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Pathophysiology Of Diabetic Ketoacidosis

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Actrapid: Eight Steps For Managing Diabetic Ketoacidosis

Diabetic Ketoacidosis (DKA) is a potentially life threatening condition that occurs when excessive amounts of ketones are released into the bloodstream as a result of the body breaking down lipids, instead of utilising glucose as the energy source. This process is known as gluconeogenesis and occurs when the body does not have sufficient insulin to allow the uptake of glucose from the bloodstream into the cells. It is observed primarily in people with type one diabetes (insulin dependent), but it can occur in type two diabetes (non-insulin dependent) under certain circumstances. To understand the symptoms of DKA and therefore how to manage it effectively, it is important to understand the pathophysiology of hyperglycaemia which is explained in the flowchart below: The further down this flowchart the patient gets, the more serious their symptoms become. For this reason, there are varying degrees of severity with DKA: Mild pH 7.25 – 7.30, bicarbonate decreased to 15–18 mmol/L, the person is alert Moderate pH 7.00 – 7.25, bicarbonate 10–15 mmol/L, drowsiness may be present Severe pH below 7.00, bicarbonate below 10 mmol/L, stupor or coma may occur A.C.T.R.A.P.I.D. To remember Continue reading >>

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Popular Questions

  1. Masoodtokyo

    HBA1C and Thelasimia Minor

    Hi
    I was wondering if anyone knows how HBA1C is impacted by Thelasimia Minor. I have both and my HBA1c is comign in around 7.3 which is still too high. I was wondering if it can be elevated by the Thelasimia as I have more RBC's than normal.
    thanks

  2. Flynlobird

    I had to look up what that is and Im not a DR but A1C is your BG from the last 90 days not your blood protein. It could have an impact on how your blood has the glucose in it but Im not really sure. What does your DR say?
    Welcome to DD!

  3. Ken S

    People with thalassemia make less hemoglobin and fewer circulating red blood cells than normal, which results in mild or severe anemia.
    Any form of anemia can cause higher than normal A1Cs.

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