Metformin Lactic Acidosis Mechanism

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Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes,[4][5] particularly in people who are overweight.[6] It is also used in the treatment of polycystic ovary syndrome.[4] Limited evidence suggests metformin may prevent the cardiovascular disease and cancer complications of diabetes.[7][8] It is not associated with weight gain.[8] It is taken by mouth.[4] Metformin is generally well tolerated.[9] Common side effects include diarrhea, nausea and abdominal pain.[4] It has a low risk of causing low blood sugar.[4] High blood lactic acid level is a concern if the medication is prescribed inappropriately and in overly large doses.[10] It should not be used in those with significant liver disease or kidney problems.[4] While no clear harm comes from use during pregnancy, insulin is generally preferred for gestational diabetes.[4][11] Metformin is in the biguanide class.[4] It works by decreasing glucose production by the liver and increasing the insulin sensitivity of body tissues.[4] Metformin was discovered in 1922.[12] French physician Jean Sterne began study in humans in the 1950s.[12] It was introduced as Continue reading >>

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Popular Questions

  1. melindotty

    I kept telling myself "It's okay that my weight has basically been the same since October. It's probably water & I'm still losing inches."
    Well, I just took my measurements 5 weeks after the last time I took them and they're the same. One or two went up, one or two went down.
    I've been keto since the beginning of July. I was losing weight steadily, stalling a bit, the usual. Down a total of 37 pounds... until I decided to stop counting calories. I've barely lost any weight since then- about 3 months- and I apparently haven't been losing inches either.
    I'm so upset and frustrated.
    I still have plenty to lose. 5'0 27 yr old female. Started at 241 and down to 204. Still firmly obese. Really annoyed. I don't really eat nuts. I guess I'm going to cut out my coffee? I dunno, but I'm pretty upset. :-/
    ETA: I still wake up hungry every day. I still feel the need to eat 3 meals a day though snacking is little or none. Everything I eat is fatty. I don't track anything, but I stay under 20g carbs.

    I really want to cry.

  2. larry


    Down a total of 37 pounds... until I decided to stop counting calories.

    Personally, I'm not an advocate of counting calories. But if that's what works for you, why don't you go back to that method?

  3. melindotty

    I know I might have to now, but I don't want to. I thought I was free from that.

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