Why Does Diabetes Cause Ketosis?
In diabetes due to the insulin deficiency there is increased hepatic gluconeogenesis and lipolysis And this lipolysis inturn increases free fatty acids. Now you know that as insulin is deficient in diabetes glucose cant be utilised as a energy source. So to get the energy an alternative source of these free fatty acids are used. End ketones being the end product of this fatty acid metabolism it gets accumulated. Initially it causes ketonemia(increased ketone bodies in blood) but this cycle keeps on going at ketoacidosis occurs. P.S- I just tried to simplify the answer,the exact mechanism is complex as there are lot of steps involved in it. Continue reading >>