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What Happens In Respiratory Acidosis?

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4.5 Respiratory Acidosis - Compensation

Acid-Base Physiology 4.5.1 The compensatory response is a rise in the bicarbonate level This rise has an immediate component (due to a resetting of the physicochemical equilibrium point) which raises the bicarbonate slightly. Next is a slower component where a further rise in plasma bicarbonate due to enhanced renal retention of bicarbonate. The additional effect on plasma bicarbonate of the renal retention is what converts an "acute" respiratory acidsosis into a "chronic" respiratory acidosis. As can be seen by inspection of the Henderson-Hasselbalch equation (below), an increased [HCO3-] will counteract the effect (on the pH) of an increased pCO2 because it returns the value of the [HCO3]/0.03 pCO2 ratio towards normal. pH = pKa + log([HCO3]/0.03 pCO2) 4.5.2 Buffering in Acute Respiratory Acidosis The compensatory response to an acute respiratory acidosis is limited to buffering. By the law of mass action, the increased arterial pCO2 causes a shift to the right in the following reaction: CO2 + H2O <-> H2CO3 <-> H+ + HCO3- In the blood, this reaction occurs rapidly inside red blood cells because of the presence of carbonic anhydrase. The hydrogen ion produced is buffered by intrac Continue reading >>

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  1. Courtney Schumacher

    Ketoacidosis

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    Why does Ketoacidosis cause coma? How is it treated?




    1 Answer







    I’m assuming that you do know that ketoacidosis does not have to mean that you have high blood sugar. It means that you have a high level of ketones in your blood, which are usually by-products of your body trying to break down fatty acids for fuel it’s not getting from your food intake.
    It is usually treated with fluids, electrolytes, and insulin. It is much more common in those with type 1 diabetes then type 2, but it can still occur.

    You can look up more specific information on diabetes at the Mayo Clinic site.

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    What causes coma?


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