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What Do Exogenous Ketones Do?

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Effects Of Exogenous Ketone Supplementation On Blood Ketone, Glucose, Triglyceride, And Lipoprotein Levels In Sprague–dawley Rats

Abstract Nutritional ketosis induced by the ketogenic diet (KD) has therapeutic applications for many disease states. We hypothesized that oral administration of exogenous ketone supplements could produce sustained nutritional ketosis (>0.5 mM) without carbohydrate restriction. We tested the effects of 28-day administration of five ketone supplements on blood glucose, ketones, and lipids in male Sprague–Dawley rats. The supplements included: 1,3-butanediol (BD), a sodium/potassium β-hydroxybutyrate (βHB) mineral salt (BMS), medium chain triglyceride oil (MCT), BMS + MCT 1:1 mixture, and 1,3 butanediol acetoacetate diester (KE). Rats received a daily 5–10 g/kg dose of their respective ketone supplement via intragastric gavage during treatment. Weekly whole blood samples were taken for analysis of glucose and βHB at baseline and, 0.5, 1, 4, 8, and 12 h post-gavage, or until βHB returned to baseline. At 28 days, triglycerides, total cholesterol and high-density lipoprotein (HDL) were measured. Exogenous ketone supplementation caused a rapid and sustained elevation of βHB, reduction of glucose, and little change to lipid biomarkers compared to control animals. This study demon Continue reading >>

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Popular Questions

  1. richard

    Someone asked in Dr Fungs FB wall what people thought about Prüvit's exogenous ketone product Keto//OS but rather than single out just that product (and I have a lot to say about the multi level marketing practices) I decided to comment generally about eating ketones, and repost here so people can find the post ... because : .
    The point of being in ketosis for weight loss is to use body fat to make into ketones - eating ketones means you get to keep all your body fat.
    The point of being in ketosis for Diabetes is you had to eat no sugar or starch in order to make ketones. For a diabetic eating no sugar or starch gives your liver a chance to make the perfect amount of glucose for you. If you eat ketones to get into ketosis then you will have the wrong amount of glucose and could lose a toe, your eyes, a kidney.
    Plus ketones made in a vat are both left and right handed - we only use the right handed ones for energy. No-one knows what a caloric amount of the left handed ones for several decades will do to your cells. No-one.

    If you want to eat ketones, better to eat MCT oils like Coconut oil and you will make them, the right kind, at about 1/100th of the cost of edible ketones.

  2. Chris_Bair

    I can't be the only one around here that can almost literally hear @richard 's voice when reading his posts. I keep expecting to hear "yeahhh!" =)

    Making your own ketones from old doughnuts is so much better than exogenous ketones. Hey cells, you want fuel? Tell the liver to make some! Problem with the MCT oil is the potential for... "bowel problems" - it's also not necessary for weight loss. I'll admit that replacing other calories with MCT isn't a BAD idea but consuming extra calories via MCT oil isn't a winner either.

  3. trekkin1

    Good post, Richard.
    There's generally little point to consuming raw energy food-like substances. These include oil, sugar, exogenous ketones, MCT oil). These are all energy separated from food. They are not food. These can lead to fat gain, among other things. Most of us don't need extra concentrated food energy...
    Why do that?

    It's best to consume real food with high nutrient density. No?

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