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Renal Tubular Acidosis

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Hemodynamic Consequences Of Severe Lactic Acidosis In Shock States: From Bench To Bedside

Hemodynamic consequences of severe lactic acidosis in shock states: from bench to bedside Kimmoun et al.; licensee BioMed Central.2015 The Erratum to this article has been published in Critical Care 2017 21:40 Lactic acidosis is a very common biological issue for shock patients. Experimental data clearly demonstrate that metabolic acidosis, including lactic acidosis, participates in the reduction of cardiac contractility and in the vascular hyporesponsiveness to vasopressors through various mechanisms. However, the contributions of each mechanism responsible for these deleterious effects have not been fully determined and their respective consequences on organ failure are still poorly defined, particularly in humans. Despite some convincing experimental data, no clinical trial has established the level at which pH becomes deleterious for hemodynamics. Consequently, the essential treatment for lactic acidosis in shock patients is to correct the cause. It is unknown, however, whether symptomatic pH correction is beneficial in shock patients. The latest Surviving Sepsis Campaign guidelines recommend against the use of buffer therapy with pH 7.15 and issue no recommendation for pH lev Continue reading >>

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Popular Questions

  1. nobodysfool

    Hello,
    I'm nearly 32 weeks and i have lots of complications-high risk beacuse of a previous emercency c section with ds1,low lying placenta,and now gestational diabetes.
    Saw the MW today and she found ketones in my urine sample.
    She asked if i was eating properly-i am albeit on a very strict diabetic diet-then she didnt mention it anymore.
    I have come home and started worrying.
    I'm not sure if the diabetes lack of food has caused the ketones or is it something else.
    Any ideas will be great.
    Many thanks

  2. nailpolish

    ketones arise in urine when you ahvent eaten ina while
    they are a result of the body breaking down fatty acids for energy

  3. SpringySunshine

    Going from A Level biology (I'm really not an expert!):
    Ketones come from breaking down fatty acids. Diabetics have their urine monitored for ketones as it can indicate that the diabetes is being poorly managed & the body is beginning to struggle.
    If I were you, until a medical professional says anything differently, I'd just make sure that I wasn't going hungry & that I stuck to the diabetic diet to the letter. If you're feeling okay within yourself (no nausea or tummy pain) & your midwife hasn't said anything specific, I wouldn't worry too much.
    Is she sending the urine off to microbiology to be checked or anything like that?

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