Pathophysiology Of Diabetic Ketoacidosis Ppt

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Diabetes Mellitus Ch. 49

Sort Leading cause of: End-stage renal disease, adult blindness and non traumatic lower limb amputations. Major contributing factors are heart disease and stroke. Adults with diabetes have heart disease death rates 2 to 4 times higher than adults without diabetes. The risk for stroke is also 2 to 4 times higher among people with diabetes. (ppt slide) Insulin Promotes glucose transport from bloodstream across cell membrane to cytoplasm of cell Decreases glucose in the bloodstream ↑ insulin after a meal Stimulates storage of glucose as glycogen in liver and muscle Inhibits gluconeogenesis Enhances fat deposition ↑ protein synthesis (ppt slides) Insulin dependent tissues Skeletal muscle and adipose tissue (other tissues [brain, liver, blood cells] do not directly depend on insulin for glucose transport) Although liver cells are not considered insulin-dependent tissue, insulin receptor sites on the liver facilitate the hepatic uptake of glucose and its conversion to glycogen. (ppt slide) Counterregulatory hormones -Oppose effects of insulin -Increase blood glucose levels -Provide regulated release of glucose for energy -Help maintain normal blood glucose levels -Examples: Glucagon, Continue reading >>

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