diabetestalk.net

Starvation Ketoacidosis Pathophysiology

Share on facebook

An Unusual Cause For Ketoacidosis

Abstract Introduction In our continuing series on the application of principles of integrative physiology at the bedside, once again the central figure is an imaginary consultant, the renal and metabolic physiologist, Professor McCance, who deals with data from a real case. On this occasion his colleague Sir Hans Krebs, an expert in the field of glucose and energy metabolism, assists him in the analysis. Their emphasis is on concepts that depend on an understanding of physiology that crosses subspecialty boundaries. To avoid overwhelming the reader with details, key facts are provided, but only when necessary. The overall objective of this teaching exercise is to demonstrate how application of simple principles of integrative physiology at the bedside can be extremely helpful for clinical decision-making (Table 1). Principle Comment 1. A high H+ concentration per se is seldom life-threatening The threat to survival is usually due to the cause for the acidosis rather than the pH per se 2. Finding a new anion means a new acid was added Look in plasma (anion gap) and urine (net charge) to identify the new anions 3. Identify the acid by thinking of the properties of the anion Rate of p Continue reading >>

Share on facebook

Popular Questions

  1. Becca22

    I have been in Ketosis for 5 months as of today. My color has been moderate or more (never on the light side) and I have never fallen out of ketosis in the entire 5 months.
    I am insulin resistant and I also take metformin (glumetza these days). Because of this, I have not reintroduced too many carbs back into my system. The carbs I get come from vegies and sometimes peanuts, as well as small add-ups daily (like a tablespoon of milk in my tea or maybe a tablespoon of bbq sauce on chicken).
    Overall, my carbs have been below 20 for the past 5 months and I have had NO trouble maintaining Ketosis. I feel great, have little to no cravings and I have lost about 35 lbs / possibly 40. (OMG I dont crave chinese food alllllll day long anymore ). I have encountered weeks where I was stalled - but the stall was only in the scale - I was still in ketosis, and eventually the scale moved again - without me changing the food I have been eating.
    Here's my problem.......
    this week, I notice my ketostix getting very light.... and today, pooooof! - no longer turning color!!!!! I know its not the stix (my sister uses them too).
    I have changed NOTHING. I have not "swayed towards the sugar-side", nor had any more carbs/vegies/anything more than the past 21 weeks. I prepare all my own food so I know that nothing has been different.
    WHY is this happening? I'm really bothered by it. Has anyone experienced this? How to I get the stix to change color again... I could TOTALLY drop all carbs (ummm all 15 of them?) but basically, I feel that I never really left Induction-stage anyway.
    So now someone again has suggested that the low/no carbing - ketosis is bad for my body & kidneys if I continue this way for 5 or 6 months.
    Please tell me WHY this happened,
    How do I get back in ketosis
    and regardless of what people have told me, what is YOUR experience with this being dangerous to me.

  2. LessLiz

    Relax. Your goal is to lose weight not to see color on ketostix. If your body has finally completely adapted to ketosis you will not see color as your body is using the ketones.
    Give it a week and see what your weight does. But in the meantime relax.

  3. jschwab

    If your weight continues to go down or you don't gain, no worries. You might also be better hydrated and actually still in ketosis but not have enough to show up on the strip. I see you are maybe starting your stats with your current weight when you joined, but you should put your highest weight so everyone can see your progress because you're doing great!
    Janine

  4. -> Continue reading
read more close

Related Articles

  • Starvation Ketoacidosis Pathophysiology

    GENERAL ketoacidosis is a high anion gap metabolic acidosis due to an excessive blood concentration of ketone bodies (keto-anions). ketone bodies (acetoacetate, beta-hydroxybutyrate, acetone) are released into the blood from the liver when hepatic lipid metabolism has changed to a state of increased ketogenesis. a relative or absolute insulin deficiency is present in all cases. CAUSES The three major types of ketosis are: (i) Starvation ketosis ( ...

    ketosis Mar 29, 2018
  • Starvation Ketoacidosis

    Not to be confused with Ketoacidosis. Ketosis is a metabolic state in which some of the body's energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis in which blood glucose provides energy. Ketosis is a result of metabolizing fat to provide energy. Ketosis is a nutritional process characterised by serum concentrations of ketone bodies over 0.5 mM, with low and stable levels of insulin and blood glucose.[1][2] It ...

    ketosis Mar 29, 2018
  • Starvation Ketoacidosis Medscape

    Physiological Adaptation to Prolonged Starvation This is a summary of the physiological responses to the total or near-total absence of nutrition. The metabolic response to starvation is characterised by a switch from carbohydrate metabolism to fat cmetabolism, in the context of a hypometabolic state, with minimised catabolism. Initially, stores of carbohydrate precursors (eg. glycogen) are depleted. Then, in the first 24-48 hours there is incre ...

    ketosis Mar 29, 2018
  • Starvation Ketoacidosis Signs And Symptoms

    Introduction: Starvation ketosis outside pregnancy is a rare phenomenon and is unlikely to cause a severe acidosis. Pregnancy is an insulin resistant state due to placental production of hormones including glucagon and human placental lactogen. Insulin resistance increases with advancing gestation and this confers a susceptibility to ketosis, particularly in the third trimester. Starvation ketoacidosis in pregnancy has been reported and is usuall ...

    ketosis Mar 29, 2018
  • Ketoacidosis Starvation

    Ketoacidosis is a metabolic state associated with high concentrations of ketone bodies, formed by the breakdown of fatty acids and the deamination of amino acids. The two common ketones produced in humans are acetoacetic acid and β-hydroxybutyrate. Ketoacidosis is a pathological metabolic state marked by extreme and uncontrolled ketosis. In ketoacidosis, the body fails to adequately regulate ketone production causing such a severe accumulation o ...

    ketosis Mar 27, 2018
  • Starvation Ketoacidosis Symptoms

    Ketosis is a metabolic condition in which the body begins breaking down fats, thus releasing carbon fragments known as ketones from the liver. The liver produces ketones as a byproduct of breaking down fatty acids. When your body is in a state of ketosis, your appetite is typically reduced. For this reason, some diets -- such as a low-carbohydrate diet -- aim to trigger a state of ketosis in your body. If too many ketones are released, however, t ...

    ketosis Jan 11, 2018

Popular Articles

More in ketosis