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Metformin Is Poison

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Metformin Overdosage

Metformin is a biguanide used to treat type 2 diabetes mellitus and most commonly prescribed oral hypoglycemic agent. Metformin is now also used to treat polycystic ovary syndrome and some malignancies. Despite a good safety profile in a majority of patients with diabetes, the risk of metformin-associated lactic acidosis is genuine when safety guidelines are ignored. Overdoses with metformin are rare, but may result in serious consequences. Case reports and small case series of serious toxicity from metformin overdosage can be found in the medical literature, often with the portrayal of extracorporeal methods for the management of the subsequent severe lactic acidosis. Lactic acidosis can defined as a metabolic acidosis with a blood pH less than 7.35 and a serum lactate more than 2 mmol per liter. It can occur either with therapeutic metformin dosing (which is rare) or in overdose situations. 0.03 cases of lactic acidosis per 1000 patient-years occur within therapeutic dosing, with a majority of these cases among patients that have contraindications to metformin (such as renal insufficiency). In overdose situations, lactic acidosis is seen much more habitually, even though the prec Continue reading >>

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  1. Vita oldie

    I have been puzzling over this for some time.
    I read or understood after reading, that it is better to test at night (diabetics are a different case as they need to check for medical reasons but may be interested.)
    Most people seem to test in the morning and also people have suggested cutting the sticks in half as they are a little pricy! This being the case then when to use them is important.
    To me testing in the morning after no food overnight seems strange as the ketosis reading will be different to that at the end of the day-when food has been eaten!
    The evening reading will be a warning that you've over done it or "joy of joys" you are on plan!
    THE DAWN INSULIN SURGE is something every has as it the bodies way of preparing us for waking and rising.
    Insulin makes the cells use energy but what we want is to have the body use an alternative-our body fat and not our muscle mass!
    This MUST have an effect on Ketosis and for those only just in Ketosis the reading could be disappointing because the insulin has caused a shift in the readings.
    This is a second reason why evening is perhaps the answer.
    I don't know if this is correct but perhaps someone with an understanding of chemistry could tell me if my reasoning is correct or if not, then why not!
    I have too much time on my hands and I want the correct answer!

  2. Vita oldie

    Showing my age!
    Could't find this on the site so assumed I hadn't posted it properly now it is down twice!!!

  3. svenskamae

    Are you talking about the pricey strips that use blood to test for nutritional ketosis, rather than the urine ketostix? The Phinney and Volek book says that readings for ketosis level are lowest in the morning, so if you were "in ketosis" (reading 0.5 or higher) then, you would presumably be so throughout the day, unless you ate enough carbs to throw you out of ketosis. (Presumably your early morning ketosis reading is reflecting more or less how your body processed what you ate the preceding day). But I think you could pick any time that was convenient for you, so long as you always tested at that time of day. Hope this helps.

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