Partially Compensated Metabolic Acidosis Causes

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5.5 Metabolic Acidosis - Compensation

Acid-Base Physiology 5.5.1 Hyperventilation Compensation for a metabolic acidosis is hyperventilation to decrease the arterial pCO2. This hyperventilation was first described by Kussmaul in patients with diabetic ketoacidosis in 1874. The metabolic acidosis is detected by both the peripheral and central chemoreceptors and the respiratory center is stimulated. The initial stimulation of the central chemoreceptors is due to small increases in brain ISF [H+]. The subsequent increase in ventilation causes a fall in arterial pCO2 which inhibits the ventilatory response. Maximal compensation takes 12 to 24 hours The chemoreceptor inhibition acts to limit and delay the full ventilatory response until bicarbonate shifts have stabilised across the blood brain barrier. The increase in ventilation usually starts within minutes and is usually well advanced at 2 hours of onset but maximal compensation may take 12 to 24 hours to develop. This is �maximal� compensation rather than �full� compensation as it does not return the extracellular pH to normal. In situations where a metabolic acidosis develops rapidly and is short-lived there is usually little time for much compensatory ventilato Continue reading >>

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Popular Questions

  1. scatch25

    I'm curious because other than cooking everything in butter and adding cheese to everything, I seem to be having a hard time maintaining a 65% fat to 30% protein ratio. Is keto still effective if the ratio is closer to 50-50? I'm not a fan of heavy cream, which is a common way it seems of getting there.

  2. [deleted]

    it's not as effective, for most people. You need the fat to convince your body that fat is the way to go, if not, it will likely burn protein by turning it into glucose. When you run out of dietary protein, you will burn your muscles. That sucks. Man up and eat your butter.

  3. digital11

    This makes me happy.

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