What Medications Can Cause Metabolic Acidosis?

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Metabolic Acidosis

Metabolic acidosis is primary reduction in bicarbonate (HCO3−), typically with compensatory reduction in carbon dioxide partial pressure (Pco2); pH may be markedly low or slightly subnormal. Metabolic acidoses are categorized as high or normal anion gap based on the presence or absence of unmeasured anions in serum. Causes include accumulation of ketones and lactic acid, renal failure, and drug or toxin ingestion (high anion gap) and GI or renal HCO3− loss (normal anion gap). Symptoms and signs in severe cases include nausea and vomiting, lethargy, and hyperpnea. Diagnosis is clinical and with ABG and serum electrolyte measurement. The cause is treated; IV sodium bicarbonate may be indicated when pH is very low. Acidemia (arterial pH < 7.35) results when acid load overwhelms respiratory compensation. Causes are classified by their effect on the anion gap (see The Anion Gap and see Table: Causes of Metabolic Acidosis). High anion gap acidosis Ketoacidosis is a common complication of type 1 diabetes mellitus (see diabetic ketoacidosis), but it also occurs with chronic alcoholism (see alcoholic ketoacidosis), undernutrition, and, to a lesser degree, fasting. In these conditions, t Continue reading >>

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Popular Questions

  1. Samantha K(239)

    Ketones and Glucose in Urine

    Hi Guys,
    Any advice would be much appreicated.
    I went to the midwife on wednesday for my usual appointment along with my first urine sample of the day, she said there are presance of Ketones and Glucose, she asked me when i had last eaten which would of been like 12 hours ago and also if i had eaten junk or sugary food which i hadn't, she kind of gave me like a hmmmm as if she thought something was wrong and then told me too ask my own midwife at 28week appointment (4 weeks time) cause she was standing in. I didn't really think much of this until i was told that ketones and glucose can be a sign of diabetes in pregnancy.
    I read some other symptoms online and fall under pretty much them all, blurred vision, excessive passing of urine, i remember having a conversation with my mum about 3 weeks ago that i had a never ending thirst that couldn't be cured no matter how much i drunk. I absolutely NEED to eat every 2 hours otherwise i start feeling really unwell, i go really pale and get the shakes. Also my baby already measures 2 weeks bigger than he is and so does my bump.
    I don't know whether to follow midwifes advise and wait another 4 weeks or contact my own midwife and ask her about it and my symptoms? Even if i could only change my diet to suit diabetes until i get my proper bloods taken i wouldn't mind but i wouldn't even know where to start!

  2. Rachelle M(11)

    Morning! try not to worry about the results of your urine. Gestational diabetes is just that, gestational only. If I were you I would probably be phoning the midwives, expecting you to wait for weeks isn't very good! Your pregnant, worrying about what's best for your baby and hormones are flying all over, and they have given you something to worry about for a month! I'm sure they will understand if you phone and say your worried and want to come in to discuss it further - they aren't aloud to turn you down. If it turns out it is gestational diabetes the sooner you know, the sooner you can do something about it. Xx

  3. Liz F(48)

    hi i'm no expert,, bt i thibk for you own peace of mind book to see your midwife,
    ketones cud be cuz you havent eaten for a while,,, bt like you sed excessive thirst cud also be diabeties
    i am diabetic (not pg though) and never ending thirst is a biggy for me
    it cud also be nothing at all, bt best get checked so you can put your mind at rest
    liz xx

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