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Drug-induced Diabetes

Many therapeutic agents can predispose to or precipitate diabetes, especially when pre-existing risk factors are present, and these may cause glucose control to deteriorate if administered to those with existing diabetes. They may act by increasing insulin resistance, by affecting the secretion of insulin, or both. For convenience, these agents may be subdivided into widely used medications that are weakly diabetogenic, and drugs used for special indications that are more strongly diabetogenic. Examples of the former include antihypertensive agents and statins, and examples of the latter include steroids, antipsychotics and a range of immunosuppressive agents. There are also a number of known beta cell poisons including the insecticide Vacor, alloxan and streptozotocin. Introduction A wide range of therapeutic agents may affect glucose tolerance, and the list of known or suspected drugs is lengthy. This entry summarizes evidence concerning the agents most frequently implicated. Widely used medications A number of drugs used to reduce cardiovascular risk also predispose to the development of diabetes. These include the thiazide diuretics, beta-blockers and statins. It should however Continue reading >>

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    Difference between Novolog and Humalog insulin?

    Like Regular, Humalog and Novolog are used to cover meals and snacks. Most meals raise the blood sugar for only 2 to 3 hours afterwards. Once injected, Regular insulin takes 30 minutes to begin working, peaks between 2 and 4 hours and hangs on for 6 to 8 hours, long after the meal stopped raising the blood sugar. Humalog and Novolog, on the other hand, begin working in about 10 minutes, peaks at one to one and a half hours and are gone in about three and a half to four hours.
    Many people who've tried these faster insulins report that their control is improved and that they feel better. The great advantage of fast insulins are that they match the "action time" for most meals. You can take them as you begin eating, rather than the 30 to 45 minutes prior to eating required of Regular. No longer do you need to accurately anticipate when you (or your young child with diabetes) will begin eating. In addition, Humalog and Novolog leave your body faster so you don't have residual insulin causing low blood sugars in the late afternoon or, even worse, in the middle of the night.
    For most meals, fast insulins will be lowering the blood sugar at the same time the food is raising it. The rise in the blood sugar seen in the couple of hours after eating is much lower, especially with Novolog, and by the end of three hours the blood sugar is often back to its starting point.
    With Humalog or Novolog, you're better equipped to prevent spiking blood sugar between meals, while avoiding the lows that result from the combined buildup of Regular and long-acting insulins. The new Lantus insulin is an excellent choice when using these fast insulins to cover meals. The clearly defined action times for the fast insulins makes it easier to correctly adjust meal doses.
    Humalog and Novolog are also excellent insulins to use to lower high blood sugars. Their faster action means that less time is spent at high blood sugar levels, and there will be less residual insulin triggering low blood sugars later.
    Humalog is produced by Lilly and was first released in the U.S. in 1996, while Novolog is made by Novo Nordisk and was released in 2001. Both insulins offer quicker action time than the original "short-acting" Regular insulin, which first became available in 1921. However, users also report significant differences in activity between each of the three insulins. Let's first look at these differences.
    couple of major differences are being reported by users between Novolog and Humalog. Especially among pumpers who switch from Humalog to Novolog, reports have surfaced that Novolog appears to be both stronger and quicker than Humalog, and doses have to be cut in order to prevent hypoglycemia. Dose reductions are often in the 10% range, and it may be wise to reduce doses right away to prevent unwanted lows. If, instead, blood sugars rise, doses can always be raised again.
    Novolog also starts working faster than Humalog. Although no direct comparison of Novolog and Humalog has been reported, one research study found that in normal individuals, Novolog reaches peak activity at 52 minutes, compared to 145 minutes (2 hours and 25 minutes) for Regular insulin. Humalog peaks at about 75 minutes (Eur J Clin Pharmacol 1999 May;55(3):199-203). Both pumpers and injectors may note lower post-meal readings due to the faster onset of action.
    The clearly defined action times of the fast insulin makes it easier to troubleshoot problems. For information on how to determine the number of carbs covered by each unit, see the 500 Rule in the Pocket Pancreas. Humalog and Novolog are also excellent for lowering high blood sugars with less time spent at high blood sugar levels, and less residual insulin left to trigger low blood sugars later. For information on how to safely lower highs, see the 1800 Rule, also in the Pocket Pancreas.

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    Insulin Pump For Diabetes - About.com About.com/Insulin Pump for Diabetes Insulin Pump for Diabetes Search Now! Over 85 Million Visitors.

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    Source(s): I Cured My Diabetes : http://DiabetesGoFar.com/?sJdU

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