Where Are Ketone Bodies Broken Down?

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Ketone Bodies

Ketone bodies Acetone Acetoacetic acid (R)-beta-Hydroxybutyric acid Ketone bodies are three water-soluble molecules (acetoacetate, beta-hydroxybutyrate, and their spontaneous breakdown product, acetone) that are produced by the liver from fatty acids[1] during periods of low food intake (fasting), carbohydrate restrictive diets, starvation, prolonged intense exercise,[2], alcoholism or in untreated (or inadequately treated) type 1 diabetes mellitus. These ketone bodies are readily picked up by the extra-hepatic tissues, and converted into acetyl-CoA which then enters the citric acid cycle and is oxidized in the mitochondria for energy.[3] In the brain, ketone bodies are also used to make acetyl-CoA into long-chain fatty acids. Ketone bodies are produced by the liver under the circumstances listed above (i.e. fasting, starving, low carbohydrate diets, prolonged exercise and untreated type 1 diabetes mellitus) as a result of intense gluconeogenesis, which is the production of glucose from non-carbohydrate sources (not including fatty acids).[1] They are therefore always released into the blood by the liver together with newly produced glucose, after the liver glycogen stores have bee Continue reading >>

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Popular Questions

  1. Hasshman

    Question about Ketone bodies

    Since I started Keto my lifts is suffering. I get fatigued really qickly. I try to do the same weights before I started Keto. Now I'm starting my third week of keto. I did a carb-up end of week two and it did help with my lifts.
    Does the muscles ever start to use body fat as a source of fuel or will it need the carbs? If my muscles did adapt to use fat (when fatty acids are broken down to Ketone bodies) as fuel I would never carb up.
    Is Ketone bodies only used as energy for the brain and heart?
    Why is that the keto diet emphasises that we get most of my cals from fat?Isn't that counter productive? If you feed your body fat, won't it be used to make Ketone bodies instead of your already stored body fat?

  2. Doobie2270

    I think muscles use ketones for energy until you do something really strenuous, like lifting heavy; then it uses stored carbs. If you keep lifting heavy, you deplete glycogen, and eventually you won't be able to sustain your usual level of activity. Then you carb-up and repeat the cycle.
    If you don't have fat in your diet, then you won't be able to stay in ketosis for long. If all you eat is protein, then the protein will turn into glucose, and your body will rely on glycolysis for energy as oposed to ketones. That would probably be very bad for your muscles as well. Once you're in ketosis, dietary fat will be used for energy, and, if you eat a deficit of calories, then body fat will also be used.

  3. Eileen

    Your body can use ketones for lifting weights as well as cardio and all the other stuff, but where there can be a slight problem is that the body won't always supply enough fatty acids at once for the demands of really heavy lifting over a long period. You can cope by either using longer rests between sets, or just lifting heavy for a shorter session. Personally, I reckon that if you are spending longer than 45 minutes in the pit, you are probably messing about. Lift heavy and go home.
    The longer you do keto, the more efficient your body will get it a using fat for fuel for all activities.
    You eat fat to encourage your body to go into ketosis where it is burning fat for energy. You eat below maintenance to make sure it is using your bodyfat as well as dietry fat.

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