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Metformin Myocardial Infarction

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Acc: Metformin No Help In Mi Recovery

For best viewing, click the bottom right corner for full screen. Click here for more ACC 2014 video coverage. by Crystal Phend Crystal Phend, Senior Staff Writer, MedPage Today This article is a collaboration between MedPage Today and: WASHINGTON -- Metformin started soon after reperfusion in the acute setting didn't help cardiac function recover in non-diabetic heart attack patients, a trial showed. Left ventricular ejection fraction was no different with a 4-month course of the drug started immediately after percutaneous intervention for acute ST-segment myocardial infarction (STEMI) than with placebo (53% versus 55% of predicted, P=0.096). N-terminal pro-brain natriuretic peptide (NT-proBNP) as a marker of cardiac stress came out at an identical 167 ng/L in both groups at that point, Chris Lexis, MD, of University Medical Center Groningen, the Netherlands, and colleagues found. "The current results do not support use of metformin in this setting ," Lexis concluded here at the American College of Cardiology meeting and simultaneously online in the Journal of the American Medical Association. That wasn't surprising, Howard Weintraub, MD , of NYU Langone Medical Center in New York Continue reading >>

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Popular Questions

  1. timothyw

    Ketosis & BG

    Has anyone ever made a correlation between their blood sugar numbers and Ketosis? I imagine it would be different for everyone. seems to me that if the BG went down to x then you would switch into ketosis for fuel needs. Too high a BG and you wouldn't be in ketosis. Or am I off track here and it is purely the carb count that matters? I have read how atkins suggested increasing carbs each week to find the right level of carbs to maintain weight on his diet.
    Any ideas or thoughts?

  2. MarkM

    You can be in ketosis and have high blood sugar levels but low insulin levels. This what happens to T1s at onset, but it gets worse and there can be ketoacidosis. T2s, if they are insulin resistant and/or insulin deficient, can also be in ketosis and have above normal blood glucose levels.
    Normal people go in and out of ketosis every day. But for someone who has normal insulin production and insulin sensitivity, sustained ketosis would only occur if carb consumption dropped below what is needed to satisfy the normal daily glucose requirement. Some say this is 130 grams of carb a day. Low carbers will tell you it is a lot lower, based on their observations of ketone test results and eating patterns.
    That is my take on it anyway. And in answer to your question, no, I don't think there is a clear correlation there.

  3. Nicoletti

    I never gave it a thought. My concern is keeping blood sugar down.

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