diabetestalk.net

Metformin Overdose Antidote

Share on facebook

Metformin Overdosage

Metformin is a biguanide used to treat type 2 diabetes mellitus and most commonly prescribed oral hypoglycemic agent. Metformin is now also used to treat polycystic ovary syndrome and some malignancies. Despite a good safety profile in a majority of patients with diabetes, the risk of metformin-associated lactic acidosis is genuine when safety guidelines are ignored. Overdoses with metformin are rare, but may result in serious consequences. Case reports and small case series of serious toxicity from metformin overdosage can be found in the medical literature, often with the portrayal of extracorporeal methods for the management of the subsequent severe lactic acidosis. Lactic acidosis can defined as a metabolic acidosis with a blood pH less than 7.35 and a serum lactate more than 2 mmol per liter. It can occur either with therapeutic metformin dosing (which is rare) or in overdose situations. 0.03 cases of lactic acidosis per 1000 patient-years occur within therapeutic dosing, with a majority of these cases among patients that have contraindications to metformin (such as renal insufficiency). In overdose situations, lactic acidosis is seen much more habitually, even though the prec Continue reading >>

Share on facebook

Popular Questions

  1. mfuston39

    How much Metformin is too much? Can you overdose on Metformin?

    I am prescribed to 2.5 1000mg Metformin per day. However, that doesn't seem to be enough, because my blood sugar had been around 300 lately. I feel like I need to take 4 pills per day to keep it in check. Is that too much, and can you overdose on Metformin?

  2. AN

    Hello,
    I suggest you contact your Dr. or Pharmacist, do not self medicate as this can happen:
    What happens if I overdose?
    Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of metformin may cause lactic acidosis. Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.
    read more at: https://www.drugs.com/metformin.html
    Take care,
    maso.-
    Votes: +0 Comment Vote up Report

  3. AN

    I totally agree with masos answer. My hubby is diabetic & was also on metforim & glyberide, but because his glucose were too high he has had his meds changed by his doctor completely. You need to see your endoctrinologist about this. Do not self medicate...

  4. -> Continue reading
read more close

Related Articles

Popular Articles

More in ketosis