work with your doctor on the right way to use them. If you have diabetes or you’re watching your blood sugar, ask your doctor before you take new medicines or change any medicines, even if it’s just something for a cough or cold. (Remember, just being sick can raise your blood sugar.) Make sure your doctor knows all the medicines you take -- for diabetes or any other reason. If one of them may affect your blood sugar, she may prescribe a lower dose or tell you to take the medicine for a shorter time. You may need to check your blood s Continue reading >>

Effect Of Antibiotics On Gut Microbiota, Gut Hormones And Glucose Metabolism

Effect Of Antibiotics On Gut Microbiota, Gut Hormones And Glucose Metabolism

Effect of Antibiotics on Gut Microbiota, Gut Hormones and Glucose Metabolism 1Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark 2NNF Centre for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 2NNF Centre for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 2NNF Centre for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 3Endocrine Research Unit, University of Southern Denmark, Odense, Denmark 2NNF Centre for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 1Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark 2NNF Centre for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 1Center for Diabetes Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark 2NNF Centre for Basic Metabolic Research and Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark 3Endocrine Research Unit, University of Southern Denmark, Odense, Denmark 4National Food Institute, Technical University of Denmark, Sborg, Denmark 5Department of Clinical Microbiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark 6Department of Surgery, Herlev Hospital, University of Copenhagen, Herlev, Denmark 7Department of Clinical Biochemistry, R Continue reading >>

How Many Factors Actually Affect Blood Glucose?

How Many Factors Actually Affect Blood Glucose?

A printable, colorful PDF version of this article can be found here. twitter summary: Adam identifies at least 22 things that affect blood glucose, including food, medication, activity, biological, & environmental factors. short summary: As patients, we tend to blame ourselves for out of range blood sugars – after all, the equation to “good diabetes management” is supposedly simple (eating, exercise, medication). But have you ever done everything right and still had a glucose that was too high or too low? In this article, I look into the wide variety of things that can actually affect blood glucose - at least 22! – including food, medication, activity, and both biological and environmental factors. The bottom line is that diabetes is very complicated, and for even the most educated and diligent patients, it’s nearly impossible to keep track of everything that affects blood glucose. So when you see an out-of-range glucose value, don’t judge yourself – use it as information to make better decisions. As a patient, I always fall into the trap of thinking I’m at fault for out of range blood sugars. By taking my medication, monitoring my blood glucose, watching what I eat, and exercising, I would like to have perfect in-range values all the time. But after 13 years of type 1 diabetes, I’ve learned it’s just not that simple. There are all kinds of factors that affect blood glucose, many of which are impossible to control, remember, or even account for. Based on personal experience, conversations with experts, and scientific research, here’s a non-exhaustive list of 22 factors that can affect blood glucose. They are separated into five areas – Food, Medication, Activity, Biological factors, and Environmental factors. I’ve provided arrows to show the ge Continue reading >>

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