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What Causes Metabolic Acidosis In Renal Failure?

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Acid/base Disorders: Metabolic Acidosis

Are there clinical practice guidelines to inform decision-making? Does this patient have metabolic acidosis? Metabolic acidosis is generally defined by the presence of a low serum bicarbonate concentration (normal range 22-28 mEq/L), although occasionally states can exist where the serum bicarbonate is normal with an elevated anion gap (e.g., patients with a lactic acidosis who have received a bicarbonate infusion or patients on hemodialysis). In general, a metabolic acidosis is associated with a low urine pH but depending on the presence or absence of a respiratory alkalosis, this may also be normal or elevated. Thus, a patient can have an acidosis but not be acidemic. Metabolic acidoses occur when there is excess acid in the plasma. In the basal state, the body generates about 12,000 to 13,000 mmol of carbon dioxide (CO2), and 1-1.5 mmol per kilogram body weight of nonvolatile acid. The body has a large buffering capacity, with CO2-HCO3 as the major buffer system. The two major routes of acid excretion are the lungs (for CO2) and the kidneys (for nonvolatile acids) A metabolic acidosis can be caused by three major mechanisms: 1) increased acid production; 2) bicarbonate loss; an Continue reading >>

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Popular Questions

  1. FromThatOtherPlace

    Hello /keto/,
    I'm on a bit of a quest to try and figure out why my major depression of 10 years+ is completely eliminated when my brain is using ketones for it's primary fuel source.
    It doesn't just help me slightly, either. It completely eliminates every ounce of my mental illness. Nothing of it remains. I have 0 low moods or depressive thoughts throughout the day. Almost like a miracle. My energy is restored and I have a very positive outlook on life - aslong as I stay in ketosis.
    I'm trying to figure out why, but I don't really have a medical/science background. I've emailed a few experts in the field and hope they will reply and offer me some insight, but I guess it won't hurt to ask here either.
    Thanks!

  2. freedommerc

    I don't think there's much/any research done on the topic, but I know it's a common theme presented here. I've experienced this particular effect myself. The only thing I've found that comes close is this. It's possible that using BHB as opposed to glucose as the primary substrate for our brain, that what may have been off before is running normally now.

  3. FromThatOtherPlace

    I've heard on other threads here that keto had no effect on their emotional wellbeing, that's why I'm a little confused on my own situation. Was glucose causing my depression all those years? or is keto making me feel so good that the depression is starved out?

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