What Is The Cause Of Metabolic Acidosis?

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Metabolic Acidosis

Metabolic acidosis, defined as a venous pH < 7.35 is relatively common in dogs. The opposite condition is metabolic alkalosis. Metabolic acidosis is characterized by a decrease in plasma bicarbonate concentration < 18 mEq/L. It occurs as a result of loss of NaHCO3-rich fluids from the intestine or kidneys, increased acid production due to metabolism or reduced excretion of acids (anions). Causes include: Peritoneal dialysis Clinical signs often relate to underlying disease but depression and compensatory tachypnea may be observed. In metabolic acidosis a predisposition of cardiac abnormalities, particularly ventricular arrhythmia and ventricular fibrillation, can be observed. Treatment usually requires addressing underlying disease conditions and aggressive intravenous fluid therapy, usually with lactated Ringer's solution[11]. Only in patients with pH < 7.2, should NaHCO3 be added to the solution. In patients with respiratory acidosis secondary to hypoventilation, NaHCO3 therapy should be avoided because it inevitably decreases respiratory drive, thereby worsening acidosis and hypoxemia[12] As well, dogs with normochloremic metabolic acidosis caused by ketoacidosis are also less l Continue reading >>

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  1. Paraish Misra

    This side effect was very common with phenformin (metformin’s “parent drug”), and in fact led to its withdrawal from many markets. However, lactic acidosis appears to be very uncommon with metformin. In fact, whether or not lactic acidosis occurs at all with metformin is a matter of intense debate among some physicians. Nonetheless, out of safety, physicians will not prescribe metformin to patients at high risk of lactic acidosis (such as patients with advanced kidney disease).

  2. George Johnson

    This answer is not a substitute for professional medical advic...

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