diabetestalk.net

Why Ketone Bodies Are Produced In The Body?

Share on facebook

Regulation Of Ketone Body Production: Answer

What regulates ketone body synthesis? The primary regulator of ketone body synthesis is fatty acid availability. When hormonal conditions (e.g., high glucagon, low insulin) cause fatty acid concentration in the plasma to be high, malonyl CoA concentration in the liver cytoplasm is low (because acetyl CoA carboxylase is in the less active phosphorylated state). Fatty acyl CoA can enter the mitochondria at a high rate (because there is no inhibition of CAT I), and beta-oxidation proceeds at a high rate. The ensuing high mitochondrial concentration of acetyl CoA results in active ketone body synthesis. Continue reading >>

Share on facebook

Popular Questions

  1. yjj8817

    Why is it that liver goes through all the trouble of making ketone bodies from acetyl coa when the ketone bodies are converted back to acetyl coa in the other tissues?

  2. desertrat12

    Ketones are made when glucose stores are low, then, like you said, ketone bodies can be used by some non liver tissues to make acetyl coA and thus go on to make some atp. However, if glucose stores are low then the liver will turn to beta oxidation to make energy. Fatty acids go through beta oxidation and one of the products is acetyl coA. In order to go through beta oxidation, there needs to be coA avaliable. If the liver made acetyl coA and kept shipping it out the supply of coA would deplete, and the whole point to produce energy without glucose would be harmed due to a lack of coA for beta oxidation

  3. yjj8817

    desertrat12 said: ↑
    Ketones are made when glucose stores are low, then, like you said, ketone bodies can be used by some non liver tissues to make acetyl coA and thus go on to make some atp. However, if glucose stores are low then the liver will turn to beta oxidation to make energy. Fatty acids go through beta oxidation and one of the products is acetyl coA. In order to go through beta oxidation, there needs to be coA avaliable. If the liver made acetyl coA and kept shipping it out the supply of coA would deplete, and the whole point to produce energy without glucose would be harmed due to a lack of coA for beta oxidation
    But by converting acetyl coa that was provided by fatty acid to ketone bodies and shipping them out to other tissues, aren't you depleting coa?
    Am I missing something?

  4. -> Continue reading
read more close

Related Articles

Popular Articles

More in ketosis