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What Is The Significance Of Kussmaul Respirations In Ketoacidosis?

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[ketoacidotic Diabetic Metabolic Dysregulation: Pathophysiology, Clinical Aspects, Diagnosis And Therapy].

Abstract When glucose utilisation is impaired due to decreased insulin effect, ketones are produced by the liver from free fatty acids to supply an alternate source of energy. This adaptation may be associated with severe metabolic acidosis and tends to occur in patients with type I (insulin-dependent) diabetes mellitus. In addition, hypovolemia is an almost invariable finding with marked hypoglycemia and is primarily induced by the associated glucosuria. Ketoacidosis stimulates both the central and peripheral chemoreceptors controlling respiration, resulting in alveolar hyperventilation (Kussmaul's respiration). With the ensuing fall in pCO2 the patient tries to raise the extracellular pH. A fruity odor of acetone on the patient's breath sometimes suggests that ketoacidosis is present. The classical triad of symptoms associated with hyperglycemia are polyuria, polydipsia, and weight loss. Circulatory insufficiency with hypotension is not uncommon due to the marked fluid loss and acidemia. In more severely affected patients, neurologic abnormalities may be seen, including lethargy, seizures or coma. Some patients also have marked vomiting and abdominal pain. The history and physica Continue reading >>

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Popular Questions

  1. thedoctor_89

    Hey everyone. I have a question for you. After losing 70 lb in half a year i decided to stop keto. I like it but i want to move on to something else. Is there anyway that i could stop keto with gaining weight from carbs. Im prepared to spend a month to do this if i have to.

  2. jrf_1973

    Eh, not really. When you go low carb and lose the water weight in the first week, that is weight you will put back on once you reintroduce carbs.
    Basically your body will build back its reserves of glycogen, and that glycogen will store water. There's no way to avoid that.

  3. thefoxman88

    Can always go a few lb below your goal so when you go back to normal you are at your goal weight.

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