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Which Insulin Is Given Iv

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Comparative Study Of Subcutaneous, Intramuscular, And Intravenous Administration Of Human Insulin

Abstract Human insulin derived from porcine insulin was given subcutaneously (s.c.), intramuscularly (i.m.), and intravenously (i.v.) to normal men. The dosage for all three routes was 0·075 IU/kg body weight. Diluting medium was administered by s.c. injection to obtain control values. Somatostatin (100 μg/h) was given to inhibit pancreatic beta cell secretion. The plasma glucose responses to s.c. injection of this insulin into the anterior abdominal wall and to i.m. injection into the thigh were similar with respect to the extent, onset, and duration of effect. Plasma glucose fell from mean (± SE) pre-injection values of 4·3 ± 0·15 and 4·4 ± 0·27 mmol/l, to 3·06 ± 0·25 and 2·98 ± 0·16 mmol/l by 90 to 105 min for s.c. and i.m. studies, respectively, thereafter returning to mean basal level by 6 h after i.m. injection, but remaining about 0·5 mmol/l below basal level after s.c. injection. A much more sudden, but short-lived, hypoglycaemic response occurred after i.v. insulin, with plasma glucose falling from 4·50±0·42 to 1·45±0·16 mmol/l by 25 min, returning to mean basal value after 31/2 h. The mean (±SE) peak insulin levels after s.c. and i.m. injection were Continue reading >>

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Popular Questions

  1. caretotrythese

    I am in nursing school and currently on my diabetes unit. My instructors have stated that only regular insulin can be given via IV. I did find some information that suggested that rapid-acting insulin could be given IV, but they were more expensive and did not offer any additional benefits. Beyond that, I understand that it is not really practical to be giving NPH and long acting insulin IV due to why people are placed on insulin drips, but I am still wondering what would happen if you Iv'd an insulin other than regular. Any insight on this?

  2. RxBTFU15

    I assume you're asking about long acting insulins since you already mentioned the other categories. The simple answer is that injections of long acting insulins are not immediately absorbed into the bloodstream like rapid is. Both glargine (Lantus, Toujeo) degludec (Tresiba) form deposits in the tissue at the site of injection which slowly release insulin over the course of the day. Detemir (Levemir) does this to a lesser degree because it also relies on strongly binding to a protein in the blood.

  3. RektLeague

    NPH and basal insulins have a longer onset of action, and a longer half life. The longer response time makes it hard to titrate the drip up, and if you overshoot, then not only is your patient going to be hypoglycemic but they will be hypoglycemic for much longer even after you stop the drip.
    Practicality wise, if the patients ordered for a drip its probably because they need a rapid correction of there blood sugar, therefore more effective to use regular or a fast acting.
    TL;DR Theoretically you can, but it would take a long time to work, and the risk/benefit scale tilts heavily to the side of risk.

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