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Metformin Poisoning Management

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Metformin-associated Lactic Acidosis Following Intentional Overdose Successfully Treated With Tris-hydroxymethyl Aminomethane And Renal Replacement Therapy

Metformin-Associated Lactic Acidosis following Intentional Overdose Successfully Treated with Tris-Hydroxymethyl Aminomethane and Renal Replacement Therapy Ngan Lam ,1,2 Gurbir Sekhon ,3and Andrew A. House 1,3 1Division of Nephrology, Department of Medicine, Western University, London, ON, Canada N6A 3K7 2London Health Sciences Centre, Kidney Clinical Research Unit, Victoria Hospital, Westminster Tower 800 Commissioners Road East, London, ON, Canada N6A 4G5 3Department of Medicine, Western University, London, ON, Canada N6A 3K7 Received 19 February 2012; Accepted 6 May 2012 Academic Editors: Y.Fujigaki, D.Packham, A.Papagianni, and H.Schiffl Copyright 2012 Ngan Lam et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. A 43-year-old woman was brought to the hospital with severe metabolic acidosis (pH 6.56, bicarbonate 3 mmol/L, and lactate 18.4 mmol/L) and a serum creatinine of 162 mol/L with a serum potassium of 7.8 mmol/L. A delayed diagnosis of metformin-associated lactic acidosis was made, and she was treated wi Continue reading >>

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Popular Questions

  1. tk421

    Sorry if this doesn't belong in this part of the forum, but it seems better here than the other places in the forum.
    I am having trouble finding a solid answer to this. Everywhere I look online tells me something different. I see some say around 50 mg/dl which I would think is totally hypoglycemic. So I don’t really believe that. I see others saying as long as you are below about 97 mg/dl. I see others that say in the 80s. Some say other things. I just want a straight answer. So I need some advice from a successful keto person.
    What is proper blood glucose levels for someone who is in ketosis? I got this blood glucose monitor and I think it may be defective or just a crappy brand. Yesterday my fasting blood glucose (after a 14 hour fast) was 83 mg/dl. Today (again after a 14 hour fast) was 97. I couldn’t believe it so I took my blood glucose again and it said 92. Then I ate exactly 3 pieces of bacon and a piece of cheese, and two hours later my blood glucose was 102. I thought WTF, so I immediately took it again and it said 109.
    So maybe I have a defective monitor (the Nova Max Plus), but regardless, there is probably at least a little bit of truth to it. But I seriously eat 25 grams or less of carbs per day. Usually less.
    Could someone please explain glucose levels to me in regards to ketosis.

  2. JBean

    In the absence of dietary carbohydrates, your body will break down fats and proteins to maintain your blood glucose in the normal range. Here's an explanation:
    https://en.m.wikipedia.org/wiki/Gluconeogenesis

  3. tk421

    Originally posted by JBean
    In the absence of dietary carbohydrates, your body will break down fats and proteins to maintain your blood glucose in the normal range. Here's an explanation:
    https://en.m.wikipedia.org/wiki/Gluconeogenesis Very interesting. Thanks for the info, that helps me a lot!!
    Cheers

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