Why Is Ketoacidosis Fatal

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Fatal Diabetic Ketoacidosis-a Potential Complication Of Mdma (ecstasy) Use.

Abstract A 19-year-old woman with insulin-dependent diabetes mellitus was found dead in bed having allegedly recently taken ecstasy and consumed alcohol. At autopsy, there were microhemorrhages in the brain with subnuclear vacuolization and Armanni-Ebstein changes in renal tubules. Biochemical analyses confirmed diabetic ketoacidosis (vitreous glucose-46.5 mmol/L; β-OH butyrate-13.86 mmol/L.). Toxicological analyses of blood showed a low level of 3,4-methylenedioxy-methamphetamine (MDMA) (0.01 mg/L), with acetone but no alcohol or other common drugs. Death was attributed to diabetic ketoacidosis most likely provoked by mixed MDMA/alcohol ingestion. Although the use of illicit drugs by young individuals with diabetes mellitus is being increasingly recognized, it has been noted that there is minimal information about the relationship between drug use and acute diabetic complications. Toxicological screening of cases of lethal diabetic ketoacidosis in the young may clarify lethal mechanisms in individual cases and also help to determine the extent of this problem. KEYWORDS: MDMA; death; diabetes mellitus; ecstasy; forensic science; hyperglycemia; ketoacidosis Continue reading >>

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  1. Ana Gretu

    I was diagnosed with diabetes type 1insulino dependent on the age of 22 years. In the beginning I was very scared, now I have a little girl of 2 years and lead a life like everybody, but take into account diet , exercise . etc.
    There are 4 types of diabetes.
    ♦ Type 1 diabetes affects children and young adults, and is due to a major defect of the pancreas not producing insulin. Before the discovery of insulin (1920 s), people with type 1 diabetes lived one year. Today, insulin treatment allows a life where nothing is forbidden activities that may have a person with type 1 diabetes are the same as those without diabetes.
    ♦ The second main type of diabetes, and most frequently (5-6 times more common than type 1), is type 2 diabetes, also called adult diabetes, or diabetes obese after an older name due to very frequent association of diabetes type 2 and obesity. In fact, it has been demonstrated that obesity is one of the reasons for the occurrence of type 2 diabetes, which explains the onset of the epidemic of Type 2 diabetes with obesity epidemic today. Type 2 diabetes differs from Type 1 diabetes in that it occurs most often along with a group of diseases, which also includes, alongside obesity, and hypertension, fatty liver...
    ♦ A third type of diabetes is diabetes that occurs along or due to other diseases (diabetes specific or secondary). This type of diabetes takes many forms, and treated with a disease that accompanies it.

    ♦ The last category is a special category, called gestational diabetes, a carbohydrate metabolism disorder that first appears during pregnancy, which can result in the absence of treatment, the risks, especially for children. This condition is different from the situation in which a woman with diabetes becomes pregnant.

  2. Dianne DeCook

    Yes. My son was diagnosed with Type One Diabetes which means he requires insulin injections to maintain normal blood sugars. Type One Diabetes is an autoimmune disease which causes the immune system to attack the Pancreatic Beta cells, destroying them and stopping the body’s ability to produce Insulin. You need insulin to live. Without it a T1D patient will not be able to metabolize carbohydrates (sugar) so their body will live off their protein (muscle mass) which often brings on Diabetic KetoAcidosis which, without insulin, is fatal.

  3. Pippi M. R. Groving

    If someone in my household has diabetes and I stated that, I would know which kind it were.
    After all most of my education is about human diseases, so I usually know the specifics of any diseases in my household.

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