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Metformin Not Working Anymore Pcos

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Diabetes Drugs: Metformin

Editor’s Note: This is the second post in our miniseries about diabetes drugs. Tune in on August 21 for the next installment. Metformin (brand names Glucophage, Glucophage XR, Riomet, Fortamet, Glumetza) is a member of a class of medicines known as biguanides. This type of medicine was first introduced into clinical practice in the 1950’s with a drug called phenformin. Unfortunately, phenformin was found to be associated with lactic acidosis, a serious and often fatal condition, and was removed from the U.S. market in 1977. This situation most likely slowed the approval of metformin, which was not used in the U.S. until 1995. (By comparison, metformin has been used in Europe since the 1960’s.) The U.S. Food and Drug Administration (FDA) required large safety studies of metformin, the results of which demonstrated that the development of lactic acidosis as a result of metformin therapy is very rare. (A finding that has been confirmed in many other clinical trials to date.) Of note, the FDA officer involved in removing phenformin from the market recently wrote an article highlighting the safety of metformin. Metformin works primarily by decreasing the amount of glucose made by Continue reading >>

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Popular Questions

  1. Charlotte4588

    PCOS - Clomid not working - what's next?

    I've recently been diagnosed with PCOS after trying to conceive for a year. I started clomid (50mg) and the first cycle it worked, stimulated follicles and I had a trigger injection because I wasn't ovulating. Unfortunately we didnt conceive that first month but then we both assumed that the next month it would all work in the same way. This was not the case and the next month at 50mg nothing happened, then we went up to 100mg, that didn't work and then 150mg and no luck there either. I've been taking metformin as well which my doctor thought would help. My doctor has said this can sometimes happen but I don't understand why it worked the first time and then not again, even when the dose was increased. It's so upsetting going to the doctor every month hoping for something to have happened and then seeing nothing in the scans. Has this happened to anyone else? What's the next step if the Clomid doesn't work? Just want to hear some good news stories to try and keep us positive.

  2. ZoeyRudy

    I would google natural remedies via herbs,

  3. amber67131

    I have been reading that ladies who were taking clomid and not concieving also started taking metformin and that worked for them! Ask your doc

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