Starvation Ketoacidosis Medscape

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Hepatocellular Carcinoma Redirects To Ketolysis For Progression Under Nutrition Deprivation Stress

Cancer cells are known for their capacity to rewire metabolic pathways to support survival and proliferation under various stress conditions. Ketone bodies, though produced in the liver, are not consumed in normal adult liver cells. We find here that ketone catabolism or ketolysis is re-activated in hepatocellular carcinoma (HCC) cells under nutrition deprivation conditions. Mechanistically, 3-oxoacid CoA-transferase 1 (OXCT1), a rate-limiting ketolytic enzyme whose expression is suppressed in normal adult liver tissues, is re-induced by serum starvation-triggered mTORC2-AKT-SP1 signaling in HCC cells. Moreover, we observe that enhanced ketolysis in HCC is critical for repression of AMPK activation and protects HCC cells from excessive autophagy, thereby enhancing tumor growth. Importantly, analysis of clinical HCC samples reveals that increased OXCT1 expression predicts higher patient mortality. Taken together, we uncover here a novel metabolic adaptation by which nutrition-deprived HCC cells employ ketone bodies for energy supply and cancer progression. Compared with their normal counterparts, cancer cells are metabolically reprogrammed in order to obtain sufficient energy or add Continue reading >>

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Popular Questions

  1. Spidey's mom

    Thanks, that was interesting. I've been on the Atkins Diet while breastfeeding but my son was over two.
    I think personally I'd wait until my baby had started on solid foods and breastfeeding before doing the Atkins Diet. Just to be safe.

  2. klone

    Actually, La Leche League does not recommend any diets that throw your body into ketosis, as there is not enough research on how it will affect your baby. Also keep in mind that weight loss of more than 1-2 lbs. a week is considered unhealthy. As you burn fat, it releases environmental toxins. These toxins are eliminated through the body chiefly through the breastmilk (when lactating).
    If you're going to do low carb and you're breastfeeding, I would not recommend Atkins Induction, but instead start at aroun 40-50 grams of carbs a day.

  3. SnowymtnRN

    That's what's so interesting about this to me. So many people say "i'd recommend not doing induction" etc...or not dieting for that matter, etc...but many people are doing Atkins (some with induction, some not) and they are still getting those products regardless of how its broken down. Its amazing how people just perceive what's safe and what's not. (not any poster here, just a generalization).
    And it IS proven that weight loss is slower, regardless of the low carb route you take and what phase. As for me, i started it when my son was 6 mths old and exclusively bf. I continued til he was almost 10 mths when i found out i was pregnant again and had to stop. now i just follow a general low carb lifestyle (ok usually! :chuckle ). But i believe any diet laden with lean healthy meats, good carb veggies, good fats, low grains, and certain fruits is a great way to go. Can't go wrong there! And my milk was EXTREMELY thick and creamy, very satisfying to my son, and i had a great supply while doing this too. Kinda interesting isn't it? I lost 22-24 pounds (can't remember ) during that 4 mths. So i thought that was pretty good too.

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