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What Causes Respiratory Acidosis And Alkalosis?

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5.1 - Metabolic Acidosis : Definition

Acid-Base Physiology A metabolic acidosis is an abnormal primary process or condition leading to an increase in fixed acids in the blood. This causes the arterial plasma bicarbonate to fall to a level lower than expected. The fall in plasma bicarbonate is due to titration of HCO3- by H+. Secondary or compensatory processes which cause a fall in plasma bicarbonate should not be confused with primary processes. A fall in bicarbonate occurring in response to a chronic respiratory alkalosis should be referred to as a compensatory response and never as a �secondary metabolic acidosis�. This distinction between a primary process and a secondary one has been discussed previously in section 3.1.2 when discussing terminology of acid-base disorders. It is of course possible for a patient to have a mixed acid-base disorder with both a metabolic acidosis and a respiratory alkalosis. An example would be an adult presenting following a salicylate overdose. In this situation, direct stimulation of the respiratory centre occurs resulting in a respiratory alkalosis as well as the salicylate-related metabolic acidosis. 'Acid-base pHysiology' by Kerry Brandis -from Acid-Base Physiology 5.2.1 Clas Continue reading >>

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Popular Questions

  1. Prairie-dawg

    So I went to the pharmacy yesterday to pick up a new scale and some Ketostix. The pharmacist (who works right next door to me and I've become friendly with) asked me if I was "starting some kind of crazy diet." I told him I've started a ketogenic diet and I'm just trying it out to see if it's right for me. He asked me a few questions about it, mostly about macro ratios and if it's been working so far. When I told him about the higher fat ratio (as opposed to high protein) he seemed somewhat intrigued, but still a little skeptical. The other pharmacist who was working with him chimed in at that point. He said apparently in some Scandinavian countries, they've found that a higher fat content and fewer simple carbs in a person's diet is ideal and actually recommended. However, they both agreed that ketosis for an extended period of time can be very hard on the kidneys. I did a little investigating on my own and there's very little info regarding the long-term effects of the high fat/moderate protein/low carb keto diet. So my question is, has anybody experienced any kidney issues on this diet? Has anyone received any similar warnings from their physician?
    TL;DR
    Pharmacist warned about kidney issues caused by long term ketosis. Seeking out facts/sources to prove or disprove this claim.

  2. cloudmind

    When I first started keto I ended up going to hospital because I had severe internal pain that wouldn't go away. Turns out I was eating far too much protein so my kidneys were giving me grief. Fixed it by upping the fat macros in my diet and I went back to being pain free. Hooray for butter and coconut oil!
    Given my experience, I can understand where the pharmacists are coming from since I think there might* have been a spate of people doing atkins-like diets with kidney problems in the past (too much protein, not enough fat).
    *rampant speculation on my part

  3. Prairie-dawg

    I don't blame them for that at all. In fact, before I really started doing my homework on keto, I used to internally roll my eyes when people would talk about low carb dieting. I think there's a lot of risidual negativity held over from the early days of Atkins regarding low carb diets. Fortunately, I'm always happy to have a teaching moment when the chance arises!

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