Role Of Kidneys In Metabolic Acidosis

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Metabolic Acidosis And The Progression Of Chronic Kidney Disease

Abstract Metabolic acidosis is a common complication of chronic kidney disease. Accumulating evidence identifies acidosis not only as a consequence of, but as a contributor to, kidney disease progression. Several mechanistic pathways have been identified in this regard. The dietary acid load, even in the absence of overt acidosis, may have deleterious effects. Several small trials now suggest that the treatment of acidosis with oral alkali can slow the progression of kidney disease. Keywords BicarbonateDietary acidNet endogenous acid productionSodium bicarbonateAlkaliAmmoniaComplementEndothelinAldosterone Review Metabolic acidosis is a common complication of chronic kidney disease (CKD). Based on a cross-sectional analysis of the National Health and Nutrition Examination Survey, an estimated 26 million adults in the United States have CKD, and approximately 700,000 individuals have an estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m2[1]. As 30-50% of those with eGFR <30 mL/min/1.73 m2 have metabolic acidosis [2–4], approximately 200,000 to 350,000 individuals with CKD stage 4 and 5 have chronic metabolic acidosis in the United States. Chronic metabolic acido Continue reading >>

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Popular Questions

  1. Saphire

    So the last few days I have been sleeping really well. Barely got up, was able to sleep in the morning which is something I have always done, I am a night person and I like it that way. However, while I was not cheating, between all the supplements I have been taking for some aches and pains and the extra nuts I have been snacking on I suspected I was not in ketosis. Yesterday I skipped lunch unintentionally and started what is now a 40 hour fast. Last night my sleep went back to how it is on keto/fasting. I woke up several times to use the facilities and this morning woke up an hour earlier than usual and could not go back to sleep (no matter how much I wanted to). I do not feel refreshed but I do feel alert. On the flip side I usually fall asleep earlier than usual with keto.

    I have always had a bit of a delayed circadian issue but I like it and am used to it. When on keto it seems to fix it? Is that possible?

  2. David_Driver

    I am going to have to give up on Keto. I have had insomnia for almost a year and I discovered that when I cheat I sleep all night. This week I have bumped up the carbs significantly and I have slept all the way through every night. If you google low carb and insomnia you will find that it is fairly common.

  3. Loulou

    Perhaps that is why my insomnia has been so bad recently. Only slept 4 hours last night. However, if I eat more than 20 grams carbs I immediately put on 1 or 2 lbs over night which is a no no for me,

  4. -> Continue reading
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